RU2015100533A - Естественная комбинация составов и способов гормонозаместительной терапии - Google Patents
Естественная комбинация составов и способов гормонозаместительной терапии Download PDFInfo
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Abstract
1. Фармацевтический состав, содержащий растворяющий агент, данный растворяющий агент представляет собой жир, который преимущественно представлен С6-С12 жиром; эстрадиол или эстрадиола полугидрат, данный эстрадиол или эстрадиола полугидрат растворим в растворяющем агенте по меньшей мере приблизительно на 90%; и прогестерон.2. Фармацевтический состав по п. 1, в котором С6-С12 жир выбран по меньшей мере из одного из моноглицеридов, диглицеридов, триглицеридов и их комбинаций, которые преимущественно содержат цепи С6-С12 жирных кислот.3. Фармацевтический состав по п. 2, в котором С6-С12 жир является насыщенным С6-С12 жиром.4. Фармацевтический состав по п. 3, в котором моноглицериды, диглицериды и триглицериды в >50% случаев содержат цепи С6-С12 жирных кислот.5. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,25 мг эстрадиола или около 0,26 мг эстрадиола полугидрата; и около 50 мг прогестерона.6. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,50 мг эстрадиола или около 0,52 мг эстрадиола полугидрата; и около 50 мг прогестерона.7. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,50 мг эстрадиола или около 0,52 мг эстрадиола полугидрата; и около 100 мг прогестерона.8. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,50 мг эстрадиола или около 0,52 мг эстрадиола полугидрата; и около 50 мг прогестерона.9. Фармацевтический состав по п. 5, дополнительно содержащий около 98,24 мг растворяющего агента, растворяющий агент содержит моноглицериды и диглицериды, представляющие собой эфиры каприловой и каприновой кислот (CAPMUL МСМ); и около 1,50 мг по меньшей мере одного
Claims (20)
1. Фармацевтический состав, содержащий растворяющий агент, данный растворяющий агент представляет собой жир, который преимущественно представлен С6-С12 жиром; эстрадиол или эстрадиола полугидрат, данный эстрадиол или эстрадиола полугидрат растворим в растворяющем агенте по меньшей мере приблизительно на 90%; и прогестерон.
2. Фармацевтический состав по п. 1, в котором С6-С12 жир выбран по меньшей мере из одного из моноглицеридов, диглицеридов, триглицеридов и их комбинаций, которые преимущественно содержат цепи С6-С12 жирных кислот.
3. Фармацевтический состав по п. 2, в котором С6-С12 жир является насыщенным С6-С12 жиром.
4. Фармацевтический состав по п. 3, в котором моноглицериды, диглицериды и триглицериды в >50% случаев содержат цепи С6-С12 жирных кислот.
5. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,25 мг эстрадиола или около 0,26 мг эстрадиола полугидрата; и около 50 мг прогестерона.
6. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,50 мг эстрадиола или около 0,52 мг эстрадиола полугидрата; и около 50 мг прогестерона.
7. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,50 мг эстрадиола или около 0,52 мг эстрадиола полугидрата; и около 100 мг прогестерона.
8. Фармацевтический состав по любому из пп. 1-4, в котором фармацевтический состав содержит около 0,50 мг эстрадиола или около 0,52 мг эстрадиола полугидрата; и около 50 мг прогестерона.
9. Фармацевтический состав по п. 5, дополнительно содержащий около 98,24 мг растворяющего агента, растворяющий агент содержит моноглицериды и диглицериды, представляющие собой эфиры каприловой и каприновой кислот (CAPMUL МСМ); и около 1,50 мг по меньшей мере одного из глицеридов лауроилмакрогола-32 Евр. Ф., глицеридов лауроилполиоксила-32 NF или лаупроилполиоксилглицеридов (GELUCIRE 44/14).
10. Фармацевтический состав по п. 6, дополнительно содержащий около 97,98 мг растворяющего агента, содержащего моноглицериды и диглицериды каприловой и каприновой кислот (CAPMUL МСМ); и около 1,50 мг по меньшей мере одного из глицеридов лауроилмакрогола-32 Евр. Ф., глицеридов лауроилполиоксила-32 NF или лаупроилполиоксилглицеридов (GELUCIRE 44/14).
11. Фармацевтический состав по п. 7, дополнительно содержащий около 196,48 мг моноглицеридов и диглицеридов каприловой и каприновой кислот (CAPMUL МСМ); и около 3,0 мг по меньшей мере одного из глицеридов лауроилмакрогола-32 Евр. Ф., глицеридов лауроилполиоксила-32 NF или лаупроилполиоксилглицеридов (GELUCIRE 44/14).
