AP306A - Water soluble camptothecin derivatives. - Google Patents

Water soluble camptothecin derivatives. Download PDF

Info

Publication number
AP306A
AP306A APAP/P/1992/000439A AP9200439A AP306A AP 306 A AP306 A AP 306A AP 9200439 A AP9200439 A AP 9200439A AP 306 A AP306 A AP 306A
Authority
AP
ARIPO
Prior art keywords
compound
lower alkyl
camptothecin
formula
ethylenedioxy
Prior art date
Application number
APAP/P/1992/000439A
Other languages
English (en)
Other versions
AP9200439A0 (en
Inventor
Michael Joseph Luzzio
Jeffrey M Besterman
Michael Glenn Evans
Peter Leslie Myers
Original Assignee
Glaxo Wellcome Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc
Publication of AP9200439A0 publication Critical patent/AP9200439A0/xx
Application granted granted Critical
Publication of AP306A publication Critical patent/AP306A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
APAP/P/1992/000439A 1991-10-29 1992-10-28 Water soluble camptothecin derivatives. AP306A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78427591A 1991-10-29 1991-10-29
US82672992A 1992-01-28 1992-01-28

Publications (2)

Publication Number Publication Date
AP9200439A0 AP9200439A0 (en) 1992-10-31
AP306A true AP306A (en) 1994-01-28

Family

ID=27120258

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000439A AP306A (en) 1991-10-29 1992-10-28 Water soluble camptothecin derivatives.

Country Status (25)

Country Link
EP (1) EP0540099B1 (es)
JP (2) JP3020760B2 (es)
KR (1) KR100246154B1 (es)
CN (1) CN1072683A (es)
AP (1) AP306A (es)
AT (1) ATE136898T1 (es)
AU (1) AU657007B2 (es)
CA (1) CA2081580A1 (es)
CZ (1) CZ284023B6 (es)
DE (1) DE69209969T2 (es)
DK (1) DK0540099T3 (es)
ES (1) ES2086643T3 (es)
FI (3) FI982185A7 (es)
GR (1) GR3020120T3 (es)
HU (2) HU217970B (es)
IL (1) IL103571A (es)
IS (1) IS1708B (es)
MX (1) MX9206211A (es)
MY (1) MY108261A (es)
NO (1) NO302073B1 (es)
NZ (1) NZ244914A (es)
OA (1) OA09767A (es)
RU (1) RU2119921C1 (es)
SK (1) SK279298B6 (es)
TW (1) TW221994B (es)

Families Citing this family (46)

