IL97158A0 - Side-chain homologous vitamin d derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents
Side-chain homologous vitamin d derivatives,processes for the preparation thereof and pharmaceutical compositions containing the sameInfo
- Publication number
- IL97158A0 IL97158A0 IL97158A IL9715891A IL97158A0 IL 97158 A0 IL97158 A0 IL 97158A0 IL 97158 A IL97158 A IL 97158A IL 9715891 A IL9715891 A IL 9715891A IL 97158 A0 IL97158 A0 IL 97158A0
- Authority
- IL
- Israel
- Prior art keywords
- derivatives
- bond
- processes
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The description relates to novel side-chain-homologous vitamin D derivatives of formula (I), in which R<1>, R<2>, R<3>, R<4>, R<5> and R<6> have the significance given in the description, B and D are either a hydrogen atom or together a second bond (E-configuration double bond) and either A is a direct bond between the carbon atoms 20 and 22 and X is an alkyloxy radical -(CH2)nO- with n = 1 to 3 or A is a methylene bridge (-CH2-) between the carbon atoms 20 and 22 and X is an alkylene radical -(CH2)n- or an alkylenoxy radical -(CH2)nO- with n = 1 to 3, or if A is a direct bond and B and D together are a second bond, (a) is one of the radicals (b) , -(CH2)2-= or -(CH2)2-=, and a process for their production, pharmaceutical preparations containing this compound and its use in making medicaments. The new compounds have proliferation-inhibiting and cell-differentiating effects.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4003854A DE4003854A1 (en) | 1990-02-06 | 1990-02-06 | New vitamin=D derivs. - are cell differentiators and proliferation inhibitors useful for treating psoriasis and malignant tumours |
| DE19904034730 DE4034730A1 (en) | 1990-10-30 | 1990-10-30 | New vitamin=D derivs. with modified side chain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL97158A0 true IL97158A0 (en) | 1992-05-25 |
| IL97158A IL97158A (en) | 1994-12-29 |
Family
ID=25889898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9715891A IL97158A (en) | 1990-02-06 | 1991-02-06 | Side-chain homologous vitamin D derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0441467B1 (en) |
| JP (1) | JPH05501718A (en) |
| CN (1) | CN1029400C (en) |
| AT (1) | ATE106391T1 (en) |
| AU (1) | AU652739B2 (en) |
| CA (1) | CA2058637A1 (en) |
| CZ (1) | CZ280203B6 (en) |
| DE (1) | DE59101738D1 (en) |
| DK (1) | DK0441467T3 (en) |
| ES (1) | ES2055521T3 (en) |
| FI (1) | FI100598B (en) |
| HU (1) | HUT59665A (en) |
| IE (1) | IE70239B1 (en) |
| IL (1) | IL97158A (en) |
| NO (1) | NO300209B1 (en) |
| PT (1) | PT96679B (en) |
| WO (1) | WO1991012238A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5532228A (en) * | 1990-02-06 | 1996-07-02 | Schering Aktiengesellschaft | Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents |
| DE4221961A1 (en) * | 1992-06-30 | 1994-01-05 | Schering Ag | 22-en-25-oxa derivatives in the vitamin D series, processes for their preparation, pharmaceutical preparations containing these derivatives and their use as medicines |
| GB9223061D0 (en) * | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| TW267161B (en) * | 1992-11-20 | 1996-01-01 | Hoffmann La Roche | |
| DE4343694C2 (en) * | 1993-12-16 | 1997-02-13 | Schering Ag | Process for the homologation of protected C-22 vitamin D aldehydes and process intermediates |
