ES2055521T3 - Derivados de vitamina d que son homologos en la cadena lateral, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos. - Google Patents
Derivados de vitamina d que son homologos en la cadena lateral, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos.Info
- Publication number
- ES2055521T3 ES2055521T3 ES91250032T ES91250032T ES2055521T3 ES 2055521 T3 ES2055521 T3 ES 2055521T3 ES 91250032 T ES91250032 T ES 91250032T ES 91250032 T ES91250032 T ES 91250032T ES 2055521 T3 ES2055521 T3 ES 2055521T3
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- bond
- pharmaceutical preparations
- vitamin
- medicines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE DESCRIBEN NUEVOS DERIVADOS DE VITAMINA D DE CADENAS LATERALES HOMOLOGAS DE LA FORMULA (I) EN DONDE R ELEVADO 1, R ELEVADO 2, R ELEVADO 3 R, ELEVADO 4, R ELEVADO 5, Y R ELEVADO 6 TIENEN EL SIGNIFICADO INDICADO EN LA DESCRIPCION, B Y D FORMAN UN ATOMO DE HIDROGENO CADA UNO O UNA SEGUNDA COMBINACION (COMBINACION DOBLE DE CONFIGURACION E) Y FORMAN, O A UNA COMBINACION DIRECTA ENTRE ATOMOS DE CARBONO 20 Y 22 X Y UN RESTO ALQUILENOXIDO-(CH SUB 2)SUB N)-CON N=1 A 3 O A UN PUENTE DE METILENO (-CH SUB 2-) ENTRE LOS ATOMOS DE CARBONO 20 Y 22 Y X UN RESTO DE ALQUILENO -(CH SUB 2)SUB N-, O UN RESTO DE ALQUILENO -(CH SUB 2)SUB N O-CON N=1 A 3, O CUANDO A ESTA DISPONIBLE PARA UNA COMBINACION DIRECTA, ASI COMO B Y D EN CONJUNTO PARA UNA SEGUNDA COMBINACION, EN DONDE SIGNIFICAN UNO DE LOS RESTOS -CH SUB 2-O-CH SUB 2,-(CH SUB 2)SUB 2-= O -(CH SUB 2)SUB 2-, ASI COMO UN PROCEDIMIENTO PARA LA OBTENCION DE PREPARADOS FARMACEUTICOS QUE CONTIENEN ESTA COMBINACION, ADEMAS DE SU APLICACION PARA OBTENCION DE MEDICAMENTOS. LOS NUEVOS COMPUESTOS TIENEN UN EFECTO INHIBIDOR DE PROLIFERACION Y DE DIFERENCIACION DE CELULAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4003854A DE4003854A1 (de) | 1990-02-06 | 1990-02-06 | Seitenketten-homologe vitamin d-derivate, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel |
DE19904034730 DE4034730A1 (de) | 1990-10-30 | 1990-10-30 | Seitenketten-homologe vitamin-d-derivate, verfahren zu ihrer herstellung, diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2055521T3 true ES2055521T3 (es) | 1994-08-16 |
Family
ID=25889898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91250032T Expired - Lifetime ES2055521T3 (es) | 1990-02-06 | 1991-02-06 | Derivados de vitamina d que son homologos en la cadena lateral, procedimiento para su preparacion, preparados farmaceuticos que contienen estos derivados asi como su utilizacion como medicamentos. |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0441467B1 (es) |
JP (1) | JPH05501718A (es) |
CN (1) | CN1029400C (es) |
AT (1) | ATE106391T1 (es) |
AU (1) | AU652739B2 (es) |
CA (1) | CA2058637A1 (es) |
CZ (1) | CZ280203B6 (es) |
DE (1) | DE59101738D1 (es) |
DK (1) | DK0441467T3 (es) |
ES (1) | ES2055521T3 (es) |
FI (1) | FI100598B (es) |
HU (1) | HUT59665A (es) |
IE (1) | IE70239B1 (es) |
IL (1) | IL97158A (es) |
NO (1) | NO300209B1 (es) |
PT (1) | PT96679B (es) |
WO (1) | WO1991012238A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5532228A (en) * | 1990-02-06 | 1996-07-02 | Schering Aktiengesellschaft | Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents |
