DK142987A - Hidtil ukendte vitamin d-analoger - Google Patents

Hidtil ukendte vitamin d-analoger

Info

Publication number
DK142987A
DK142987A DK142987A DK142987A DK142987A DK 142987 A DK142987 A DK 142987A DK 142987 A DK142987 A DK 142987A DK 142987 A DK142987 A DK 142987A DK 142987 A DK142987 A DK 142987A
Authority
DK
Denmark
Prior art keywords
lower alkyl
hydroxyl
halogen
denotes hydrogen
optionally substituted
Prior art date
Application number
DK142987A
Other languages
English (en)
Other versions
DK142987D0 (da
DK166617B1 (da
Inventor
Martin John Calverley
Ernst Torndal Binderup
Original Assignee
Leo Pharm Prod Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26289597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK142987(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB858519502A external-priority patent/GB8519502D0/en
Application filed by Leo Pharm Prod Ltd filed Critical Leo Pharm Prod Ltd
Publication of DK142987A publication Critical patent/DK142987A/da
Publication of DK142987D0 publication Critical patent/DK142987D0/da
Application granted granted Critical
Publication of DK166617B1 publication Critical patent/DK166617B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK142987A 1985-08-02 1987-03-20 24-hydroxylerede d-vitamin-derivater og farmaceutiske praeparater indeholdende disse DK166617B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB858519502A GB8519502D0 (en) 1985-08-02 1985-08-02 Chemical compounds
GB8519502 1985-08-02
DK8600081 1986-07-14
PCT/DK1986/000081 WO1987000834A1 (en) 1985-08-02 1986-07-14 Novel vitamin d analogues
PH34061A PH25496A (en) 1985-08-02 1986-08-11 New vitamin d analogues
PH3406186 1986-08-11

Publications (3)

Publication Number Publication Date
DK142987A true DK142987A (da) 1987-03-20
DK142987D0 DK142987D0 (da) 1987-03-20
DK166617B1 DK166617B1 (da) 1993-06-21

Family

ID=26289597

Family Applications (1)

Application Number Title Priority Date Filing Date
DK142987A DK166617B1 (da) 1985-08-02 1987-03-20 24-hydroxylerede d-vitamin-derivater og farmaceutiske praeparater indeholdende disse

Country Status (16)

Country Link
US (1) US4866048A (da)
EP (1) EP0227826B1 (da)
JP (1) JPH07100685B2 (da)
KR (1) KR940010767B1 (da)
AU (1) AU603340B2 (da)
CA (1) CA1307288C (da)
DE (1) DE3666587D1 (da)
DK (1) DK166617B1 (da)
ES (1) ES2000823A6 (da)
GR (1) GR862029B (da)
HK (1) HK63492A (da)
IE (1) IE58545B1 (da)
PH (1) PH25496A (da)
PT (1) PT83119B (da)
SG (1) SG64192G (da)
WO (1) WO1987000834A1 (da)

