TW201613979A - Anti-LAG3 antibodies and antigen-binding fragments - Google Patents

Anti-LAG3 antibodies and antigen-binding fragments

Info

Publication number
TW201613979A
TW201613979A TW104126866A TW104126866A TW201613979A TW 201613979 A TW201613979 A TW 201613979A TW 104126866 A TW104126866 A TW 104126866A TW 104126866 A TW104126866 A TW 104126866A TW 201613979 A TW201613979 A TW 201613979A
Authority
TW
Taiwan
Prior art keywords
antibodies
fragments
antigen
binding fragments
lag3 antibodies
Prior art date
Application number
TW104126866A
Other languages
English (en)
Other versions
TWI673286B (zh
Inventor
Linda Liang
Laurence Fayadat-Dilman
Rene De Waal Malefyt
Gopalan Raghunathan
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53938468&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW201613979(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of TW201613979A publication Critical patent/TW201613979A/zh
Application granted granted Critical
Publication of TWI673286B publication Critical patent/TWI673286B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW104126866A 2014-08-19 2015-08-18 抗ｌａｇ３抗體及抗原結合片段 TWI673286B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462039081P 2014-08-19 2014-08-19
US62/039,081 2014-08-19
US201562171319P 2015-06-05 2015-06-05
US62/171,319 2015-06-05

Publications (2)

Publication Number Publication Date
TW201613979A true TW201613979A (en) 2016-04-16
TWI673286B TWI673286B (zh) 2019-10-01

Family

ID=53938468

Family Applications (3)

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TW108123466A TWI742395B (zh) 2014-08-19 2015-08-18 抗ｌａｇ３抗體及抗原結合片段
TW104126866A TWI673286B (zh) 2014-08-19 2015-08-18 抗ｌａｇ３抗體及抗原結合片段
TW108102061A TWI698448B (zh) 2014-08-19 2015-08-18 抗lag3抗體及抗原結合片段

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TW108102061A TWI698448B (zh) 2014-08-19 2015-08-18 抗lag3抗體及抗原結合片段

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US (6) US20170290914A1 (zh)
EP (2) EP3182999B1 (zh)
JP (3) JP2017532059A (zh)
KR (2) KR102037197B1 (zh)
CN (1) CN107001470B (zh)
AP (1) AP2017009763A0 (zh)
AU (3) AU2015305770C1 (zh)
BR (1) BR112017003194B8 (zh)
CA (2) CA3082655A1 (zh)
CL (1) CL2017000311A1 (zh)
CO (1) CO2017001558A2 (zh)
CR (1) CR20170059A (zh)
CY (1) CY1124252T1 (zh)
DK (1) DK3182999T3 (zh)
DO (1) DOP2017000047A (zh)
ES (1) ES2857505T3 (zh)
GE (1) GEP20227343B (zh)
GT (1) GT201700034A (zh)
HR (1) HRP20210372T1 (zh)
HU (1) HUE053641T2 (zh)
IL (2) IL297053A (zh)
JO (1) JO3663B1 (zh)
LT (1) LT3182999T (zh)
MA (2) MA55347A (zh)
MD (1) MD4716C1 (zh)
MX (2) MX2017002230A (zh)
MY (1) MY187262A (zh)
NI (1) NI201700018A (zh)
PE (1) PE20170288A1 (zh)
PH (1) PH12017500297A1 (zh)
PL (1) PL3182999T3 (zh)
PT (1) PT3182999T (zh)
RS (1) RS61559B1 (zh)
SG (1) SG11201701090VA (zh)
SI (1) SI3182999T1 (zh)
TN (1) TN2017000025A1 (zh)
TW (3) TWI742395B (zh)
UA (2) UA119571C2 (zh)
WO (1) WO2016028672A1 (zh)
ZA (2) ZA201700956B (zh)

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CN110088134A (zh) * 2016-08-02 2019-08-02 阿杜罗生物科技控股有限公司 针对人ctla-4的抗体
TWI773694B (zh) * 2016-10-11 2022-08-11 美商艾吉納斯公司 抗ｌａｇ－３抗體及其使用方法
US11661452B2 (en) 2018-03-20 2023-05-30 WuXi Biologics Ireland Limited Anti-lag-3 antibody polypeptide
TWI833738B (zh) * 2018-03-20 2024-03-01 中國大陸商上海藥明生物技術有限公司 新型抗lag-3抗體多肽

