UA94038C2 - Продуцирование каротиноидов в маслянистых дрожжах и грибах - Google Patents

Продуцирование каротиноидов в маслянистых дрожжах и грибах

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Publication number
UA94038C2
UA94038C2 UAA200710335A UAA200710335A UA94038C2 UA 94038 C2 UA94038 C2 UA 94038C2 UA A200710335 A UAA200710335 A UA A200710335A UA A200710335 A UAA200710335 A UA A200710335A UA 94038 C2 UA94038 C2 UA 94038C2
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Prior art keywords
fungi
oleaginous
theirs
produce
carotenoid
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UAA200710335A
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English (en)
Ukrainian (uk)
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Ричард Бейли
Кевин Т. Медден
Джошуа Трухарт
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Майкробиа, Инк.
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Publication of UA94038C2 publication Critical patent/UA94038C2/ru

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Abstract

Изобретение относится к рекомбинантным грибам, которые характеризуются тем, что: грибы являются маслянистыми, то есть могут накапливать липиды как минимум до 20% их сухой клеточной массы и продуцируют как минимум один каротиноид, и могут накапливать продуцированный каротиноид как минимум до примерно 1% их сухой клеточной массы, причем грибы включают как минимум одну модификацию, отобранную из группы, которая состоит из каротиногенных модификаций, олеагенных модификаций и их комбинаций, и причем как минимум одна модификация изменяет олеагенность грибов и придает грибам олеагенность и способность продуцировать как минимум один каротиноид до уровня, который составляет как минимум примерно 1% их сухой клеточной массы, или придает грибам способность продуцировать как минимум один каротиноид, который грибы в природе не продуцируют.
UAA200710335A 2005-03-18 2006-03-20 Продуцирование каротиноидов в маслянистых дрожжах и грибах UA94038C2 (ru)

Applications Claiming Priority (1)

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US66362105P 2005-03-18 2005-03-18

Publications (1)

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UA94038C2 true UA94038C2 (ru) 2011-04-11

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Country Link
US (3) US7851199B2 (ru)
EP (2) EP2371967B1 (ru)
JP (4) JP2008537878A (ru)
KR (1) KR101482081B1 (ru)
CN (2) CN103589650A (ru)
AU (1) AU2006227165B2 (ru)
BR (1) BRPI0609040B1 (ru)
CA (1) CA2602183C (ru)
EA (1) EA016258B1 (ru)
ES (1) ES2546484T3 (ru)
IL (1) IL185713A0 (ru)
NO (1) NO20075200L (ru)
UA (1) UA94038C2 (ru)
WO (1) WO2006102342A2 (ru)
ZA (1) ZA200707651B (ru)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8577205B2 (en) * 1998-07-30 2013-11-05 Tivo Inc. Digital video recording system
CA2588630C (en) * 2004-11-19 2013-08-20 Tivo Inc. Method and apparatus for secure transfer of previously broadcasted content
EA016258B1 (ru) 2005-03-18 2012-03-30 Микробиа, Инк. Рекомбинантные грибы, продуцирующие каротиноиды, и способы их применения
CN102861332A (zh) 2005-10-26 2013-01-09 诺瓦提斯公司 IL-1β化合物的新用途
WO2007120423A2 (en) * 2006-03-20 2007-10-25 Microbia Precision Engineering Production of quinone derived compounds in oleaginous yeast and fungi
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
US8846374B2 (en) * 2006-12-12 2014-09-30 E I Du Pont De Nemours And Company Carotenoid production in a recombinant oleaginous yeast
MY154965A (en) 2007-06-01 2015-08-28 Solazyme Inc Production of oil in microorganisms
JP2009000046A (ja) * 2007-06-21 2009-01-08 Hitachi Zosen Corp トチュウのメバロン酸経路の酵素をコードする遺伝子
WO2009006386A2 (en) * 2007-06-29 2009-01-08 The Regents Of The University Of California Host cells and methods for producing isoprenyl alkanoates
WO2009010826A2 (en) * 2007-07-13 2009-01-22 Ocean Nutrition Canada Ltd. Novel genes and methods of producing carotenoids
JP5451398B2 (ja) * 2007-10-26 2014-03-26 サントリーホールディングス株式会社 新規なatp:クエン酸リアーゼ遺伝子
EP2235193B1 (en) 2007-12-23 2015-11-25 GEVO, Inc. Yeast organism producing isobutanol at a high yield
US8455239B2 (en) 2007-12-23 2013-06-04 Gevo, Inc. Yeast organism producing isobutanol at a high yield
AU2008345126A1 (en) 2007-12-27 2009-07-09 Gevo, Inc. Recovery of higher alcohols from dilute aqueous solutions
MX2010011065A (es) 2008-04-09 2010-12-06 Solazyme Inc Modificacion química directa de biomasa microbiana y aceites microbianos.
US20120149886A1 (en) * 2008-04-10 2012-06-14 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
WO2009143490A1 (en) * 2008-05-23 2009-11-26 Cibus International, L.P. Production of squalene using yeast
EP2326707B1 (en) 2008-08-12 2016-11-23 Evolva, Inc. Method for production of isoprenoids
WO2010062707A1 (en) * 2008-10-30 2010-06-03 Joule Unlimited, Inc. Methods and compositions for producing carbon-based products of interest in micro-organisms
WO2010053636A1 (en) * 2008-11-06 2010-05-14 Tate & Lyle Technology Ltd Enhanced production and purification of a natural high intensity sweetener
JP5859311B2 (ja) 2008-11-28 2016-02-10 ソラザイム, インコーポレイテッドSolazyme Inc 組み換え従属栄養微生物における、用途に応じた油の生産
WO2010126063A1 (ja) 2009-05-01 2010-11-04 日産自動車株式会社 燃料電池用ガス拡散層
DK2443248T3 (en) 2009-06-16 2018-03-12 Du Pont IMPROVEMENT OF LONG-CHAIN POLYUM Saturated OMEGA-3 AND OMEGA-6 FATTY ACID BIOS SYNTHESIS BY EXPRESSION OF ACYL-CoA LYSOPHOSPHOLIPID ACYL TRANSFERASES
EP2292741A1 (en) * 2009-08-26 2011-03-09 OrganoBalance GmbH Genetically modified organisms for the production of lipids
AU2010321722B2 (en) * 2009-11-23 2016-03-24 Cibus Europe B.V. Methods and compositions for producing squalene using yeast
US20110263709A1 (en) 2010-04-22 2011-10-27 E. I. Du Pont De Nemours And Company Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass
CN106135460B (zh) 2010-05-28 2020-07-24 柯碧恩生物技术公司 包含特制油的食品组合物
KR101283149B1 (ko) 2010-08-06 2013-07-05 문기혁 만가닥버섯 느타리버섯 팽이버섯 새송이 버섯과 파피아 로도자이마 효모의 혼합배양기술 개발과 아스타잔틴이 함유된 항산화효과가 있는 사료첨가용 생균제의 개발
US20120040076A1 (en) 2010-08-11 2012-02-16 E. I. Du Pont De Nemours And Company Aquaculture feed compositions
JP2013535987A (ja) 2010-08-26 2013-09-19 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 高レベルのエイコサペンタエン酸生産のための組換え微生物宿主細胞
AU2011293167B2 (en) 2010-08-26 2016-12-08 E. I. Du Pont De Nemours And Company Mutant delta-9 elongases and their use in making polyunsaturated fatty acids
BR112013004355A2 (pt) 2010-08-26 2021-05-04 E.I. Du Pont De Nemours And Company polipeptídeo mutante possuindo atividade delta-5 dessaturase, molécula de ácido nucleico isolada e célula transformada.
