ES2043515A1 - Procedimiento para la preparacion de nuevos derivados de 1-difenilmetilpiperazina. - Google Patents

Procedimiento para la preparacion de nuevos derivados de 1-difenilmetilpiperazina.

Info

Publication number
ES2043515A1
ES2043515A1 ES9101739A ES9101739A ES2043515A1 ES 2043515 A1 ES2043515 A1 ES 2043515A1 ES 9101739 A ES9101739 A ES 9101739A ES 9101739 A ES9101739 A ES 9101739A ES 2043515 A1 ES2043515 A1 ES 2043515A1
Authority
ES
Spain
Prior art keywords
general formula
preparation
compound
procedure
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES9101739A
Other languages
English (en)
Other versions
ES2043515B1 (es
Inventor
Altisent M Rosa Cuberes
Constansa Jordi Frigola
Corominas Juan Pares
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2043515A1 publication Critical patent/ES2043515A1/es
Application granted granted Critical
Publication of ES2043515B1 publication Critical patent/ES2043515B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE L-DIFENILMETILPERAZINA. UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE L-DIFENILMETIL PIPERAZINIL DE FORMULA GENERAL I, Y SUS SALES TERAPEUTICAMENTE ACEPTABLES CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA GENERAL IIA CON UN COMPUESTO DE FORMULA GENERAL III. OTRO PROCEDIMIENTO CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA GENERAL IIA, EN LA CUAL A REPRESENTA UN RADICAL NHSI2 SC, CON EL 2, 5-DIMETOXITETRAHIDROFURANO. LOS DERIVADOS OBTENIDOS SE UTILIZAN PARA LA FABRICACION DE MEDICAMENTOS DESTINADOS A LA PROFILAXIS Y AL TRATAMIENTO DE DIVERSAS ENFERMEDADES ALERGICAS PROVOCADAS POR LA HISTAMINA.
ES09101739A 1990-07-26 1991-07-25 Procedimiento para la preparacion de nuevos derivados de 1-difenilmetilpiperazina. Expired - Lifetime ES2043515B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9009562A FR2665160A1 (fr) 1990-07-26 1990-07-26 Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.

Publications (2)

Publication Number Publication Date
ES2043515A1 true ES2043515A1 (es) 1993-12-16
ES2043515B1 ES2043515B1 (es) 1994-06-16

Family

ID=9399130

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09101739A Expired - Lifetime ES2043515B1 (es) 1990-07-26 1991-07-25 Procedimiento para la preparacion de nuevos derivados de 1-difenilmetilpiperazina.

Country Status (17)

Country Link
US (1) US5166205A (es)
EP (1) EP0468885A1 (es)
JP (1) JPH04234359A (es)
KR (1) KR920002581A (es)
CN (1) CN1058397A (es)
AU (1) AU638856B2 (es)
CA (1) CA2047879A1 (es)
CS (1) CS235091A3 (es)
ES (1) ES2043515B1 (es)
FR (1) FR2665160A1 (es)
HU (1) HUT58319A (es)
MX (1) MX9100378A (es)
NO (1) NO912670L (es)
NZ (1) NZ239105A (es)
PL (1) PL291246A1 (es)
PT (1) PT98408A (es)
ZA (1) ZA915838B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2072627T3 (es) * 1990-10-10 1995-07-16 Schering Corp Derivados de piridina y n-oxido de piridina de diarilmetilpiperidinas o piperazinas, composiciones y uso de las mismas.
CA2132528C (en) * 1992-03-23 2004-06-08 Gerard Frans Maria Jan Cauwenbergh Agent for use as an anti-irritant
ATE140224T1 (de) * 1992-03-27 1996-07-15 Schering Corp Unverbrückte bis-aryl-carbinol-derivate, zusammensetzungen und ihre verwendung
GB9312806D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
US5741800A (en) * 1993-06-22 1998-04-21 Knoll Aktiengesellachaft Azolyl-cyclic amine derivates with immunomodulatory activity
JP3338913B2 (ja) * 1993-06-29 2002-10-28 大鵬薬品工業株式会社 テトラゾール誘導体
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines
EP1318996B1 (en) * 2000-09-20 2004-12-01 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377578A (en) * 1976-12-21 1983-03-22 Janssen Pharmaceutica, N.V. Piperazine derivatives
EP0254627A1 (fr) * 1986-07-10 1988-01-27 Société anonyme: LES LABORATOIRES MERAM Dérivés de la benzhydryloxyéthylpipérazine, procédés d'obtention et compositions pharmaceutiques les contenant
EP0307014A1 (en) * 1987-07-10 1989-03-15 Janssen Pharmaceutica N.V. Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR58146E (fr) * 1948-05-03 1953-09-21 Dispositif pour le soutènement des mines, et en particulier des galeries
GB1184714A (en) * 1965-12-16 1970-03-18 Science Union & Cie Di- and Tri-Phenylpropyl Piperazine Derivatives
US3491098A (en) * 1967-05-29 1970-01-20 Sterling Drug Inc 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
US4338453A (en) * 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
US5043447A (en) * 1987-04-24 1991-08-27 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
JPH02124871A (ja) * 1988-07-27 1990-05-14 Dainippon Pharmaceut Co Ltd １位が置換された複素環式カルボン酸アミド誘導体
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377578A (en) * 1976-12-21 1983-03-22 Janssen Pharmaceutica, N.V. Piperazine derivatives
EP0254627A1 (fr) * 1986-07-10 1988-01-27 Société anonyme: LES LABORATOIRES MERAM Dérivés de la benzhydryloxyéthylpipérazine, procédés d'obtention et compositions pharmaceutiques les contenant
EP0307014A1 (en) * 1987-07-10 1989-03-15 Janssen Pharmaceutica N.V. Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BULL. SOC. CHIM. BELG., Vol. 60, 1951, pp. 282-295; H. MORREN, S. TROLIN, R.DENAYER, E. GRIVSKY & J. MARICQ: "Nouvelles substances antihistaminiques ß action prolongÚe: les 1-4 bis (aralcoyl) piperazines". * Pßg. 282-288 * *