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* Cited by examiner, † Cited by third party
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GB9015774D0 (en) * 1990-07-18 1990-09-05 Leo Pharm Prod Ltd Novel treatment
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US5763428A (en) * 1990-09-21 1998-06-09 Bone Care International, Inc. Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof
US6025346A (en) * 1990-09-21 2000-02-15 Bone Care International, Inc. 1α-hydroxy vitamin D4 and novel intermediates and analogues
US5798345A (en) * 1990-09-21 1998-08-25 Bone Care International, Inc. Method of inhibiting the hyperproliferation of malignant cells
WO1992005130A1 (en) * 1990-09-21 1992-04-02 Lunar Corporation NOVEL 1α-HYDROXY VITAMIN D4 AND NOVEL INTERMEDIATES AND ANALOGUES
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US6166000A (en) * 1991-01-08 2000-12-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-Dihydroxy vitamin . D.sub2
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ES2093180T3 (es) * 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.
US5225569A (en) * 1991-08-09 1993-07-06 Hoffmann-La Roche Inc. Process for precursors to calcitriol and related compounds
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US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
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US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US20030129194A1 (en) * 1997-02-13 2003-07-10 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
PL336231A1 (en) 1997-02-13 2000-06-19 Bone Care International System for aimed therapeutic delivery of vitamin d compounds
DE19744127B4 (de) 1997-10-01 2006-10-05 Schering Ag Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln
AU743582B2 (en) 1997-12-09 2002-01-31 Chugai Seiyaku Kabushiki Kaisha Lotions containing vitamin D3 derivatives
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US20010002396A1 (en) * 1998-07-16 2001-05-31 Charles Achkar Compositions and methods of treating skin conditions
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
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US6962891B2 (en) 2001-08-27 2005-11-08 The Research Foundation Of State University Of New York Solid support dirhodium catalyst compositions and methods for making and using same
US7030051B2 (en) 2001-08-27 2006-04-18 The Research Foundation Of State University Of New York Dirhodium catalyst compositions and methods for using same
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KR20050044655A (ko) * 2001-12-03 2005-05-12 노바세아, 인크. 활성 비타민 ｄ 화합물을 함유하는 약제학적 조성물
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TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
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US7205420B2 (en) * 2002-06-13 2007-04-17 Teva Pharmaceutical Industries Ltd. Epimerization of analogs of vitamin D
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EP1458678A1 (en) * 2002-11-18 2004-09-22 Teva Pharmaceutical Industries Limited A crystallization method for purification of calcipotriene
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US20050153941A1 (en) * 2003-06-27 2005-07-14 Tomoyuki Miyabayashi Cell differntiation inhibiting agent, cell culture method using the same, culture medium, and cultured cell line
PL1656372T3 (pl) 2003-07-30 2013-08-30 Rigel Pharmaceuticals Inc Związki 2,4-pirymidynodiaminy do stosowania w leczeniu lub zapobieganiu chorobom autoimmunologicznym
US7205006B2 (en) * 2003-09-25 2007-04-17 Prime Pharmaceutical Corporation Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
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DE05715124T1 (de) * 2004-04-02 2008-02-21 Leo Pharma A/S Neues verfahren zur herstellung von für die synthese von vitamin-d-analoga geeigneten zwischenprodukten
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
TWI318203B (en) * 2004-09-01 2009-12-11 Leo Pharma As Epimerization of allylic alcohols
AU2005303773A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin D derivatives and anti-proliferative agents for treating bladder cancer
JP2006204292A (ja) * 2004-12-27 2006-08-10 Asahi Kasei Corp ヒト胚性幹細胞分化抑制剤
AU2006245282A1 (en) * 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for skin care
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US7816536B2 (en) * 2005-06-10 2010-10-19 The Research Foundation Of State University Of New York 4-substituted and 7-substituted indoles, benzofurans, benzothiophenes, benzimidazoles, benzoxazoles, and benzothiazoles and methods for making same
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KR20090060306A (ko) 2006-08-25 2009-06-11 코우가 바이오테크놀로지, 인크. 비타민 ｄ 화합물 및 추가 치료제, 및 그를 함유하는 조성물을 투여하는 것을 포함하는, 암을 치료하는 방법
BRPI0715636A2 (pt) * 2006-08-29 2013-07-02 Teva Pharma composiÇÕes farmacologicamente ativas estÁveis incluindo compostos contendo vitamina d e corticosteràide com compatibilidade para ph baixo
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US8716334B2 (en) * 2008-06-17 2014-05-06 Ben Gurion University Of The Negev Research And Development Authority Substituted cyclohexylidene-ethylidene-octahydro-indene compounds
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CN103508999B (zh) 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途
CN103694156B (zh) * 2014-01-07 2015-09-02 成都医路康医学技术服务有限公司 一种银屑病治疗药物钙泊三醇的制备方法
CN105348164B (zh) * 2015-10-29 2017-03-29 无锡福祈制药有限公司 一种1α‑羟基维生素D2的制备方法
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury
CN107501150A (zh) * 2016-06-14 2017-12-22 江苏吉贝尔药业股份有限公司 两种他卡西醇中间体的制备方法
UA124972C2 (uk) 2016-07-29 2021-12-22 Янссен Фармацевтика Нв Способи лікування раку передміхурової залози
CN110156836A (zh) * 2019-06-10 2019-08-23 成家钢 一种环丙基羰基亚甲基三苯基磷的制备方法
CN111662221B (zh) * 2020-06-29 2022-04-19 重庆华邦胜凯制药有限公司 一种卡泊三醇杂质的制备方法
CN115177586A (zh) * 2022-08-31 2022-10-14 江苏知原药业股份有限公司 一种卡泊三醇组合物

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US4728643A (en) * 1984-11-02 1988-03-01 The General Hospital Corporation Method of treating psoriasis
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Also Published As

Publication number Publication date
HK63492A (en) 1992-08-28
US4866048A (en) 1989-09-12
AU6196186A (en) 1987-03-05
IE58545B1 (en) 1993-10-06
GR862029B (en) 1986-12-24
WO1987000834A1 (en) 1987-02-12
PT83119B (pt) 1989-03-30
DK142987D0 (da) 1987-03-20
ES2000823A6 (es) 1988-03-16
JPH07100685B2 (ja) 1995-11-01
DE3666587D1 (en) 1989-11-30
KR940010767B1 (ko) 1994-11-11
DK166617B1 (da) 1993-06-21
KR870700600A (ko) 1987-12-30
EP0227826B1 (en) 1989-10-25
PH25496A (en) 1991-07-24
EP0227826A1 (en) 1987-07-08
AU603340B2 (en) 1990-11-15
IE861894L (en) 1987-02-02
SG64192G (en) 1992-09-04
JPS63500661A (ja) 1988-03-10
CA1307288C (en) 1992-09-08
PT83119A (en) 1986-09-01

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