| GB9524812D0 (en) * | 1995-12-05 | 1996-02-07 | Leo Pharm Prod Ltd | Chemical compounds |
| JP2001510183A (en) * | 1997-07-17 | 2001-07-31 | エフ．ホフマン−ラ ロシュ アーゲー | Dihomo-seco-cholestan having two unsaturated bonds in the side chain |
| DE19935771A1 (en) | 1999-07-23 | 2001-02-01 | Schering Ag | New vitamin D derivatives with cyclic substructures in the side chains, processes and intermediates for their manufacture and their use in the manufacture of pharmaceuticals |
| JP2005257271A (en) * | 2002-02-25 | 2005-09-22 | Chugai Pharmaceut Co Ltd | Method of detecting bond between vitamin d 3 derivative and vitamin d 3 receptor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4225596A (en) * | 1978-10-13 | 1980-09-30 | Wisconsin Alumni Research Foundation | Method for treating calcium imbalance and improving calcium absorption in mammals |
| US4588528A (en) * | 1984-05-31 | 1986-05-13 | Wisconsin Alumni Research Foundation | 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same |
| WO1987000834A1 (en) * | 1985-08-02 | 1987-02-12 | Leo Pharmaceutical Products Ltd. A/S | Novel vitamin d analogues |
-
1991
- 1991-02-06 ES ES91250032T patent/ES2055521T3/en not_active Expired - Lifetime
- 1991-02-06 AU AU72161/91A patent/AU652739B2/en not_active Ceased
- 1991-02-06 EP EP91250032A patent/EP0441467B1/en not_active Expired - Lifetime
- 1991-02-06 IE IE38991A patent/IE70239B1/en not_active IP Right Cessation
- 1991-02-06 AT AT91250032T patent/ATE106391T1/en active
- 1991-02-06 IL IL9715891A patent/IL97158A/en not_active IP Right Cessation
- 1991-02-06 DK DK91250032.9T patent/DK0441467T3/en active
- 1991-02-06 CZ CS91281A patent/CZ280203B6/en not_active IP Right Cessation
- 1991-02-06 CA CA002058637A patent/CA2058637A1/en not_active Abandoned
- 1991-02-06 JP JP3503657A patent/JPH05501718A/en active Pending
- 1991-02-06 PT PT96679A patent/PT96679B/en not_active IP Right Cessation
- 1991-02-06 DE DE59101738T patent/DE59101738D1/en not_active Expired - Lifetime
- 1991-02-06 CN CN91101506A patent/CN1029400C/en not_active Expired - Fee Related
- 1991-02-06 WO PCT/DE1991/000104 patent/WO1991012238A1/en active IP Right Grant
- 1991-10-04 NO NO913913A patent/NO300209B1/en unknown
- 1991-10-04 FI FI914677A patent/FI100598B/en active
- 1991-11-05 HU HU913475A patent/HUT59665A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05501718A (en) | 1993-04-02 |
| FI100598B (en) | 1998-01-15 |
| IL97158A (en) | 1994-12-29 |
| IE70239B1 (en) | 1996-11-13 |
| DK0441467T3 (en) | 1994-10-03 |
| HU913475D0 (en) | 1992-05-28 |
| PT96679B (en) | 1998-07-31 |
| NO913913L (en) | 1991-12-05 |
| WO1991012238A1 (en) | 1991-08-22 |
| NO300209B1 (en) | 1997-04-28 |
| CS28191A3 (en) | 1992-04-15 |
| AU652739B2 (en) | 1994-09-08 |
| CN1054588A (en) | 1991-09-18 |
| IE910389A1 (en) | 1991-08-14 |
| ATE106391T1 (en) | 1994-06-15 |
| PT96679A (en) | 1991-10-31 |
| EP0441467A1 (en) | 1991-08-14 |
| HUT59665A (en) | 1992-06-29 |
| FI914677A0 (en) | 1991-10-04 |
| EP0441467B1 (en) | 1994-06-01 |
| ES2055521T3 (en) | 1994-08-16 |
| CZ280203B6 (en) | 1995-11-15 |
| NO913913D0 (en) | 1991-10-04 |
| CN1029400C (en) | 1995-08-02 |
| AU7216191A (en) | 1991-09-03 |
| DE59101738D1 (en) | 1994-07-07 |
| CA2058637A1 (en) | 1991-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |