US20060263415A1 - Production of beta-glucans and mannans - Google Patents
Production of beta-glucans and mannans Download PDFInfo
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- US20060263415A1 US20060263415A1 US11/418,922 US41892206A US2006263415A1 US 20060263415 A1 US20060263415 A1 US 20060263415A1 US 41892206 A US41892206 A US 41892206A US 2006263415 A1 US2006263415 A1 US 2006263415A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/14—Pretreatment of feeding-stuffs with enzymes
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
- A23L29/271—Curdlan; beta-1-3 glucan; Polysaccharides produced by agrobacterium or alcaligenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Definitions
- This invention relates to ⁇ -glucan/mannan preparations and to methods for their preparation.
- the invention relates to preparations, including ⁇ -(1,3/1,6) glucan and mannan, produced from microorganisms including, but not limited, to yeasts.
- Glucan is a generic term referring to an oligo- or polysaccharide composed predominantly or wholly of the monosaccharide D-glucose. Glucans are widely distributed in nature, and are particularly important for their role in maintaining the structural integrity of bacterial, yeast, and plant cells. For example, glucan, in combination with other polysaccharides such as mannan and chitin, is responsible for the shape and mechanical strength of the cell wall. Glucans typically accounts for approximately 40% to 50% of the weight of the cell wall in these cells.
- the D-glucose units may be linked together in a variety of ways.
- glucans with (1,3), (1,4), (1,6) and (1,2) linkages are all known.
- the variety of linkages possible means that glucans are normally highly branched compounds. Many forms are possible as a result of this highly variable manner in which this individual glucose units can be joined as well as the overall steric shape of the parent molecule.
- a common glucan is ⁇ -(1,3)-linked glucopyranose (commonly referred to as ⁇ -glucan).
- Cell walls of several species include ⁇ -(1,3)-linked glucopyranose coupled with ⁇ -(1,6)-linked glucopyranose.
- the cell wall of Saccharaomyces cerevisiae is primarily composed of ⁇ -linked glucan, which is mainly a backbone of ⁇ -(1-3)-linked glucose units, with a minor component of inter and intra molecular branching via ⁇ -(1-6)-linkages.
- glucans Because of their chemical properties, glucans have found a wide variety of uses in the chemical, food and pharmaceutical industries. For example, they may be useful as viscosity imparting agents, emulsifiers, fibers, films, coating substances, supports for affinity chromatography and gel electrophoresis, in cell culture media, as filter pads, and in cement. They are also widely used as food thickeners and as a source of dietary fiber, and as carriers and coating agents in pharmaceutical products. Glucans have been shown to have immunopharmacological activity in humans and animals. For example, strong immunostimulation and protection against pathogenic microorganisms have been demonstrated in shrimp, fish, poultry, swine, cattle, rabbits, mice, rats and humans.
- Yeast ⁇ -glucans may stimulate the innate (non-specific) immune response of vertebrates and invertebrates via interaction with the Toll-like receptor Dectin-1. Such binding stimulates the production of active oxygen species in macrophages and enhances their phagocytosis and killing of microorganisms. These stimulated immune cells also produce cytokins which can circulate throughout the animal and interact with other immune cells to enhance the immune status of the animal.
- Mannan is a polymer composed of mannose units.
- mannan is associated with protein in both the external surface of the yeast cell wall, as a muscigenous polysaccharide, and in the inner cell membrane. It generally accounts for about 20-50% of the dry weight of the cell wall.
- Mannan is linked to a core-peptide chain as an oligomer or polymer.
- the complex contains about 5-50% proteins.
- Oligomeric mannan is bonded directly to serine and threonine, whereas polymeric mannan is bonded to aspargine via N-acetylglucosamine.
- the mannose units are linked by ⁇ -1,6, ⁇ -1,2 and ⁇ -1,3-linkages.
- Mannan-oligosaccharides can be released from yeast cell walls by proteolytic action.
- the released MOS can effectively bind to bacterial pathogens of the intestinal tract and block their ability to colonize the intestinal tract.
- E. coli, Salmonella spp. and Vibrio cholera have proteins on their surface (lectins) which bind specifically to the mannose sugar residues of the MOS.
- FIG. 1 is a flowchart of one embodiment of a process for production of ⁇ -glucan/mannan preparations in accordance with the present invention.
- FIG. 2 is a flowchart of another embodiment for process for production of ⁇ -glucan/mannan preparations in accordance with the present invention.
- the present invention provides a method for processing yeast cells using the steps of autolyzing the yeast cells to release yeast cell walls, incubating the yeast cell walls with an exogenous protease, separating the yeast cell walls into a glucan-enriched component and a mannan enriched component, and ultrafiltering the mannan-enriched component to form a filtrate and a retentate.
- the invention provides a method for processing yeast cells using the steps of autolyzing the yeast cells at a temperature of 40° C. to 65° C. to release yeast cell walls, incubating the yeast cell walls with an exogenous protease at a pH of 9 to 10, and incubating the protease-treated cell walls with an enzyme such as an amylase, lipase or a combination thereof.
- the invention provides a composition comprising ⁇ -mannans, wherein at least 85% (w/w) of the total ⁇ -mannans have a molecular weight of 10,000 Da or more.
- inventions include animal feeds, food supplements, pharmaceuticals, cosmetics and neutraceuticals that comprise glucans or mannans made by methods of the invention.
- the invention provides a process that produces insoluble cell wall preparations enriched in ⁇ (1,3) and ⁇ (1,6) glucans and a soluble fraction enriched in mannans.
- the process in accordance with the present invention includes an autolysis step of a source of cell walls, for example, yeast, such as brewer's yeast or baker's yeast, followed by an enzymatic digestion step.
- the enzymatic digestion is carried out using a high-pH protease.
- the enzymatic digestion is carried out using a combination of enzymes, such as a high-pH protease, an amylase, glucoamylase and/or lipase.
- the enzymatic digestion is carried out using a high-pH protease followed by one or more other enzymes, such as amylase, glucoamylase and/or lipase.
- the invention provides a cell wall preparation that is enriched ⁇ -(1,3) and ⁇ -(1,6) glucans, and in another embodiment, a soluble fraction enriched in mannans.
- any numerical range recited herein includes all values from the lower value to the upper value. For example, if a concentration range is stated as 1% to 50%, it is intended that values such as 2% to 40%, 10% to 30%, or 1% to 3%, etc., are expressly enumerated in this specification. These are only examples of what is specifically intended, and all possible combinations of numerical values between the lowest value and the highest value enumerated are to be considered to be expressly stated in this application.
- ⁇ -glucan/mannan preparations can be prepared from microorganisms, such as yeast, using a simple autolysis process, at slightly acidic/near-neutral pH and only moderately elevated temperature. Autolysis is followed by an enzymatic digestion.
- the enzymatic step utilizes a high pH protease (e.g., Protex 6L available from Genencore International or from fermentation of Bacillus lichenformis ), typically about 0.05%-1% by weight, at an alkaline pH, and elevated temperature.
- a high pH protease e.g., Protex 6L available from Genencore International or from fermentation of Bacillus lichenformis
- Suitable yeast species as a source of ⁇ -glucans/mannans include, but are not limited to, yeast strains of Saccharomyces cerevisiae (including baker's yeast strains and brewer's yeast strains), Kluyveromyces fragilis , and Candida strains, such as Candida utilis , and combinations thereof.
- yeast strains of yeast which are suitable sources of ⁇ -glucans/mannans include, but are not limited to, Saccharomyces delbruekii, Saccharomyces rosei, Saccharomyces microellipsodes, Saccharomyces carlsbergensis, Schizosaccharomyces pombe, Kluyveromyces lactis, Kluyveromyces polysporus, Candida albicans, Candida cloacae, Candida tropicalis, Candida guilliermondii, Hansenula wingei, Hansenula arni, Hansenula henricii, Hansenula Americana and combinations thereof. These yeast strains can be produced using culture in food grade nutrients either by batch fermentation or continuous fermentation.
- microorganisms including, but are not limited to, bacteria, fungi, and plants, for example, unicellular algae, have been reported in the art as a source of ⁇ -glucans/mannans.
- Other microorganisms which may be useful in the invention as sources of ⁇ -glucans and/or mannans include, but are not limited to, bacteria, such as Alkaligenes , especially Alkaligenes faecalis Var.
- Non-microorganisms such as plants, may also be useful in the invention as sources of ⁇ -glucans and/or mannans.
- the process in accordance to the present invention relates to the generation of cell wall preparations enriched in ⁇ -(1,3)- and ⁇ -(1,6)-glucan content and mannan content, produced from microorganisms including, but not limited to, yeast.
- the process includes a first step of autolysis of yeast, e.g., brewer's yeast, (typically a 7% to 18%, particularly a 10% to 17%, and more particularly a 8% to 12% or 13% to 16% solids slurry).
- the autolysis may suitably be carried out at a pH of at least 4, particularly at least 4.5, and more particularly at least 5.
- the yeast is then separated, suitably by centrifugation, to produce an extract, and a cell wall stream of low ⁇ -glucan content.
- a further step treats the cell wall stream with an enzyme including, but not limited to, a protease, e.g., an alkaline protease, at a pH of at least 8.5, particularly at least 9, and more particularly at least 9.2.
- the pH may also suitably be less than 10.5, particularly less than 10, and even more particularly less than 9.8.
- the protease treatment may suitably be carried out at a temperature of at least 45° C., particularly at least 50° C., more particularly at least 53° C.
- This ⁇ -(1,3/1,6) cell wall product is then dried, e.g., spray dried, which results in aggregation of the product to particles of about 100-300 microns or larger.
- the mannan extract is then subjected to a 10,000 molecular weight ultrafiltration to yield a high-molecular weight retentate that is enriched in mannan.
- Live yeast are subjected to autolysis in a process in which endogenous yeast enzymes break down and solubilize some yeast macromolecules.
- Soluble extract is separated from insoluble yeast cell walls by centrifugation.
- the cell walls are then treated with a high-pH protease to further remove protein from the cell walls, and subsequently also remove the mannan which is attached to the cell wall protein.
- the ⁇ -glucan enriched cell walls are then separated from the secondary extract by centrifugation. Mannan, which has a high molecular weight, can be further purified and concentrated by passing the secondary extract through a 10,000 Da ultrafilter.
- the autolysis may suitably be carried out for at least 10 hours, particularly at least 16 hours, and more particularly at least 24 hours.
- the autolysis may suitably be carried out for less than 100 hours, particularly less than 48 hours, and even more particularly less than 36 hours.
- the yeast is then separated, suitably by centrifugation, to produce an extract, and a cell wall stream of low ⁇ -glucan content.
- a further step treats the cell wall stream with enzymes.
- the enzymatic step utilizes first a high pH protease at an alkaline pH, for example, at a pH of at least 8.5, particularly at least 9, and more particularly at least 9.2.
- the pH may also suitably be less than 10.5, particularly less than 10, and even more particularly less than 9.8.
- the protease treatment may suitably be carried out at a temperature of at least 45° C., particularly at least 50° C., more particularly at least 53° C.
- the protease treatment may suitably be carried out at a temperature of less than 70° C., particularly less than 65° C., and more particularly less than 60° C., and even more particularly less than 57° C.
- the protease treatment may be suitably carried out for at least 5 hours, particularly at least 8 hours, more particularly at least 10 hours, even more particularly at least 12 hours.
- the protease treatment may be suitably carried out for less than 48 hours, particularly less than 36 hours, more particularly less than 24 hours, and even more particularly less than 18 hours.
- the pH may suitably range from at least 3.5, particularly from at least 4, and even more particularly from at least 4.5.
- the pH may also suitably range from less than 7, particularly less than 6, and even more particularly less than 5.5.
- the temperature for carrying out the incubation with glucoamylase, amylase and/or lipase may suitably range from at least 40° C., particularly at least 45° C. more particularly at least 50° C. and even more particularly at least 53° C.
