IT1254517B - 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico - Google Patents
14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeuticoInfo
- Publication number
- IT1254517B IT1254517B ITMI920528A ITMI920528A IT1254517B IT 1254517 B IT1254517 B IT 1254517B IT MI920528 A ITMI920528 A IT MI920528A IT MI920528 A ITMI920528 A IT MI920528A IT 1254517 B IT1254517 B IT 1254517B
- Authority
- IT
- Italy
- Prior art keywords
- derivatives
- idrossi
- deacetil
- prepation
- beta
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Abstract
Vengono descritti l'isolamento di un nuovo tassano di interesse farmaceutico la 14-idrossi-10-deacetil-baccatina III, e la semisintesí di alcuni derivati utili come agenti antitumorali e intermedi.
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920528A IT1254517B (it) | 1992-03-06 | 1992-03-06 | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
US07/881,150 US5264591A (en) | 1992-03-06 | 1992-05-11 | Baccatine III derivatives |
DE69326369T DE69326369T2 (de) | 1992-03-06 | 1993-02-19 | 14-Beta-Hydroxy-10-Deacetyl-Baccatin-III und seine Derivate als Antitumormittel |
AT93102633T ATE184599T1 (de) | 1992-03-06 | 1993-02-19 | 14-beta-hydroxy-10-deacetyl-baccatin-iii und seine derivate als antitumormittel |
EP93102633A EP0559019B1 (en) | 1992-03-06 | 1993-02-19 | 14-beta-hydroxy-10-deacytyl-baccatine III and its derivatives as antitumour agents |
ES93102633T ES2136096T3 (es) | 1992-03-06 | 1993-02-19 | 14-beta-hidroxi-10-desacetil-baccatina iii y sus derivados como agentes antitumorales. |
DK93102633T DK0559019T3 (da) | 1992-03-06 | 1993-02-19 | 14-beta-hydroxy-10-deacetyl-baccatin III og derivater deraf som antitumormidler |
SK152-93A SK279257B6 (sk) | 1992-03-06 | 1993-03-02 | Deriváty baccatínu, spôsob ich výroby a farmaceuti |
NO930774A NO305080B1 (no) | 1992-03-06 | 1993-03-03 | Baccatin-III-derivater |
HU9300594A HU218665B (hu) | 1992-03-06 | 1993-03-04 | Bakkatin-III származékok, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és eljárás előállításukra |
FI930978A FI109904B (fi) | 1992-03-06 | 1993-03-04 | Menetelmä lääkeaineina käyttökelpoisten 14-b-hydroksi-10-asetyylibakkatiini-III:n ja sen johdannaisten valmistamiseksi |
CN93102326A CN1051082C (zh) | 1992-03-06 | 1993-03-04 | 浆果赤霉素iii的衍生物及其制备方法 |
PL93297940A PL171982B1 (pl) | 1992-03-06 | 1993-03-04 | Nowe pochodne bakatyny I I I PL PL PL PL PL PL |
KR1019930003213A KR100255525B1 (ko) | 1992-03-06 | 1993-03-04 | 바카틴 iii 유도체 |
JP5067336A JP2708346B2 (ja) | 1992-03-06 | 1993-03-04 | バッカチンiii誘導体、その製造方法及びそれを含有する抗腫瘍剤 |
CA002091001A CA2091001C (en) | 1992-03-06 | 1993-03-04 | Baccatine iii derivatives |
CZ93336A CZ284265B6 (cs) | 1992-03-06 | 1993-03-04 | Deriváty baccatinu III |
US08/094,969 US5453520A (en) | 1992-03-06 | 1993-07-22 | Baccatine III derivatives |
US08/467,739 US5698712A (en) | 1992-03-06 | 1995-06-06 | Baccatine III derivatives |
HU95P/P00594P HU211824A9 (en) | 1992-03-06 | 1995-06-29 | Baccatine iii derivatives |
HK98112886A HK1011686A1 (en) | 1992-03-06 | 1998-12-07 | 14-Beta-hydroxy-10-deacytyl-baccatine iii and its derivatives as antitumour agents |
GR990402378T GR3031280T3 (en) | 1992-03-06 | 1999-09-22 | 14-beta-hydroxy-10-deacytyl-baccatine III and its derivatives as antitumour agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI920528A IT1254517B (it) | 1992-03-06 | 1992-03-06 | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI920528A0 ITMI920528A0 (it) | 1992-03-06 |
ITMI920528A1 ITMI920528A1 (it) | 1993-09-06 |
IT1254517B true IT1254517B (it) | 1995-09-25 |
Family
ID=11362321
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI920528A IT1254517B (it) | 1992-03-06 | 1992-03-06 | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