SG190154A1 (en) 2010-11-03 2013-06-28 Solazyme Inc Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods
CN102071154B (zh) * 2010-12-08 2013-05-22 江南大学 一种产α-酮戊二酸酵母工程菌及其构建方法
CA2823210A1 (en) * 2010-12-30 2012-07-05 E.I. Du Pont De Nemours And Company Increased oil content by increasing yap1 transcription factor activity in oleaginous yeasts
MX2013008062A (es) * 2011-01-28 2013-08-09 Amyris Inc Seleccion de microcolonias encapsuladas en gel.
CN103827307A (zh) 2011-02-02 2014-05-28 索拉兹米公司 产自重组产油微生物的定制油
US9051587B2 (en) * 2011-02-28 2015-06-09 Organobalance Gmbh Yeast cell for the production of terpenes and uses thereof
US8969049B2 (en) 2011-03-31 2015-03-03 E I Du Pont De Nemours And Company Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast
EP2694665A1 (en) 2011-04-01 2014-02-12 E. I. Du Pont de Nemours and Company Yarrowia esterase/lipase promoter regions for gene expression in yeast
US20120247066A1 (en) 2011-04-01 2012-10-04 Ice House America, Llc Ice bagging apparatus and methods
WO2012138613A1 (en) 2011-04-05 2012-10-11 E. I. Du Pont De Nemours And Company Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast
US8609369B2 (en) 2011-04-07 2013-12-17 E I Du Pont De Nemours And Company Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast
BR112013028621A2 (pt) 2011-05-06 2016-11-29 Solazyme Inc "microalgas oleaginosas recombinantes, método para produzir biomassa de microalga ou um produto produzido da biomassa, e método para produzir uma composição lipídica de microalga".
CN102250958B (zh) * 2011-07-08 2013-01-02 山东大学 一种体外酶反应生成的类胡萝卜素的快速提取方法
CN102286593B (zh) * 2011-07-08 2013-03-13 山东大学 一种提高八氢番茄红素脱氢酶体外反应速率的方法
CA2862980A1 (en) 2012-01-23 2013-08-01 Dsm Ip Assets B.V. Diterpene production
WO2013119552A2 (en) * 2012-02-06 2013-08-15 The Research Foundation Of The City University Of New York Cells and methods for producing lutein
WO2013144781A2 (en) * 2012-03-30 2013-10-03 Koninklijke Philips N.V. Portable medical imager with gui interface
US8916365B2 (en) 2012-04-03 2014-12-23 E I Du Pont De Nemours And Company Expression of cytosolic malic enzyme in transgenic Yarrowia to increase lipid production
AU2013249172C1 (en) 2012-04-18 2017-08-10 Corbion Biotech, Inc. Tailored oils
JP2015519921A (ja) 2012-06-19 2015-07-16 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company 突然変異アシルCoA:リゾホスファチジルコリンアシルトランスフェラーゼ
EP3305907A1 (en) * 2012-07-13 2018-04-11 Calysta, Inc. Biorefinery system, methods and compositions thereof
US10738328B1 (en) 2012-11-27 2020-08-11 University Of Kentucky Research Foundation Method and system for terpene production platforms in yeast
EP2935571B1 (en) 2012-12-20 2018-03-07 DSM IP Assets B.V. Acetyl transferases and their use for producing carotenoids
WO2014096990A1 (en) 2012-12-20 2014-06-26 Dsm Ip Assets B.V. Carotene hydroxylase and its use for producing carotenoids
WO2014140924A2 (en) * 2013-03-12 2014-09-18 International Park Of Creativity Biological devices and methods for increasing the production of lycopene from plants
EA035489B1 (ru) 2013-03-15 2020-06-24 ДСМ АйПи АССЕТС Б.В. Применение термофильных нуклеаз для разрушения нуклеиновых кислот в клетках-хозяевах
WO2014176515A2 (en) 2013-04-26 2014-10-30 Solazyme, Inc. Low polyunsaturated fatty acid oils and uses thereof
DE102013209950A1 (de) 2013-05-28 2014-12-04 Technische Universität Dresden Hefestamm und Verfahren zur Produktion von Lycopin
CA2853585A1 (en) * 2013-06-05 2014-12-05 Vale S.A. Process for obtaining copper nanoparticles from rhodotorula mucilaginosa and use of rhodotorula mucilaginosa in bioremediation of wastewater and production of copper nanoparticles
CA2925527A1 (en) 2013-10-04 2015-04-09 Solazyme, Inc. Tailored oils
WO2015082688A1 (en) 2013-12-06 2015-06-11 Dsm Ip Assets B.V. Biomass formulation
EP3102683B1 (en) * 2014-01-31 2019-10-23 DSM IP Assets B.V. Promoters suitable for heterologous gene expression in yeast
CA2949381A1 (en) * 2014-05-16 2015-11-19 Academia Sinica Recombinant polynucleotide sequence for producing astaxanthin and uses thereof
CN105316246B (zh) * 2014-06-03 2019-10-01 上海来益生物药物研究开发中心有限责任公司 β-胡萝卜素高产菌种及其应用
EP3620517A3 (en) 2014-07-10 2020-07-29 Corbion Biotech, Inc. Ketoacyl acp synthase genes and uses thereof
CN104152473B (zh) * 2014-08-18 2019-07-12 中国烟草总公司郑州烟草研究院 烟草类胡萝卜素异构酶基因及其应用
CN104293874B (zh) * 2014-09-23 2017-12-01 中国海洋大学 一种制备游离虾青素的方法
JP6436417B2 (ja) * 2014-12-01 2018-12-12 住友ゴム工業株式会社 アモルファ−4,11−ジエン増産方法及び天然ゴム増産方法
EP3242937B1 (en) 2014-12-09 2019-10-23 DSM IP Assets B.V. Methods for producing abienol
SG11201704890UA (en) 2014-12-15 2017-07-28 Temasek Life Sciences Laboratory Ltd Methods for tuning carotenoid production levels and compositions in rhodosporidium and rhodotorula genera
WO2016110512A1 (en) 2015-01-06 2016-07-14 Dsm Ip Assets B.V. A crispr-cas system for a yeast host cell
CN104673813B (zh) * 2015-03-24 2017-07-28 武汉大学 一种蛇孢假壳素类化合物母核合成基因AuOS及其应用
WO2016172282A1 (en) 2015-04-21 2016-10-27 Dsm Ip Assets B.V. Microbial production of terpenoids
CN105087406B (zh) * 2015-07-22 2019-03-05 天津大学 一种重组酵母菌株及其构建方法和应用
CN104962488B (zh) * 2015-07-22 2019-03-05 天津大学 一种重组酵母菌株及其构建方法和应用
BR112018013969A2 (pt) * 2016-01-08 2019-02-05 Dsm Ip Assets Bv troca de tipo de acasalamento em yarrowia lipolytica
JP2019165635A (ja) 2016-08-10 2019-10-03 味の素株式会社 L−アミノ酸の製造法
JP2019532655A (ja) * 2016-10-27 2019-11-14 ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. ゲラニルゲラニルピロリン酸シンターゼ
CN106676019B (zh) * 2016-11-28 2019-09-17 无锡新和源发酵技术研究院有限公司 一种利用微生物发酵生产虾青素的方法
CN108118007A (zh) * 2016-11-30 2018-06-05 上海医药工业研究院 一种基因工程菌生产β-胡萝卜素的方法及其基因工程菌
CN106858552B (zh) * 2017-01-21 2020-07-31 湖北工业大学 一种富含类胡萝卜素的油橄榄酱的制备方法
US11946087B2 (en) 2017-01-25 2024-04-02 Amyris Bio Products Portugal, Unipessoal, Lda Co-production of a sesquiterpene and a carotenoid
CN107058526B (zh) * 2017-03-21 2020-12-29 济南大学 一种基于基因对共表达模式动态关联解析玉米籽粒类胡萝卜素代谢调控机制的方法
CN109234216B (zh) * 2017-07-10 2022-05-20 上海医药工业研究院 一种生产鲨烯的基因工程菌及其方法
WO2019055326A1 (en) 2017-09-12 2019-03-21 Biocapital Holdings, Llc BIOLOGICAL DEVICES AND METHODS OF USE FOR PRODUCING CAROTENOIDS
JP2020535794A (ja) 2017-09-25 2020-12-10 ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. トランス−レチナールの生産
WO2019058000A1 (en) 2017-09-25 2019-03-28 Dsm Ip Assets B.V. BIOSYNTHESIS OF RETINOIDS
