JPS6461482A - Dehydrocamptothecin and production thereof - Google Patents

Dehydrocamptothecin and production thereof

Info

Publication number
JPS6461482A
JPS6461482A JP21536987A JP21536987A JPS6461482A JP S6461482 A JPS6461482 A JP S6461482A JP 21536987 A JP21536987 A JP 21536987A JP 21536987 A JP21536987 A JP 21536987A JP S6461482 A JPS6461482 A JP S6461482A
Authority
JP
Japan
Prior art keywords
aqueous solution
organic solvent
dehydrocamptothecin
production
feetide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP21536987A
Other languages
Japanese (ja)
Other versions
JPH0533955B2 (en
Inventor
Seigo Sawada
Ritsuo Aiyama
Hisako Nagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yakult Honsha Co Ltd
Original Assignee
Yakult Honsha Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Co Ltd filed Critical Yakult Honsha Co Ltd
Priority to JP21536987A priority Critical patent/JPS6461482A/en
Publication of JPS6461482A publication Critical patent/JPS6461482A/en
Publication of JPH0533955B2 publication Critical patent/JPH0533955B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by the formula. USE:A raw material for a carcinostatic agent or an intermediate therefor. PREPARATION:Stems, leaves, roots, etc. of Nothapodytes feetide are extracted with water, aqueous solution of an alkali (example; aqueous solution of sodium hydroxide) and/or organic solvent (example; acetone, chloroform, methanol). An essence thereof is then concentrated and precipitates formed during the process is collected by filtration and washed with an organic solvent such as alcohol or ethyl acetate.
JP21536987A 1987-08-31 1987-08-31 Dehydrocamptothecin and production thereof Granted JPS6461482A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP21536987A JPS6461482A (en) 1987-08-31 1987-08-31 Dehydrocamptothecin and production thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21536987A JPS6461482A (en) 1987-08-31 1987-08-31 Dehydrocamptothecin and production thereof

Publications (2)

Publication Number Publication Date
JPS6461482A true JPS6461482A (en) 1989-03-08
JPH0533955B2 JPH0533955B2 (en) 1993-05-20

Family

ID=16671153

Family Applications (1)

Application Number Title Priority Date Filing Date
JP21536987A Granted JPS6461482A (en) 1987-08-31 1987-08-31 Dehydrocamptothecin and production thereof

Country Status (1)

Country Link
JP (1) JPS6461482A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5525609A (en) * 1994-05-30 1996-06-11 Indena S.P.A. Alkaloids from Mappia foetida, the use thereof and formulations containing them
US5608066A (en) * 1993-02-25 1997-03-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US6218399B1 (en) 1996-01-30 2001-04-17 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6893668B2 (en) * 2003-03-31 2005-05-17 Council Of Scientific And Industrial Research Process for isolation of anticancer agent camptothecin from Nothapodytes foetida
WO2007126046A1 (en) 2006-04-27 2007-11-08 Kabushiki Kaisha Yakult Honsha Process for production of camptothecin derivative

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0576680U (en) * 1992-03-04 1993-10-19 千住金属工業株式会社 Preheater for automatic soldering equipment
CN100592871C (en) * 2008-03-14 2010-03-03 浙江林学院 Insecticide composition and its processing method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4832900A (en) * 1971-08-26 1973-05-02
JPS49117499A (en) * 1973-03-26 1974-11-09
JPS5198300A (en) * 1975-02-20 1976-08-30 Kanputoteshin oyobi sonoruijitaino seizoho
JPS62195384A (en) * 1986-02-24 1987-08-28 Yakult Honsha Co Ltd Novel camptothecin derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4832900A (en) * 1971-08-26 1973-05-02
JPS49117499A (en) * 1973-03-26 1974-11-09
JPS5198300A (en) * 1975-02-20 1976-08-30 Kanputoteshin oyobi sonoruijitaino seizoho
JPS62195384A (en) * 1986-02-24 1987-08-28 Yakult Honsha Co Ltd Novel camptothecin derivative

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5608066A (en) * 1993-02-25 1997-03-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US6107486A (en) * 1993-02-25 2000-08-22 The Stehlin Foundation For Cancer Research Method for purifying 20(S)-camptothecin
US5525609A (en) * 1994-05-30 1996-06-11 Indena S.P.A. Alkaloids from Mappia foetida, the use thereof and formulations containing them
US6218399B1 (en) 1996-01-30 2001-04-17 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6407239B1 (en) 1999-08-03 2002-06-18 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6893668B2 (en) * 2003-03-31 2005-05-17 Council Of Scientific And Industrial Research Process for isolation of anticancer agent camptothecin from Nothapodytes foetida
WO2007126046A1 (en) 2006-04-27 2007-11-08 Kabushiki Kaisha Yakult Honsha Process for production of camptothecin derivative
US8476438B2 (en) 2006-04-27 2013-07-02 Kabushiki Kaisha Yakult Honsha Process for production of camptothecin derivative
JP5238493B2 (en) * 2006-04-27 2013-07-17 株式会社ヤクルト本社 Method for producing camptothecin derivative

Also Published As

Publication number Publication date
JPH0533955B2 (en) 1993-05-20

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees