ES2081783T1 - Alcaloides procedentes de mappia foetida, uso de estos y formulaciones que los contienen. - Google Patents
Alcaloides procedentes de mappia foetida, uso de estos y formulaciones que los contienen.Info
- Publication number
- ES2081783T1 ES2081783T1 ES94110864T ES94110864T ES2081783T1 ES 2081783 T1 ES2081783 T1 ES 2081783T1 ES 94110864 T ES94110864 T ES 94110864T ES 94110864 T ES94110864 T ES 94110864T ES 2081783 T1 ES2081783 T1 ES 2081783T1
- Authority
- ES
- Spain
- Prior art keywords
- alcaloids
- formulations containing
- water
- mappia
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000261227 Mappia foetida Species 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 241001326482 Foetidia Species 0.000 abstract 1
- 241000060384 Mappia Species 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G5/00—Alkaloids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A NUEVOS ALCALOIDES OBTENIDOS DE LA MAPPIA FOETIDIA, FOETIDINA 1 Y 2, QUE TIENE PROPIEDADES ANTICANCERIGENAS Y ANTIVIRALES. ESTOS ALCALOIDES, SOLUBLES EN AGUA, SE ENCUENTRAN PRESENTES EN TODAS LAS PARTES DE LA PLANTA Y SON LOS PRECURSORES DE LA CAMPTOTECINA Y DE LA 9-METOXICAMPTOTECINA QUE SON ALCALOIDES QUE SE SABE POSEEN PROPIEDADES FARMACODINAMICAS PERO QUE TAMBIEN SON INSOLUBLES EN AGUA. EL PARTICULAR SOLUBILIDAD EN AGUA DE LOS NUEVOS COMPUESTOS HACE QUE SEAN PARTICULARMENTE ADECUADOS PARA TRATAR A PACIENTES POR VIA PARENTERAL, CON LO QUE SE EVITA EL USO DE EXCIPIENTES TOXICOS O DE DERIVADOS QUIMICOS NO ADECUADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941112A IT1269862B (it) | 1994-05-30 | 1994-05-30 | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2081783T1 true ES2081783T1 (es) | 1996-03-16 |
ES2081783T3 ES2081783T3 (es) | 1997-12-16 |
Family
ID=11369016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94110864T Expired - Lifetime ES2081783T3 (es) | 1994-05-30 | 1994-07-13 | Alcaloides de mappia foetida, su uso y formulaciones que los contienen. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5525609A (es) |
EP (1) | EP0685481B1 (es) |
JP (1) | JP3615240B2 (es) |
KR (1) | KR0149723B1 (es) |
CN (1) | CN1052233C (es) |
AT (1) | ATE159527T1 (es) |
CA (1) | CA2127763C (es) |
CZ (1) | CZ290320B6 (es) |
DE (2) | DE685481T1 (es) |
DK (1) | DK0685481T3 (es) |
ES (1) | ES2081783T3 (es) |
FI (1) | FI106202B (es) |
GR (2) | GR960300006T1 (es) |
HK (1) | HK1003833A1 (es) |
HU (1) | HU216844B (es) |
IT (1) | IT1269862B (es) |
NO (1) | NO179640C (es) |
PL (1) | PL177042B1 (es) |
RU (1) | RU2123005C1 (es) |
SK (1) | SK279615B6 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
AU3684395A (en) * | 1994-10-06 | 1996-05-02 | Leon T. Atlas | Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases |
IT1283635B1 (it) * | 1996-05-10 | 1998-04-23 | Indena Spa | Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi |
FR2792937B1 (fr) | 1999-04-27 | 2001-08-10 | Cemaf | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
AUPQ987400A0 (en) * | 2000-09-04 | 2000-09-28 | Food Ingredients Technologies Intangibles (Bermuda) Limited | Process for selectively extracting bioactive components |
US20040058948A1 (en) * | 2002-03-01 | 2004-03-25 | Curran Dennis P. | Mappicine analogs, methods of inhibiting retroviral reverse transcriptase and methods of treating retroviruses |
US6893668B2 (en) * | 2003-03-31 | 2005-05-17 | Council Of Scientific And Industrial Research | Process for isolation of anticancer agent camptothecin from Nothapodytes foetida |
US20060135546A1 (en) * | 2004-12-16 | 2006-06-22 | Jagadevappa Basavaraja | Methods for the purification of 20(S)- camptothecin |
CN103181272A (zh) * | 2011-12-28 | 2013-07-03 | 广东神农衍生物科技有限公司 | 一种药用原材料臭马比木的人工种植方法 |
CN104619322B (zh) * | 2013-07-24 | 2016-10-19 | 张苑金 | 抗癌药物组合物及其制备方法和用途 |
CN105053041A (zh) * | 2015-08-11 | 2015-11-18 | 长沙秋点兵信息科技有限公司 | 一种用于农作物的杀虫剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6461482A (en) * | 1987-08-31 | 1989-03-08 | Yakult Honsha Kk | Dehydrocamptothecin and production thereof |
DE69209969T2 (de) * | 1991-10-29 | 1996-09-12 | Glaxo Wellcome Inc | Wasserlösliche Camptothecinderivate |
CA2087898A1 (en) * | 1992-01-24 | 1993-07-25 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
AP9300587A0 (en) * | 1992-11-12 | 1995-05-05 | Glaxo Inc | Water soluble camptothecin derivatives. |
US5352789A (en) * | 1993-02-25 | 1994-10-04 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
-
1994
- 1994-05-30 IT ITMI941112A patent/IT1269862B/it active IP Right Grant
- 1994-07-11 US US08/273,510 patent/US5525609A/en not_active Expired - Fee Related
- 1994-07-11 CA CA002127763A patent/CA2127763C/en not_active Expired - Fee Related
- 1994-07-11 FI FI943294A patent/FI106202B/fi not_active IP Right Cessation
- 1994-07-12 SK SK834-94A patent/SK279615B6/sk unknown
- 1994-07-13 ES ES94110864T patent/ES2081783T3/es not_active Expired - Lifetime
- 1994-07-13 NO NO942633A patent/NO179640C/no unknown
- 1994-07-13 DE DE0685481T patent/DE685481T1/de active Pending
- 1994-07-13 RU RU94026100A patent/RU2123005C1/ru not_active IP Right Cessation
- 1994-07-13 EP EP94110864A patent/EP0685481B1/en not_active Expired - Lifetime
- 1994-07-13 AT AT94110864T patent/ATE159527T1/de not_active IP Right Cessation
- 1994-07-13 DE DE69406430T patent/DE69406430T2/de not_active Expired - Fee Related
- 1994-07-13 DK DK94110864.9T patent/DK0685481T3/da active
- 1994-07-13 HU HU9402089A patent/HU216844B/hu not_active IP Right Cessation
- 1994-07-14 KR KR1019940016949A patent/KR0149723B1/ko not_active IP Right Cessation
- 1994-07-15 CZ CZ19941718A patent/CZ290320B6/cs not_active IP Right Cessation
- 1994-07-25 JP JP17254294A patent/JP3615240B2/ja not_active Expired - Fee Related
- 1994-07-30 CN CN94114908A patent/CN1052233C/zh not_active Expired - Fee Related
- 1994-08-05 PL PL94304577A patent/PL177042B1/pl not_active IP Right Cessation
-
1996
- 1996-02-29 GR GR960300006T patent/GR960300006T1/el unknown
-
1997
- 1997-10-23 GR GR970402650T patent/GR3025120T3/el unknown
-
1998
- 1998-04-08 HK HK98102955A patent/HK1003833A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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