Country Status (19)
Country | Link |
---|---|
US (2) | US5264591A (it) |
EP (1) | EP0559019B1 (it) |
JP (1) | JP2708346B2 (it) |
KR (1) | KR100255525B1 (it) |
CN (1) | CN1051082C (it) |
AT (1) | ATE184599T1 (it) |
CA (1) | CA2091001C (it) |
CZ (1) | CZ284265B6 (it) |
DE (1) | DE69326369T2 (it) |
DK (1) | DK0559019T3 (it) |
ES (1) | ES2136096T3 (it) |
FI (1) | FI109904B (it) |
GR (1) | GR3031280T3 (it) |
HK (1) | HK1011686A1 (it) |
HU (2) | HU218665B (it) |
IT (1) | IT1254517B (it) |
NO (1) | NO305080B1 (it) |
PL (1) | PL171982B1 (it) |
SK (1) | SK279257B6 (it) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5654447A (en) * | 1991-09-23 | 1997-08-05 | Florida State University | Process for the preparation of 10-desacetoxybaccatin III |
US5710287A (en) * | 1991-09-23 | 1998-01-20 | Florida State University | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
US5714513A (en) * | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
US6011056A (en) | 1991-09-23 | 2000-01-04 | Florida State University | C9 taxane derivatives and pharmaceutical compositions containing them |
US6335362B1 (en) | 1991-09-23 | 2002-01-01 | Florida State University | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them |
US5998656A (en) * | 1991-09-23 | 1999-12-07 | Florida State University | C10 tricyclic taxanes |
US6018073A (en) * | 1991-09-23 | 2000-01-25 | Florida State University | Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
US5739362A (en) * | 1991-09-23 | 1998-04-14 | Florida State University | Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
US6495704B1 (en) | 1991-09-23 | 2002-12-17 | Florida State University | 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes |
US5698712A (en) * | 1992-03-06 | 1997-12-16 | Indena S.P.A. | Baccatine III derivatives |
US5481007A (en) * | 1992-06-23 | 1996-01-02 | The Scripps Research Institute | Taxoid synthesis |
US5281727A (en) | 1992-11-27 | 1994-01-25 | Napro Biotherapeutics, Inc. | Method of using ion exchange media to increase taxane yields |
US5973160A (en) | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
US6710191B2 (en) * | 1993-03-05 | 2004-03-23 | Florida State University | 9β-hydroxytetracyclic taxanes |
ATE232854T1 (de) * | 1993-03-05 | 2003-03-15 | Univ Florida State | Verfahren zur herstellung von 9-desoxotaxanen |
US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
FR2711370B1 (fr) * | 1993-10-18 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
FR2714053B1 (fr) * | 1993-12-22 | 1996-03-08 | Pf Medicament | Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III. |
CN1112433A (zh) * | 1994-05-24 | 1995-11-29 | 郭明 | 红豆杉属植物提取物及其应用 |
IT1269862B (it) * | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
US5763477A (en) * | 1994-07-22 | 1998-06-09 | Dr. Reddy's Research Foundation | Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III |
FR2723094A1 (fr) * | 1994-07-26 | 1996-02-02 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
IT1275936B1 (it) * | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
FR2732341A1 (fr) * | 1995-03-27 | 1996-10-04 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
IT1275435B (it) * | 1995-05-19 | 1997-08-07 | Indena Spa | Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono |
EP0747372A1 (en) * | 1995-06-06 | 1996-12-11 | Dr. Reddy's Research Foundation | Taxane derivatives from 14-beta-hydroxy-10 deacetybaccatin III |
US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
WO1997044026A1 (en) * | 1996-05-22 | 1997-11-27 | Neuromedica, Inc. | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