WO2019057996A1 (en) 2017-09-25 2019-03-28 Dsm Ip Assets B.V. PRODUCTION OF RETINYL ESTERS
JP7443656B2 (ja) 2017-09-25 2024-03-06 ディーエスエム アイピー アセッツ ビー.ブイ. レチニルエステルの生産
JP2020534808A (ja) 2017-09-25 2020-12-03 ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. レチノールの生産
WO2020060948A1 (en) 2018-09-17 2020-03-26 Levadura Biotechnology, Inc. Production of cannabinoids in yeast using a fatty acid feedstock
CN109536518A (zh) * 2018-10-31 2019-03-29 昆明理工大学 一种八氢番茄红素脱氢酶基因RKcrtI及其应用
CN111321156B (zh) * 2018-12-14 2021-05-25 华中农业大学 OsLUT1基因在调控水稻光保护中的应用
US20220064607A1 (en) 2018-12-31 2022-03-03 Dsm Ip Assets B.V. Novel acetyl-transferases
CN109666683B (zh) * 2019-02-27 2021-10-29 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
CN109777815B (zh) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CN114127273A (zh) 2019-07-16 2022-03-01 帝斯曼知识产权资产管理有限公司 新型β-胡萝卜素氧化酶
CN110499259B (zh) * 2019-07-22 2021-07-27 浙江工业大学 一种解酯耶氏酵母yw100-1及其应用
US20220290205A1 (en) 2019-08-01 2022-09-15 Dsm Ip Assets B.V. Methods for improving titer and purity of beta carotene fermentation in blakeslea trispora (beta-carotene fermentation method)
CN110540952B (zh) * 2019-09-09 2021-05-11 北京科技大学 产叶黄素原核微生物及其在生产叶黄素中的应用
CN110747206B (zh) * 2019-11-05 2021-11-23 昆明理工大学 3-羟基-3-甲基戊二酸单酰辅酶a还原酶基因rkhmgr及其应用
EP4085132A1 (en) 2019-12-30 2022-11-09 DSM IP Assets B.V. Lipase-modified strain
CN111171129B (zh) * 2020-03-09 2022-02-01 山东省农业科学院作物研究所 小麦类胡萝卜素合成途径关键基因Lcye突变体及其应用
CN111454854B (zh) * 2020-05-02 2022-05-06 昆明理工大学 一株产虾青素的红冬孢酵母基因工程菌株
WO2022003130A2 (en) 2020-07-01 2022-01-06 Dsm Ip Assets B.V. Yeast expression system
JP2023533969A (ja) * 2020-07-08 2023-08-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア イソプレノールの生産に有用な改変酵母宿主細胞
EP4189079A1 (en) 2020-07-27 2023-06-07 DSM IP Assets B.V. Reduction of fatty acid retinyl ester formation
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
CN116391044A (zh) 2020-10-30 2023-07-04 帝斯曼知识产权资产管理有限公司 类异戊二烯的发酵生产
WO2022090549A1 (en) 2020-10-30 2022-05-05 Dsm Ip Assets B.V. In situ two-phase extraction system
WO2022090547A1 (en) 2020-10-30 2022-05-05 Dsm Ip Assets B.V. Production of carotenoids by fermentation
CN113151340B (zh) * 2020-11-25 2023-03-24 广州智特奇生物科技股份有限公司 一种提高β-胡萝卜素产量的基因工程菌及其应用
CN113308387B (zh) * 2021-03-31 2023-01-03 南京工业大学 联产不饱和脂肪酸和类胡萝卜素的菌株及其应用
KR20230171982A (ko) 2021-04-16 2023-12-21 카프라 바이오사이언시즈 인코포레이티드 생물막 생물반응기에서 유전자 조작된 탄화수소 분해성 유기체를 사용한 아이소프레노이드 합성 방법
KR102600520B1 (ko) * 2021-06-09 2023-11-09 씨제이제일제당 주식회사 제라닐제라닐 피로포스페이트 신타아제 변이체 및 이를 이용한 테트라테르펜, 이의 전구체, 및 테트라테르펜을 전구체로 하는 물질의 생산방법
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
CN113621631A (zh) * 2021-08-11 2021-11-09 昆明理工大学 一种甲羟戊酸激酶基因rkmk及其应用
WO2023067030A1 (en) 2021-10-19 2023-04-27 Dsm Ip Assets B.V. Retinoid production
CN114540403B (zh) * 2021-11-12 2024-04-05 嘉必优生物技术(武汉)股份有限公司 酯化虾青素的制造方法及酯化基因的应用
WO2023147410A2 (en) * 2022-01-28 2023-08-03 Massachusetts Institute Of Technology Methods of producing carotenoids from acid whey
WO2023148187A1 (en) 2022-02-02 2023-08-10 Dsm Ip Assets B.V. Yarrowia production process
CN115029257B (zh) * 2022-05-05 2023-09-26 南京工业大学 产β-胡萝卜素的重组解脂耶氏酵母及其构建方法和应用
CN114806914B (zh) * 2022-05-20 2024-01-30 南京工业大学 一种高产β-胡萝卜素的解脂耶氏酵母菌及其应用
WO2024119170A2 (en) 2022-12-02 2024-06-06 Dsm Ip Assets B.V. Fermentatively-produced retinoid containing compositions, and the methdos of making and using the same

Family Cites Families (274)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ190194A (en) 1978-05-08 1982-02-23 Cpc International Inc Production of oil by fermenting yeast in fatty acids
US4318987A (en) 1979-11-16 1982-03-09 Murillo Araujo Francisco J β-Carotene producing strains of the fungus phycomyces blakesleenus
EP0052777A1 (de) 1980-11-20 1982-06-02 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Extraktion von beta-Carotin aus Algen
US5071764A (en) 1983-10-06 1991-12-10 Pfizer Inc. Process for integrative transformation of yarrowia lipolytica
US4880741A (en) 1983-10-06 1989-11-14 Pfizer Inc. Process for transformation of Yarrowia lipolytica
IN163393B (ru) 1983-10-06 1988-09-17 Pfizer
EP0166659B1 (fr) 1984-06-26 1989-08-30 Institut National De La Recherche Agronomique (Inra) Vecteurs de transformation de la levure yarrowia lipolytica, procédé de transformation et levure transformée
WO1986004354A1 (en) 1985-01-22 1986-07-31 Japan As Represented By Director General Of Agency Method for obtaining lipids from fungus bodies
US4680314A (en) 1985-08-30 1987-07-14 Microbio Resources, Inc. Process for producing a naturally-derived carotene/oil composition by direct extraction from algae
US4937189A (en) 1985-10-18 1990-06-26 Pfizer Inc. Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants
US4851339A (en) 1986-04-01 1989-07-25 Hills Christopher B Extraction of anti-mutagenic pigments from algae and vegetables
DK199887D0 (da) 1987-04-15 1987-04-15 Danisco Bioteknologi As Gaerstamme
US5356810A (en) 1987-04-15 1994-10-18 Gist-Brocades N.V. Astaxanthin-producing yeast cells, methods for their preparation and their use
US5360730A (en) 1987-06-05 1994-11-01 Universal Foods Corporation Zeaxanthin producing strains of Neospongiococcum Excentricum
DE68927676T2 (de) 1988-08-08 1997-07-24 Igene Biotechnology Inc Verfahren zur In vivo-Produktion von Astaxanthin und Phaffia rhodozyma Hefe mit erhöhtem Astaxanthingehalt
US5356809A (en) 1988-08-08 1994-10-18 Igene Biotechnology, Inc. Processes for in vivo production of astaxanthin and phaffia rhodozyma yeast of enhanced astaxanthin content
US5182208A (en) 1988-08-08 1993-01-26 Igene Biotechnology, Inc. Processes for in vivo production of astaxanthin and phaffia rhodozyma yeast of enhanced astaxanthin content
US6849434B2 (en) 1988-08-31 2005-02-01 University Of Florida Research Foundation, Inc. Ethanol production in recombinant hosts
JP2950888B2 (ja) 1989-04-21 1999-09-20 麒麟麦酒株式会社 カロチノイドの合成に有用なdna鎖
US5429939A (en) 1989-04-21 1995-07-04 Kirin Beer Kabushiki Kaisha DNA sequences useful for the synthesis of carotenoids
NZ232366A (en) 1989-07-28 1991-08-27 Igene Biotechnology Inc Production of astaxanthin and the enhancement of its content in yeast
NO904447L (no) 1989-10-27 1991-04-29 Enzymatix Ltd Fremgangsmaate for fremstilling av en gjaerstamme.
US5164308A (en) 1990-05-21 1992-11-17 Martek Corporation Preparation of labelled triglyceride oils by cultivation of microorganisms
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5212088A (en) 1990-10-23 1993-05-18 Phillips Petroleum Company Spheroplast fusions of phaffia rhodozyma cells
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
EP1832181A3 (en) 1991-01-24 2010-03-31 Martek Biosciences Corporation Microbial oil mixtures and uses thereof
JP3117714B2 (ja) 1991-06-06 2000-12-18 協和醗酵工業株式会社 発酵法によるアスタキサンチンの製造法
US5648261A (en) 1991-12-17 1997-07-15 Gist-Brocades, N.V. Strains of Phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3',4'-didehydro-β, Ψ-caroten-4-one (HDCO)
US5328845A (en) 1992-03-27 1994-07-12 Universal Foods Corporation Fungal negative microorganism capable of producing high levels of beta-carotene
IL104736A0 (en) 1992-03-27 1993-06-10 Zeagen Inc Method for producing beta-carotene using a fungal mated culture
EP0587872B1 (en) 1992-04-03 2000-05-31 Dsm N.V. Intersexual heterozygous phycomyces
CN1079001A (zh) 1992-04-03 1993-12-01 吉斯特·布罗卡迪斯公司 间性杂合的须霉属(phycomyces)
NZ248628A (en) 1992-09-11 1996-02-27 Gist Brocades Nv Transformed phaffia (yeast) strains and methods and vectors used
US5310554A (en) 1992-10-27 1994-05-10 Natural Carotene Corporation High purity beta-carotene
FR2700552B1 (fr) 1993-01-19 1995-04-21 Pernod Ricard Mutants de Phaffia rhodozyma, procédé de production de beta-carotène et utilisation de biomasse riche en beta-carotène.
ZA94614B (en) 1993-02-11 1994-08-12 Sasol Chem Ind Pty Solvent extraction
US5466599A (en) 1993-04-19 1995-11-14 Universal Foods Corporation Astaxanthin over-producing strains of phaffia rhodozyma
US5607839A (en) 1993-07-22 1997-03-04 Nippon Oil Company, Ltd. Bacteria belonging to new genus process for production of carotenoids using same
US5786212A (en) 1993-09-02 1998-07-28 Pfizer Inc. Multiple integrative vectors and Yarrowia lipolytica transformants
US5792903A (en) 1993-10-25 1998-08-11 Yissum Research Development Company Of Hebrew University Of Jerusalem Lycopene cyclase gene
ATE274585T1 (de) 1993-12-27 2004-09-15 Kirin Brewery Dna - kette zur synthese von xanthophyll und prozess zur herstellung von xanthophyll
JPH07242621A (ja) 1994-03-02 1995-09-19 Nippon Oil Co Ltd カロチノイド化合物の抽出方法
JP3198842B2 (ja) 1994-03-24 2001-08-13 トヨタ自動車株式会社 ゲラニルゲラニル二リン酸合成酵素およびそれをコードするdna
JPH08173170A (ja) 1994-05-25 1996-07-09 Kirin Brewery Co Ltd キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現
JP3087575B2 (ja) 1994-07-29 2000-09-11 トヨタ自動車株式会社 ヘプタプレニル二リン酸合成酵素およびそれをコードするdna
US5928696A (en) 1994-08-16 1999-07-27 Dr. Frische Gmbh Process for extracting native products which are not water-soluble from native substance mixtures by centrifugal force
EP0725137B2 (en) 1994-08-23 2005-03-02 Kirin Beer Kabushiki Kaisha Keto group introducing enzyme, dna coding for the same, and process for producing ketocarotenoid
DE69526842T3 (de) 1994-08-23 2005-10-27 Kirin Beer K.K. Ketogruppe-einführendes enzym, dafür kodierende dna und verfahren zur herstellung von ketocarotenoid
JP3727077B2 (ja) 1994-09-27 2005-12-14 新日本石油株式会社 バクテリア菌体からのカロチノイド化合物の抽出方法
WO1996012013A1 (en) 1994-10-14 1996-04-25 Novo Nordisk A/S A NOVEL ENZYME WITH β-1,3-GLUCANASE ACTIVITY
US5786193A (en) 1995-01-11 1998-07-28 Human Genome Sciences, Inc. Human geranylgeranyl pyrophosphate synthethase
EP0812360A4 (en) 1995-01-11 2000-08-09 Human Genome Sciences Inc HUMAN GERANYL-GERANYL-PYROPHOSPHATE SYNTHETASE
US5583019A (en) 1995-01-24 1996-12-10 Omegatech Inc. Method for production of arachidonic acid
JP3120684B2 (ja) 1995-02-14 2000-12-25 トヨタ自動車株式会社 ゲラニルゲラニル二リン酸を合成する変異型ファルネシル二リン酸合成酵素及びそれをコードするdna
JP3151371B2 (ja) 1995-03-10 2001-04-03 麒麟麦酒株式会社 カロチノイド生産量の増量に有用なdna鎖
WO1996033276A1 (en) 1995-04-21 1996-10-24 Human Genome Sciences, Inc. NUCLEOTIDE SEQUENCE OF THE HAEMOPHILUS INFLUENZAE Rd GENOME, FRAGMENTS THEREOF, AND USES THEREOF
EP0747484A1 (en) 1995-06-08 1996-12-11 Institut National De La Recherche Agronomique (Inra) Upstream activator sequences and recombinant promoter sequences functional in yarrowia and vectors containing them
DE69631924T2 (de) 1995-06-09 2004-08-12 Dsm Ip Assets B.V. Fermentative Herstellung von Carotenoiden
JPH11512927A (ja) 1995-08-17 1999-11-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア コレステロール合成を制御する遺伝子およびタンパク質
JP3538998B2 (ja) 1995-09-01 2004-06-14 トヨタ自動車株式会社 長鎖プレニル二燐酸合成酵素
JPH09107974A (ja) 1995-10-19 1997-04-28 Toyota Motor Corp 耐熱性ゲラニルゲラニル二燐酸合成酵素
US5916791A (en) 1995-11-24 1999-06-29 Hirschberg; Joseph Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a β--C--4--oxygenase activity for biotechnological production of (3S,3S)astaxanthin
EP0870042B1 (en) 1995-12-22 2004-09-08 DSM IP Assets B.V. Improved methods for transforming phaffia strains, transformed phaffia strains so obtained and recombinant dna in said methods
IL116995A (en) 1996-02-01 2000-08-31 Univ Ben Gurion Procedure for large-scale production of astaxanthin from haematococcus
WO1997029114A1 (en) 1996-02-08 1997-08-14 Board Of Regents Of The University Of Washington Biotin-containing compounds, biotinylation reagents and methods
US6255505B1 (en) 1996-03-28 2001-07-03 Gist-Brocades, B.V. Microbial polyunsaturated fatty acid containing oil from pasteurised biomass
EP0904359A1 (en) 1996-04-12 1999-03-31 Novo Nordisk A/S AN ENZYME WITH $g(b)-1,3-GLUCANASE ACTIVITY
EP0922109A1 (en) 1996-05-21 1999-06-16 Novo Nordisk A/S Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast
US6174715B1 (en) 1996-06-14 2001-01-16 Toyota Jidosha Kabushiki Kaisha Prenyl diphosphate synthetase genes
JP3209103B2 (ja) 1996-07-03 2001-09-17 トヨタ自動車株式会社 変異型プレニル二燐酸合成酵素
JP3379344B2 (ja) 1996-07-24 2003-02-24 トヨタ自動車株式会社 ファルネシル二リン酸合成酵素
