CN1195758C - 喜树碱的光学纯类似物 - Google Patents
喜树碱的光学纯类似物 Download PDFInfo
- Publication number
- CN1195758C CN1195758C CNB031021662A CN03102166A CN1195758C CN 1195758 C CN1195758 C CN 1195758C CN B031021662 A CNB031021662 A CN B031021662A CN 03102166 A CN03102166 A CN 03102166A CN 1195758 C CN1195758 C CN 1195758C
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- acid
- ethyl
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
细胞系 | 实施例2 | 实施例3 |
SW620 | 5×10-9 | 3×10-8 |
OVCAR-5 | 8×10-9 | 4×10-8 |
PC-3 | 1×10-8 | 3×10-8 |
DU 145 | 1×10-9 | 7×10-9 |
NCI-H69 | 3×10-10 | 1×10-9 |
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9710785A FR2768431B1 (fr) | 1997-08-29 | 1997-08-29 | Nouveaux analogues optiquement purs de la camptothecine, nouvel intermediaire de synthese optiquement pur et son procede de preparation |
FR97/10785 | 1997-08-29 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98808720A Division CN1104434C (zh) | 1997-08-29 | 1998-08-07 | 喜树碱的光学纯类似物及其组合物和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1440973A CN1440973A (zh) | 2003-09-10 |
CN1195758C true CN1195758C (zh) | 2005-04-06 |
Family
ID=9510590
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98808720A Expired - Lifetime CN1104434C (zh) | 1997-08-29 | 1998-08-07 | 喜树碱的光学纯类似物及其组合物和用途 |
CNB031021662A Expired - Fee Related CN1195758C (zh) | 1997-08-29 | 1998-08-07 | 喜树碱的光学纯类似物 |
CN03102165A Pending CN1440972A (zh) | 1997-08-29 | 2003-02-08 | 喜树碱的光学纯合成中间体及其制备方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN98808720A Expired - Lifetime CN1104434C (zh) | 1997-08-29 | 1998-08-07 | 喜树碱的光学纯类似物及其组合物和用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN03102165A Pending CN1440972A (zh) | 1997-08-29 | 2003-02-08 | 喜树碱的光学纯合成中间体及其制备方法 |
Country Status (26)
Country | Link |
---|---|
EP (2) | EP1007527B1 (zh) |
JP (1) | JP2001514261A (zh) |
KR (1) | KR100570254B1 (zh) |
CN (3) | CN1104434C (zh) |
AR (1) | AR016856A1 (zh) |
AT (1) | ATE253069T1 (zh) |
AU (1) | AU760863B2 (zh) |
BR (1) | BR9811405A (zh) |
CA (1) | CA2301739C (zh) |
CZ (1) | CZ297896B6 (zh) |
DE (1) | DE69819340T2 (zh) |
DK (1) | DK1007527T3 (zh) |
ES (1) | ES2209196T3 (zh) |
FR (1) | FR2768431B1 (zh) |
HK (2) | HK1031732A1 (zh) |
HR (1) | HRP20000110A2 (zh) |
HU (1) | HUP0003429A3 (zh) |
IL (2) | IL134437A0 (zh) |
NO (1) | NO324882B1 (zh) |
NZ (1) | NZ502862A (zh) |
PL (1) | PL195289B1 (zh) |
PT (1) | PT1007527E (zh) |
RU (1) | RU2233283C2 (zh) |
TW (1) | TW419479B (zh) |
WO (1) | WO1999011646A1 (zh) |
ZA (1) | ZA987445B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2790261B1 (fr) | 1999-02-26 | 2004-09-10 | Sod Conseils Rech Applic | Nouveaux analogues optiquement purs de la camptothecine et leurs procedes de preparation |
US6207832B1 (en) | 1999-04-09 | 2001-03-27 | University Of Pittsburgh | Camptothecin analogs and methods of preparation thereof |
US6372906B1 (en) | 2001-04-12 | 2002-04-16 | University Of Pittsburgh | Synthesis of silyl camptothecins and silyl homocamptothecins |
US6723853B2 (en) | 2001-08-27 | 2004-04-20 | University Of Pittsburgh | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins |
CN100408582C (zh) * | 2004-02-12 | 2008-08-06 | 中国人民解放军第二军医大学 | 高喜树碱类化合物及其制备方法和用途 |
JP2008513437A (ja) * | 2004-09-21 | 2008-05-01 | ソシエテ ド コンセイユ ド ルシェルシェ エ ダアップリカーション シャンティフィック(エス.セー.エール.アー.エス.) | 有用な中間体の新規製造方法 |
CN100465175C (zh) * | 2005-11-29 | 2009-03-04 | 中国人民解放军第二军医大学 | 7-位取代高喜树碱类化合物及作为药物的用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5459269A (en) * | 1992-06-18 | 1995-10-17 | North Carolina State University | 14-halo-camptothecins |