- the temperature may also suitably range from less than 70° C., particularly less than 65° C., more particularly less than 60° C., and even more particularly less than 58° C.
- the incubation with the amylase and/or a lipase is suitably carried out at a pH of 4 to 7 and a temperature of 50° to 65° C. for approximately 4 to 10 hours.
- the amylase may digest residual alpha-glucans such as glycogen that may still reside with the cell wall.
- the lipase may degrade cell wall membranes enriched with lipids and fats.
- the cell wall stream may then be separated by centrifugation to produce a secondary extract enriched with mannan, and a cell wall product enriched in ⁇ -glucans.
- the cell wall product may be dried, e.g., spray dried.
- the secondary mannan extract may be passed through an ultrafilter, such as a 10,000 Da ultrafilter, a 50,000 Da ultrafilter, or a 100,000 Da ultrafilter to enrich the mannan content of the retentate.
- the preparations of the invention may be dried by any suitable process including, but not limited to, freeze-drying, roller drum drying, oven-drying, spray-drying, ring-drying, and combinations thereof and/or dried using film-forming equipment, and either may be used without further processing, or may be milled using any suitable technique.
- the high-pH protease may have an optimum proteolytic activity at a pH above 7.
- Suitable proteases include, but are not limited to, those obtained from Actinidia chinensis, Ananas comosus, Aspergillus spp. (e.g. A. niger, A. niger var. awamori, A. oryzae, A. sojae, A. melleus ), Bacillus spp. (e.g. B. subtilis, B. alcalophilus, B. amyloliquefaciens, B. halodurans, B. lentus, B. licheniformis, B. stearothermophilus, B.
- Actinidia chinensis e.g. A. niger, A. niger var. awamori, A. oryzae, A. sojae, A. melleus
- Bacillus spp. e.g. B. subtilis
- thermoproteolyticus Carica papya, Cryphonectria parasitica, Endothia parasitica, Ficus glabrata, Kluyveromyces lactis, Penicillum citrinum, Rhizomucor miehei, Rhizopus niveus , from calf, goat or ox stomachs or porcine pancreases, and combinations thereof.
- Suitable proteases may include, but are not limited to, commercially available enzymes such as subtilisin Carlsberg, subtilisin BPN′, subtilisin Novo, subtilisin 309, subtilisin 147 and subtilisin 168, AlcalaseTM, SavinaseTM, PrimaseTM, DuralaseTM, DurazymTM, EsperaseTM, and KannaseTM (available from Novo Nordisk A/S); MaxataseTM, MaxacalTM, MaxapemTM, OptimaseTM, ProperaseTM, PurafectTM, Purafect OxPTM, FN2TM, and FN3TM (available from Genencor International Inc.); and ValidaseTM AFP, ValidaseTM FP Concentrate, ValidaseTM FP 500, ValidaseTM FP II, ValidaseTM TSP Concentrate, Alkaline Protease Concentrate, Bromelain (available from Valley Research, South Bend, Ind.), and combinations thereof.
- commercially available enzymes
- Suitable amylases include those of plant, animal, bacterial or fungal origin, and combinations thereof.
- Amylases include, but are not limited to, glucoamylases or ⁇ -amylases obtained from Bacillus spp., (e.g., B. licheniformis, B. amyloliquefaciens, B. subtilis, B. stearothermophilus ), Aspergillus oryzae, Aspergillus niger, Aspergillus niger var. awamori, Microbacterium imperiale, Thermomonospora viridis , barley malt ( Hordeum spp.), porcine pancreas ( Sus spp.), and combinations thereof.
- Bacillus spp. e.g., B. licheniformis, B. amyloliquefaciens, B. subtilis, B. stearothermophilus
- Aspergillus oryzae Aspergill
- amylases examples include, but are not limited to, commercially available amylases such as Glucoamylase Concentrate, DuramylTM, TermamylTM, FungamylTM and BANTM (available from Novo Nordisk A/S); RapidaseTM and PurastarTM (available from Genencor International Inc.); and ValidaseTM BAA, ValidasemTM HT340L, ValidaseTM FAA, ValidaseTM AGS, ValidaseTM GA, ValidaseTM RGA (available from Valley Research, South Bend, Ind.), and combinations thereof.
- the amylase may be suitably used at a final concentration of at least 0.001%, particularly at least 0.01% and even more particularly at least 0.02%.
- the amylase may be suitably used at a final concentration of less than 0.1%, particularly less than 0.05%, and even more particularly less than 0.1%.
- Lipases useful in the invention include, but are not limited to, lipases from Humicola (synonym Thermomyces ), e.g. from H. lanuginosa ( T. lanuginosus ), H. insolens , a Pseudomonas lipase , e.g. from P. alcaligenes or P. pseudoalcaligenes, P. cepacia, P. stutzeri, P. fluorescens, Pseudomonas sp. strain SD 705, P. wisconsinensis , a Bacillus lipase , e.g. from B. subtilis, B. stearothermophilus or B.
- lipase enzymes include, but are not limited to, LipolaseTM and Lipolase UltraTM (Novo Nordisk A/S), and Fungal Lipase 8000 and Pancreatic Lipase 250 (available from Valley Research, South Bend, Ind.).
- the product resulting from autolysis of the yeast cells suitably also comprises, at least 20%, particularly at least 23% and more particularly at least 25% protein of the total product on a dry solids basis.
- the product also suitably comprises less than 45%, particularly less than 40% and more particularly less than 35% protein of the total product on a dry solids basis.
- the product resulting from autolysis of the yeast cells suitably comprises at least 20%, particularly at least 23% and more particularly at least 25% total glucans of the total product on a dry solids basis.
- the product also suitably comprises less than 45%, particularly less than 40% and more particularly less than 35% total glucans of the total product on a dry solids basis.
- the product resulting from autolysis of the yeast cells suitably comprises, at least 5%, particularly at least 7% and more particularly at least 10% alpha-glucans of the total product on a dry solids basis.
- the product also suitably comprises less than 20%, particularly less than 18% and more particularly less than 15% alpha-glucans of the total product on a dry solids basis.
- the product resulting from autolysis of the yeast cells suitably comprises, at least 7%, particularly at least 10% and more particularly at least 12% beta-glucans of the total product on a dry solids basis.
- the product also suitably comprises less than 22%, particularly less than 20% and more particularly less than 18% beta-glucans of the total product on a dry solids basis.
- the product resulting from autolysis of the yeast cells suitably comprises, at least 5%, particularly at least 7% and more particularly at least 10% mannans of the total product on a dry solids basis.
- the product also suitably comprises less than 20%, particularly less than 18% and more particularly less than 15% mannans of the total product on a dry solids basis.
- the enriched ⁇ -(1,3/1,6) glucan product cell wall product is characterized, for example, as at least 50%, at least 55%, at least 60% or at least 65% ⁇ -(1,3/1,6) glucan with a protein content of less than 20%, less than 15%, or less than 10%.
- the enriched mannan product (secondary mannan extract) may be characterized as containing at least 50%, particularly at least 55% and even more particularly at least 57% mannan.
- the enriched mannan product may also be characterized as containing less than 70%, particularly less than 68%, and even more particularly less than 65% mannan.
- the enriched mannan product may be also characterized as containing at least 25%, particularly at least 27%, and more particularly at least 29% protein.
- the enriched mannan product may be also characterized as containing less than 35%, particularly less than 32%, and more particularly less than 30% protein.
- the ultrafiltration step may be carried out by forcing an extract produced from the processes described herein, such as a secondary mannan extract, through an ultrafilter under pressure.
- the ultrafilter comprises one or more semi-permeable membranes.
- the semi-permeable membrane or ultrafilter may have a molecular weight cut-off of, for example, at least 8,000 Da, particularly at least 10,000 Da, more particularly at least 25,000 Da, even more particularly at least 50,000 Da, still more particularly at least 100,000 Da, and yet still more particularly at least 150,000 Da.
- the ultrafilter may have a molecular weight cut of any value between those recited herein including, but not limited to, a molecular weight cut off of at least 15,000 Da, 20,000 Da, 30,000 Da, 40,000 Da, 60,000 Da, 70,000 Da, 80,000 Da, 90,000 Da, 110,000 Da, 120,000 Da, 130,000 Da and 140,000 Da.
- Suitable ultrafilter membranes include, but are not limited to, hollow fiber membranes available from A/G Technology Corp, Needham, Mass.
- At least 80% (w/w), particularly at least 85% (w/w), and more particularly at least 90% (w/w) of the total secondary mannans in the retentate following filtration of a secondary mannan extract may have a molecular weight above the molecular weight cut off of the filter used. For example, if a 10,000 Da cut off is used with a secondary mannan extract, typically at least 80% (w/w), particularly at least 85% (w/w), and more particularly at least 90% (w/w) of the total mannans in the retentate may have a molecular weight above 10,000 Da.
- a 50,000 Da cut off is used with a secondary mannan extract, typically at least 80% (w/w), particularly at least 85% (w/w), and more particularly at least 90% (w/w) of the total mannans in the retentate may have a molecular weight above 50,000 Da.
- a 100,000 Da cut off is used with a secondary mannan extract, typically at least 80% (w/w), particularly at least 85% (w/w), and more particularly at least 90% (w/w) of the total mannans in the retentate may have a molecular weight above 100,000 Da.
- a 150,000 Da cut off is used with a secondary mannan extract, typically at least 80% (w/w), particularly at least 85% (w/w), and more particularly at least 90% (w/w) of the total mannans in the retentate may have a molecular weight above 150,000 Da.
- the ultrafiltration step may optionally include passing the mannan extract through two or more ultrafilters of different molecular weight cut offs.
- the final retentate comprises an enriched mannan product wherein a majority of mannans have a molecular weight falling between the molecular weight cut-offs of the ultrafilters.
- at least 80% (w/w), particularly at least 85% (w/w), and more particularly at least 90% (w/w) of the total mannans of the final retentate may suitably have a molecular weight between the molecular weight cut-offs of the ultrafilters.
- the secondary mannan extract which results from separation from the glucan enriched product following enzymatic treatment of autolyzed cell walls is characterized, for example, from 15% to 50% mannan, 20% to 30% protein, and 20% to 25% other components.
- the retentant may comprise at least 50%, particularly at least 52%, more particularly at least 55% and even more particularly at least 60% mannan.
- the retentate may comprise less than 70%, particularly less than 65%, and more particularly less than 62% mannan.
- the retentate may further comprise at least 10%, particularly at least 12%, more particularly at least 15% and even more particularly at least 17% protein.
- the retentate may further comprise less than 33%, particularly less than 30%, and more particularly less than 22% protein.
- the preparations in accordance with the present invention are contemplated to be of value in, e.g., food supplements, pharmaceuticals (e.g., improving immune response), cosmetics, animal feeds, and neutraceuticals.
- an animal feed may suitably contain 1 to 10 g of preparation/kg feed.
- the preparation may be comprise at least 0.01%, particularly at least 0.02%, more particularly at least 0.05%, and even more particularly at least 0.1% and less than 5%, particularly less than 2%, more particularly less than 0.5%, and even more particularly less than 0.3% of the total weight of the feed, on a weight/weight basis.
- Suitable animal feeds include, but are not limited to, cattle, horse, swine, poultry, fish (e.g., crustacean, shellfish), bird and pet (e.g., cat, dog) feeds.
- a liquid composition may contain 0.1%-1% by weight of the preparation in accordance with the present invention.
- Preparations according to the invention may also be used in a plant protection composition together with an agriculturally acceptable carrier, and optionally an agriculturally acceptable nutrient, herbicide or pesticide.
- the enriched beta-glucan fractions made according to the present invention may suitably be used as immune stimulators in animal and human foods, pharmaceuticals or emollients, agents to reduce cholesterol, and thickening agents in foods and beverages.
- the beta glucan may be suitably present at a concentration (w/w) of at least 0.05%, particularly at least 0.1% and more particularly at least 0.5%, and less than 10%, particularly less than 5% and more particularly less than 2%.
- the beta-glucan fractions made according to the present invention may be used to treat eczema, for example, by incorporation into a cream, lotion or emollient.
- Eczema encompasses various inflamed skin conditions, including atopic dermatitis (“atopic eczema”), and affects about 10% to about 20% of the world population during childhood. Eczema appears to be an abnormal response of the body's immune system.
- mannan-enriched products made according to the present invention.
- mannan products may be used in the animal feed industry, having advantageously the ability to bind mycotoxins and also pathogenic bacteria, preventing bacteria from colonizing the intestinal tract.
- the invention provides, among other things, enriched preparations of ⁇ -glucans and mannans, utilizing processes of relatively mild process conditions.
- the insoluble cell wall fraction was washed three times with a volume of water equal to the volume of extract removed.
- the washed cell wall fraction was condensed to 15.4% solids, the pH was adjusted to 7.0 with hydrochloric acid and the fraction was spray dried.
- a portion of the extract from the Protex 6L treatment (corresponding to the 20 extract shown in FIG. 1 ) was condensed to 28.3% solids, the pH was adjusted to 7.0 and the extract was spray dried.
- the remainder of the 2° extract was ultrafiltered using a UFP-10-C-6A 10,000 NMWC hollow fiber membrane (available from A/G Technology Corp, Needham, Mass.).
- the high molecular weight enriched mannan retentate was adjusted to pH 7.0 and spray dried.
- the 3° extract (filtrate) was adjusted to pH 7.0, condensed and spray dried.
- composition of the products resulting from this process were analyzed using the following techniques: protein was determined using a LECO protein determinator (LECO Corp., St. Joseph, Mich.); total glucans, alpha-glucans and beta-glucans were measured using Megazyme International Mushroom and Yeast Beta-glucan kit (available from Megazyme International, Wicklow, Ireland); mannans were determined by acid hydrolysis of carbohydrates and linked spectrophotometric assay for free mannose, using hexokinase, glucose-6-phosphate dehydrogenase, phosphoglucose isomerase and phosphomannose isomerase; fat was determined using the methanol-chloroform extraction method of Blich, E. G. and Dyer, W. J. Can.
- the heated material was separated with a Westfalia bowl separator (available from Westfalia Separator, Inc., Northvale, N.J.). Most of the extract (shown as the 2° extract in FIG. 2 ) was condensed and spray dried. A portion of the 2° extract was ultrafiltered using a UFP-10-C-6A 10,000 NMWC hollow fiber membrane (available from A/G Technology Corp, Needham, Mass.). The retentate and the filtrate were condensed and spray dried. The spray dried products were analyzed according to the techniques described in Example 1. The results are presented in Table 2. The cell wall fraction was water washed by centrifugation, condensed and spray dried. TABLE 2 Characterization of Products made according to Process Depicted in FIG.
- the data of table 3 indicate that when glucoamylase is added before the Protex 6L, as in Vessel 1, then the cell walls are not sufficiently altered to permit the glucoamylase to access and digest the large molecular weight ⁇ -glucan (glycogen) that is trapped inside the cell walls following the autolysis of brewer's yeast.
- adding protease prior to the glucoamylase permitted the glucoamylase to access and digest the ⁇ -glucan, and to release substantially more glucose. This is the case, even though the glucoamylase in vessel 1 had a longer time (14 hours) to work at pH 5.0 than the glucoamylase of Vessel 2 (4 hours). Therefore, for optimal removal of glycogen/ ⁇ -glucan from brewer's yeast cell walls, the alkaline protease Protex 6L should be added before the glucoamylase.
- Pigs fed the treatment diet were significantly heavier on day 14 and there was a tendency for the pigs to show increased in weight for the 28 days.
- a highly purified yeast cell wall product of Saccharomyces cerevisiae is produced o the process described in Example 2. It has a high concentration of ( ⁇ -1,3/1,6) product is G.R.A.S. (Generally Recognized as Safe) by the FDA.
- the product to supplement in a wide variety of foods with a high quality natural source of ( ⁇ -1,3/1,6) glucan. This biologically active material has been shown to stimulate the immune wide range of animals.
- the composition and characteristics of the product are ble 7.
- Standard chicken feed (without antibiotics) either containing 1 g/Kg of the enriched mannan ultrafiltration retentate of Example 1, or containing no enriched mannan (control), is fed daily to broiler chickens for two weeks.
- the broiler chickens (both the control and the mannan fed groups) are then given an oral inoculation of a strain of Salmonella pathogenic for the chickens.
- the chickens are continued on their respective diets, and mortality and morbidity are monitored for one month.
- Beta-Glucan Enriched Product of Examples 1 or 2 in Tiger Vietnamese silk Cultivation
- a select group of children suffering from eczema that is not responsive to current accepted skin lotion treatments is treated with a lotion containing a 1% suspension of the enriched ⁇ -glucan product of Example 2.
- the lotion is applied twice daily.
- the skin is evaluated weekly by a dermatologist for improvement of lesions and pain.
- the ⁇ -glucan lotion is expected to decrease the lesions associated pain and quickens the healing of the lesions.
- the yeast beta-glucan extract from Example 2 is added at 0.5% (w/w) and 1% (w/w) to cookies, snack bars and bakery items.
- the beta-glucan supplemented cookies, snack bars and bakery items contain fewer calories than cookies, snack bars and bakery items not containing beta-glucan.
- the beta glucans are expected to stimulate the innate immune system of the intestinal tract and benefit the immune status of the consumer.
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US12/693,164 US8753668B2 (en) | 2005-05-05 | 2010-01-25 | Production of beta-glucans and mannans |
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US11701417B2 (en) * | 2019-03-27 | 2023-07-18 | West Virginia University | Vaccine formulation to protect against pertussis |
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CO2020004754A1 (es) * | 2020-04-17 | 2020-10-20 | Compania Nac De Levaduras Levapan S A | Proceso de obtención de β-glucano a partir de levadura de panadería |
US20220218772A1 (en) * | 2021-01-13 | 2022-07-14 | AMI Newco LLC | Mushroom blend for increasing butyrate production in the gut biome |
EP4119654A1 (de) * | 2021-07-12 | 2023-01-18 | Yeastup AG | Verfahren zur isolierung von proteinen und sacchariden aus hefe |
CN115501246B (zh) * | 2022-10-31 | 2023-08-08 | 湖南天根乐微君科技有限公司 | 一种能有效修复、淡化、祛除疤痕的组合物及其制备方法与应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3880742A (en) * | 1972-02-22 | 1975-04-29 | Glaxo Lab Ltd | {62 -1,4,/{62 1,3 Glucanase |
US5589591A (en) * | 1986-07-03 | 1996-12-31 | Advanced Magnetics, Inc. | Endotoxin-free polysaccharides |
US20080193485A1 (en) * | 2005-02-15 | 2008-08-14 | Gorbach Sherwood L | Food Containing a Probiotic and an Isolated Beta-Glucan and Methods of Use Thereof |
US20080194517A1 (en) * | 2007-02-09 | 2008-08-14 | L.C.M. Equine Nutraceuticals, Inc. | Equine or canine immunomodulating composition and treatment method |
Family Cites Families (391)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1003976A (en) | 1961-02-23 | 1965-09-08 | Kinki Yakult Seizo Kabushiki K | Method of decomposing the cell walls of yeasts with ª‰-glucanase produced by microorganisms |
DE1216486B (de) | 1964-04-23 | 1966-05-12 | Merck Ag E | Verfahren zur Herstellung von Dragees |
US3975553A (en) | 1965-03-08 | 1976-08-17 | Henri Griffon | Deproteination of yeast cells |
US3495990A (en) * | 1967-03-02 | 1970-02-17 | Pillsbury Co | Aerated food products |
US3754925A (en) | 1970-03-24 | 1973-08-28 | Takeda Chemical Industries Ltd | New thermo gelable polysaccharide containing foodstuffs |
US3973008A (en) | 1970-12-30 | 1976-08-03 | Kabushiki Kaisha Shimizu Manzo Shoten | Konjac mannan |
US3943247A (en) * | 1972-05-22 | 1976-03-09 | Kaken Kagaku Kabushiki Kaisha | Treatment of bacterial infections with glucan compositions |
JPS5413496B2 (ja) | 1972-10-17 | 1979-05-31 | ||
US3867554A (en) * | 1972-11-29 | 1975-02-18 | Robert William Sucher | Yeast glycan and process of making same |
IT982367B (it) * | 1972-11-30 | 1974-10-21 | Sir Soc Italiana Resine Spa | Procedimento per la produzione di lisati da microorganism |
FR2244543B1 (ja) | 1973-07-27 | 1977-07-01 | Inst Nl Sante Rech Medica | |
CH617963A5 (ja) | 1973-10-05 | 1980-06-30 | Derivati Organici Lab | |
GB1484264A (en) | 1973-10-18 | 1977-09-01 | Mars Ltd | Proteinaceous food product |
GB1483339A (en) | 1973-10-18 | 1977-08-17 | Mars Ltd | Solid proteinaceous food product |
US4066793A (en) * | 1974-03-18 | 1978-01-03 | Ajinomoto Co., Inc. | Seasoning composition and preparation thereof |
DE2452303A1 (de) | 1974-11-05 | 1976-05-13 | Bayer Ag | Extraktionsprodukte aus hefezellwandbestandteile enthaltendem material, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4122196A (en) | 1974-11-18 | 1978-10-24 | Anheuser-Busch, Incorporated | Process for the manufacture of yeast glycan |
DE2551438C2 (de) | 1974-11-26 | 1986-04-03 | Takeda Chemical Industries, Ltd., Osaka | Verfahren zur Herstellung von β-1,3-Glucanderivaten |
JPS51125773A (en) | 1975-04-25 | 1976-11-02 | Amao Suisan Kk | Method of producing fish meat extract |
JPS51136865A (en) | 1975-05-20 | 1976-11-26 | Shinji Kurihara | Production of animal edible seasonings |
US4207344A (en) | 1975-06-14 | 1980-06-10 | Cerrillo Vincente P | Processes for protecting proteic foodstuffs against spoilage |
US4138479A (en) * | 1975-11-07 | 1979-02-06 | Bayer Aktiengesellschaft | Process for the preparation of immunopotentiating agents from components of yeast cell wall material |
JPS5274406A (en) | 1975-12-05 | 1977-06-22 | Dainippon Toryo Kk | Ink for ink jet recording |
JPS52117492A (en) * | 1975-12-11 | 1977-10-01 | Hayashibara Biochem Lab Inc | Preparation of water-insoluble glucan |
MX4738E (es) | 1976-05-07 | 1982-08-25 | Nattermann A & Cie | Procedimiento para fabricar preparados enzimaticos ricos en lipasa |
CA1131371A (en) | 1976-07-16 | 1982-09-07 | James E. Zajic | Foam flotation activated sludge process |
PL193146A1 (pl) | 1976-10-19 | 1978-04-24 | Inst Przemyslu Mleczarskiego | Preparat enzymatyczny do dojrzewania bialkowych produktow mleczarskich |
JPS5366442A (en) | 1976-11-18 | 1978-06-13 | Takuma Sasaki | Antitumors |
US4071890A (en) | 1976-11-29 | 1978-01-31 | Data General Corporation | CPU-Synchronous parallel data processor apparatus |
US4299630A (en) | 1977-04-27 | 1981-11-10 | The Mead Corporation | Infrared absorptive jet printing ink |
JPS54148702A (en) * | 1978-05-12 | 1979-11-21 | Kirin Brewery | Kss22b |
IT1104351B (it) * | 1978-06-14 | 1985-10-21 | Muzzarelli Riccardo | Il complesso glucano chitosano il metodo della sua produzione a partire da muffe funghi e lieviti e i suoi usi |
DE2962386D1 (en) * | 1978-06-26 | 1982-05-06 | Unilever Nv | A process for producing a detoxified rapeseed protein concentrate |
US4218481A (en) | 1978-10-06 | 1980-08-19 | Standard Oil Company (Indiana) | Yeast autolysis process |
US4295889A (en) | 1978-12-01 | 1981-10-20 | Canon Kabushiki Kaisha | Recording liquid composition |
JPS6042766B2 (ja) | 1978-12-09 | 1985-09-25 | 日本化薬株式会社 | 基剤 |
JPS5592672A (en) | 1979-01-05 | 1980-07-14 | Ajinomoto Co Inc | Preparation of yeast extract |
JPS55130909A (en) | 1979-03-31 | 1980-10-11 | Agency Of Ind Science & Technol | Granular material containing active substance and having inactive surface-protecting layer, and its preparation |
US4313934A (en) * | 1979-05-08 | 1982-02-02 | Kirin Beer Kabushiki Kaisha | Physiologically active polysaccharides, production and uses thereof |
DK143412C (da) | 1979-05-17 | 1982-05-24 | Forenede Bryggerier As | Fremgangsmaade til udvinding af cu,zn-superoxid-dismutase fra gaer |
US4311714A (en) * | 1979-06-12 | 1982-01-19 | Endowment And Research Foundation At Montana State University | Production of products from waxy barley grain |
US4247574A (en) * | 1979-06-22 | 1981-01-27 | The Calpis Food Industry Co., Ltd. | Method of producing textured protein and textured protein produced thereby |
US4285976A (en) | 1979-11-23 | 1981-08-25 | Standard Oil Company (Indiana) | Method for accelerating autolysis of yeast |
US4543370A (en) | 1979-11-29 | 1985-09-24 | Colorcon, Inc. | Dry edible film coating composition, method and coating form |
US4310553A (en) * | 1980-02-25 | 1982-01-12 | Odintsova Ekaterina N | Process for producing food vitamin concentrate from wine yeast |
JPS56118471A (en) | 1980-02-25 | 1981-09-17 | Konishiroku Photo Ind Co Ltd | Ink composition for ink jet recording |
US4311717A (en) * | 1980-05-19 | 1982-01-19 | Fmc Corporation | Stabilizing agent for dry mix food products |
JPS6050393B2 (ja) | 1980-06-13 | 1985-11-08 | 富士写真フイルム株式会社 | 水性インキ組成物 |
US4332894A (en) | 1980-08-15 | 1982-06-01 | Purdue Research Foundation | Conversion of guar gum to gel-forming polysaccharides by the action of α-galactosidase |
DE3043611C2 (de) | 1980-11-19 | 1984-07-05 | Messerschmitt-Bölkow-Blohm GmbH, 8000 München | Drehpositionierbare Anlage |
US4361843A (en) | 1981-03-27 | 1982-11-30 | Exxon Research And Engineering Co. | Ink jet compositions and method |
US4383859A (en) | 1981-05-18 | 1983-05-17 | International Business Machines Corporation | Ink jet inks and method of making |
US4508570A (en) | 1981-10-21 | 1985-04-02 | Ricoh Company, Ltd. | Aqueous ink for ink-jet printing |
US4427710A (en) * | 1981-12-23 | 1984-01-24 | Nissin Shokuhin Kabushiki Kaisha | Method of manufacturing an instant bean curd or tofu, and the toju made by such method |
JPS59161319A (ja) | 1983-03-04 | 1984-09-12 | Nippon Bussan Kk | 薬理作用を有する魚貝類エキスの製造方法 |
US4526794A (en) | 1982-03-08 | 1985-07-02 | General Foods Corporation | Citrus albedo bulking agent and process therefor |
EP0091224B1 (en) | 1982-04-05 | 1988-05-04 | Imperial Chemical Industries Plc | Process for producing a shaped article of beta-hydroxybutyrate polymer |
DE3213159A1 (de) | 1982-04-08 | 1983-10-13 | Puls, Jürgen, Dr., 2057 Reinbek | Waessrige waermehaertbare massen und deren verwendung |
US5118673A (en) | 1982-05-07 | 1992-06-02 | Carrington Laboratories, Inc. | Uses of aloe products |
US5308838A (en) | 1982-05-07 | 1994-05-03 | Carrington Laboratories, Inc. | Uses of aloe products |
US5468737A (en) | 1982-05-07 | 1995-11-21 | Carrington Laboratories, Inc. | Wound healing accelerated by systemic administration of polysaccharide from aloe |
ZA833446B (en) | 1982-05-28 | 1984-02-29 | Solco Basel Ag | Process for the preparation of cell-and tissue-regenerating substances |
JPS5936174A (ja) | 1982-08-23 | 1984-02-28 | Ricoh Co Ltd | インクジエツト記録用水性インク |
CA1208558A (en) * | 1982-10-07 | 1986-07-29 | Kazuo Kigasawa | Soft buccal |
JPS5980475A (ja) * | 1982-10-29 | 1984-05-09 | Ricoh Co Ltd | 水性インキ組成物 |
DE3377506D1 (en) | 1982-12-30 | 1988-09-01 | Nordmark Arzneimittel Gmbh | Process for obtaining pancreatin |
US4508745A (en) | 1982-12-30 | 1985-04-02 | General Foods Corporation | Production of a mannan oligomer hydrolysate |
JPS59140860A (ja) * | 1983-01-28 | 1984-08-13 | Nippon Suisan Kaisha Ltd | 魚翅類似食品を製造する方法及び装置 |
FR2548675B1 (fr) | 1983-07-06 | 1987-01-09 | Seppic Sa | Compositions filmogenes pour enrobage des formes solides de produits pharmaceutiques ou alimentaires et produits obtenus revetus desdites compositions |
US4576646A (en) * | 1983-07-06 | 1986-03-18 | Seppic | Film-forming compositions for enveloping solid forms, particularly pharmaceutical or food products or seeds, and products obtained, coated with said compositions |
US4692404A (en) | 1983-11-18 | 1987-09-08 | Fujirebio Kabushiki Kaisha | Method of measuring biological ligand by the use of enzymes |
SE456911B (sv) | 1983-12-19 | 1988-11-14 | Olle Larm | Vattenloeslig, aminerad beta-1,3-bunden d-glukan och makrofagstimulerande komposition innehaallande densamma |
EP0153680B1 (de) | 1984-02-23 | 1989-01-25 | BASF Aktiengesellschaft | Verfahren zur Herstellung von Tetrahydrofuran |
US4484012A (en) | 1984-02-29 | 1984-11-20 | General Foods Corporation | Production of mannitol and higher manno-saccharide alcohols |
JPH0757761B2 (ja) | 1984-03-08 | 1995-06-21 | 株式会社林原生物化学研究所 | β−グルカンとその製造方法及び用途 |
JPS60196195A (ja) * | 1984-03-21 | 1985-10-04 | Dainippon Seito Kk | イ−ストグルカンの製造法 |
JPS60221063A (ja) * | 1984-04-19 | 1985-11-05 | Sugiyo:Kk | えび肉様魚肉練製品 |
US4765992A (en) | 1984-06-01 | 1988-08-23 | Universite De Bordeaux Ii | Stimulation of alcoholic fermentation by adsorption of toxic substances with cell walls |
JPS60260517A (ja) | 1984-06-08 | 1985-12-23 | Daicel Chem Ind Ltd | 食品及び薬剤用組成物 |
US4804545A (en) * | 1984-08-10 | 1989-02-14 | Barco, Inc. | Production of beta-glucan, bran, protein, oil and maltose syrup from waxy barley |
SE466289B (sv) * | 1984-09-19 | 1992-01-27 | James Hoffman | Makrofagstimulerande komposition jaemte foerfarande foer dess framstaellning |
JPS61101574A (ja) | 1984-10-23 | 1986-05-20 | Ricoh Co Ltd | 水性インク |
US5250436A (en) | 1984-11-28 | 1993-10-05 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
US5028703A (en) | 1988-03-11 | 1991-07-02 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
US5037972A (en) | 1984-11-28 | 1991-08-06 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
US4810646A (en) * | 1984-11-28 | 1989-03-07 | Massachusetts Institute Of Technology | Glucan compositions and process for preparation thereof |
US4992540A (en) * | 1984-11-28 | 1991-02-12 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
US5082936A (en) * | 1984-11-28 | 1992-01-21 | Massachusetts Institute Of Technology | Glucan composition and process for preparation thereof |
FR2573656B1 (fr) | 1984-11-29 | 1987-02-27 | Sanofi Sa | Medicament comportant en tant qu'association au moins une immunotoxine et au moins un polymere contenant du mannose |
AU588164B2 (en) | 1984-12-17 | 1989-09-07 | Japan Tobacco Inc. | A freash dough and a method for producing the same |
JPH0679545B2 (ja) | 1985-03-08 | 1994-10-12 | 味の素株式会社 | コンニヤクマンナン含有可逆性ゲル |
US4806474A (en) * | 1985-06-10 | 1989-02-21 | Miles Inc. | Preparation of mycelial chitosan and glucan fractions from microbial biomass |
IT1190380B (it) | 1985-06-21 | 1988-02-16 | Consiglio Nazionale Ricerche | Glucani funzionalizzati e reticolati,procedimento e intermedi di preparazione,loro usi |
US4774093A (en) | 1985-06-25 | 1988-09-27 | Fmc Corporation | Polysaccharide compositions, preparation and uses |
US4818751A (en) | 1985-07-02 | 1989-04-04 | Zeria Shinyaku Kogyo Kabushiki Kaisha | Cosmetics |
US4900722A (en) * | 1985-08-19 | 1990-02-13 | Bioglucans, L.P. | Methods and compositions for prophylactic and therapeutic treatment of infections |
US4739046A (en) | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
US4975421A (en) | 1985-08-19 | 1990-12-04 | Bioglucan, Lp. | Soluble phosphorylated glucan: methods and compositions for wound healing |
US4759942A (en) | 1985-09-19 | 1988-07-26 | General Foods Corporation | Process for producing high fiber expanded cereals |
US4882160A (en) | 1985-12-20 | 1989-11-21 | Warner Lambert Co. | Confectionery delivery system for dictary fiber |
US4731248A (en) * | 1986-02-18 | 1988-03-15 | Ralston Purina Company | Production of palatability enhancers from the autolysis of filamentous fungi |
JPH0692441B2 (ja) | 1986-03-03 | 1994-11-16 | 株式会社林原生物化学研究所 | β−D−グルカンとその製造方法及び用途 |