DE4221961A1 (de) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel |
GB9223061D0 (en) * | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
TW267161B (es) * | 1992-11-20 | 1996-01-01 | Hoffmann La Roche | |
DE4343694C2 (de) * | 1993-12-16 | 1997-02-13 | Schering Ag | Verfahren zur Homologisierung von geschützten C-22-Vitamin D-Aldehyden und Zwischenprodukte des Verfahrens |
GB9524812D0 (en) * | 1995-12-05 | 1996-02-07 | Leo Pharm Prod Ltd | Chemical compounds |
JP2001510183A (ja) * | 1997-07-17 | 2001-07-31 | エフ.ホフマン−ラ ロシュ アーゲー | 側鎖に2つの不飽和結合を有するジホモ−セコ−コレスタン |
DE19935771A1 (de) | 1999-07-23 | 2001-02-01 | Schering Ag | Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln |
JP2005257271A (ja) * | 2002-02-25 | 2005-09-22 | Chugai Pharmaceut Co Ltd | ビタミンd3誘導体とビタミンd3受容体の結合の検出方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
US4588528A (en) * | 1984-05-31 | 1986-05-13 | Wisconsin Alumni Research Foundation | 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same |
WO1987000834A1 (en) * | 1985-08-02 | 1987-02-12 | Leo Pharmaceutical Products Ltd. A/S | Novel vitamin d analogues |
-
1991
- 1991-02-06 ES ES91250032T patent/ES2055521T3/es not_active Expired - Lifetime
- 1991-02-06 AU AU72161/91A patent/AU652739B2/en not_active Ceased
- 1991-02-06 EP EP91250032A patent/EP0441467B1/de not_active Expired - Lifetime
- 1991-02-06 IE IE38991A patent/IE70239B1/en not_active IP Right Cessation
- 1991-02-06 AT AT91250032T patent/ATE106391T1/de active
- 1991-02-06 IL IL9715891A patent/IL97158A/en not_active IP Right Cessation
- 1991-02-06 DK DK91250032.9T patent/DK0441467T3/da active
- 1991-02-06 CZ CS91281A patent/CZ280203B6/cs not_active IP Right Cessation
- 1991-02-06 CA CA002058637A patent/CA2058637A1/en not_active Abandoned
- 1991-02-06 JP JP3503657A patent/JPH05501718A/ja active Pending
- 1991-02-06 PT PT96679A patent/PT96679B/pt not_active IP Right Cessation
- 1991-02-06 DE DE59101738T patent/DE59101738D1/de not_active Expired - Lifetime
- 1991-02-06 CN CN91101506A patent/CN1029400C/zh not_active Expired - Fee Related
- 1991-02-06 WO PCT/DE1991/000104 patent/WO1991012238A1/de active IP Right Grant
- 1991-10-04 NO NO913913A patent/NO300209B1/no unknown
- 1991-10-04 FI FI914677A patent/FI100598B/fi active
- 1991-11-05 HU HU913475A patent/HUT59665A/hu unknown
Also Published As
Publication number | Publication date |
---|---|
JPH05501718A (ja) | 1993-04-02 |
FI100598B (fi) | 1998-01-15 |
IL97158A (en) | 1994-12-29 |
IE70239B1 (en) | 1996-11-13 |
DK0441467T3 (da) | 1994-10-03 |
HU913475D0 (en) | 1992-05-28 |
PT96679B (pt) | 1998-07-31 |
NO913913L (no) | 1991-12-05 |
WO1991012238A1 (de) | 1991-08-22 |
NO300209B1 (no) | 1997-04-28 |
CS28191A3 (en) | 1992-04-15 |
AU652739B2 (en) | 1994-09-08 |
CN1054588A (zh) | 1991-09-18 |
IE910389A1 (en) | 1991-08-14 |
ATE106391T1 (de) | 1994-06-15 |
PT96679A (pt) | 1991-10-31 |
EP0441467A1 (de) | 1991-08-14 |
HUT59665A (en) | 1992-06-29 |
FI914677A0 (fi) | 1991-10-04 |
IL97158A0 (en) | 1992-05-25 |
EP0441467B1 (de) | 1994-06-01 |
CZ280203B6 (cs) | 1995-11-15 |
NO913913D0 (no) | 1991-10-04 |
CN1029400C (zh) | 1995-08-02 |
AU7216191A (en) | 1991-09-03 |
DE59101738D1 (de) | 1994-07-07 |
CA2058637A1 (en) | 1991-08-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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