NO913913L - PROCEDURE FOR PREPARING SIDE BOILER HOMOLOGICAL VITAMIN-D DERIVATIVES. - Google Patents

PROCEDURE FOR PREPARING SIDE BOILER HOMOLOGICAL VITAMIN-D DERIVATIVES.

Info

Publication number
NO913913L
NO913913L NO91913913A NO913913A NO913913L NO 913913 L NO913913 L NO 913913L NO 91913913 A NO91913913 A NO 91913913A NO 913913 A NO913913 A NO 913913A NO 913913 L NO913913 L NO 913913L
Authority
NO
Norway
Prior art keywords
bond
derivatives
vitamin
homological
procedure
Prior art date
Application number
NO91913913A
Other languages
Norwegian (no)
Other versions
NO300209B1 (en
NO913913D0 (en
Inventor
Guenter Neef
Gerald Kirsch
Andreas Steinmeyer
Katica Schwarz
Matthias Braeutigam
Ruth Thieroff-Ekerdt
Petra Rach
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4003854A external-priority patent/DE4003854A1/en
Priority claimed from DE19904034730 external-priority patent/DE4034730A1/en
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO913913D0 publication Critical patent/NO913913D0/en
Publication of NO913913L publication Critical patent/NO913913L/en
Publication of NO300209B1 publication Critical patent/NO300209B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The description relates to novel side-chain-homologous vitamin D derivatives of formula (I), in which R<1>, R<2>, R<3>, R<4>, R<5> and R<6> have the significance given in the description, B and D are either a hydrogen atom or together a second bond (E-configuration double bond) and either A is a direct bond between the carbon atoms 20 and 22 and X is an alkyloxy radical -(CH2)nO- with n = 1 to 3 or A is a methylene bridge (-CH2-) between the carbon atoms 20 and 22 and X is an alkylene radical -(CH2)n- or an alkylenoxy radical -(CH2)nO- with n = 1 to 3, or if A is a direct bond and B and D together are a second bond, (a) is one of the radicals (b) , -(CH2)2-= or -(CH2)2-=, and a process for their production, pharmaceutical preparations containing this compound and its use in making medicaments. The new compounds have proliferation-inhibiting and cell-differentiating effects.
NO913913A 1990-02-06 1991-10-04 Analogous Process for Preparation of Side-Chain Homologous Vitamin D Derivatives NO300209B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4003854A DE4003854A1 (en) 1990-02-06 1990-02-06 New vitamin=D derivs. - are cell differentiators and proliferation inhibitors useful for treating psoriasis and malignant tumours
DE19904034730 DE4034730A1 (en) 1990-10-30 1990-10-30 New vitamin=D derivs. with modified side chain
PCT/DE1991/000104 WO1991012238A1 (en) 1990-02-06 1991-02-06 Side-chain-homologous vitamin d derivatives, process for producing them, pharmaceutical preparations containing these derivatives and their use as medicaments

Publications (3)

Publication Number Publication Date
NO913913D0 NO913913D0 (en) 1991-10-04
NO913913L true NO913913L (en) 1991-12-05
NO300209B1 NO300209B1 (en) 1997-04-28

Family

ID=25889898

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913913A NO300209B1 (en) 1990-02-06 1991-10-04 Analogous Process for Preparation of Side-Chain Homologous Vitamin D Derivatives

Country Status (17)

Country Link
EP (1) EP0441467B1 (en)
JP (1) JPH05501718A (en)
CN (1) CN1029400C (en)
AT (1) ATE106391T1 (en)
AU (1) AU652739B2 (en)
CA (1) CA2058637A1 (en)
CZ (1) CZ280203B6 (en)
DE (1) DE59101738D1 (en)
DK (1) DK0441467T3 (en)
ES (1) ES2055521T3 (en)
FI (1) FI100598B (en)
HU (1) HUT59665A (en)
IE (1) IE70239B1 (en)
IL (1) IL97158A (en)
NO (1) NO300209B1 (en)
PT (1) PT96679B (en)
WO (1) WO1991012238A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532228A (en) * 1990-02-06 1996-07-02 Schering Aktiengesellschaft Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents
DE4221961A1 (en) * 1992-06-30 1994-01-05 Schering Ag 22-en-25-oxa derivatives in the vitamin D series, processes for their preparation, pharmaceutical preparations containing these derivatives and their use as medicines
GB9223061D0 (en) * 1992-11-04 1992-12-16 Leo Pharm Prod Ltd Chemical compounds
TW267161B (en) * 1992-11-20 1996-01-01 Hoffmann La Roche
DE4343694C2 (en) * 1993-12-16 1997-02-13 Schering Ag Process for the homologation of protected C-22 vitamin D aldehydes and process intermediates
GB9524812D0 (en) * 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
JP2001510183A (en) * 1997-07-17 2001-07-31 エフ．ホフマン−ラ ロシュ アーゲー Dihomo-seco-cholestan having two unsaturated bonds in the side chain
DE19935771A1 (en) * 1999-07-23 2001-02-01 Schering Ag New vitamin D derivatives with cyclic substructures in the side chains, processes and intermediates for their manufacture and their use in the manufacture of pharmaceuticals
JP2005257271A (en) * 2002-02-25 2005-09-22 Chugai Pharmaceut Co Ltd Method of detecting bond between vitamin d 3 derivative and vitamin d 3 receptor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4588528A (en) * 1984-05-31 1986-05-13 Wisconsin Alumni Research Foundation 1,24-dihydroxy-Δ22 -vitamin D3 and process for preparing same
EP0227826B1 (en) * 1985-08-02 1989-10-25 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues

