HUP0003429A1 - Kamptotecin optikailag tiszta analógjai, és az azokat tartalmazó gyógyszerkészítmények, optikailag tiszta szintetikus közbenső termékek és eljárás azok előállítására - Google Patents

Kamptotecin optikailag tiszta analógjai, és az azokat tartalmazó gyógyszerkészítmények, optikailag tiszta szintetikus közbenső termékek és eljárás azok előállítására

Info

Publication number
HUP0003429A1
HUP0003429A1 HU0003429A HUP0003429A HUP0003429A1 HU P0003429 A1 HUP0003429 A1 HU P0003429A1 HU 0003429 A HU0003429 A HU 0003429A HU P0003429 A HUP0003429 A HU P0003429A HU P0003429 A1 HUP0003429 A1 HU P0003429A1
Authority
HU
Hungary
Prior art keywords
optically pure
compositions containing
pharmaceutical compositions
preparing same
camptothecin analogues
Prior art date
Application number
HU0003429A
Other languages
English (en)
Inventor
Dennis Bigg
Jean-Bernard Cazaux
Olivier Lavergne
Christine Le Breton
Eric Manginot
Original Assignee
Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) filed Critical Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)
Publication of HUP0003429A1 publication Critical patent/HUP0003429A1/hu
Publication of HUP0003429A3 publication Critical patent/HUP0003429A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány új kamptotecin-analógokra és különösen a (+)-5-etil-9,10-difluor-5-hidroxi-4,5,13,15-tetrahidro-1H,3H-oxepino-[3',4':6,7]indolizino[1,2-b]kinolin-3,15-dionra, ilyen vegyületekettartalmazó gyógyászati kompozíciókra, a kamptotecin optikailag tisztaszintetikus közbenső termékeire, valamint a felsoroltak előállításárais vonatkozik. A találmány szerinti vegyületek gátló hatást fejtenekki a topoizomeráz I-re és II-re, és tumorellenes hatékonyságotmutatnak. Ó
HU0003429A 1997-08-29 1998-08-07 Optically pure camptothecin analogues and pharmaceutical compositions containing them, optically pure synthesis intermediates and method for preparing same HUP0003429A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710785A FR2768431B1 (fr) 1997-08-29 1997-08-29 Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation
PCT/FR1998/001768 WO1999011646A1 (fr) 1997-08-29 1998-08-07 Analogues optiquement purs de la camptothecine, intermediaire de synthese optiquement pur et son procede de preparation

Publications (2)

Publication Number Publication Date
HUP0003429A1 true HUP0003429A1 (hu) 2001-07-30
HUP0003429A3 HUP0003429A3 (en) 2002-11-28

Family

ID=9510590

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003429A HUP0003429A3 (en) 1997-08-29 1998-08-07 Optically pure camptothecin analogues and pharmaceutical compositions containing them, optically pure synthesis intermediates and method for preparing same

Country Status (26)

Country Link
EP (2) EP1007527B1 (hu)
JP (1) JP2001514261A (hu)
KR (1) KR100570254B1 (hu)
CN (3) CN1195758C (hu)
AR (1) AR016856A1 (hu)
AT (1) ATE253069T1 (hu)
AU (1) AU760863B2 (hu)
BR (1) BR9811405A (hu)
CA (1) CA2301739C (hu)
CZ (1) CZ297896B6 (hu)
DE (1) DE69819340T2 (hu)
DK (1) DK1007527T3 (hu)
ES (1) ES2209196T3 (hu)
FR (1) FR2768431B1 (hu)
HK (2) HK1031732A1 (hu)
HR (1) HRP20000110A2 (hu)
HU (1) HUP0003429A3 (hu)
IL (2) IL134437A0 (hu)
NO (1) NO324882B1 (hu)
NZ (1) NZ502862A (hu)
PL (1) PL195289B1 (hu)
PT (1) PT1007527E (hu)
RU (1) RU2233283C2 (hu)
TW (1) TW419479B (hu)
WO (1) WO1999011646A1 (hu)
ZA (1) ZA987445B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (fr) 1999-02-26 2004-09-10 Sod Conseils Rech Applic Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
CN100408582C (zh) * 2004-02-12 2008-08-06 中国人民解放军第二军医大学 高喜树碱类化合物及其制备方法和用途
CA2580747A1 (en) * 2004-09-21 2006-03-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R .A.S.) Novel processes for the production of useful intermediates
CN100465175C (zh) * 2005-11-29 2009-03-04 中国人民解放军第二军医大学 7-位取代高喜树碱类化合物及作为药物的用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459269A (en) * 1992-06-18 1995-10-17 North Carolina State University 14-halo-camptothecins
PT835258E (pt) * 1995-06-21 2003-02-28 Sod Conseils Rech Applic Novos analogos de camptotecina, processos para a sua preparacao, sua utilizacao como farmacos e composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
CZ297896B6 (cs) 2007-04-25
PL338835A1 (en) 2000-11-20
RU2233283C2 (ru) 2004-07-27
DE69819340T2 (de) 2004-08-19
HRP20000110A2 (en) 2001-02-28
NO20000995D0 (no) 2000-02-28
NO324882B1 (no) 2007-12-27
HK1031732A1 (en) 2001-06-22
IL134437A0 (en) 2001-04-30
ATE253069T1 (de) 2003-11-15
DK1007527T3 (da) 2004-03-08
JP2001514261A (ja) 2001-09-11
AU8989698A (en) 1999-03-22
FR2768431A1 (fr) 1999-03-19
HUP0003429A3 (en) 2002-11-28
EP1007527A1 (fr) 2000-06-14
CN1195758C (zh) 2005-04-06
AR016856A1 (es) 2001-08-01
CZ2000711A3 (cs) 2000-08-16
HK1058665A1 (en) 2004-05-28
DE69819340D1 (de) 2003-12-04
FR2768431B1 (fr) 2000-03-24
CA2301739A1 (fr) 1999-03-11
ZA987445B (en) 1999-02-17
NO20000995L (no) 2000-02-28
CA2301739C (fr) 2009-11-17
NZ502862A (en) 2002-10-25
CN1440973A (zh) 2003-09-10
KR100570254B1 (ko) 2006-04-12
PL195289B1 (pl) 2007-08-31
AU760863B2 (en) 2003-05-22
TW419479B (en) 2001-01-21
CN1440972A (zh) 2003-09-10
IL134437A (en) 2006-08-01
WO1999011646A1 (fr) 1999-03-11
BR9811405A (pt) 2000-08-29
ES2209196T3 (es) 2004-06-16
EP1007527B1 (fr) 2003-10-29
KR20010023394A (ko) 2001-03-26
CN1104434C (zh) 2003-04-02
EP1378512A1 (fr) 2004-01-07
PT1007527E (pt) 2004-03-31
CN1268948A (zh) 2000-10-04

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Owner name: IPSEN PHARMA S.A.S., FR

Free format text: FORMER OWNER(S): SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.), FR

FD9A Lapse of provisional protection due to non-payment of fees