US5750736A (en) * | 1996-07-11 | 1998-05-12 | Napro Biotherapeutics, Inc. | Method for acylating 10-deacetylbaccatin III selectively at the c-10 position |
US5856532A (en) * | 1996-08-14 | 1999-01-05 | Council Of Scientific & Industrial Research | Process for the production of taxol |
AU3740997A (en) * | 1996-08-26 | 1998-03-19 | Bristol-Myers Squibb Company | Sulfenamide taxane derivatives |
WO1998013359A1 (de) * | 1996-09-24 | 1998-04-02 | Marigen S.A. | Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen |
US5811452A (en) * | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
AU741143B2 (en) * | 1998-01-14 | 2001-11-22 | Bristol-Myers Squibb Company | Novel crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol |
US6002024A (en) * | 1998-07-27 | 1999-12-14 | Dabur Research Foundation | Process for the isolation of 14β-hydroxy-10-deacetyl baccatin-III |
US6124482A (en) * | 1998-07-27 | 2000-09-26 | Dabur Research Foundation | Process for isolation of 10-deacetyl baccatin-III |
US7235583B1 (en) * | 1999-03-09 | 2007-06-26 | Luitpold Pharmaceuticals, Inc., | Fatty acid-anticancer conjugates and uses thereof |
CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
HUP0302599A3 (en) * | 2000-09-22 | 2005-05-30 | Bristol Myers Squibb Co | Method for reducing toxicity of combined chemotherapic compositions |
EP1427407A4 (en) | 2001-03-23 | 2005-05-11 | Luitpold Pharm Inc | CONJUGATES BASED ON FATTY AMINES AND PHARMACEUTICAL AGENTS |
ATE556706T1 (de) * | 2001-03-23 | 2012-05-15 | Luitpold Pharm Inc | Fettalkohol-arzneimittel-konjugate |
ITMI20012186A1 (it) | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato |
ITMI20012185A1 (it) | 2001-10-19 | 2003-04-19 | Indena Spa | Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato |
ITMI20050614A1 (it) * | 2005-04-12 | 2006-10-13 | Indena Spa | Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii |
CN101517813B (zh) * | 2006-09-20 | 2011-05-25 | Lg化学株式会社 | 用于非水电解质的添加剂及使用该添加剂的二次电池 |
DK2080764T3 (da) | 2008-01-18 | 2012-09-24 | Indena Spa | Faste former af ortataxel |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
-
1992
- 1992-03-06 IT ITMI920528A patent/IT1254517B/it active
- 1992-05-11 US US07/881,150 patent/US5264591A/en not_active Expired - Lifetime
-
1993
- 1993-02-19 ES ES93102633T patent/ES2136096T3/es not_active Expired - Lifetime
- 1993-02-19 DE DE69326369T patent/DE69326369T2/de not_active Expired - Lifetime
- 1993-02-19 DK DK93102633T patent/DK0559019T3/da active
- 1993-02-19 EP EP93102633A patent/EP0559019B1/en not_active Expired - Lifetime
- 1993-02-19 AT AT93102633T patent/ATE184599T1/de active
- 1993-03-02 SK SK152-93A patent/SK279257B6/sk not_active IP Right Cessation
- 1993-03-03 NO NO930774A patent/NO305080B1/no not_active IP Right Cessation
- 1993-03-04 HU HU9300594A patent/HU218665B/hu not_active IP Right Cessation
- 1993-03-04 KR KR1019930003213A patent/KR100255525B1/ko not_active IP Right Cessation
- 1993-03-04 CN CN93102326A patent/CN1051082C/zh not_active Expired - Fee Related
- 1993-03-04 JP JP5067336A patent/JP2708346B2/ja not_active Expired - Lifetime
- 1993-03-04 FI FI930978A patent/FI109904B/fi not_active IP Right Cessation
- 1993-03-04 CA CA002091001A patent/CA2091001C/en not_active Expired - Lifetime
- 1993-03-04 PL PL93297940A patent/PL171982B1/pl not_active IP Right Cessation
- 1993-03-04 CZ CZ93336A patent/CZ284265B6/cs not_active IP Right Cessation
- 1993-07-22 US US08/094,969 patent/US5453520A/en not_active Expired - Lifetime
-
1995
- 1995-06-29 HU HU95P/P00594P patent/HU211824A9/hu unknown
-
1998
- 1998-12-07 HK HK98112886A patent/HK1011686A1/xx not_active IP Right Cessation
-
1999
- 1999-09-22 GR GR990402378T patent/GR3031280T3/el unknown
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