WO1998007830A2 (en) 1996-08-22 1998-02-26 The Institute For Genomic Research COMPLETE GENOME SEQUENCE OF THE METHANOGENIC ARCHAEON, $i(METHANOCOCCUS JANNASCHII)
EP0942983B2 (en) 1996-10-31 2014-09-10 Human Genome Sciences, Inc. Streptococcus pneumoniae antigens and vaccines
JP3376838B2 (ja) 1996-11-05 2003-02-10 トヨタ自動車株式会社 プレニル二リン酸合成酵素
EP0872554B1 (en) 1996-12-02 2003-06-11 F. Hoffmann-La Roche Ag Improved fermentative carotenoid production
EP2345734A3 (en) 1997-02-20 2012-03-21 DSM IP Assets B.V. Fermentative production of valuable compounds on an industrial scale using chemically defined media
ATE408701T1 (de) 1997-03-04 2008-10-15 Suntory Ltd Verfahren zur herstellung von hochungesättigten fettsäuren und hochungesättigte fettsäuren enthaltendes lipid
US6131086A (en) 1997-04-02 2000-10-10 Walker Digital, Llc Method and system for allowing viewers to purchase program products
US5858700A (en) 1997-04-03 1999-01-12 Kemin Foods, Lc Process for the isolation and purification of lycopene crystals
US5968809A (en) 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
EP0979302B1 (en) 1997-05-02 2009-12-16 DSM IP Assets B.V. Isolation of carotenoid crystals from microbial biomass
CN1268178A (zh) 1997-05-06 2000-09-27 人体基因组科学有限公司 粪肠球菌多核苷酸和多肽
CA2292768C (en) 1997-06-05 2011-11-29 Calgene Llc Fatty acyl-coa: fatty alcohol acyltransferases
EP1009859A1 (en) 1997-06-20 2000-06-21 Human Genome Sciences Lyme disease vaccines
US5935808A (en) 1997-07-29 1999-08-10 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Carotenoid-producing bacterial species and process for production of carotenoids using same
AU748220C (en) 1997-08-01 2003-02-27 Martek Biosciences Corporation DHA-containing nutritional compositions and methods for their production
WO1999055887A2 (en) 1998-04-24 1999-11-04 E.I. Du Pont De Nemours And Company Carotenoid biosynthesis enzymes
US6600089B1 (en) 1998-04-24 2003-07-29 E. I. Du Pont De Nemours And Company Carotenoid biosynthesis enzymes
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
DE19821009A1 (de) 1998-05-11 1999-11-18 Siegfried Peter Verfahren zur Extraktion von Carotinen aus Fetten und Ölen biologischen Ursprungs
WO1999061652A1 (en) 1998-05-22 1999-12-02 University Of Maryland Carotenoid ketolase genes and gene products, production of ketocarotenoids and methods of modifying carotenoids using the genes
US20020012979A1 (en) 1998-06-08 2002-01-31 Alan Berry Vitamin c production in microorganisms and plants
ATE490332T1 (de) 1998-07-06 2010-12-15 Dcv Inc Verfahren zur vitaminherstellung
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
AU4794199A (en) 1998-07-23 2000-02-14 Genset A nucleic acid encoding a geranyl-geranyl pyrophosphate synthetase (ggpps) and polymorphic markers associated with said nucleic acid
EP0982404A1 (en) 1998-08-27 2000-03-01 Wallaart, Thorvald Eelco DNA encoding amorpha-4,11-diene synthase
FR2782733B1 (fr) 1998-09-01 2002-02-08 Agronomique Inst Nat Rech Procede de transformation non-homologue de yarrowia lipolytica
US6166231A (en) 1998-12-15 2000-12-26 Martek Biosciences Corporation Two phase extraction of oil from biomass
WO2000037060A2 (en) 1998-12-22 2000-06-29 National Research Council Of Canada Transgenic plants comprising a conditionally lethal gene
DK1141350T3 (da) 1998-12-22 2010-11-08 Dow Agrosciences Llc Fremgangsmåde og genetiske sammensætninger til begrænsning af udkrydsning og uønskede genstrømme i nytteplanter
JP4307609B2 (ja) 1999-02-10 2009-08-05 株式会社カネカ コエンザイムq10の製造法
DE19909637A1 (de) 1999-03-05 2000-09-07 Peter Beyer Verfahren zur Verbesserung des agronomischen Wertes und der ernährungsphysiologischen Eigenschaften von Pflanzen
US6365386B1 (en) 1999-03-09 2002-04-02 Roche Vitamins Inc. Astaxanthin synthase
DE19916140A1 (de) 1999-04-09 2000-10-12 Basf Ag Carotinhydroxylase und Verfahren zur Herstellung von Xanthophyllderivaten
NO309386B1 (no) 1999-04-19 2001-01-22 Norsk Hydro As Pigment
FR2792651B1 (fr) 1999-04-21 2005-03-18 Centre Nat Rech Scient Sequence genomique et polypeptides de pyrococcus abyssi, leurs fragments et leurs utilisations
DE19919751A1 (de) 1999-04-29 2000-11-09 Basf Ag Stabile, wäßrige Dispersionen und stabile, wasserdispergierbare Trockenpulver von Xanthophyllen, deren Herstellung und Verwendung
WO2000078935A1 (en) 1999-06-22 2000-12-28 Smithkline Beecham Corporation Mevalonate pathway genes
ES2157166B1 (es) 1999-08-12 2002-02-16 Antibioticos Sau Procedimiento para la obtencion de licopeno.
SE9903336D0 (sv) 1999-09-17 1999-09-17 Astacarotene Ab DNA construct and its use
CA2324625C (en) 1999-12-01 2011-09-27 F. Hoffmann-La Roche Ag Recombinant production of carotenoids, particularly astaxanthin
US20020051998A1 (en) 1999-12-08 2002-05-02 California Institute Of Technology Directed evolution of biosynthetic and biodegradation pathways
US20030157592A1 (en) 1999-12-16 2003-08-21 Jens Lerchl Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols and carotenoids
EP1244696A2 (en) 1999-12-16 2002-10-02 BASF Plant Science GmbH Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols, carotenoids and aromatic amino acids
GB2358862B (en) 1999-12-21 2004-07-21 Fermentron Ltd Processes for Extracting Carotenoids from Biomass Carotenoid Sources
EP1244777A2 (en) 1999-12-24 2002-10-02 Syngenta Participations AG Method for the production of vitamin a
KR20140079870A (ko) 2000-01-19 2014-06-27 마텍 바이오싸이언스스 코포레이션 무용매 추출 방법
US7015014B2 (en) 2000-01-27 2006-03-21 Dsm Ip Assets B.V. Isolation of carotenoid crystals
AU2001240069A1 (en) 2000-03-07 2001-09-17 Cargill Incorporated Production of lutein in microorganisms
KR100388110B1 (ko) 2000-05-04 2003-06-18 해태제과식품주식회사 효모 균주에서 아스타산틴 색소 추출방법 및 추출된 색소
ES2254285T3 (es) 2000-05-24 2006-06-16 Dsm Ip Assets B.V. Proceso para la produccion de astaxantina.
