RU2496473C2 - Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты - Google Patents
Гели на основе гиалуроновой кислоты, включающие обезболивающие агенты Download PDFInfo
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- RU2496473C2 RU2496473C2 RU2011107878/15A RU2011107878A RU2496473C2 RU 2496473 C2 RU2496473 C2 RU 2496473C2 RU 2011107878/15 A RU2011107878/15 A RU 2011107878/15A RU 2011107878 A RU2011107878 A RU 2011107878A RU 2496473 C2 RU2496473 C2 RU 2496473C2
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- Prior art keywords
- lidocaine
- gel
- composition
- crosslinked
- component
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 274
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- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims abstract description 122
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- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 21
- PGMKGZOHRBZSSQ-UHFFFAOYSA-N 2-[2-(oxiran-2-ylmethoxy)ethenoxymethyl]oxirane Chemical group C1OC1COC=COCC1CO1 PGMKGZOHRBZSSQ-UHFFFAOYSA-N 0.000 claims abstract description 5
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- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 claims description 17
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- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
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| US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
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- 2012-03-13 US US13/419,079 patent/US8822676B2/en active Active
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2014
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| RU2276998C2 (ru) * | 2001-05-01 | 2006-05-27 | Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук | Гидрогелевые композиции |
| US20050136122A1 (en) * | 2003-12-22 | 2005-06-23 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
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| RU2780323C2 (ru) * | 2017-12-29 | 2022-09-21 | Матекс Лаб С.П.А. | Способ получения наполнителя на основе гиалуроновой кислоты с использованием специфических сшивающих агентов |
| RU2790229C2 (ru) * | 2017-12-29 | 2023-02-15 | Матекс Лаб С.П.А. | Способ получения наполнителя на основе гиалуроновой кислоты, включающий стадию нейтрализации |
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