CS28191A3 - Vitamin d derivatives with homologs of a side chain and process for preparing thereof - Google Patents

Vitamin d derivatives with homologs of a side chain and process for preparing thereof

Info

Publication number
CS28191A3
CS28191A3 CS91281A CS28191A CS28191A3 CS 28191 A3 CS28191 A3 CS 28191A3 CS 91281 A CS91281 A CS 91281A CS 28191 A CS28191 A CS 28191A CS 28191 A3 CS28191 A3 CS 28191A3
Authority
CS
Czechoslovakia
Prior art keywords
bond
derivatives
vitamin
radical
homologs
Prior art date
Application number
CS91281A
Other languages
Czech (cs)
Inventor
Gunter Dr Neef
Gerald Dr Kirsch
Andreas Dr Steinmeyer
Katica Schwarz
Matthias Dr Brautigam
Ruth Dr Thieroff-Ekerdt
Petra Rach
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4003854A external-priority patent/DE4003854A1/en
Priority claimed from DE19904034730 external-priority patent/DE4034730A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS28191A3 publication Critical patent/CS28191A3/en
Publication of CZ280203B6 publication Critical patent/CZ280203B6/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The description relates to novel side-chain-homologous vitamin D derivatives of formula (I), in which R<1>, R<2>, R<3>, R<4>, R<5> and R<6> have the significance given in the description, B and D are either a hydrogen atom or together a second bond (E-configuration double bond) and either A is a direct bond between the carbon atoms 20 and 22 and X is an alkyloxy radical -(CH2)nO- with n = 1 to 3 or A is a methylene bridge (-CH2-) between the carbon atoms 20 and 22 and X is an alkylene radical -(CH2)n- or an alkylenoxy radical -(CH2)nO- with n = 1 to 3, or if A is a direct bond and B and D together are a second bond, (a) is one of the radicals (b) , -(CH2)2-= or -(CH2)2-=, and a process for their production, pharmaceutical preparations containing this compound and its use in making medicaments. The new compounds have proliferation-inhibiting and cell-differentiating effects.
CS91281A 1990-02-06 1991-02-06 Vitamin d derivatives with homologic side chains, process of their preparation, pharmaceutical preparations in which said derivatives are comprised and their use CZ280203B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4003854A DE4003854A1 (en) 1990-02-06 1990-02-06 New vitamin=D derivs. - are cell differentiators and proliferation inhibitors useful for treating psoriasis and malignant tumours
DE19904034730 DE4034730A1 (en) 1990-10-30 1990-10-30 New vitamin=D derivs. with modified side chain

Publications (2)

Publication Number Publication Date
CS28191A3 true CS28191A3 (en) 1992-04-15
CZ280203B6 CZ280203B6 (en) 1995-11-15

Family

ID=25889898

Country Status (17)

Country Link
EP (1) EP0441467B1 (en)
JP (1) JPH05501718A (en)
CN (1) CN1029400C (en)
AT (1) ATE106391T1 (en)
AU (1) AU652739B2 (en)
CA (1) CA2058637A1 (en)
CZ (1) CZ280203B6 (en)
DE (1) DE59101738D1 (en)
DK (1) DK0441467T3 (en)
ES (1) ES2055521T3 (en)
FI (1) FI100598B (en)
HU (1) HUT59665A (en)
IE (1) IE70239B1 (en)
IL (1) IL97158A (en)
NO (1) NO300209B1 (en)
PT (1) PT96679B (en)
WO (1) WO1991012238A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
DE4221961A1 (en) * 1992-06-30 1994-01-05 Schering Ag 22-en-25-oxa derivatives in the vitamin D series, processes for their preparation, pharmaceutical preparations containing these derivatives and their use as medicines
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (en) * 1992-11-20 1996-01-01 Hoffmann La Roche
DE4343694C2 (en) * 1993-12-16 1997-02-13 Schering Ag Process for the homologation of protected C-22 vitamin D aldehydes and process intermediates
GB9524812D0 (en) * 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
AU8860298A (en) * 1997-07-17 1999-02-10 F. Hoffmann-La Roche Ag Dihomo-seco-cholestanes with two unsaturated bones in the side chain
DE19935771A1 (en) * 1999-07-23 2001-02-01 Schering Ag New vitamin D derivatives with cyclic substructures in the side chains, processes and intermediates for their manufacture and their use in the manufacture of pharmaceuticals
JP2005257271A (en) * 2002-02-25 2005-09-22 Chugai Pharmaceut Co Ltd Method of detecting bond between vitamin d 3 derivative and vitamin d 3 receptor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
DE3666587D1 (en) * 1985-08-02 1989-11-30 Leo Pharm Prod Ltd Novel vitamin d analogues