US4859488A (en) | 1987-09-15 | 1989-08-22 | Kabushiki Kaisha Yakult Honsha | Liquid food for curing constipation: polydextrose and oligosaccharide |
JPS62232472A (ja) | 1986-04-02 | 1987-10-12 | Ricoh Co Ltd | 水性インク組成物 |
JPS63112965A (ja) * | 1986-06-09 | 1988-05-18 | Takeda Chem Ind Ltd | 酵母エキスの製造法 |
US4795653A (en) * | 1986-06-16 | 1989-01-03 | Bommarito Alexander A | Dietary fiber and method of making |
US5554386A (en) | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
DE3690798T1 (ja) * | 1986-10-22 | 1989-01-19 | ||
GR871692B (en) * | 1986-11-14 | 1988-07-11 | Npo Napitkov Mineral Vod | Process for producing sparkling wines |
FI75973C (fi) | 1986-12-12 | 1988-09-09 | Kemira Oy | Foerfarande foer eliminering av mikrober i processvatten av pappersfabriker. |
US4828845A (en) | 1986-12-16 | 1989-05-09 | Warner-Lambert Company | Xylitol coated comestible and method of preparation |
US4808419A (en) * | 1987-02-02 | 1989-02-28 | Hsu Edward J | Automated method for a semi-solid fermentation used in the production of ancient quality rice vinegar and/or rice wine |
US5185327A (en) * | 1987-02-20 | 1993-02-09 | Ajinomoto Company, Inc. | Glucan derivatives having tumoricidal activity |
US4942540A (en) | 1987-03-02 | 1990-07-17 | Wang Laboratories, Inc. | Method an apparatus for specification of communication parameters |
US4761405A (en) | 1987-03-04 | 1988-08-02 | Nova Pharmaceutical Corporation | Antagonists of specific excitatory amino acid neurotransmitter receptors having increased potency |
US4863746A (en) | 1987-03-05 | 1989-09-05 | Asahi Denka Kogyo Kabushiki Kaisha | Proteinous material |
US5356810A (en) * | 1987-04-15 | 1994-10-18 | Gist-Brocades N.V. | Astaxanthin-producing yeast cells, methods for their preparation and their use |
DK199887D0 (da) | 1987-04-15 | 1987-04-15 | Danisco Bioteknologi As | Gaerstamme |
US4798730A (en) * | 1987-06-01 | 1989-01-17 | General Foods Corporation | Hydrolysis of a partially extracted roasted and ground coffee |
US4871571A (en) | 1987-06-30 | 1989-10-03 | Novo Industri A/S | Dietetic foodstuff containing low calorie bulking agent |
JPS6423878A (en) * | 1987-07-20 | 1989-01-26 | Nippon Bussan Kk | Agent for preventing denaturation of paste food |
DE3775401D1 (de) | 1987-10-09 | 1992-01-30 | Governor Of Gunma Ken Maebashi | Behandelte fleischprodukte, die ein konjac mannan-gel enthalten und verfahren zu deren herstellung. |
US5358731A (en) | 1987-12-09 | 1994-10-25 | Ajinomoto Co., Inc. | Process for producing konjak mannan containing processed minced meat foods |
JPH01165347A (ja) * | 1987-12-22 | 1989-06-29 | Kibun Kk | 果肉様ゼリー及びその製造方法 |
AU616928B2 (en) | 1988-01-20 | 1991-11-14 | Biodyn Ag | Process for the production of sparkling wine |
US5543302A (en) | 1988-05-27 | 1996-08-06 | Solvay Enzymes, Inc. | Proteases of altered stability to autolytic degradation |
AU614137B2 (en) | 1988-06-06 | 1991-08-22 | Takeda Chemical Industries Ltd. | Stabilized fgf composition and production thereof |
US4891220A (en) * | 1988-07-14 | 1990-01-02 | Immudyne, Inc. | Method and composition for treating hyperlipidemia |
US5506210A (en) | 1988-08-19 | 1996-04-09 | The Australian National University | Phosphosugar-based anti-inflammatory and/or immunosuppressive drugs |
US5690981A (en) | 1988-08-23 | 1997-11-25 | Ajinomoto Co., Inc. | Low calorie foodstuff, aqueous paste composition, as well as production process thereof |
US4962094A (en) | 1988-10-28 | 1990-10-09 | Alpha Beta Technology, Inc. | Glucan dietary additives |
US5116631A (en) | 1988-12-26 | 1992-05-26 | Ajinomoto Company, Inc. | Low-calorie food products containing konjak mannan and processes for preparing the same |
US4950749A (en) | 1989-01-06 | 1990-08-21 | The Standard Oil Company | Recovery of glucan by employing a divalent cation at an alkaline pH |
US5057503A (en) | 1989-01-23 | 1991-10-15 | The Brigham And Women's Hospital | Derivativized polysaccharides with biologic activity, method of their isolation, and uses therefor |
US5332667A (en) | 1989-02-08 | 1994-07-26 | Sapporo Breweries Limited | Method for producing biologically active polysaccharide RON substance |
US5189028A (en) * | 1989-02-20 | 1993-02-23 | Taito Co., Ltd. | Composition and method to enhance the efficacy of a fish vaccine and to stimulate the immune system of fish |
CA1330303C (en) | 1989-02-20 | 1994-06-21 | Libor Henry Nikl | Composition and process to enhance the efficacy of a fish vaccine |
US5084386A (en) * | 1989-03-31 | 1992-01-28 | Sri International | Production of beta-1,3-glucan in euglena |
US5008125A (en) | 1989-04-17 | 1991-04-16 | Kraft General Foods, Inc. | Soluble coffee with aroma recovered from the thermal hydrolysis of spent grounds |
JP2729833B2 (ja) | 1989-05-10 | 1998-03-18 | 株式会社パイロット | 耐水性を有するインキ組成物 |
US5032401A (en) * | 1989-06-15 | 1991-07-16 | Alpha Beta Technology | Glucan drug delivery system and adjuvant |
US4978551A (en) | 1989-08-08 | 1990-12-18 | Sugiyo Co., Ltd. | Simulated fish meat and method of producing same |
US5165968A (en) | 1989-08-17 | 1992-11-24 | Hewlett-Packard Company | Ink composition having rapid dry time and high print quality for plain paper printing |
IT1232310B (it) | 1989-09-04 | 1992-01-28 | Consiglio Nazionale Ricerche | Processo per la preparazione di un prodotto contenente glucano a partire da candida albicans bmm-12 |
CA2066172A1 (en) | 1989-09-08 | 1991-03-09 | Alpha Beta Technology, Inc. | Method for producing soluble glucans |
US5811542A (en) | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
DE69030880T2 (de) | 1989-09-08 | 1997-09-18 | Alpha Beta Technology | Zusammensetzung zur Stimulierung des Immunsystems |
US5488040A (en) | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
US6143731A (en) | 1989-10-20 | 2000-11-07 | The Collaborative Group, Ltd. | Glucan dietary additives |
US6020324A (en) * | 1989-10-20 | 2000-02-01 | The Collaborative Group, Ltd. | Glucan dietary additives |
US5223491A (en) | 1989-11-09 | 1993-06-29 | Donzis Byron A | Method for revitalizing skin by applying topically water insoluble glucan |
DE3939771A1 (de) | 1989-12-01 | 1991-06-06 | Behringwerke Ag | Verfahren zur biologischen inaktivierung von nukleinsaeuren |
US5468510A (en) | 1989-12-11 | 1995-11-21 | Danish Crown Inc. A/S | Low calorie meat products |
EP0466922B1 (en) * | 1990-02-01 | 1994-08-24 | Oriental Yeast Co., Ltd. | Production of yeast extract |
US5194600A (en) * | 1990-03-05 | 1993-03-16 | Royal Institute For The Advancement Of Learning | Genes which participate in β-glucan assembly and use thereof |
FR2660317B1 (fr) * | 1990-03-27 | 1994-01-14 | Seppic | Produit filmogene destine a l'enrobage des formes solides; son procede de fabrication et produits revetus de ce produit. |
EP0531437B1 (en) | 1990-05-29 | 1997-12-29 | Chemgen Corporation | Hemicellulase supplement to improve the energy efficiency of hemicellulose-containing food and animal feed |
CA2040374C (en) | 1990-07-06 | 1998-06-16 | Gunnar Rorstad | Process for enhancing the resistance of aquatic animals to disease |
US5191016A (en) * | 1990-07-19 | 1993-03-02 | Manssur Yalpani | Functionalized poly(hydroxyalkanoates) and method of manufacturing same |
JP3122454B2 (ja) | 1990-09-27 | 2001-01-09 | 生化学工業株式会社 | カブトガニ・アメボサイト・ライセートの調製法 |
GB9022560D0 (en) | 1990-10-17 | 1990-11-28 | G B Biotechnology Limited | Processing of waste |
US6093552A (en) | 1990-12-03 | 2000-07-25 | Laine; Roger A. | Diagnosis of fungal infections with a chitinase |
AU1052492A (en) * | 1991-01-31 | 1992-08-06 | Farmitalia Carlo Erba S.R.L. | Synergistic composition comprising a fibroblast growth factor and a sulfated polylsaccharide, for use as antiviral agent |
JP3115625B2 (ja) | 1991-03-30 | 2000-12-11 | 帝國製薬株式会社 | リドカイン含有外用貼付剤 |
DE4110880C1 (ja) | 1991-04-04 | 1992-12-03 | Bayer Ag, 5090 Leverkusen, De | |
CA2069234A1 (en) | 1991-05-24 | 1992-11-25 | Akira Haze | Method of purifying beta-1,3-glucans |
JP3176418B2 (ja) | 1991-06-29 | 2001-06-18 | 日本バイエルアグロケム株式会社 | 農園芸用殺菌剤 |
JP3034352B2 (ja) | 1991-08-08 | 2000-04-17 | 生化学工業株式会社 | 安定な一重らせん構造の分子内架橋(1→3)−β−D−グルカン類及びその製造法 |
US5364462A (en) | 1991-08-14 | 1994-11-15 | Graphic Utilities, Incorporated | Waterfast inks |
US5378232A (en) * | 1991-08-28 | 1995-01-03 | Orion Therapeutic Systems, Inc. | Injection/activation apparatus |
US5158772A (en) | 1991-09-23 | 1992-10-27 | Davis Walter B | Unique bacterial polysaccharide polymer gel in cosmetics, pharmaceuticals and foods |
US5273772A (en) | 1991-10-25 | 1993-12-28 | Arco Chemical Technology, L.P. | Food compositions containing esterified alkoxylated polysaccharide fat substitutes |
US5570015A (en) | 1992-02-05 | 1996-10-29 | Mitsubishi Denki Kabushiki Kaisha | Linear positional displacement detector for detecting linear displacement of a permanent magnet as a change in direction of magnetic sensor unit |
US5449526A (en) | 1992-03-04 | 1995-09-12 | Kabushikikaisha Mannan Ouyou Kaihatsu Kenkyusho | Process for producing dietary fibrous food |
FR2688134B1 (fr) * | 1992-03-05 | 1994-04-29 | Oreal | Composition cosmetique sous forme de poudre contenant un liant gras silicone. |
US5458893A (en) | 1992-03-06 | 1995-10-17 | The Quaker Oats Company | Process for treating water-soluble dietary fiber with beta-glucanase |
US5545557A (en) | 1993-04-15 | 1996-08-13 | Cpc International Inc. | Water insoluble coloring agent |
GB9208371D0 (en) | 1992-04-16 | 1992-06-03 | Cpc International Inc | Yeast debris products |
IL105503A (en) | 1992-04-28 | 1999-05-09 | Astra Ab | Carbon peptide couplets capable of eliciting an immune response of T cells |
US6254869B1 (en) | 1996-03-27 | 2001-07-03 | The Regents Of The University Of California | Cryptopain vaccines, antibodies, proteins, peptides, DNA and RNA for prophylaxis, treatment and diagnosis and for detection of cryptosporidium species |
JP2766829B2 (ja) | 1992-06-25 | 1998-06-18 | 株式会社スギヨ | 一部ゲル化した親水性マンナンペースト状食品素材お よびその製造方法 |
