IT1275936B1 - Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni - Google Patents

Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni

Info

Publication number
IT1275936B1
IT1275936B1 IT95MI000533A ITMI950533A IT1275936B1 IT 1275936 B1 IT1275936 B1 IT 1275936B1 IT 95MI000533 A IT95MI000533 A IT 95MI000533A IT MI950533 A ITMI950533 A IT MI950533A IT 1275936 B1 IT1275936 B1 IT 1275936B1
Authority
IT
Italy
Prior art keywords
iii
deacetyl
derivatives
formulations
preparation
Prior art date
Application number
IT95MI000533A
Other languages
English (en)
Inventor
Ezio Bombardelli
Bellis Paolo De
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI950533A0 publication Critical patent/ITMI950533A0/it
Priority to IT95MI000533A priority Critical patent/IT1275936B1/it
Priority to US08/471,137 priority patent/US5750562A/en
Priority to CA002558908A priority patent/CA2558908C/en
Priority to CA002215682A priority patent/CA2215682C/en
Priority to KR10-2002-7014226A priority patent/KR100388877B1/ko
Priority to AU48320/96A priority patent/AU705923B2/en
Priority to CNB01137067XA priority patent/CN1176914C/zh
Priority to AT96904100T priority patent/ATE193286T1/de
Priority to ES96904100T priority patent/ES2146389T3/es
Priority to US08/913,861 priority patent/US5973163A/en
Priority to KR1019970706439A priority patent/KR100388878B1/ko
Priority to PT96904100T priority patent/PT815095E/pt
Priority to EP96904100A priority patent/EP0815095B1/en
Priority to DK96904100T priority patent/DK0815095T3/da
Priority to RU97117166/04A priority patent/RU2152936C1/ru
Priority to JP52801996A priority patent/JP4101289B2/ja
Priority to DE69608548T priority patent/DE69608548T2/de
Priority to CNB961926074A priority patent/CN100335470C/zh
Priority to PCT/EP1996/000904 priority patent/WO1996029321A1/en
Publication of ITMI950533A1 publication Critical patent/ITMI950533A1/it
Priority to NO19974266A priority patent/NO317056B1/no
Application granted granted Critical
Publication of IT1275936B1 publication Critical patent/IT1275936B1/it
Priority to HK98104095A priority patent/HK1005242A1/xx
Priority to GR20000401437T priority patent/GR3033742T3/el
Priority to JP2007049738A priority patent/JP2007137898A/ja
Priority to JP2010271599A priority patent/JP2011046744A/ja
Priority to JP2012091985A priority patent/JP2012140465A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT95MI000533A 1995-03-17 1995-03-17 Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni IT1275936B1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
IT95MI000533A IT1275936B1 (it) 1995-03-17 1995-03-17 Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US08/471,137 US5750562A (en) 1995-03-17 1995-06-06 10-deacetylbaccatine III and 10-deacetyl 14β-hydroxybaccatine III derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
EP96904100A EP0815095B1 (en) 1995-03-17 1996-03-04 10-deacetylbaccatine iii and 10-deacetyl 14 beta-hydroxybaccatine iii derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
JP52801996A JP4101289B2 (ja) 1995-03-17 1996-03-04 １０−デアセチルバッカチンＩＩＩおよび１０−デアセチル １４β−ヒドロキシバッカチンＩＩＩ誘導体類、それらの調製方法およびそれらを含む医薬製剤
KR10-2002-7014226A KR100388877B1 (ko) 1995-03-17 1996-03-04 10-데아세틸바카틴Ⅲ과10-데아세틸-14β-하이드록시바카틴Ⅲ 유도체, 그들의제조 방법 및 그들을 함유한 약제학적 조성물
