DK0815095T3 - 10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma - Google Patents

10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma

Info

Publication number
DK0815095T3
DK0815095T3 DK96904100T DK96904100T DK0815095T3 DK 0815095 T3 DK0815095 T3 DK 0815095T3 DK 96904100 T DK96904100 T DK 96904100T DK 96904100 T DK96904100 T DK 96904100T DK 0815095 T3 DK0815095 T3 DK 0815095T3
Authority
DK
Denmark
Prior art keywords
iii
deacetyl
14beta
pharmaceuticals
preparation
Prior art date
Application number
DK96904100T
Other languages
English (en)
Inventor
Ezio Bombardelli
Bellis Paolo De
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK0815095T3 publication Critical patent/DK0815095T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK96904100T 1995-03-17 1996-03-04 10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma DK0815095T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI000533A IT1275936B1 (it) 1995-03-17 1995-03-17 Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
PCT/EP1996/000904 WO1996029321A1 (en) 1995-03-17 1996-03-04 10-DEACETYLBACCATINE III AND 10-DEACETYL 14β-HYDROXYBACCATINE III DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
DK0815095T3 true DK0815095T3 (da) 2000-08-07

Family

ID=11370949

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96904100T DK0815095T3 (da) 1995-03-17 1996-03-04 10-deacetylbaccatin III- og 10-deacetyl-14beta-hydroxybaccatin III-derivater, fremgangsmåde til fremstilling deraf og farma

Country Status (18)

Country Link
US (2) US5750562A (da)
EP (1) EP0815095B1 (da)
JP (4) JP4101289B2 (da)
KR (2) KR100388877B1 (da)
CN (2) CN1176914C (da)
AT (1) ATE193286T1 (da)
AU (1) AU705923B2 (da)
CA (1) CA2215682C (da)
DE (1) DE69608548T2 (da)
DK (1) DK0815095T3 (da)
ES (1) ES2146389T3 (da)
GR (1) GR3033742T3 (da)
HK (1) HK1005242A1 (da)
IT (1) IT1275936B1 (da)
NO (1) NO317056B1 (da)
PT (1) PT815095E (da)
RU (1) RU2152936C1 (da)
WO (1) WO1996029321A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1283633B1 (it) * 1996-05-10 1998-04-23 Indena Spa Derivati tassanici loro sintesi e formulazioni che li contengono
ITMI991483A1 (it) 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1318678B1 (it) 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012185A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20021921A1 (it) * 2002-09-10 2004-03-11 Indena Spa Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.
AU2004275881A1 (en) 2003-09-25 2005-04-07 Tapestry Pharmaceuticals, Inc. 9,10-alpha,alpha-OH-taxane analogs and methods for production thereof
MX2008012424A (es) * 2006-03-27 2008-11-18 Tapestry Pharmaceuticals Inc Proceso convergente para la sintesis de derivados de taxanos.
US7847111B2 (en) 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
EP2029563A4 (en) * 2006-06-12 2009-12-02 Canada Inc 6570763 SEMI-SYNTHETIC PATHWAY FOR THE PREPARATION OF PACLITAXEL, DOCETAXEL AND 10-DEACETYLBACCATINE III FROM 9-DIHYDRO-13-ACETYLBACCATINE III
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
IT1254517B (it) * 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
DK0577082T3 (da) * 1992-07-01 1996-05-06 Bristol Myers Squibb Co Fluortaxoler med antitumor aktivitet
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
MX9308012A (es) * 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) * 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
US5965739A (en) * 1993-06-11 1999-10-12 Pharmacia & Upjohn Company Δ6,7 -taxols antineoplastic use and pharmaceutical compositions containing them
IL109926A (en) * 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
FR2707293A1 (fr) * 1993-07-08 1995-01-13 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ATE193286T1 (de) 2000-06-15
CA2215682C (en) 2008-01-29
US5750562A (en) 1998-05-12
KR19980703031A (ko) 1998-09-05
ES2146389T3 (es) 2000-08-01
AU705923B2 (en) 1999-06-03
JP2007137898A (ja) 2007-06-07
ITMI950533A1 (it) 1996-09-17
CN1410421A (zh) 2003-04-16
RU2152936C1 (ru) 2000-07-20
AU4832096A (en) 1996-10-08
PT815095E (pt) 2000-09-29
WO1996029321A1 (en) 1996-09-26
GR3033742T3 (en) 2000-10-31
KR100388878B1 (ko) 2003-10-04
NO974266D0 (no) 1997-09-16
JP2012140465A (ja) 2012-07-26
KR100388877B1 (ko) 2003-06-25
EP0815095A1 (en) 1998-01-07
CN1178528A (zh) 1998-04-08
IT1275936B1 (it) 1997-10-24
DE69608548D1 (de) 2000-06-29
US5973163A (en) 1999-10-26
HK1005242A1 (en) 1998-12-31
JP4101289B2 (ja) 2008-06-18
JPH11502206A (ja) 1999-02-23
NO317056B1 (no) 2004-08-02
ITMI950533A0 (it) 1995-03-17
CA2215682A1 (en) 1996-09-26
EP0815095B1 (en) 2000-05-24
NO974266L (no) 1997-09-16
DE69608548T2 (de) 2001-02-01
CN100335470C (zh) 2007-09-05
CN1176914C (zh) 2004-11-24
JP2011046744A (ja) 2011-03-10

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