US5387423A (en) * | 1992-07-24 | 1995-02-07 | Otsuka Foods Co., Ltd. | Low calorie food material and method of manufacturing the same |
US5428383A (en) | 1992-08-05 | 1995-06-27 | Hewlett-Packard Corporation | Method and apparatus for preventing color bleed in a multi-ink printing system |
SE507207C2 (sv) | 1992-10-21 | 1998-04-20 | T & M Biopolymer Ab | alpha-1,4-glukanlyas från alg, sätt att bryta ned terminala alpha-1,4-D-glukosidbindningar med sagda enzym samt nedbrytningsprodukten 1,5-anhydrofruktos och dess användning som läkemedel och som antioxidant |
US5599697A (en) * | 1992-12-14 | 1997-02-04 | Takeda Chemical Industries, Ltd. | Method of producing β-1,3-glucan |
US5387427A (en) * | 1992-12-30 | 1995-02-07 | Rhone-Poulenc Specialty Chemicals Co. | Inlaid dairy products and processes |
US6210677B1 (en) | 1993-01-29 | 2001-04-03 | Robert C. Bohannon | Method to reduce the physiologic effects of drugs on mammals |
WO1994019376A1 (en) | 1993-02-26 | 1994-09-01 | Drug Delivery System Institute, Ltd. | Polysaccharide derivative and drug carrier |
AU6375394A (en) * | 1993-03-25 | 1994-10-11 | Unilever Plc | Fat-reduced laminated doughs |
US5342626A (en) | 1993-04-27 | 1994-08-30 | Merck & Co., Inc. | Composition and process for gelatin-free soft capsules |
US5773227A (en) | 1993-06-23 | 1998-06-30 | Molecular Probes, Inc. | Bifunctional chelating polysaccharides |
JP3204804B2 (ja) | 1993-06-25 | 2001-09-04 | 日本特殊陶業株式会社 | ダイヤモンドの選択形成法 |
JPH078177A (ja) | 1993-06-28 | 1995-01-13 | Nisshin Oil Mills Ltd:The | 食肉様蛋白食品の製造方法 |
GB9313484D0 (en) | 1993-06-30 | 1993-08-11 | Univ Montfort | Drug system ii |
IT1264696B1 (it) | 1993-07-09 | 1996-10-04 | Applied Pharma Res | Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata |
US5447505A (en) | 1993-08-04 | 1995-09-05 | Merocel Corporation | Wound treatment method |
JP4074659B2 (ja) | 1993-08-06 | 2008-04-09 | バイオテック エイエスエイ | 酵母菌グルカンを含有する動物飼料 |
US5519009A (en) | 1993-10-01 | 1996-05-21 | Donzis; Byron A. | Solubilized yeast glucan |
US5912153A (en) | 1993-11-18 | 1999-06-15 | Selitrennikoff; Claude P. | (1,3) β-glucan synthase genes and inducible inhibition of fungal growth using the antisense constructs derived therefrom |
IT1265240B1 (it) | 1993-11-30 | 1996-10-31 | Ekita Investments Nv | Compressa farmaceutica a rilascio controllato, di forma lenticolare |
US5958755A (en) | 1993-12-01 | 1999-09-28 | Cpc International Inc. | Process of making flavored yeast extracts |
AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
US5518710A (en) | 1994-01-11 | 1996-05-21 | University Of Saskatchewan | Methods for extracting cereal β-glucans |
US5747045A (en) | 1994-01-13 | 1998-05-05 | University Of Georgia Research Foundation, Inc. | Avian polyomavirus vaccine in psittacine birds |
US5523088A (en) | 1994-01-13 | 1996-06-04 | University Of Georgia Research Foundation, Inc. | Inactivated avian polyomavirus vaccine in psittacine birds |
CA2141007C (en) | 1994-02-01 | 1997-12-23 | Naomichi Tai | Batter, material for frying, freezing and microwave cooking and frozen fried material for microwave cooking |
US6056981A (en) | 1994-02-28 | 2000-05-02 | Biozyme Systems Inc. | Euphausiid harvesting and processing method and apparatus |
US5519287A (en) | 1994-03-21 | 1996-05-21 | Goodale, Jr.; Garold J. | Two terminal pulsed low voltage incandescent lamp dimmer with increased illuminating efficiency |
US5462755A (en) | 1994-03-25 | 1995-10-31 | Kraft Foods, Inc. | Flavor enhancement in cultured dairy products |
US5595571A (en) * | 1994-04-18 | 1997-01-21 | Hancock Jaffe Laboratories | Biological material pre-fixation treatment |
EP0759073A1 (en) * | 1994-05-11 | 1997-02-26 | Novo Nordisk A/S | AN ENZYME WITH ENDO-1,3(4)-$g(b)-GLUCANASE ACTIVITY |
US5888984A (en) * | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
US5512287A (en) | 1994-05-12 | 1996-04-30 | Centennial Foods, Inc. | Production of β-glucan and β-glucan product |
US6488929B2 (en) | 1994-05-23 | 2002-12-03 | Montana State University | Candida albicans phosphomannan complex as a vaccine |
CA2169266C (en) | 1994-06-10 | 2006-01-10 | Shogo Ito | Receiver with symbol rate sync |
GB9414045D0 (en) * | 1994-07-12 | 1994-08-31 | Berwind Pharma Service | Moisture barrier film coating composition, method, and coated form |
US5955072A (en) | 1994-07-13 | 1999-09-21 | Sankyo Company, Limited | Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide |
US5622940A (en) | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
US6060429A (en) | 1994-07-25 | 2000-05-09 | State of Israel--Ministry of Agriculture | Composition and method for controlling plant diseases caused by fungi |
JP3240102B2 (ja) | 1994-08-11 | 2001-12-17 | 江崎グリコ株式会社 | リン酸化糖とその製造方法 |
US6248566B1 (en) | 1994-09-13 | 2001-06-19 | Ezaki Glico Co., Ltd. | Glucan having cyclic structure and method for producing the same |
US6099876A (en) | 1994-10-11 | 2000-08-08 | Yissum Research Development Co. Of The Hebrew University Of Jerusalem | Temperature-stable liquid cells |
FR2726284B1 (fr) | 1994-10-31 | 1996-12-27 | Inst Oenologie | Produit biologique pour la stabilisation physico-chimique d'un vin |
US6548643B1 (en) | 1994-11-16 | 2003-04-15 | Austin Research Institute | Antigen carbohydrate compounds and their use in immunotherapy |
AUPN033894A0 (en) | 1994-12-29 | 1995-01-27 | Rowe, J.B. | Prevention of adverse behaviour in humans and animals |
US5989598A (en) | 1995-01-26 | 1999-11-23 | American Oats, Inc. | Process for forming an oat-based frozen confection |
US5576015A (en) * | 1995-03-02 | 1996-11-19 | Donzis; Byron A. | Substantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses |
AUPN166195A0 (en) | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
US6214337B1 (en) | 1995-04-18 | 2001-04-10 | Biotec Asa | Animal feeds comprising yeast glucan |
JP3536187B2 (ja) * | 1995-04-28 | 2004-06-07 | 株式会社スギヨ | パテ状乃至ムース状風味をもつ低カロリー調理食品 |
US5976580A (en) | 1995-06-07 | 1999-11-02 | Novus International, Inc. | Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals |
GB9512106D0 (en) * | 1995-06-14 | 1995-08-09 | Norsk Naeringsmiddelforskning | Animal feed |
US5785975A (en) | 1995-06-26 | 1998-07-28 | Research Triangle Pharmaceuticals | Adjuvant compositions and vaccine formulations comprising same |
AUPN398295A0 (en) * | 1995-07-05 | 1995-07-27 | Carlton And United Breweries Limited | Chemical compounds and processes for their production |
US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
US6117850A (en) | 1995-08-28 | 2000-09-12 | The Collaborative Group, Ltd. | Mobilization of peripheral blood precursor cells by β(1,3)-glucan |
WO1997008960A1 (de) | 1995-09-05 | 1997-03-13 | Tetra Werke Dr. Rer. Nat. Ulrich Baensch Gmbh | Antistressmittel für wassertiere |
US5902796A (en) | 1995-09-22 | 1999-05-11 | Carrington Laboratories, Inc. | Bioactive factors of aloe vera plants |
US5614242A (en) * | 1995-09-27 | 1997-03-25 | Barkley Seed, Inc. | Food ingredients derived from viscous barley grain and the process of making |
JPH0984529A (ja) * | 1995-09-27 | 1997-03-31 | Kohjin Co Ltd | 微生物由来のマンナンを含む家畜および家禽用飼料 |
DE69738292T2 (de) | 1996-02-09 | 2008-09-18 | Société des Produits Nestlé S.A. | Nahrungszusammensetzung für sport |
US6117641A (en) | 1996-04-11 | 2000-09-12 | Mitotix, Inc. | Assays and reagents for identifying anti-fungal agents and uses related thereto |
AU2568697A (en) | 1996-04-12 | 1997-11-07 | Novo Nordisk A/S | An enzyme with beta-1,3-glucanase activity |
US6110692A (en) | 1996-05-01 | 2000-08-29 | The Collaborative Group, Ltd. | Receptor for underivatized aqueous soluble β(1-3)-glucan |
US6084092A (en) | 1997-01-31 | 2000-07-04 | The Collaborative Group, Ltd. | β(1-3)-glucan diagnostic assays |
US6090938A (en) | 1996-05-01 | 2000-07-18 | Collaborative Group, Ltd. | Activation of signal transduction by underivatized, aqueous soluble . .beta(1-3)-Glucan |
JP3919227B2 (ja) | 1996-05-02 | 2007-05-23 | テルモ株式会社 | アミジン誘導体及びそれを構成成分とする薬物担体 |
GB9609474D0 (en) | 1996-05-08 | 1996-07-10 | Innovative Tech Ltd | Hydrogels |
US5773427A (en) | 1996-05-31 | 1998-06-30 | Day; Charles E. | Prevention of fiber-induced intestinal gas production by chitosan |
TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
JP3687194B2 (ja) | 1996-06-06 | 2005-08-24 | 味の素株式会社 | 水不溶性グルカンの精製方法 |
DE69706298T2 (de) | 1996-06-14 | 2002-06-13 | Cabot Corp | Modifizierte farbpigmente und diese enthaltende tintenstrahltinte |
US5916029A (en) | 1996-06-26 | 1999-06-29 | Liphatech, Inc. | Process for producing seeds coated with a microbial composition |
DE59711933D1 (de) * | 1996-07-19 | 2004-10-28 | Mibelle Ag Cosmetics | Polymere Glucanäther-Derivate, ihre Herstellung sowie ihre Verwendung |
US6929807B1 (en) | 1996-08-09 | 2005-08-16 | Mannatech, Inc. | Compositions of plant carbohydrates as dietary supplements |
ATE200864T1 (de) | 1996-08-29 | 2001-05-15 | Sanofi Synthelabo | Tablette mit gesteuerter freisetzung von alfuzosinhydrochlorid |
US6656481B1 (en) | 1996-09-06 | 2003-12-02 | Mitsubishi Chemical Corporation | Vaccinal preparations |
CN1081038C (zh) | 1996-09-25 | 2002-03-20 | 格雷斯林克有限公司 | β-葡聚糖产物及从谷物中提取的方法 |
US5716652A (en) * | 1996-10-02 | 1998-02-10 | Wm. Wrigley Jr. Company | Coated chewing gum products and methods of manufacturing same |
FR2754713B1 (fr) * | 1996-10-22 | 1999-01-08 | Roc Sa | Utilisation de complexes pour la preparation de compositions pour le traitement des peaux sensibles, procede de preparation et compositions hypoallergeniques |
US6020422A (en) * | 1996-11-15 | 2000-02-01 | Betzdearborn Inc. | Aqueous dispersion polymers |
ATE348155T1 (de) * | 1996-11-20 | 2007-01-15 | Introgen Therapeutics Inc | Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren |
TW386941B (en) | 1996-11-29 | 2000-04-11 | Hayashibara Biochem Lab | Inclusion packaged product and preparation of the same |
US5753266A (en) | 1996-12-03 | 1998-05-19 | Youssefyeh; Parvin | Safflower seed powder compositions for the treatment of rheumatoid based arthritic diseases |