EP1251125B1 (fr) * | 1995-06-21 | 2005-12-07 | Société de Conseils et de Recherches d'Applications Scientifiques (S.C.R.A.S.) | Nouveaux analogues de la camptoth-cine, des proc-d-s de pr-paration, leur application comme m-dicaments et les compositions pharmaceutiques les contenant |
-
1997
- 1997-08-29 FR FR9710785A patent/FR2768431B1/fr not_active Expired - Fee Related
-
1998
- 1998-08-07 CN CN98808720A patent/CN1104434C/zh not_active Expired - Lifetime
- 1998-08-07 CZ CZ20000711A patent/CZ297896B6/cs not_active IP Right Cessation
- 1998-08-07 PT PT98941567T patent/PT1007527E/pt unknown
- 1998-08-07 EP EP98941567A patent/EP1007527B1/fr not_active Expired - Lifetime
- 1998-08-07 DE DE69819340T patent/DE69819340T2/de not_active Expired - Lifetime
- 1998-08-07 JP JP2000508685A patent/JP2001514261A/ja active Pending
- 1998-08-07 CA CA002301739A patent/CA2301739C/fr not_active Expired - Fee Related
- 1998-08-07 EP EP03077049A patent/EP1378512A1/fr not_active Withdrawn
- 1998-08-07 AT AT98941567T patent/ATE253069T1/de active
- 1998-08-07 DK DK98941567T patent/DK1007527T3/da active
- 1998-08-07 IL IL13443798A patent/IL134437A0/xx active IP Right Grant
- 1998-08-07 RU RU2000107822/04A patent/RU2233283C2/ru not_active IP Right Cessation
- 1998-08-07 ES ES98941567T patent/ES2209196T3/es not_active Expired - Lifetime
- 1998-08-07 HU HU0003429A patent/HUP0003429A3/hu unknown
- 1998-08-07 PL PL98338835A patent/PL195289B1/pl not_active IP Right Cessation
- 1998-08-07 BR BR9811405-0A patent/BR9811405A/pt not_active Application Discontinuation
- 1998-08-07 WO PCT/FR1998/001768 patent/WO1999011646A1/fr active IP Right Grant
- 1998-08-07 AU AU89896/98A patent/AU760863B2/en not_active Ceased
- 1998-08-07 KR KR1020007002034A patent/KR100570254B1/ko not_active IP Right Cessation
- 1998-08-07 NZ NZ502862A patent/NZ502862A/xx unknown
- 1998-08-07 CN CNB031021662A patent/CN1195758C/zh not_active Expired - Fee Related
- 1998-08-18 ZA ZA987445A patent/ZA987445B/xx unknown
- 1998-08-19 TW TW087113646A patent/TW419479B/zh not_active IP Right Cessation
- 1998-08-21 AR ARP980104157A patent/AR016856A1/es active IP Right Grant
-
2000
- 2000-02-08 IL IL134437A patent/IL134437A/en not_active IP Right Cessation
- 2000-02-28 NO NO20000995A patent/NO324882B1/no not_active IP Right Cessation
- 2000-02-29 HR HR20000110A patent/HRP20000110A2/hr not_active Application Discontinuation
-
2001
- 2001-04-03 HK HK01102373A patent/HK1031732A1/xx not_active IP Right Cessation
-
2003
- 2003-02-08 CN CN03102165A patent/CN1440972A/zh active Pending
-
2004
- 2004-02-25 HK HK04101371A patent/HK1058665A1/xx not_active IP Right Cessation
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SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1058665 Country of ref document: HK |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: IPSEN MEDICINE CO.,LTD. Free format text: FORMER NAME: SOCIETE DE CONSEILS DE RECHERCHES ET D APPLICATIONS SCIENTIFIQUES S.A. |
|
CP03 | Change of name, title or address |
Address after: France Patentee after: Ipsen Pharma Address before: France Patentee before: SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) |
|
C56 | Change in the name or address of the patentee | ||
CP03 | Change of name, title or address |
Address after: The French city of Boulogne Billancourt 92650, Georges Plantagenet pier No. 65 Patentee after: Ipsen Pharma Address before: France Patentee before: Ipsen Pharma |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050406 Termination date: 20110807 |