12. Фармацевтический состав по п. 8, дополнительно содержащий около 195,97 мг моноглицеридов и диглицеридов каприловой и каприновой кислот (CAPMUL МСМ); и около 3,0 мг по меньшей мере одного из глицеридов лауроилмакрогола-32 Евр. Ф., глицеридов лауроилполиоксила-32 NF или лаупроилполиоксилглицеридов (GELUCIRE 44/14).
13. Фармацевтический состав по п. 1, в котором часть прогестерона суспендирована.
14. Фармацевтический состав по любому из пп. 1-4, в котором эстрадиол или эстрадиола полугидрат и прогестерон растворены в растворяющем агенте; и/или в которых эстрадиол или эстрадиола полугидрат и прогестерон образуют однородную дисперсию в растворяющем агенте.
15. Способ лечения симптомов, связанных с менопаузой, у женщин подразумевает введение эффективного количества фармацевтического состава по любому из пп. 1-14.
16. Способ лечения вазомоторных симптомов у женщин подразумевает введение эффективного количества фармацевтического состава по любому из пп. 1-14 один раз в день.
17. Способ по п. 15 или 16, в котором фармацевтический состав вводится в рамках непрерывного комбинированного режима терапии или последовательного комбинированного режима терапии.
18. Способ по п. 15 или 16, в котором фармацевтический состав вводится один раз в день.
19. Способ по п. 15 или 16, в котором С6-С12 жиры представлены С6-С12 моноглицеридами и диглицеридами.
20. Способ по п. 19, в котором моноглицериды и диглицериды представлены эфирами каприловой кислоты (С8) и каприновой кислоты (С10).
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661302P | 2012-06-18 | 2012-06-18 | |
US61/661,302 | 2012-06-18 | ||
US201261662265P | 2012-06-20 | 2012-06-20 | |
US61/662,265 | 2012-06-20 | ||
US13/684,002 | 2012-11-21 | ||
US13/684,002 US8633178B2 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
US13/843,428 US9301920B2 (en) | 2012-06-18 | 2013-03-15 | Natural combination hormone replacement formulations and therapies |
US13/843,428 | 2013-03-15 | ||
PCT/US2013/046445 WO2013192251A1 (en) | 2012-06-18 | 2013-06-18 | Natural combination hormone replacement formulations and therapies |
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RU2019142696A Division RU2019142696A (ru) | 2012-06-18 | 2013-06-18 | Естественная комбинация составов и способов гормонозаместительной терапии |
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RU2019142696A RU2019142696A (ru) | 2012-06-18 | 2013-06-18 | Естественная комбинация составов и способов гормонозаместительной терапии |
RU2015100533A RU2015100533A (ru) | 2012-06-18 | 2013-06-18 | Естественная комбинация составов и способов гормонозаместительной терапии |
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US (13) | US9301920B2 (ru) |
EP (2) | EP4309646A1 (ru) |
JP (3) | JP6334519B2 (ru) |
KR (5) | KR20200128214A (ru) |
AU (4) | AU2013277236B2 (ru) |
BR (1) | BR112014031910B1 (ru) |
CA (1) | CA2876977A1 (ru) |
ES (1) | ES2967709T3 (ru) |
IL (1) | IL236358B (ru) |
MX (2) | MX2014015898A (ru) |
PL (1) | PL2861072T3 (ru) |
PT (1) | PT2861072T (ru) |
RU (2) | RU2019142696A (ru) |
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PL2861073T3 (pl) * | 2012-06-18 | 2021-09-27 | Therapeuticsmd, Inc. | Rozpuszczalna kapsułka estradiolu do wprowadzania do pochwy |
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US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
AU2015237243A1 (en) * | 2014-03-28 | 2016-09-29 | Therapeuticsmd, Inc. | Progesterone formulations |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
CA2951284A1 (en) | 2014-07-29 | 2016-02-04 | Therapeuticsmd, Inc. | Transdermal cream |
US10467382B2 (en) * | 2014-11-14 | 2019-11-05 | Brazen Incorporated | Conceivable basal body temperatures and menstrual cycle |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
JP2019513709A (ja) | 2016-04-01 | 2019-05-30 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | ステロイドホルモン薬学的組成物 |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US20170281647A1 (en) * | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
CA3045024A1 (en) * | 2016-12-05 | 2018-07-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
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