IT1269862B - Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono - Google Patents
Alcaloidi da mappia foetida, loro uso e formulazioni che li contengonoInfo
- Publication number
- IT1269862B IT1269862B ITMI941112A ITMI941112A IT1269862B IT 1269862 B IT1269862 B IT 1269862B IT MI941112 A ITMI941112 A IT MI941112A IT MI941112 A ITMI941112 A IT MI941112A IT 1269862 B IT1269862 B IT 1269862B
- Authority
- IT
- Italy
- Prior art keywords
- alkaloids
- water
- foetida
- map
- formulations containing
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 241000261227 Mappia foetida Species 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001212 derivatisation Methods 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G5/00—Alkaloids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invenzione ha per oggetto nuovi alcaloidi isolati da Mappia foetida, Foetidina 1 e 2, dotati di proprietà anticancro ed antivirale. Questi alcaloidi, solubili in acqua, presenti in tutte le parti della pianta, rappresentano precursori della camptotecina e della 9-metossi-camptotecina, alcaloidi ben noti per le loro proprietà farmacodinamiche ma anche per la loro insolubilità in acqua. La particolare solubilità in acqua dei nuovi composti li rende particolarmente adatti al trattamento dei pazienti per via parenterale senza la necessita di ricorrere all'uso di eccipienti tossici o a derivatizzazioni chimiche artificiose.
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941112A IT1269862B (it) | 1994-05-30 | 1994-05-30 | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
US08/273,510 US5525609A (en) | 1994-05-30 | 1994-07-11 | Alkaloids from Mappia foetida, the use thereof and formulations containing them |
FI943294A FI106202B (fi) | 1994-05-30 | 1994-07-11 | Menetelmä lääkeaineina käyttökelpoisten foetidiinien 1 ja 2 valmistamiseksi |
CA002127763A CA2127763C (en) | 1994-05-30 | 1994-07-11 | Alkaloids from mappia foetida, the use thereof and formulations containing them |
SK834-94A SK279615B6 (sk) | 1994-05-30 | 1994-07-12 | Alkaloidy z mappia foetida, spôsob ich výroby, ich |
DK94110864.9T DK0685481T3 (da) | 1994-05-30 | 1994-07-13 | Alkaloider fra mappia foetida, anvendelsen deraf og formuleringer indeholdende dem |
HU9402089A HU216844B (hu) | 1994-05-30 | 1994-07-13 | Mappia Foetidából származó alkaloidok, ezeket tartalmazó gyógyászati készítmények, és eljárás előállításukra |
EP94110864A EP0685481B1 (en) | 1994-05-30 | 1994-07-13 | Alkaloids from mappia foetida, the use thereof and formulations containing them |
DE0685481T DE685481T1 (de) | 1994-05-30 | 1994-07-13 | Alkaloide von Mappie foetida, deren Anwendung und diese enthaltende Zusammensetzungen. |
NO942633A NO179640C (no) | 1994-05-30 | 1994-07-13 | Alkaloider fra Mappia foetida, anvendelse derav og formuleringer inneholdende dem |
RU94026100A RU2123005C1 (ru) | 1994-05-30 | 1994-07-13 | Алкалоидные соединения, способ их получения, фармацевтическая композиция |
AT94110864T ATE159527T1 (de) | 1994-05-30 | 1994-07-13 | Alkaloide von mappie foetida, deren anwendung und diese enthaltende zusammensetzungen |
ES94110864T ES2081783T3 (es) | 1994-05-30 | 1994-07-13 | Alcaloides de mappia foetida, su uso y formulaciones que los contienen. |
DE69406430T DE69406430T2 (de) | 1994-05-30 | 1994-07-13 | Alkaloide von Mappie foetida, deren Anwendung und diese enthaltende Zusammensetzungen |
KR1019940016949A KR0149723B1 (ko) | 1994-05-30 | 1994-07-14 | 마피아 포에티다로부터의 알칼로이드, 이의 용도 및 이를 함유하는 제제 |
CZ19941718A CZ290320B6 (cs) | 1994-05-30 | 1994-07-15 | Alkaloidy z Mappia foetida, způsob jejich výroby, jejich pouľití k výrobě farmaceutických prostředků a farmaceutické prostředky s jejich obsahem |
JP17254294A JP3615240B2 (ja) | 1994-05-30 | 1994-07-25 | マピア・ホエチダからのアルカロイド及び抗ウイルス剤を含む製剤 |
CN94114908A CN1052233C (zh) | 1994-05-30 | 1994-07-30 | 从青脆枝中提取的生物碱及其应用和含该碱的组合物 |
PL94304577A PL177042B1 (pl) | 1994-05-30 | 1994-08-05 | Nowe alkaloidy i sposób ich wytwarzania oraz środek farmaceutyczny |
GR960300006T GR960300006T1 (en) | 1994-05-30 | 1996-02-29 | Alkaloids from mappia foetida, the use thereof and formulations containing them. |
GR970402650T GR3025120T3 (en) | 1994-05-30 | 1997-10-23 | Alkaloids from mappia foetida, the use thereof and formulations containing them. |