JP4427167B2 (ja) 2000-06-12 2010-03-03 新日本石油株式会社 カロテノイド色素の製法
ES2168971B1 (es) 2000-07-19 2003-11-01 Antibioticos Sau Procedimiento de produccion de beta-caroteno.
US6807568B1 (en) 2000-07-27 2004-10-19 Union Beach, L.P. Recipient selection of information to be subsequently delivered
WO2002010398A2 (en) 2000-07-31 2002-02-07 Hahn Frederick M Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
BR0114080A (pt) 2000-09-22 2003-07-29 Mars Uk Ltd Suplemento alimentìcio, uso do mesmo, método para auxiliar a prevenção ou tratamento de dano oxidativo, alimento, e, métodos para fabricar o mesmo, e para melhorar ou aumentar a produção de trabalho de um animal
US20030219798A1 (en) 2000-09-29 2003-11-27 Gokarn Ravi R. Isoprenoid production
US6645767B1 (en) 2000-10-03 2003-11-11 Carnegie Mellon University Cells engineered to contain genes of interest without expressed bacterial sequences and materials and methods therefor
WO2002041833A2 (en) 2000-11-22 2002-05-30 Cargill Incorporated Carotenoid biosynthesis
JP3838033B2 (ja) 2000-12-28 2006-10-25 トヨタ自動車株式会社 プレニルアルコールの製造方法
CN1491282A (zh) 2000-12-28 2004-04-21 丰田自动车株式会社 异戊二烯醇的制备方法
CA2433534A1 (en) 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Process for producing prenyl alcohol
JP2002253284A (ja) 2000-12-28 2002-09-10 Toyota Motor Corp 微生物によるゲラニルゲラニオール及びその類縁化合物の製造方法
JP4013535B2 (ja) 2000-12-28 2007-11-28 トヨタ自動車株式会社 微生物によるプレニルアルコールの高生産方法
US7238514B2 (en) 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
JP2002209574A (ja) 2001-01-19 2002-07-30 Kanegafuchi Chem Ind Co Ltd 遺伝子破壊酵母
ATE408683T1 (de) 2001-01-25 2008-10-15 Evolva Ltd Verfahren zur entwicklung einer zelle mit einem gewünschten phänotyp und entwickelte zellen
ATE501251T1 (de) 2001-01-25 2011-03-15 Evolva Ltd Zellbibliothek
CA2436366A1 (en) 2001-01-26 2002-10-10 Cargill, Incorporated Carotenoid biosynthesis
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
EP1379549A2 (fr) 2001-02-07 2004-01-14 Institut Pasteur Sequence du genome de photorhabdus luminescens souche tto1 et utilisations
US20030207947A1 (en) 2001-03-07 2003-11-06 Desouza Mervyn L. Production of lutein in microorganisms
WO2002070721A2 (en) 2001-03-08 2002-09-12 Bioteknologisk Institut Recombinant dimorphic fungal cell
US20030134353A1 (en) 2001-03-08 2003-07-17 Bioteknologisk Institut Recombinant dimorphic fungal cell
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
JP2002345469A (ja) 2001-04-25 2002-12-03 Kanegafuchi Chem Ind Co Ltd コエンザイムq10の製造法
ITMI20011019A1 (it) 2001-05-17 2002-11-17 Carlo Ghisalberti Sostanze furiliche per uso topico
KR100704072B1 (ko) 2001-06-06 2007-04-05 디에스엠 아이피 어셋츠 비.브이. 개선된 이소프레노이드 제조 방법
US7252964B2 (en) 2001-06-12 2007-08-07 Institut De Recherche Pour Le Developpement (I.R.D.) Isolated carotenoid biosynthesis gene cluster involved in canthaxanthin production and applications thereof
WO2003000902A1 (fr) 2001-06-21 2003-01-03 Japan Science And Technology Agency Groupe d'aphidicoline-biosynthases
US6984523B2 (en) 2001-08-02 2006-01-10 E.I. Du Pont De Nemours And Company Carotenoid ketolase gene
US20030148319A1 (en) 2001-08-15 2003-08-07 Brzostowicz Patricia C. Genes encoding carotenoid compounds
EP1418822B1 (en) 2001-08-23 2005-03-30 DSM IP Assets B.V. Novel stabilized carotenoid compositions
US7635798B2 (en) 2001-08-31 2009-12-22 Dow Agrosciences, Llc Nucleic acid compositions conferring altered metabolic characteristics
US20040077068A1 (en) 2001-09-04 2004-04-22 Brzostowicz Patricia C. Carotenoid production from a single carbon substrate
US6797303B2 (en) 2001-09-04 2004-09-28 Lycored Natural Products Industries Ltd. Carotenoid extraction process
US20030054070A1 (en) 2001-09-07 2003-03-20 Aquasearch, Inc. Edible solvent extraction of carotenoids from microorganisms
DE10145043A1 (de) 2001-09-13 2003-04-03 Degussa Verfahren und Herstellung von Feinchemikalien
US20050124031A1 (en) 2001-09-26 2005-06-09 Vitatene, S.A. Biosyntheticse genes of blakeslea trispora beta-carotene that code for lycopene cyclase/phytoene synthase (carrp) and phytoene dehydrogenase (carb)
US7196189B2 (en) 2001-10-09 2007-03-27 Microbia, Inc. love variant regulator molecules
US7026460B2 (en) 2001-10-09 2006-04-11 Microbia, Inc. lovE variant regulator molecules
RU2211862C2 (ru) 2001-10-29 2003-09-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (-) ШТАММ ГЕТЕРОТАЛЛИЧНОГО ФИКОМИЦЕТА Blakeslea trispora, ПРОДУЦИРУЮЩИЙ ЛИКОПИН В ПАРЕ С РАЗНЫМИ (+)ШТАММАМИ Blakeslea trispora, И СПОСОБ МИКРОБИОЛОГИЧЕСКОГО СИНТЕЗА ЛИКОПИНА
ES2266604T3 (es) * 2001-11-05 2007-03-01 Dorma Gmbh + Co. Kg Sistema de herraje.
IL146449A0 (en) 2001-11-12 2002-07-25 Lycored Natural Prod Ind Ltd Method and pharmaceutical preparations for reducing the activity of cells
US7063955B2 (en) 2001-11-20 2006-06-20 E. I. Du Pont De Nemours And Company Method for production of asymmetric carotenoids
EP1318192A2 (en) 2001-12-06 2003-06-11 greenovation Biotech GmbH Prenyltransferase from Arabidopsis
ES2195758B1 (es) 2001-12-31 2005-03-01 Antibioticos, S.A.U. Procedimiento mejorado de produccion de licopeno mediante la fermentacion de cepas seleccionadas de blakeslea trispora, formulaciones y usos del licopeno obtenido.
WO2003062416A1 (fr) 2002-01-21 2003-07-31 Takeda Chemical Industries, Ltd. Procede de criblage d'agents preventifs et de remedes pour l'arteriosclerose
CA2511229A1 (en) 2002-01-25 2003-07-31 Evolva Ltd. Methods for multiple parameter screening and evolution of cells to produce small molecules with multiple functionalities
ES2195766B1 (es) 2002-01-29 2005-04-01 Antibioticos, S.A.U. Procedimiento de produccion de beta-caroteno por fermentacion en cultivo mixto utilizando cepas (+) 4 (-) de blakeslea trispora.