US6197952B1 (en) * | 1996-12-18 | 2001-03-06 | Barkley Seed, Inc. | Long chained beta glucan isolates derived from viscous barley grain, and the process of making |
DE69736779T2 (de) | 1996-12-20 | 2007-08-16 | Merck & Co., Inc. | Zusammensetzungen von rekombinanten papillomavirus vakzinen |
US5939129A (en) | 1997-02-28 | 1999-08-17 | Kawano; Nobuhisa | Process for production of ground fish meat products or their analogues |
EP0967984A1 (en) | 1997-03-04 | 2000-01-05 | Peregrine Pharmaceutical, Inc. | Composition and method for treating cancer and immunological disorders resulting in chronic conditions |
AUPO556297A0 (en) | 1997-03-11 | 1997-04-10 | Australian National University, The | Sulfated oligosaccharides having anticoagulant/ antithrombotic activity |
US6897046B2 (en) | 1997-04-08 | 2005-05-24 | Japan Applied Microbiology Research Institute Ltd. | Process of preparing biologically active substance |
US6465218B1 (en) | 1997-04-08 | 2002-10-15 | Japan Applied Microbiology Research Institute Co., Ltd. | Biologically active substance and process of preparing the same |
SE522410C2 (sv) | 1997-06-06 | 2004-02-10 | Biotec Pharmacon Asa | Beta 1-3-glukanderivat med immunomodulerande verkan |
US6046323A (en) | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
DE69830302T2 (de) | 1997-08-15 | 2006-02-02 | Unitika Ltd., Amagasaki | Mannose enthaltendes futtermittel sowie verfahren zu dessen herstellung |
JP4071438B2 (ja) | 1997-09-01 | 2008-04-02 | 生化学工業株式会社 | 真菌からの(1→3)−β−D−グルカンの調製法 |
US5932561A (en) | 1997-10-24 | 1999-08-03 | Rexall Sundown, Inc. | Dietary composition with lipid binding properties for weight management and serum lipid reduction |
US5980918A (en) * | 1997-10-24 | 1999-11-09 | Brennen Medical, Inc. | β-D-glucan topical composition |
US6036946A (en) * | 1997-12-24 | 2000-03-14 | Shaklee Corporation | Methods for protecting skin from damaging effects of ultraviolet light |
US6143551A (en) | 1997-12-29 | 2000-11-07 | Schering Aktiengesellschaft | Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria |
CA2319090C (en) * | 1998-01-30 | 2004-05-04 | The Procter & Gamble Company | Beverages with improved texture and flavor impact at lower dosage of solids |
US6673384B1 (en) * | 1998-01-30 | 2004-01-06 | The Procter & Gamble Co. | Creamy mouthfeel agent for foods and beverages |
TW427966B (en) | 1998-03-02 | 2001-04-01 | Hidekatsu Kawamoto | Organic liquid nutrition source for plants and manufacturing method for same |
EP0954978B1 (en) | 1998-03-12 | 2011-11-30 | VHsquared Limited | New products comprising inactivated yeasts or moulds provided with active antibodies |
ATE535154T1 (de) * | 1998-03-12 | 2011-12-15 | Vhsquared Ltd | Produkten die inaktivierte hefen oder schimmel enthalten, die auf ihrer aussenoberfläche aktive antikörper haben |
US6251877B1 (en) | 1998-03-24 | 2001-06-26 | Pacific Corporation | Composition for external application containing a β-1,6-branched-β-1,3-glucan |
US6365185B1 (en) | 1998-03-26 | 2002-04-02 | University Of Cincinnati | Self-destructing, controlled release peroral drug delivery system |
US6020016A (en) * | 1998-04-01 | 2000-02-01 | The J.M. Smucker Company | Glucan containing beverage and method of making the same |
DE19816070A1 (de) | 1998-04-09 | 1999-10-14 | Aventis Res & Tech Gmbh & Co | Retardtablette hergestellt aus linearen wasserunlöslichen Polysacchariden |
FR2777193B1 (fr) | 1998-04-14 | 2001-06-08 | Coletica | Particule a groupement hydroxamique chelatante d'ions metalliques et leur utilisation en cosmetique ou en pharmacie |
WO1999055715A2 (en) | 1998-04-28 | 1999-11-04 | Galenica Pharmaceuticals, Inc. | Polysaccharide-antigen conjugates |
US6455083B1 (en) | 1998-05-05 | 2002-09-24 | Natural Polymer International Corporation | Edible thermoplastic and nutritious pet chew |
US6379725B1 (en) | 1998-05-05 | 2002-04-30 | Natural Polymer International Corporation | Protein-based chewable pet toy |
EP1083896A4 (en) | 1998-05-11 | 2002-09-11 | Endowment For Res In Human Bio | USE OF NEOMYCIN FOR TREATING ANGIOGENESIS-RELATED DISEASES |
US6284886B1 (en) | 1998-05-27 | 2001-09-04 | Ceapro Inc | Cereal beta glucan compositions and methods of Formulation |
JP3798913B2 (ja) | 1998-07-31 | 2006-07-19 | 伊那食品工業株式会社 | 増粘用添加液 |
GB9817183D0 (en) | 1998-08-06 | 1998-10-07 | Unilever Plc | Frozen low-fat food emulsions and processes therefor |
GB9817182D0 (en) | 1998-08-06 | 1998-10-07 | Unilever Plc | Low-fat food emulsions having controlled flavour release and processes therefor |
DE19835767A1 (de) * | 1998-08-07 | 2000-02-17 | Kulicke Werner Michael | Verfahren zur Gewinnung hochmolekularer biologisch aktiver immunmodulierender Polysaccharide aus Hefe Saccharomyces Cerevisiae |
US6214376B1 (en) | 1998-08-25 | 2001-04-10 | Banner Pharmacaps, Inc. | Non-gelatin substitutes for oral delivery capsules, their composition and process of manufacture |
DE19839216C1 (de) | 1998-08-28 | 2000-01-20 | Aventis Res & Tech Gmbh & Co | Verfahren zur Herstellung von sphärischen Mikropartikeln, die ganz oder teilweise aus mindestens einem wasserunlöslichen Verzweigungen enthaltenden Polyglucan bestehen, sowie mit diesem Verfahren erhältliche Mikropartikel und die Verwendung |
DE19839212C2 (de) | 1998-08-28 | 2002-05-23 | Celanese Ventures Gmbh | Verfahren zur Herstellung von sphärischen Nanopartikeln, die ganz oder teilweise aus mindestens einem wasserunlöslichen linearen Polysaccharid bestehen |
WO2000012564A1 (fr) | 1998-08-31 | 2000-03-09 | Nof Corporation | Polysaccharide a haut degre de purete contenant des groupes hydrophobes et procede de production de ce polysaccharide |
EP1121135B1 (en) * | 1998-09-14 | 2009-01-28 | Nabi Biopharmaceuticals | Compositions of beta-glucans and specific immunoglobulins |
US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
AU6261999A (en) | 1998-09-25 | 2000-04-17 | Collaborative Group, Ltd., The | Very high molecular weight beta-glucans |
US6635275B1 (en) | 1999-01-29 | 2003-10-21 | Warner-Lambert Company | Modified starch film compositions |
ES2339619T3 (es) | 1998-10-09 | 2010-05-21 | Bayer Bioscience Gmbh | Moleculas de acidos nucleicos que codifican una enzima ramificadora procedente de bacterias del genero neisseria, asi como procedimientos para la preparacion de alfa-1,4-glucanos ramnificados en las posiciones alfa-1,6. |
JP2002528062A (ja) | 1998-10-26 | 2002-09-03 | セバ エービー | オートムギからβ−グルカン組成物を分離する方法及びそれから得られた生成物 |
IL142557A0 (en) | 1998-10-28 | 2002-03-10 | Snow Brand Milk Products Co Ltd | Remedies for bone metabolic errors |
US6287612B1 (en) | 1998-12-01 | 2001-09-11 | Nestec S.A. | Liquid food products and package therefore |
US6210686B1 (en) | 1998-12-18 | 2001-04-03 | Beth Israel Deaconess Medical Center | Dietary supplement and method for lowering risk of heart disease |
DE19860376A1 (de) * | 1998-12-28 | 2000-07-06 | Aventis Res & Tech Gmbh & Co | Alpha-1,4 Glucanketten enthaltende Polysaccharide sowie Verfahren zu ihrer Herstellung |
DE19860371A1 (de) | 1998-12-28 | 2000-06-29 | Aventis Res & Tech Gmbh & Co | Kosmetische oder medizinische Zubereitung für die topische Anwendung |
US6143883A (en) | 1998-12-31 | 2000-11-07 | Marlyn Nutraceuticals, Inc. | Water-soluble low molecular weight beta-glucans for modulating immunological responses in mammalian system |
US6159504A (en) | 1999-01-11 | 2000-12-12 | Kitii Corporation, Ltd. | Core substance-containing calcium microparticles and methods for producing the same |
US6482942B1 (en) | 1999-01-12 | 2002-11-19 | Biotechnology Services And Consulting, Inc. | Method of isolating mucilaginous polysaccharides and uses thereof |
US6083547A (en) | 1999-01-14 | 2000-07-04 | Conagra, Inc. | Method for obtaining a high beta-glucan barley fraction |
US6165994A (en) | 1999-02-08 | 2000-12-26 | Blue Ridge Pharmaceuticals, Inc. | Methods for promoting the healing of cutaneous wounds and ulcers using compositions of α-D-glucans |
US6485945B1 (en) | 1999-02-17 | 2002-11-26 | Nurture, Inc. | Polysaccharide compositions and uses thereof |
US6323338B1 (en) | 1999-02-17 | 2001-11-27 | Nurture, Inc. | Method for concentrating β-glucan |
MXPA01008603A (es) | 1999-02-24 | 2002-07-02 | Tno | Proceso para la oxidacion selectiva de alcoholes primarios y aldehidos de carbohidrato novedosos. |
AU3657100A (en) | 1999-03-12 | 2000-10-04 | Biotec Asa | Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents |
DE19911058B4 (de) * | 1999-03-12 | 2004-09-30 | Biotec Asa | Verwendung von nanoskaligen wasserlöslichen β-(1,3)-Glucanen |
NZ334627A (en) * | 1999-03-12 | 2002-07-26 | Horticulture & Food Res Inst | A therapeutic composition containing a therapeutic agent such as an anthelmintic and an antistress agent such as metyrapone or a nitric oxide promoter for increasing efficacy of therapeutic agents and animal growth |
US6482632B1 (en) | 1999-03-29 | 2002-11-19 | Council Of Scientic And Industrial Research | Bacteriophage, a process for the isolation thereof, and a universal growth medium useful in the process thereof |
JP2001008636A (ja) | 1999-06-30 | 2001-01-16 | Tanabe Seiyaku Co Ltd | 感染症防止用飼料組成物 |
US6448323B1 (en) | 1999-07-09 | 2002-09-10 | Bpsi Holdings, Inc. | Film coatings and film coating compositions based on polyvinyl alcohol |
CN1252154C (zh) | 1999-07-22 | 2006-04-19 | 沃纳-兰伯特公司 | 支链淀粉膜组合物 |
US6737089B2 (en) | 1999-08-27 | 2004-05-18 | Morinda, Inc. | Morinda citrifolia (Noni) enhanced animal food product |
US6541678B2 (en) | 1999-09-27 | 2003-04-01 | Brennen Medical, Inc. | Immunostimulating coating for surgical devices |
FI113938B (fi) | 1999-10-13 | 2004-07-15 | Suomen Viljava Oy | Menetelmä beta-glukaanin suhteen rikastetun kauratuotteen valmistamiseksi sekä menetelmällä saatavan tuotteen käyttö |
US6669771B2 (en) | 1999-12-08 | 2003-12-30 | National Institute Of Advanced Industrial Science And Technology | Biodegradable resin compositions |