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US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
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EP3620473A1 (en) 2013-01-14 2020-03-11 Xencor, Inc. Novel heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
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ES2746805T3 (es) 2013-12-12 2020-03-06 Shanghai hengrui pharmaceutical co ltd Anticuerpo de PD-1, fragmento de unión a antígeno del mismo y aplicación médica del mismo
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
WO2015138920A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
CN111410691B (zh) 2014-03-28 2024-02-13 Xencor公司 结合至cd38和cd3的双特异性抗体
EA201692458A1 (ru) 2014-05-28 2017-06-30 Агенус Инк. Анти-gitr антитела и способы их применения
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JO3663B1 (ar) * 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
US20170281624A1 (en) 2014-09-13 2017-10-05 Novartis Ag Combination therapies of alk inhibitors
EA201790737A1 (ru) * 2014-10-03 2017-08-31 Новартис Аг Комбинированная терапия
EP4245376A3 (en) 2014-10-14 2023-12-13 Novartis AG Antibody molecules to pd-l1 and uses thereof
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
LT3223845T (lt) 2014-11-26 2021-08-25 Xencor, Inc. Heterodimeriniai antikūnai, kurie suriša cd3 ir cd20
WO2016086196A2 (en) 2014-11-26 2016-06-02 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cd38
EP3237449A2 (en) 2014-12-22 2017-11-01 Xencor, Inc. Trispecific antibodies
CA2984794A1 (en) 2015-05-07 2016-11-10 Agenus Inc. Anti-ox40 antibodies and methods of use thereof
BR112017025564B8 (pt) 2015-05-29 2022-01-04 Agenus Inc Anticorpos anti-ctla-4 e métodos de uso dos mesmos
TWI773646B (zh) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 結合lag-3的分子和其使用方法
JP7032311B2 (ja) * 2015-07-16 2022-03-08 バイオエクセル セラピューティクス，インコーポレイテッド 免疫調節を使用してがんを処置するための新規手法
MX2018001227A (es) 2015-07-30 2018-03-26 Macrogenics Inc Moleculas de union a pd-1 y metodos de uso de las mismas.
AU2016329126B2 (en) 2015-10-02 2023-04-13 F. Hoffmann-La Roche Ag Bispecific antibodies specific for PD1 and TIM3
TWI756187B (zh) 2015-10-09 2022-03-01 美商再生元醫藥公司 抗ｌａｇ３抗體及其用途
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UA125611C2 (uk) 2015-12-14 2022-05-04 Макродженікс, Інк. Біспецифічні молекули, що мають імунореактивність відносно pd-1 і ctla-4, і способи їх застосування
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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
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KR102531889B1 (ko) 2016-06-20 2023-05-17 키맵 리미티드 항-pd-l1 및 il-2 사이토카인
CA3027612A1 (en) 2016-06-20 2017-12-28 F-Star Delta Limited Binding molecules binding pd-l1 and lag-3
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DOP2017000047A (es) 2017-05-15
PT3182999T (pt) 2021-03-01
ES2857505T3 (es) 2021-09-29
MD4716C1 (ro) 2021-05-31
GT201700034A (es) 2019-10-10
UA119571C2 (uk) 2019-07-10
CN107001470A (zh) 2017-08-01
TWI742395B (zh) 2021-10-11
MX2017002230A (es) 2017-05-09
SG11201701090VA (en) 2017-03-30
US20190091332A1 (en) 2019-03-28
ZA201700956B (en) 2022-05-25
TW201920284A (zh) 2019-06-01
PL3182999T3 (pl) 2021-05-31
IL250566B2 (en) 2023-03-01
AU2015305770B2 (en) 2018-09-13
CO2017001558A2 (es) 2017-07-19
MD4716B1 (ro) 2020-10-31
IL297053A (en) 2022-12-01
TWI673286B (zh) 2019-10-01
TW201938589A (zh) 2019-10-01
CA3082655A1 (en) 2016-02-25
US20190083614A1 (en) 2019-03-21
GEP20227343B (en) 2022-01-25
CA2957275C (en) 2020-08-25
TN2017000025A1 (en) 2018-07-04
US11207406B2 (en) 2021-12-28
BR112017003194A2 (pt) 2017-11-28
KR102037197B1 (ko) 2019-10-28
IL250566A0 (en) 2017-03-30
RS61559B1 (sr) 2021-04-29
EP3182999A1 (en) 2017-06-28
AP2017009763A0 (en) 2016-02-28
JP6843174B2 (ja) 2021-03-17
MA55347A (fr) 2022-01-26
CR20170059A (es) 2017-04-28
AU2020230256A1 (en) 2020-10-01
AU2018278910A1 (en) 2019-01-03
MD20170031A2 (ro) 2017-07-31
US10188730B2 (en) 2019-01-29
AU2015305770A1 (en) 2017-03-09
ZA202003742B (en) 2022-08-31
CL2017000311A1 (es) 2017-08-18
US20220257762A1 (en) 2022-08-18
US10898571B2 (en) 2021-01-26
HRP20210372T1 (hr) 2021-07-09
SI3182999T1 (sl) 2021-04-30
KR20170043589A (ko) 2017-04-21
EP3182999B1 (en) 2021-01-06
JO3663B1 (ar) 2020-08-27
BR112017003194B8 (pt) 2023-04-18
MA40476A (fr) 2017-06-28
JP2018183173A (ja) 2018-11-22
MX2019005426A (es) 2023-04-27
PE20170288A1 (es) 2017-04-05
DK3182999T3 (da) 2021-03-15
JP2017532059A (ja) 2017-11-02
MY187262A (en) 2021-09-16
TWI698448B (zh) 2020-07-11
AU2020230256B2 (en) 2024-01-18
HUE053641T2 (hu) 2021-07-28
US20170290914A1 (en) 2017-10-12
US20170267759A1 (en) 2017-09-21
CA2957275A1 (en) 2016-02-25
AU2015305770C1 (en) 2024-08-01
KR20190122881A (ko) 2019-10-30
US11278620B2 (en) 2022-03-22
WO2016028672A1 (en) 2016-02-25
US20190083615A1 (en) 2019-03-21
JP2019122405A (ja) 2019-07-25
JP6538247B2 (ja) 2019-07-03
MA40476B1 (fr) 2021-03-31
PH12017500297A1 (en) 2017-07-17
BR112017003194B1 (pt) 2020-06-09
EP3834842A1 (en) 2021-06-16
NI201700018A (es) 2017-03-08
CY1124252T1 (el) 2022-07-22
UA127888C2 (uk) 2024-02-07
CN107001470B (zh) 2021-06-22

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