Also Published As

Publication number Publication date
NZ239105A (en) 1993-09-27
CA2047879A1 (fr) 1992-01-27
HU912517D0 (en) 1992-01-28
MX9100378A (es) 1992-02-28
JPH04234359A (ja) 1992-08-24
ZA915838B (en) 1992-04-29
HUT58319A (en) 1992-02-28
US5166205A (en) 1992-11-24
AU638856B2 (en) 1993-07-08
PT98408A (pt) 1992-06-30
CS235091A3 (en) 1992-05-13
FR2665160A1 (fr) 1992-01-31
CN1058397A (zh) 1992-02-05
PL291246A1 (en) 1992-03-09
KR920002581A (ko) 1992-02-28
EP0468885A1 (fr) 1992-01-29
AU8127991A (en) 1992-02-06
NO912670D0 (no) 1991-07-08
NO912670L (no) 1992-01-27
ES2043515B1 (es) 1994-06-16

Similar Documents

Publication Publication Date Title
ES2038074A1 (es) Nuevos derivados de benzimidazol, su preparacion y su aplicacion como medicamentos.
AU7815791A (en) Heterocyclene derivatives
DK142987A (da) Hidtil ukendte vitamin d-analoger
ATE102930T1 (de) Heterozyklische verbindungen, deren herstellung und medikamente diese enthaltend.
DK0587088T3 (da) Substituerede cyclohexan-derivater, fremgangsmåde til deres fremstilling og anvendelsen af forbindelserne til behandling af sygdomme
DE59200277D1 (de) Substituierte Diaminophthalimide und Analoga.
DE69413118D1 (de) Benzolsulfonamid-Derivate zur Behandlung der Blaseninstabilität
ES2043515A1 (es) Procedimiento para la preparacion de nuevos derivados de 1-difenilmetilpiperazina.
ES2116612T3 (es) Nuevas bis-naftalimidas para el tratamiento del cancer.
DK102892A (da) Purin-derivater, farmaceutisk praeparat omfattende forbindelserne samt forbindelser til brug som mellemprodukter
SE7411243L (es)
DE69132578D1 (de) Cephemderivate
ES2073919T3 (es) Derivados de piperidina 1,3,4-trisubstituidos, su obtencion y empleo.
ATE36957T1 (de) N,n-diethyl-5-methyl-2h,1-benzothiopyrano-(4,3, - cd)-indazol-2-ethanamine, diese enthaltende zubereitungen und ihre verwendung.
MX9205408A (es) Metodo para tratar hipertension.
FR2448544A1 (fr) Derives de thiazole et leur application en therapeutique
ES8500925A1 (es) "procedimiento para la preparacion de n-(2-(((5-(dimetilamino)-metil-2-furanil) metil) tio) etil) -n'- metil-2-nitro 1,1-etenodiamina"
ES475428A1 (es) Procedimiento para la obtencion de compuestos heterociclicos
DK0622372T3 (da) Hidtil ukendt forbindelse, Leustroducsin H, dens fremstilling og dens terapeutiske anvendelse
IT1245631B (it) Impiego di composti macrolidi come agenti anti-infiammatori per il trattamento di malattie provocate da cessione di istamina
DK0580624T3 (da) Hidtil ukendte cytarabinderivater, fremstilling og anvendelse deraf

Legal Events

Date Code Title Description
FA2A Application withdrawn

Effective date: 19940520