AU48320/96A AU705923B2 (en) 1995-03-17 1996-03-04 10-deacetylbaccatine III and 10-deacetyl 14beta -hydroxybaccatine III derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
CNB01137067XA CN1176914C (zh) 1995-03-17 1996-03-04 制备10-脱乙酰浆果赤霉素Ⅲ和10-脱乙酰-14β-羟基浆果赤毒素Ⅲ衍生物的中间体
AT96904100T ATE193286T1 (de) 1995-03-17 1996-03-04 10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
ES96904100T ES2146389T3 (es) 1995-03-17 1996-03-04 Derivados de 10-desacetilbaccatina iii y 10-desacetil-14beta-hidroxibaccatina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
US08/913,861 US5973163A (en) 1995-03-17 1996-03-04 Oxazolidine carboxylic acid intermediates for esterification of taxanes
KR1019970706439A KR100388878B1 (ko) 1995-03-17 1996-03-04 10-데아세틸바카틴Ⅲ과10-데아세틸-14β-하이드록시바카틴Ⅲ유도체,그들의제조방법및그들을함유한약제학적조성물
PT96904100T PT815095E (pt) 1995-03-17 1996-03-04 Derivados de 10-desacetilbacatina iii e de 10-desacetil-14beta-hidroxibacatina iii processo para a sua preparacao e composicoes farmaceuticas que os contem
CA002558908A CA2558908C (en) 1995-03-17 1996-03-04 10-deacetylbaccatine iii and 10-deacetyl 14.beta.-hydroxybaccatine iii derivatives and intermediates useful in the preparation thereof
DK96904100T DK0815095T3 (da) 1995-03-17 1996-03-04 10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma
RU97117166/04A RU2152936C1 (ru) 1995-03-17 1996-03-04 ПРОИЗВОДНЫЕ 10-ДЕАЦЕТИЛБАККАТИНА III И 10-ДЕАЦЕТИЛ-14β-ГИДРОКСИБАККАТИНА III, СПОСОБ ИХ ПОЛУЧЕНИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
CA002215682A CA2215682C (en) 1995-03-17 1996-03-04 10-deacetylbaccatine iii and 10-deacetyl 14.beta.-hydroxybaccatine iii derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
DE69608548T DE69608548T2 (de) 1995-03-17 1996-03-04 10- deacetylbaccatin iii und 10- deacetyl 14 beta hydroxybaccatin iii derivaten, verfahren zu deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
CNB961926074A CN100335470C (zh) 1995-03-17 1996-03-04 10－脱乙酰浆果赤霉素Ⅲ和10－脱乙酰－14β－羟基浆果赤霉素Ⅲ衍生物、其制备方法以及含有它们的药物组合物
PCT/EP1996/000904 WO1996029321A1 (en) 1995-03-17 1996-03-04 10-DEACETYLBACCATINE III AND 10-DEACETYL 14β-HYDROXYBACCATINE III DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO19974266A NO317056B1 (no) 1995-03-17 1997-09-16 10-deacetylbaccatin III- og 10-deacetyl-14<beta>-hydroksybaccatin III-derivater, fremgangsmate ved deres fremstilling og farmasoytiske blandinger som inneholder dem
HK98104095A HK1005242A1 (en) 1995-03-17 1998-05-12 10-Deacetylbaccatine iii and 10-deacetyl 14 beta-hydroxybaccatine iii derivatives a process for the preparation thereof and pharmaceutical composition containing them
GR20000401437T GR3033742T3 (en) 1995-03-17 2000-06-22 10-DEACETYLBACCATINE III AND 10-DEACETYL 14-g(b)-HYDROXYBACCATINE III DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP2007049738A JP2007137898A (ja) 1995-03-17 2007-02-28 １０−デアセチルバッカチンＩＩＩおよび１０−デアセチル１４β−ヒドロキシバッカチンＩＩＩ誘導体類、それらの調製方法およびそれらを含む医薬製剤
JP2010271599A JP2011046744A (ja) 1995-03-17 2010-12-06 １０−デアセチルバッカチンＩＩＩおよび１０−デアセチル１４β−ヒドロキシバッカチンＩＩＩ誘導体類、それらの調製方法およびそれらを含む医薬製剤
JP2012091985A JP2012140465A (ja) 1995-03-17 2012-04-13 １０−デアセチルバッカチンＩＩＩおよび１０−デアセチル１４β−ヒドロキシバッカチンＩＩＩ誘導体類、それらの調製方法およびそれらを含む医薬製剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI000533A IT1275936B1 (it) 1995-03-17 1995-03-17 Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni

Publications (3)

Publication Number Publication Date
ITMI950533A0 ITMI950533A0 (it) 1995-03-17
ITMI950533A1 ITMI950533A1 (it) 1996-09-17
IT1275936B1 true IT1275936B1 (it) 1997-10-24

Family

ID=11370949

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI000533A IT1275936B1 (it) 1995-03-17 1995-03-17 Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni

Country Status (18)

Country Link
US (2) US5750562A (it)
EP (1) EP0815095B1 (it)
JP (4) JP4101289B2 (it)
KR (2) KR100388877B1 (it)
CN (2) CN1176914C (it)
AT (1) ATE193286T1 (it)
AU (1) AU705923B2 (it)
CA (1) CA2215682C (it)
DE (1) DE69608548T2 (it)
DK (1) DK0815095T3 (it)
ES (1) ES2146389T3 (it)
GR (1) GR3033742T3 (it)
HK (1) HK1005242A1 (it)
IT (1) IT1275936B1 (it)
NO (1) NO317056B1 (it)
PT (1) PT815095E (it)
RU (1) RU2152936C1 (it)
WO (1) WO1996029321A1 (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283633B1 (it) * 1996-05-10 1998-04-23 Indena Spa Derivati tassanici loro sintesi e formulazioni che li contengono
ITMI991483A1 (it) 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1318678B1 (it) * 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012185A1 (it) 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
EP1664033B1 (en) 2003-09-25 2007-11-07 Tapestry Pharmaceuticals, Inc. 9,10-alpha,alpha-oh-taxane analogs and methods for production the reof
US20070225510A1 (en) * 2006-03-27 2007-09-27 Henri John T Convergent Process for the Synthesis of Taxane Derivatives
WO2007143839A1 (en) * 2006-06-12 2007-12-21 6570763 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii
US7847111B2 (en) 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
NO302520B1 (no) * 1992-07-01 1998-03-16 Bristol Myers Squibb Co Fluortaxoler, mellomprodukt til fremstilling derav, samt farmasöytisk preparat inneholdende dem
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
CA2111527C (en) * 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
JPH09511212A (ja) * 1993-06-11 1997-11-11 ジ・アップジョン・カンパニー Δ▲上６▼，▲上７▼−タキソール類の抗悪性腫瘍的使用およびそれらを含む医薬組成物
IL109926A (en) * 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
FR2707293A1 (fr) * 1993-07-08 1995-01-13 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ITMI950533A0 (it) 1995-03-17
CA2215682A1 (en) 1996-09-26
EP0815095A1 (en) 1998-01-07
JP4101289B2 (ja) 2008-06-18
EP0815095B1 (en) 2000-05-24
CN1410421A (zh) 2003-04-16
NO974266D0 (no) 1997-09-16
DE69608548D1 (de) 2000-06-29
RU2152936C1 (ru) 2000-07-20
NO974266L (no) 1997-09-16
NO317056B1 (no) 2004-08-02
DK0815095T3 (da) 2000-08-07
ES2146389T3 (es) 2000-08-01
US5973163A (en) 1999-10-26
AU4832096A (en) 1996-10-08
JP2011046744A (ja) 2011-03-10
CN100335470C (zh) 2007-09-05
CN1176914C (zh) 2004-11-24
AU705923B2 (en) 1999-06-03
KR100388877B1 (ko) 2003-06-25
KR19980703031A (ko) 1998-09-05
CN1178528A (zh) 1998-04-08
HK1005242A1 (en) 1998-12-31
ATE193286T1 (de) 2000-06-15
JP2012140465A (ja) 2012-07-26
ITMI950533A1 (it) 1996-09-17
JP2007137898A (ja) 2007-06-07
CA2215682C (en) 2008-01-29
JPH11502206A (ja) 1999-02-23
GR3033742T3 (en) 2000-10-31
WO1996029321A1 (en) 1996-09-26
PT815095E (pt) 2000-09-29
KR100388878B1 (ko) 2003-10-04
DE69608548T2 (de) 2001-02-01
US5750562A (en) 1998-05-12

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0001 Granted