US20040116514A1 (en) 2002-01-31 2004-06-17 Hoyoku Nishino Compositions for preventing human cancer and method of preventing human cancer
US7253297B2 (en) 2002-02-06 2007-08-07 Dsm Ip Assetts B.V. Astaxanthin esters
US7105634B2 (en) 2002-02-11 2006-09-12 E. I. Du Pont De Nemours And Company Genetic constructs encoding carotenoid biosynthetic enzymes
WO2003076575A2 (en) 2002-03-04 2003-09-18 Fidelity Systems, Inc., Et Al. The complete genome and protein sequence of the hyperthermophile methanopyrus kandleri av19 and monophyly of archael methanogens and methods of use thereof
WO2003095651A1 (fr) 2002-05-10 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Procede de production d'acide mevalonique
ATE473284T1 (de) 2002-05-14 2010-07-15 Martek Biosciences Corp Carotinsynthase-gen und dessen verwendung
WO2004001057A1 (en) 2002-06-21 2003-12-31 Dsm Ip Assets B.V. Process for producing carotenoids
DE10234126A1 (de) 2002-07-26 2004-02-05 Basf Ag Verfahren zur Biotransformation von Carotinoiden
US20050049248A1 (en) 2002-07-29 2005-03-03 Lockwood Samuel Fournier Carotenoid ether analogs or derivatives for controlling C-reactive protein levels
EP1532108B1 (en) 2002-07-29 2016-06-29 Cardax Pharma, Inc. Astaxanthin esters for the inhibition and amelioration of disease
DK1529110T3 (da) 2002-08-01 2012-01-30 Evolva Ltd Fremgangsmåde til blanding af store antal af heterologe gener
ATE484198T1 (de) 2002-08-20 2010-10-15 Sungene Gmbh & Co Kgaa Verwendung von astaxanthinhaltigen pflanzen oder pflanzenteilen der gattung tagetes als futtermittel
US20060059584A1 (en) 2002-08-20 2006-03-16 Sungene Gmbh & Co. Kgaa Method for the production of $g(b)-carotinoids
WO2004022765A2 (de) 2002-08-20 2004-03-18 Sungene Gmbh & Co. Kgaa Verfahren zur hydrolyse von carotinoidestern
ATE394477T1 (de) 2002-09-27 2008-05-15 Dsm Ip Assets Bv Squalene synthase (sqs) gen
CN1788091A (zh) 2002-09-27 2006-06-14 Dsmip资产公司 通过法夫酵母生产角黄素
EP1543134B1 (en) 2002-09-27 2007-04-18 DSM IP Assets B.V. Process for actinol production from ketoisophorone
WO2004029232A2 (en) 2002-09-27 2004-04-08 Dsm Ip Assets B.V. Acc gene
JP2006500055A (ja) 2002-09-27 2006-01-05 ディーエスエム アイピー アセッツ ビー.ブイ. ファフィア属によるゼアキサンチンの製造方法
US7291749B2 (en) 2002-10-25 2007-11-06 Dsm Ip Assets B.V. Method for producing esterified astaxanthin from esterified zeaxanthin
JP2006507009A (ja) 2002-11-25 2006-03-02 カーギル,インコーポレーテッド ユビキノンの製造
US7232665B2 (en) 2002-12-19 2007-06-19 E. I. Du Pont De Nemours And Company Mutations affecting carotenoid production
US7252942B2 (en) 2002-12-19 2007-08-07 E.I. Du Pont De Nemours And Company Parallel chromosomal stacking of traits in bacteria
US20040219629A1 (en) 2002-12-19 2004-11-04 Qiong Cheng Increasing carotenoid production in bacteria via chromosomal integration
UA55331C2 (ru) 2002-12-23 2006-07-17 Товариство З Обмеженою Відповідальністю "Науково-Виробниче Підприємство "Вітан" ШТАММ (ТКСТ) BLAKESLEA TRISPORA ІМВ F-100022-ПРОДУЦЕНТ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--КАРОТИНА
EP1592784A1 (de) 2003-01-09 2005-11-09 Basf Aktiengesellschaft Verfahren zur gentechnischen veränderung von organismen der gattung blakeslea, entsprechende organismen und deren verwendung
KR20050092739A (ko) 2003-01-09 2005-09-22 바스프 악티엔게젤샤프트 유전자 변형된 블라케슬레아 속 유기체를 이용한카로티노이드 또는 그의 전구체의 생산 방법, 이 방법에의해 생산된 카로티노이드 또는 그의 전구체, 및 이들의용도
DE10300649A1 (de) 2003-01-09 2004-07-22 Basf Ag Verfahren zur Herstellung von Ketocarotinoiden durch Kultivierung von genetisch veränderten Organismen
WO2004065555A2 (en) 2003-01-17 2004-08-05 E.I. Du Pont De Nemours And Company Regulator/promoter for tunable gene expression and metabolite sensing
WO2004067709A2 (en) 2003-01-17 2004-08-12 Elitra Pharmaceuticals, Inc. Identification of essential genes of aspergillus fumigatus and methods of use
EP1591531B1 (en) * 2003-01-22 2016-03-23 Showa Denko K.K. Process for acyl-transfer enzyme reactions with acyl- coenzyme a
WO2004070035A2 (en) 2003-02-03 2004-08-19 Sungene Gmbh & Co. Kgaa Method for increasing efficiency of homologous recombination in plants
US7589256B2 (en) 2003-02-17 2009-09-15 Metanomics Gmbh Preparation of organisms with faster growth and/or higher yield
WO2004074490A2 (en) 2003-02-24 2004-09-02 Genoclipp Biotechnology B.V. Method for transforming blakeslea strains
WO2005014828A2 (en) 2003-08-01 2005-02-17 Basf Plant Science Gmbh Process for the production of fine chemicals in plants
KR20060029214A (ko) 2003-05-05 2006-04-05 다우 아그로사이언시즈 엘엘씨 이식 유전자 식물 세포들로부터 유래된 안정한 면역예방적및 치료적 조성물들 및 생산방법
US7238482B2 (en) 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7214491B2 (en) 2003-05-07 2007-05-08 E. I. Du Pont De Nemours And Company Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
US7125672B2 (en) 2003-05-07 2006-10-24 E. I. Du Pont De Nemours And Company Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
US7070952B2 (en) 2003-05-07 2006-07-04 E. I. Du Pont Nemours And Company Genes encoding carotenoid compounds
US8313911B2 (en) * 2003-05-07 2012-11-20 E I Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
US7064196B2 (en) 2003-05-20 2006-06-20 E. I. Du Pont De Nemours And Company Genes encoding carotenoid compounds
US20040234579A1 (en) 2003-05-22 2004-11-25 Mark D. Finke, Inc. Dietary supplements and methods of preparing and administering dietary supplements
US6929928B2 (en) 2003-06-12 2005-08-16 E. I. Du Pont De Nemours And Company Genes encoding carotenoid compounds
ES2323175T3 (es) 2003-06-12 2009-07-08 Dsm Ip Assets B.V. Mevalonato-quinasas resistentes a la retroalimentacion.