Also Published As

Publication number Publication date
EP0441467B1 (en) 1994-06-01
HU913475D0 (en) 1992-05-28
WO1991012238A1 (en) 1991-08-22
EP0441467A1 (en) 1991-08-14
IL97158A0 (en) 1992-05-25
IE70239B1 (en) 1996-11-13
HUT59665A (en) 1992-06-29
CZ280203B6 (en) 1995-11-15
ATE106391T1 (en) 1994-06-15
CA2058637A1 (en) 1991-08-07
DK0441467T3 (en) 1994-10-03
FI100598B (en) 1998-01-15
CN1054588A (en) 1991-09-18
AU7216191A (en) 1991-09-03
FI914677A0 (en) 1991-10-04
NO300209B1 (en) 1997-04-28
JPH05501718A (en) 1993-04-02
NO913913D0 (en) 1991-10-04
IE910389A1 (en) 1991-08-14
IL97158A (en) 1994-12-29
PT96679A (en) 1991-10-31
AU652739B2 (en) 1994-09-08
CN1029400C (en) 1995-08-02
CS28191A3 (en) 1992-04-15
PT96679B (en) 1998-07-31
ES2055521T3 (en) 1994-08-16
DE59101738D1 (en) 1994-07-07

Similar Documents

Publication Publication Date Title
HUT61742A (en) Process for producing cyclic amide derivatives and pharmaceutical compositions comprising same
DE3850740D1 (en) New benzocyclohepten derivatives, their production and use for pharmaceuticals.
HU913436D0 (en) Process for the production of amino-cumarane-derivatives and medical preparations containing them
HUP9802036A2 (en) Novel substituted piperazine derivatives having tachykinin receptor antagonists activity, process for producing them an pharmaceutical compositions containing them
MY106280A (en) Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use.
HUP0000449A2 (en) N-subsituted dioxothiazolidylbenzamide derivatives and process for producing the same
ATE36859T1 (en) 4&#39;-DEMETHYL-4-EPIPODOPHYLLOTOXIN DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
FR2416888A1 (en) NEW PHENYL-PIPERAZINE DERIVATIVES USEFUL AS MEDICINAL PRODUCTS
NO904269L (en) PROCEDURE FOR PREPARING 24-HOMO-VITAMIN-D DERIVATIVES.
ATE60579T1 (en) PYRROLIDINAMIDE DERIVATIVES WITH ANTIPROPYLENE ENDOPEPTIDASE ACTIVITY, COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM.
NO913913L (en) PROCEDURE FOR PREPARING SIDE BOILER HOMOLOGICAL VITAMIN-D DERIVATIVES.
ATE74352T1 (en) DECAHYDROCHINOLINE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE, INTERMEDIATE PRODUCTS FOR THEIR MANUFACTURE, THEIR USE AS MEDICINAL PRODUCTS AND PREPARATIONS CONTAINING THEM.
ES8702888A1 (en) Adamantan amine derivatives, process for their preparation and medicines containing them.
DK196688D0 (en) BICYCLIC RELATIONS AND PROCEDURES FOR PRODUCING THEREOF
HUP9701660A2 (en) 10,13,15-trioxatricyclo[9.2.1.1.9.6]pentadekanon derivatives, process for producing them, and pharmaceutical compositions containing them
ES8601955A1 (en) Methylflavone derivatives.
ES2068497T3 (en) DERIVATIVES OF UREA, ITS PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
SE8303913L (en) Heterocyclic Associations
ATE56713T1 (en) 1,2,3,4,4A,9B-HEXAHYDRO-4AAMINOALKYLDIBENZOFURANES, PROCESSES FOR THEIR PRODUCTION AND USE AS MEDICINAL PRODUCTS.
DE3781879D1 (en) ANTHRACYCLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS.
MY103289A (en) New 5-(w-ammonio acyloxy methylene) tetrahydrofurans and tetrahydrothiophenes
MY101765A (en) Benzopyran derivatives, compositions containing them and processes for their production
HUT45059A (en) Process for producing abeoergoline derivatives
ES2059485T3 (en) 2-AMINO-1,2,3,4-TETRAHYDROISOKINOLINE DERIVATIVES, PROCEDURE OF ITS PREPARATION AND ITS APPLICATION AS A MEDICINAL PRODUCT.
ES472573A1 (en) F3-phenoxy-n-substituted morphinan derivatives their manufacture and pharmaceutical preparations containing them