HK98102955A HK1003833A1 (en) | 1994-05-30 | 1998-04-08 | Alkaloids from mappia foetida the use thereof and formulations containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941112A IT1269862B (it) | 1994-05-30 | 1994-05-30 | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941112A0 ITMI941112A0 (it) | 1994-05-30 |
ITMI941112A1 ITMI941112A1 (it) | 1995-11-30 |
IT1269862B true IT1269862B (it) | 1997-04-15 |
Family
ID=11369016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941112A IT1269862B (it) | 1994-05-30 | 1994-05-30 | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
Country Status (20)
Country | Link |
---|---|
US (1) | US5525609A (it) |
EP (1) | EP0685481B1 (it) |
JP (1) | JP3615240B2 (it) |
KR (1) | KR0149723B1 (it) |
CN (1) | CN1052233C (it) |
AT (1) | ATE159527T1 (it) |
CA (1) | CA2127763C (it) |
CZ (1) | CZ290320B6 (it) |
DE (2) | DE69406430T2 (it) |
DK (1) | DK0685481T3 (it) |
ES (1) | ES2081783T3 (it) |
FI (1) | FI106202B (it) |
GR (2) | GR960300006T1 (it) |
HK (1) | HK1003833A1 (it) |
HU (1) | HU216844B (it) |
IT (1) | IT1269862B (it) |
NO (1) | NO179640C (it) |
PL (1) | PL177042B1 (it) |
RU (1) | RU2123005C1 (it) |
SK (1) | SK279615B6 (it) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
WO1996011005A2 (en) * | 1994-10-06 | 1996-04-18 | Atlas Leon T | Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases |
IT1283635B1 (it) * | 1996-05-10 | 1998-04-23 | Indena Spa | Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi |
FR2792937B1 (fr) | 1999-04-27 | 2001-08-10 | Cemaf | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
AUPQ987400A0 (en) * | 2000-09-04 | 2000-09-28 | Food Ingredients Technologies Intangibles (Bermuda) Limited | Process for selectively extracting bioactive components |
US20040058948A1 (en) * | 2002-03-01 | 2004-03-25 | Curran Dennis P. | Mappicine analogs, methods of inhibiting retroviral reverse transcriptase and methods of treating retroviruses |
US6893668B2 (en) * | 2003-03-31 | 2005-05-17 | Council Of Scientific And Industrial Research | Process for isolation of anticancer agent camptothecin from Nothapodytes foetida |
US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
CN103181272A (zh) * | 2011-12-28 | 2013-07-03 | 广东神农衍生物科技有限公司 | 一种药用原材料臭马比木的人工种植方法 |
CN104619322B (zh) * | 2013-07-24 | 2016-10-19 | 张苑金 | 抗癌药物组合物及其制备方法和用途 |
CN105053041A (zh) * | 2015-08-11 | 2015-11-18 | 长沙秋点兵信息科技有限公司 | 一种用于农作物的杀虫剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6461482A (en) * | 1987-08-31 | 1989-03-08 | Yakult Honsha Kk | Dehydrocamptothecin and production thereof |
EP0540099B1 (en) * | 1991-10-29 | 1996-04-17 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
EP0556585A3 (en) * | 1992-01-24 | 1993-09-01 | Takeda Chemical Industries, Ltd. | Condensed camptothecin derivatives their production and use as antitumor agents |
IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
-
1994
- 1994-05-30 IT ITMI941112A patent/IT1269862B/it active IP Right Grant
- 1994-07-11 US US08/273,510 patent/US5525609A/en not_active Expired - Fee Related
- 1994-07-11 FI FI943294A patent/FI106202B/fi not_active IP Right Cessation
- 1994-07-11 CA CA002127763A patent/CA2127763C/en not_active Expired - Fee Related
- 1994-07-12 SK SK834-94A patent/SK279615B6/sk unknown
- 1994-07-13 RU RU94026100A patent/RU2123005C1/ru not_active IP Right Cessation
- 1994-07-13 HU HU9402089A patent/HU216844B/hu not_active IP Right Cessation
- 1994-07-13 AT AT94110864T patent/ATE159527T1/de not_active IP Right Cessation
- 1994-07-13 ES ES94110864T patent/ES2081783T3/es not_active Expired - Lifetime
- 1994-07-13 NO NO942633A patent/NO179640C/no unknown
- 1994-07-13 DE DE69406430T patent/DE69406430T2/de not_active Expired - Fee Related
- 1994-07-13 EP EP94110864A patent/EP0685481B1/en not_active Expired - Lifetime
- 1994-07-13 DE DE0685481T patent/DE685481T1/de active Pending
- 1994-07-13 DK DK94110864.9T patent/DK0685481T3/da active
- 1994-07-14 KR KR1019940016949A patent/KR0149723B1/ko not_active IP Right Cessation
- 1994-07-15 CZ CZ19941718A patent/CZ290320B6/cs not_active IP Right Cessation
- 1994-07-25 JP JP17254294A patent/JP3615240B2/ja not_active Expired - Fee Related
- 1994-07-30 CN CN94114908A patent/CN1052233C/zh not_active Expired - Fee Related
- 1994-08-05 PL PL94304577A patent/PL177042B1/pl not_active IP Right Cessation
-
1996
- 1996-02-29 GR GR960300006T patent/GR960300006T1/el unknown
-
1997
- 1997-10-23 GR GR970402650T patent/GR3025120T3/el unknown
-
1998
- 1998-04-08 HK HK98102955A patent/HK1003833A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970529 |