US7259255B2 (en) 2003-06-25 2007-08-21 E. I. Du Pont De Nemours And Company Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast
US7132257B2 (en) 2003-07-10 2006-11-07 E. I. Du Pont De Nemours And Company Production or aromatic carotenoids in gram negative bacteria
EP1646713A2 (en) 2003-07-17 2006-04-19 E.I. Dupont De Nemours And Company Genes encoding carotenoid compounds
WO2005010174A2 (en) 2003-07-17 2005-02-03 University Of Dundee Methods for use of an lkb1/strad7mo25 complex
WO2005011712A1 (en) 2003-07-25 2005-02-10 Washington State University Research Foundation Natural astaxanthin extract reduces dna oxidation
DE102004007622A1 (de) 2004-02-17 2005-08-25 Sungene Gmbh & Co. Kgaa Verfahren zur Herstellung von Ketocarotinoiden in genetisch veränderten, nicht-humanen Organismen
WO2005033880A2 (en) * 2003-09-28 2005-04-14 Nbor Corporation Method and apparatus for performing multimedia operations
US7202356B2 (en) 2003-11-14 2007-04-10 E. I. Du Pont De Nemours And Company Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast
US7262257B2 (en) * 2004-02-17 2007-08-28 The Penn State Research Foundation Telechelic polymers containing reactive functional groups
US20080233620A1 (en) 2004-03-04 2008-09-25 Yuji Okubo Novel Transformant and Process for Producing Polyester Using the Same
JP2006134855A (ja) 2004-03-11 2006-05-25 Nissan Motor Co Ltd 燃料電池用セパレータ、燃料電池スタック、燃料電池車両、及び燃料電池用セパレータの製造方法
US7598521B2 (en) * 2004-03-29 2009-10-06 Sanyo Electric Co., Ltd. Semiconductor device in which the emitter resistance is reduced
JP2005301157A (ja) 2004-04-15 2005-10-27 Toyoda Gosei Co Ltd 面状発光体
JP2005301154A (ja) 2004-04-15 2005-10-27 Canon Inc 画像形成装置
JP4340186B2 (ja) 2004-04-15 2009-10-07 カナレ電気株式会社 アダプタユニット及び光プラグ
JP2005301149A (ja) 2004-04-15 2005-10-27 Ricoh Co Ltd 画像形成方法および画像形成装置
JP4212509B2 (ja) 2004-04-15 2009-01-21 シャープ株式会社 液晶表示装置
JP2005301156A (ja) 2004-04-15 2005-10-27 Sony Corp マスク欠陥検査方法、マスク欠陥検査装置、並びにマスク検査基準作成方法
JP4120940B2 (ja) 2004-04-15 2008-07-16 ソニー株式会社 レンズ鏡筒および撮像装置
JP2005301151A (ja) 2004-04-15 2005-10-27 Canare Electric Co Ltd 光コンタクトユニット及び光プラグ
JP4428121B2 (ja) 2004-04-15 2010-03-10 凸版印刷株式会社 パターン形成方法及びパターン形成装置
JP2005301150A (ja) 2004-04-15 2005-10-27 Ricoh Co Ltd 画像形成方法および画像形成装置
JP4464184B2 (ja) 2004-04-15 2010-05-19 キヤノン株式会社 光学フィルタ
JP2005301148A (ja) 2004-04-15 2005-10-27 Fuji Photo Film Co Ltd 熱現像感光材料
JP2005301153A (ja) 2004-04-15 2005-10-27 Canare Electric Co Ltd プラグ
US7260790B2 (en) 2004-04-27 2007-08-21 International Business Machines Corporation Integrated circuit yield enhancement using Voronoi diagrams
US20050266132A1 (en) 2004-06-01 2005-12-01 Feral Temelli Supercritical carbon dioxide extraction of carotenoids from natural materials using a continuous co-solvent
US7908445B2 (en) 2004-07-19 2011-03-15 Infortrend Technology, Inc. Redundant controller dynamic logical media unit reassignment
BRPI0403102A (pt) 2004-07-26 2006-03-07 Ricardo Ernesto Levy adega pantográfica
EP1778831B1 (en) 2004-07-27 2012-05-23 The Regents of The University of California Genetically modified host cells and use of same for producing isoprenoid compounds
JP4559151B2 (ja) 2004-07-29 2010-10-06 富士通株式会社 終端回路、半導体装置、及び電子機器
US7145380B2 (en) 2004-09-27 2006-12-05 Etron Technology, Inc. Low power consumed and small circuit area occupied temperature sensor
US20090176287A1 (en) 2005-02-24 2009-07-09 Regents Of The University Of Minnesota Producing carotenoids
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
JP2006008714A (ja) 2005-03-17 2006-01-12 Yamaha Motor Co Ltd マトリックスメタロプロテイナーゼ阻害剤
EA016258B1 (ru) 2005-03-18 2012-03-30 Микробиа, Инк. Рекомбинантные грибы, продуцирующие каротиноиды, и способы их применения
JP2006008712A (ja) 2005-03-24 2006-01-12 Yamaha Motor Co Ltd 血管新生阻害剤
JP2006008713A (ja) 2005-03-24 2006-01-12 Yamaha Motor Co Ltd 血管内皮細胞増殖阻害剤
JP2006008715A (ja) 2005-05-17 2006-01-12 Yamaha Motor Co Ltd ホスホリパーゼa2阻害剤
JP2006008716A (ja) 2005-05-20 2006-01-12 Yamaha Motor Co Ltd リポキシゲナーゼ阻害剤
JP2006008717A (ja) 2005-05-31 2006-01-12 Yamaha Motor Co Ltd インターロイキン阻害剤
JP2006008718A (ja) 2005-06-03 2006-01-12 Yamaha Motor Co Ltd シクロオキシゲナーゼ活性阻害剤
JP2006016407A (ja) 2005-06-15 2006-01-19 Yamaha Motor Co Ltd ホスホジエステラーゼ阻害剤
KR100664065B1 (ko) 2005-06-20 2007-01-03 엘지전자 주식회사 전동기의 마그네트 고정 구조
JP2006016408A (ja) 2005-06-23 2006-01-19 Yamaha Motor Co Ltd 血中中性脂肪抑制剤
JP2006008719A (ja) 2005-06-23 2006-01-12 Yamaha Motor Co Ltd 血中過酸化脂質抑制剤
JP2006016409A (ja) 2005-06-28 2006-01-19 Yamaha Motor Co Ltd 疲労回復剤
JP2006022121A (ja) 2005-07-04 2006-01-26 Yamaha Motor Co Ltd アトピー性皮膚炎抑制剤
JP2006008720A (ja) 2005-07-06 2006-01-12 Yamaha Motor Co Ltd 腎臓機能改善剤
US20100285993A1 (en) 2006-02-14 2010-11-11 Gregory Prelich Systematic Genomic Library and Uses Thereof
WO2008042338A2 (en) 2006-09-28 2008-04-10 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
US8846374B2 (en) 2006-12-12 2014-09-30 E I Du Pont De Nemours And Company Carotenoid production in a recombinant oleaginous yeast
US8173405B2 (en) 2006-12-13 2012-05-08 William Marsh Rice University Nerolidol, terpene, and terpene deriviative synthesis
WO2009010826A2 (en) 2007-07-13 2009-01-22 Ocean Nutrition Canada Ltd. Novel genes and methods of producing carotenoids
US20120149886A1 (en) 2008-04-10 2012-06-14 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi

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JP2008537878A (ja) 2008-10-02
US20070015237A1 (en) 2007-01-18
CN103589650A (zh) 2014-02-19
US7851199B2 (en) 2010-12-14
US9909130B2 (en) 2018-03-06
KR101482081B1 (ko) 2015-01-13
JP2009112320A (ja) 2009-05-28
WO2006102342A3 (en) 2007-10-11
KR20070121679A (ko) 2007-12-27
ES2546484T3 (es) 2015-09-24
CN101218352B (zh) 2013-09-04
ZA200707651B (en) 2011-05-25
CA2602183A1 (en) 2006-09-28
EP2371967A1 (en) 2011-10-05
BRPI0609040A2 (pt) 2010-01-12
WO2006102342A2 (en) 2006-09-28
EA016258B1 (ru) 2012-03-30
EP2371967B1 (en) 2015-06-03
AU2006227165B2 (en) 2011-11-10
JP2015226550A (ja) 2015-12-17
US20110021843A1 (en) 2011-01-27
CN101218352A (zh) 2008-07-09
US20130045504A1 (en) 2013-02-21
CA2602183C (en) 2014-05-06
BRPI0609040B1 (pt) 2018-07-31
JP6267679B2 (ja) 2018-01-24
JP2013128497A (ja) 2013-07-04
IL185713A0 (en) 2008-12-29
US8288149B2 (en) 2012-10-16
NO20075200L (no) 2007-10-11
EP1866428A2 (en) 2007-12-19
AU2006227165A1 (en) 2006-09-28
EA200701974A1 (ru) 2008-08-29

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