Also Published As

Publication number Publication date
WO1991012238A1 (en) 1991-08-22
AU7216191A (en) 1991-09-03
HU913475D0 (en) 1992-05-28
CZ280203B6 (en) 1995-11-15
FI100598B (en) 1998-01-15
PT96679B (en) 1998-07-31
JPH05501718A (en) 1993-04-02
EP0441467B1 (en) 1994-06-01
AU652739B2 (en) 1994-09-08
FI914677A0 (en) 1991-10-04
NO913913D0 (en) 1991-10-04
CN1029400C (en) 1995-08-02
EP0441467A1 (en) 1991-08-14
IE70239B1 (en) 1996-11-13
DK0441467T3 (en) 1994-10-03
HUT59665A (en) 1992-06-29
IL97158A0 (en) 1992-05-25
NO913913L (en) 1991-12-05
IE910389A1 (en) 1991-08-14
ES2055521T3 (en) 1994-08-16
IL97158A (en) 1994-12-29
CN1054588A (en) 1991-09-18
DE59101738D1 (en) 1994-07-07
NO300209B1 (en) 1997-04-28
CA2058637A1 (en) 1991-08-07
PT96679A (en) 1991-10-31
ATE106391T1 (en) 1994-06-15

Similar Documents

Publication Publication Date Title
GR3017981T3 (en) Aminocoumaran derivatives, their production and use.
MY106280A (en) Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use.
ATE36859T1 (en) 4&#39;-DEMETHYL-4-EPIPODOPHYLLOTOXIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
EP0614913A3 (en) Dynorphin derivatives.
ZA907876B (en) 24-homo vitamin d derivatives,process for their production and pharmaceutical preparations obtained therefrom
CS28191A3 (en) Vitamin d derivatives with homologs of a side chain and process for preparing thereof
ES8606282A1 (en) their derivatives and a process for preparing the compounds.
ES8602033A1 (en) N6-(1- and 2-benzocycloalkyl) adenosines, pharmaceutical compositions comprising the same and a process for the production thereof.
ES8706713A1 (en) 4&#39;-Demethyl-4-epipodophyllotoxin Derivatives, a process for their preparation and their use as medicaments.
ES8800679A1 (en) Process for preparing piperidylidene dihydrodibenzo(a,d)cycloheptenes and aza derivatives thereof, compounds obtained by such process and the use of such compounds for preparing useful pharmaceutical compositions.
EP0589038A4 (en) Tricyclic compound
ES8702888A1 (en) Adamantan amine derivatives, process for their preparation and medicines containing them.
ES8601956A1 (en) Methylflavone derivatives.
HUT58269A (en) Process for producing aralkyl-amine derivatives and pharmaceutical compositions containing them as active components
ATE80890T1 (en) ANTHRACYCLIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
ATE56713T1 (en) 1,2,3,4,4A,9B-HEXAHYDRO-4AAMINOALKYLDIBENZOFURANES, PROCESSES FOR THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS.
HU906010D0 (en) New substituted alkyl-piperidine derivatives
EP0250755A3 (en) Fluorine derivatives of vitamin d3 and process for producing the same
HUT45059A (en) Process for producing abeoergoline derivatives
EP0034462A3 (en) Imidodisulfamide derivatives, their preparation and use in pharmaceutical compositions
IT1229658B (en) BACK-REVERSE THYOPENTINE ANALOGUES WITH ONE OR MORE LINKS, THE METHOD FOR THEIR SYNTHESIS AND THEIR USE FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS.
ES2059485T3 (en) 2-AMINO-1,2,3,4-TETRAHYDROISOKINOLINE DERIVATIVES, PROCEDURE OF ITS PREPARATION AND ITS APPLICATION AS A MEDICINAL PRODUCT.
ES8606375A1 (en) Novel 3-(4&#39;-aminobutylamino)-propylamino-bleomycin derivatives, a process for their preparation and their use as medicaments.
MY110626A (en) Acridine derivatives
TH1208A (en)

Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20010206