RU97118145A - Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций - Google Patents
Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизацийInfo
- Publication number
- RU97118145A RU97118145A RU97118145/13A RU97118145A RU97118145A RU 97118145 A RU97118145 A RU 97118145A RU 97118145/13 A RU97118145/13 A RU 97118145/13A RU 97118145 A RU97118145 A RU 97118145A RU 97118145 A RU97118145 A RU 97118145A
- Authority
- RU
- Russia
- Prior art keywords
- paragraphs
- polypeptide according
- warm
- amino acid
- blooded animal
- Prior art date
Links
- 102100016662 ERBB2 Human genes 0.000 title claims 6
- 101700025368 ERBB2 Proteins 0.000 title claims 6
- 108090000623 proteins and genes Proteins 0.000 title claims 2
- 102000004169 proteins and genes Human genes 0.000 title claims 2
- 230000002265 prevention Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 11
- 150000001413 amino acids Chemical group 0.000 claims 6
- 230000003053 immunization Effects 0.000 claims 6
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 4
- 230000036210 malignancy Effects 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 210000004027 cells Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000003612 virological Effects 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000000295 complement Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Claims (12)
1. Полипептид, кодируемый последовательностью ДНК, выбранной из: (а) нуклеотидов 2026-3765 SEQ ID NO:1; и (b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO: 1 в умеренно строгих условиях, причем последовательность ДНК кодирует полипептид, который дает иммунный ответ на HER-2/nеu-белок.
2. Полипептид, имеющий аминокислотную последовательность SEQ ID NO:2 от лизина, аминокислоты 676, до валина, аминокислоты 1255, или его вариант, который вызывает, по крайней мере, эквивалентный иммунный ответ.
3. Полипептид по п. 2, имеющий аминокислотную последовательность SEQ ID NO:2 от аминокислоты 676 до аминокислоты 1255.
4. Композиция, включающая полипептид по любому из пп. 1, 2 или 3 в сочетании с фармацевтически приемлемым носителем или разбавителем.
5. Полипептид по любому из пп. 1, 2 или 3 или композиция по п. 4 для иммунизации теплокровного животного против малигнизации, ассоциированной с онкогеном HER-2/neu.
6. Использование полипептида по любому из пп. 1,2 или 3 или композиции по п. 4 для производства лекарственного средства для иммунизации теплокровного животного против малигнизации, ассоциированной с онкогеном HER-2/neu.
7. Молекула нуклеиновой кислоты, управляющая экспрессией полипептида по любому из пп. 1, 2 или 3 для иммунизации путем трансфекции клеток теплокровного животного молекулой нуклеиновой кислоты.
8. Молекула нуклеиновой кислоты по п.7, отличающаяся тем, что клетки трансфицируются ex vivo и затем доставляются в организм животного.
9. Использование молекулы нуклеиновой кислоты, управляющей экспрессией полипептида по любому из пп. 1, 2 или 3, в производстве лекарственного средства для иммунизации теплокровного животного против малигнизации, ассоциированной с онкогеном HER-2/neu.
10. Вирусный вектор, управляющий экспрессией полипептида по любому из пп. 1, 2 или 3 для иммунизации путем инфицирования клеток теплокровного животного вектором.
11. Вирусный вектор по п. 10, отличающийся тем, что клетки инфицируются ex vivo и затем доставляются в организм животного.
12. Использование вирусного вектора, управляющего экспрессией полипептида по любому из пп. 1, 2 или 3, в производстве лекарственного средства, для иммунизации теплокровного животного против малигнизации, ассоциированной с онкогеном HER-2/neu.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/414,417 | 1995-03-31 | ||
US08/414,417 US5801005A (en) | 1993-03-17 | 1995-03-31 | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2004115492/13A Division RU2004115492A (ru) | 1995-03-31 | 2004-05-21 | Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций |
Publications (2)
Publication Number | Publication Date |
---|---|
RU97118145A true RU97118145A (ru) | 1999-10-27 |
RU2236461C2 RU2236461C2 (ru) | 2004-09-20 |
Family
ID=23641368
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU97118145/13A RU2236461C2 (ru) | 1995-03-31 | 1996-03-28 | Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций |
RU2004115492/13A RU2004115492A (ru) | 1995-03-31 | 2004-05-21 | Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2004115492/13A RU2004115492A (ru) | 1995-03-31 | 2004-05-21 | Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций |
Country Status (19)
Country | Link |
---|---|
US (9) | US5801005A (ru) |
EP (2) | EP0817846B1 (ru) |
JP (2) | JP4510147B2 (ru) |
KR (1) | KR100554186B1 (ru) |
CN (3) | CN1951398A (ru) |
AT (1) | ATE299180T1 (ru) |
AU (1) | AU708237B2 (ru) |
BR (1) | BR9607889A (ru) |
CA (1) | CA2216601C (ru) |
CZ (2) | CZ296618B6 (ru) |
DE (1) | DE69634912T2 (ru) |
DK (1) | DK0817846T3 (ru) |
ES (1) | ES2245783T3 (ru) |
HU (1) | HUP9801826A3 (ru) |
NO (2) | NO321941B1 (ru) |
NZ (1) | NZ306616A (ru) |
PT (1) | PT817846E (ru) |
RU (2) | RU2236461C2 (ru) |
WO (1) | WO1996030514A1 (ru) |
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- 1996-03-28 CN CNA200610099911XA patent/CN1951398A/zh active Pending
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- 1996-03-28 KR KR1019970706857A patent/KR100554186B1/ko not_active IP Right Cessation
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- 1996-03-28 AU AU55222/96A patent/AU708237B2/en not_active Ceased
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- 1996-03-28 WO PCT/US1996/001689 patent/WO1996030514A1/en active IP Right Grant
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- 1996-03-28 HU HU9801826A patent/HUP9801826A3/hu unknown
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- 1997-09-29 NO NO19974502A patent/NO321941B1/no unknown
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- 1999-07-15 US US09/354,533 patent/US6664370B2/en not_active Expired - Fee Related
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