US6811788B2 (en) | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
US6669975B1 (en) | 2000-02-03 | 2003-12-30 | Mars Incorporated | Customized dietary health maintenance system for pets |
US7138519B2 (en) | 2000-02-07 | 2006-11-21 | Grante Seed Limited | Process for extraction of β-glucan from cereals and products obtained therefrom |
US6716462B2 (en) | 2000-04-12 | 2004-04-06 | Mid-America Commercialization Corporation | Nutritionally balanced traditional snack foods |
US6899905B2 (en) | 2000-04-12 | 2005-05-31 | Mid-America Commercialization Corporation | Tasty, ready-to-eat, nutritionally balanced food compositions |
US6827954B2 (en) | 2000-04-12 | 2004-12-07 | Mid-America Commercialization Corporation | Tasty, convenient, nutritionally balanced food compositions |
US20030130205A1 (en) | 2000-04-12 | 2003-07-10 | Christian Samuel T. | Novel pharmaceutical anti-infective agents containing carbohydrate moieties and methods of their preparation and use |
US6726943B2 (en) | 2000-04-12 | 2004-04-27 | Mid-America Commercialization Corporation | Nutritionally balanced snack food compositions |
US6720015B2 (en) | 2000-04-12 | 2004-04-13 | Mid-America Commercialization Corporation | Ready-to-eat nutritionally balanced food compositions having superior taste systems |
US6846501B2 (en) * | 2000-04-12 | 2005-01-25 | Mid-America Commercialization Corporation | Traditional snacks having balanced nutritional profiles |
EP1277413A4 (en) * | 2000-04-24 | 2004-09-15 | Ajinomoto Kk | COMPOSITIONS FOR SEASONING, FOOD AND BEVERAGES CONTAINING THEM, AND PROCESS FOR PRODUCING THE COMPOSITIONS |
US6713459B1 (en) | 2000-04-28 | 2004-03-30 | East Tennessee State University | Methods for the prophylactic and therapeutic treatment of cardiac tissue damage |
US20040091949A1 (en) | 2000-05-01 | 2004-05-13 | Akihiro Kitamura | Method of screening drug acting on cell wall |
DE10022095B4 (de) | 2000-05-08 | 2005-07-14 | Südzucker AG Mannheim/Ochsenfurt | Gel aus einem Poly-α-1,4-Glucan und Stärke |
ATE286072T1 (de) | 2000-05-22 | 2005-01-15 | Univ New York | Synthetische immunogene jedoch nicht amyloidogene peptide, die homolog zu amyloid beta sind und deren verwendung zur induktion einer immunantwort gegen amyloid beta und amyloidaggregate |
US6486314B1 (en) | 2000-05-25 | 2002-11-26 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Glucan incorporating 4-, 6-, and 4, 6- linked anhydroglucose units |
ES2313976T3 (es) * | 2000-07-03 | 2009-03-16 | Granate Seed Limited | Producto de b-glucano soluble en agua fria y procedimiento para preparar el mismo. |
DK177997B1 (da) | 2000-07-19 | 2015-02-23 | Ed Geistlich Söhne Ag Für Chemische Ind | Knoglemateriale og collagenkombination til opheling af beskadigede led |
EP1414865B1 (en) * | 2000-08-03 | 2014-04-09 | Abac R & D Ag | Isolation of glucan particles and uses thereof |
US6426077B1 (en) | 2000-08-04 | 2002-07-30 | Indoor Tennis Consultants, Inc. | Food product for health, nutrition and weight management |
US6365176B1 (en) | 2000-08-08 | 2002-04-02 | Functional Foods, Inc. | Nutritional supplement for patients with type 2 diabetes mellitus for lipodystrophy |
MXPA03001420A (es) | 2000-08-14 | 2004-01-26 | Johnson & Johnson | Pirazoles sustituidos. |
US6569475B2 (en) | 2000-10-06 | 2003-05-27 | Jae-Mahn Song | Process for mycelial culture using grain |
US20040127458A1 (en) | 2000-11-06 | 2004-07-01 | Hunter Kenneth W. | Beta-glucan containing compositions, methods for manufacturing beta-glucans, and for manufacturing and using beta-glucans and conjugates thereof as vaccine adjuvants |
US6476003B1 (en) | 2000-11-06 | 2002-11-05 | Immusonic, Inc. | Method for preparing small particle size glucan in a dry material |
US6531178B2 (en) * | 2000-12-08 | 2003-03-11 | Quaker Oats/Rhone-Poulenc Partnership | β-glucan process, additive and food product |
JP2004515508A (ja) | 2000-12-16 | 2004-05-27 | アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 化合物の健康促進組成物 |
JP2002209598A (ja) * | 2001-01-15 | 2002-07-30 | Kirin Brewery Co Ltd | 酵母由来可溶性多糖 |
US7507724B2 (en) | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
AUPR272901A0 (en) * | 2001-01-25 | 2001-02-22 | Gainful Plan Limited | Method of preparing biological materials and preparations produced using same |
NZ521894A (en) | 2001-02-15 | 2006-08-31 | Adeka Corp | Products containing beta-glucan |
US6927059B2 (en) | 2001-03-06 | 2005-08-09 | Trustees Of Dartmouth College | Compositions and methods for identifying agents which regulate autolytic processes in bacteria |
DE60232784D1 (de) | 2001-04-05 | 2009-08-13 | Fuji Oil Co Ltd | Mannose enthaltendes palmkernmehl |
US6835214B2 (en) | 2001-06-18 | 2004-12-28 | Japan Storage Battery Co., Ltd. | Process for the production of non-aqueous electrolyte battery |
JP2003000197A (ja) * | 2001-06-22 | 2003-01-07 | Morinaga & Co Ltd | 酵母由来多糖類含有組成物及びその製造方法 |
US6939864B1 (en) | 2001-07-09 | 2005-09-06 | Purdue Research Foundation | Animal feed compositions and methods of using the same |
US7786094B2 (en) | 2001-10-09 | 2010-08-31 | Biopolymer Engineering, Inc. | Use of beta-glucans against biological warfare weapons and pathogens including anthrax |
US6706305B2 (en) | 2001-10-31 | 2004-03-16 | Conagra Foods Inc. | Low glycemic index bread |
US6899892B2 (en) | 2001-12-19 | 2005-05-31 | Regents Of The University Of Minnesota | Methods to reduce body fat |
US6835558B2 (en) | 2002-02-04 | 2004-12-28 | General Mills, Inc. | Beta-glucan compositions and process therefore |
FR2836333B1 (fr) | 2002-02-25 | 2004-07-02 | Seppic Sa | Procede de coloration de dragees, composition mise en oeuvre |
DE10222358A1 (de) | 2002-05-21 | 2003-12-11 | Nutrinova Gmbh | ß-Glucanhaltiges Sorbinsäurepräparat als Futtermittelzusatz in der Nutztieraufzucht |
US7186385B2 (en) * | 2002-07-17 | 2007-03-06 | Applied Materials, Inc. | Apparatus for providing gas to a processing chamber |
WO2004014320A2 (en) | 2002-08-13 | 2004-02-19 | Biopolymer Engineering, Inc. | Methods of using beta glucan as a radioprotective agent |
JP2004099580A (ja) * | 2002-09-05 | 2004-04-02 | San Baiorekkusu:Kk | 免疫増強組成物並びにそれを含有する哺乳類、魚類用飼料 |
US7018986B2 (en) | 2002-09-20 | 2006-03-28 | Immudyne | Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption |
US6824810B2 (en) | 2002-10-01 | 2004-11-30 | The Procter & Gamble Co. | Creamer compositions and methods of making and using the same |
ITCZ20020011A1 (it) * | 2002-12-10 | 2004-06-11 | Antonio Salvatore Pacile | Sistema di certificazione delle rese |
RU2005133707A (ru) | 2003-04-02 | 2006-04-20 | Карджилл, Инкорпорейтед (Us) | Усовершенствованные, содержащие пищевые волокна материалы, включающие глюкан с низкой молекулярной массой |
US7988989B2 (en) * | 2003-05-09 | 2011-08-02 | Freedom Health, Llc | Nutritional product for enhancing growth and/or strengthening the immune system of equine foals |
US20050058671A1 (en) | 2003-05-09 | 2005-03-17 | Bedding Peter M.J. | Dietary supplement and method for treating digestive system-related disorders |
KR100491186B1 (ko) | 2003-09-29 | 2005-05-25 | (주)에이치케이바이오텍 | 아가리쿠스 버섯균사체 액체배양법에 의해 생성된이소플라본-베타디글루칸 및 그의 제조방법 |
PL1677613T3 (pl) | 2003-10-30 | 2012-10-31 | Arla Foods Amba | Stabilizatory stosowane w produkcji past do smarowania o niskiej zawartości tłuszczu |
US6936598B2 (en) | 2003-11-21 | 2005-08-30 | Hill's Pet Nutrition, Inc. | Composition and method |
WO2005078114A1 (ja) * | 2004-02-13 | 2005-08-25 | Alpron Co., Ltd. | 酵母由来グルカンの製造方法 |
JP2006037016A (ja) * | 2004-07-29 | 2006-02-09 | Shiriusu:Kk | 鹿角霊芝からのβ−グルカン抽出法 |
US20050020490A1 (en) * | 2004-10-18 | 2005-01-27 | Progressive Bioactives Incorporated | A Method of Producing an Economical and Ecologically Sound Natural Immunobiotic Extract for Use as a Health Management Instrument and a Replacement for Growth Promotion Antibiotics in Livestock and Companion Animals. |
JP4570949B2 (ja) * | 2004-12-13 | 2010-10-27 | 株式会社アルプロン | 酵母由来グルカンの製造方法 |
-
2006
- 2006-05-05 JP JP2008510230A patent/JP5296531B2/ja active Active
- 2006-05-05 WO PCT/US2006/017270 patent/WO2006121803A1/en active Application Filing
- 2006-05-05 CA CA2607004A patent/CA2607004C/en active Active
- 2006-05-05 US US11/418,922 patent/US20060263415A1/en not_active Abandoned
- 2006-05-05 CN CN2006800150267A patent/CN101184780B/zh active Active
- 2006-05-05 CA CA2912012A patent/CA2912012C/en active Active
- 2006-05-05 MX MX2007013725A patent/MX2007013725A/es active IP Right Grant
- 2006-05-05 EP EP06759096.8A patent/EP1877447B1/en active Active
-
2010
- 2010-01-25 US US12/693,164 patent/US8753668B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3880742A (en) * | 1972-02-22 | 1975-04-29 | Glaxo Lab Ltd | {62 -1,4,/{62 1,3 Glucanase |
US5589591A (en) * | 1986-07-03 | 1996-12-31 | Advanced Magnetics, Inc. | Endotoxin-free polysaccharides |
US20080193485A1 (en) * | 2005-02-15 | 2008-08-14 | Gorbach Sherwood L | Food Containing a Probiotic and an Isolated Beta-Glucan and Methods of Use Thereof |
US20080194517A1 (en) * | 2007-02-09 | 2008-08-14 | L.C.M. Equine Nutraceuticals, Inc. | Equine or canine immunomodulating composition and treatment method |
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US20090023681A1 (en) * | 2007-07-16 | 2009-01-22 | Kim Moo-Sung | Method of using beta-glucan from schizophyllum commune |
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Also Published As
Publication number | Publication date |
---|---|
JP5296531B2 (ja) | 2013-09-25 |
MX2007013725A (es) | 2008-04-09 |
CA2607004C (en) | 2016-01-26 |
BRPI0611535A2 (pt) | 2010-09-21 |
CA2607004A1 (en) | 2006-11-16 |
US20100190872A1 (en) | 2010-07-29 |
CA2912012C (en) | 2018-05-29 |
BRPI0611535A8 (pt) | 2017-03-28 |
JP2008541700A (ja) | 2008-11-27 |
CA2912012A1 (en) | 2006-11-16 |
EP1877447A1 (en) | 2008-01-16 |
CN101184780A (zh) | 2008-05-21 |
CN101184780B (zh) | 2012-10-03 |
EP1877447B1 (en) | 2016-12-21 |
US8753668B2 (en) | 2014-06-17 |
WO2006121803A1 (en) | 2006-11-16 |
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