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US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
US6005537A (en) 1992-08-21 1999-12-21 Hitachi, Ltd. Liquid-crystal display control apparatus
AP9300587A0 (en) * 1992-11-12 1995-05-05 Glaxo Inc Water soluble camptothecin derivatives.
ES2114681T3 (es) * 1993-01-15 1998-06-01 Stehlin Foundation For Cancer Tratamiento transdermico de cancer con camptotecina insoluble en agua en la forma de anillo de lactona cerrado.
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents
IS4152A (is) * 1993-04-29 1994-10-30 Glaxo Inc. Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
NZ266094A (en) * 1993-05-03 1997-10-24 Smithkline Beecham Corp Quinolinone derivatives; compounds, pharmaceutical formulations
US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5491237A (en) * 1994-05-03 1996-02-13 Glaxo Wellcome Inc. Intermediates in pharmaceutical camptothecin preparation
IT1269862B (it) * 1994-05-30 1997-04-15 Indena Spa Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
KR960029336A (ko) 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
US5496952A (en) * 1995-02-07 1996-03-05 North Carolina State University Method of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs
US5670500A (en) * 1995-05-31 1997-09-23 Smithkline Beecham Corporation Water soluble camptothecin analogs
WO1997001539A1 (en) * 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. 4-acylamino(halogeno) alkyl-quinoline derivatives, their preparation and their use as melatonin agonists
SG50747A1 (en) * 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
WO1997019085A1 (en) * 1995-11-22 1997-05-29 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
EP0918774B9 (en) * 1996-06-27 2002-04-10 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
SG116433A1 (en) 1996-10-30 2005-11-28 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof.
US6559309B2 (en) 1996-11-01 2003-05-06 Osi Pharmaceuticals, Inc. Preparation of a camptothecin derivative by intramolecular cyclisation
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
US6046209A (en) * 1997-05-27 2000-04-04 Smithkline Beecham Corporation Water soluble camptothecin analogs
EP1233787B8 (fr) * 1999-11-09 2005-05-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Produit comprenant un inhibiteur de la transduction des signaux des proteines g heterotrimeriques en association avec un autre agent anti-cancereux pour une utilisation therapeutique dans le traitement du cancer
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
SK12242002A3 (sk) 2000-02-28 2003-02-04 Aventis Pharma S. A. Farmaceutické kombinácie obsahujúce camptotecin a pyrimidínový derivát na liečenie rakoviny
US6548488B2 (en) 2000-03-17 2003-04-15 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
US6545010B2 (en) 2000-03-17 2003-04-08 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
CA2426898A1 (en) 2000-10-27 2002-05-02 Aventis Pharma S.A. A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
TW200306314A (en) * 2002-04-16 2003-11-16 Tanabe Seiyaku Co Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation
ITRM20040240A1 (it) * 2004-05-13 2004-08-13 Ist Naz Stud Cura Dei Tumori Camptotecine coniugate in posizione 7 con antagonisti delle integrine.
WO2006069344A2 (en) 2004-12-22 2006-06-29 Rutgers, The State University Of New Jersey Controlled release hydrogels
WO2012050591A1 (en) 2010-10-15 2012-04-19 Rutgers, The State University Of New Jersey Hydrogel formulation for dermal and ocular delivery
CA2658015A1 (en) 2006-03-30 2007-10-11 Diatos S.A. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
CN101407524B (zh) * 2007-10-09 2012-07-18 江苏先声药物研究有限公司 噁嗪骈喜树碱衍生物及其制备方法和用途
CN100592871C (zh) * 2008-03-14 2010-03-03 浙江林学院 一种杀虫剂组合物及其加工方法
ES2373172B1 (es) * 2010-07-16 2012-12-10 Consejo Superior De Investigaciones Científicas (Csic) Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales.
US8980909B2 (en) 2011-01-12 2015-03-17 Crystal Biopharmaceutical Llc HDAC inhibiting derivatives of camptothecin
BR112020020466A2 (pt) * 2018-04-06 2021-01-12 Seattle Genetics, Inc. Conjugados de peptídeo de camptotecina
TW202519270A (zh) 2018-06-07 2025-05-16 美商思進公司 喜樹鹼結合物
CN110590796B (zh) * 2018-06-12 2022-07-15 青岛海洋生物医药研究院股份有限公司 喜树碱衍生物及其制备方法和应用
CN113766954B (zh) * 2019-04-26 2024-09-24 伊缪诺金公司 喜树碱衍生物
WO2023020605A1 (zh) * 2021-08-19 2023-02-23 江苏先声药业有限公司 喜树碱衍生物、其药物组合物及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells

Also Published As

Publication number Publication date
FI924878A0 (fi) 1992-10-28
IS3936A (is) 1993-04-30
EP0540099A1 (en) 1993-05-05
IL103571A0 (en) 1993-03-15
NO302073B1 (no) 1998-01-19
KR100246154B1 (ko) 2000-04-01
FI982185L (fi) 1998-10-08
HU217970B (hu) 2000-05-28
RU2119921C1 (ru) 1998-10-10
DE69209969T2 (de) 1996-09-12
NO924158D0 (no) 1992-10-28
CZ323792A3 (en) 1993-10-13
GR3020120T3 (en) 1996-08-31
FI20021090L (fi) 2002-06-07
HU9203384D0 (en) 1993-01-28
FI982185A0 (fi) 1998-10-08
HUT65719A (en) 1994-07-28
FI104373B (fi) 2000-01-14
FI20021090A7 (fi) 2002-06-07
NO924158L (no) 1993-04-30
SK323792A3 (en) 1998-09-09
JPH05222048A (ja) 1993-08-31
SK279298B6 (sk) 1998-09-09
EP0540099B1 (en) 1996-04-17
ES2086643T3 (es) 1996-07-01
AU2738592A (en) 1993-05-06
CN1072683A (zh) 1993-06-02
CZ284023B6 (cs) 1998-07-15
JP2000109475A (ja) 2000-04-18
CA2081580A1 (en) 1993-04-30
IL103571A (en) 1998-01-04
JP3229298B2 (ja) 2001-11-19
DK0540099T3 (da) 1996-06-17
OA09767A (en) 1993-11-30
AU657007B2 (en) 1995-02-23
FI982185A7 (fi) 1998-10-08
FI924878A7 (fi) 1993-04-30
HU211349A9 (en) 1995-11-28
MX9206211A (es) 1993-05-01
NZ244914A (en) 1995-01-27
DE69209969D1 (de) 1996-05-23
IS1708B (is) 1998-12-16
JP3020760B2 (ja) 2000-03-15
TW221994B (es) 1994-04-01
AP9200439A0 (en) 1992-10-31
ATE136898T1 (de) 1996-05-15
MY108261A (en) 1996-09-30

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