ES2171186T3 - Composiciones liquidas de difusion. - Google Patents
Composiciones liquidas de difusion.Info
- Publication number
- ES2171186T3 ES2171186T3 ES95914202T ES95914202T ES2171186T3 ES 2171186 T3 ES2171186 T3 ES 2171186T3 ES 95914202 T ES95914202 T ES 95914202T ES 95914202 T ES95914202 T ES 95914202T ES 2171186 T3 ES2171186 T3 ES 2171186T3
- Authority
- ES
- Spain
- Prior art keywords
- controlled release
- compositions
- gelatinous
- liquid
- situ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 239000007788 liquid Substances 0.000 title abstract 4
- 238000009792 diffusion process Methods 0.000 title 1
- 238000013270 controlled release Methods 0.000 abstract 5
- 239000007943 implant Substances 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000012669 liquid formulation Substances 0.000 abstract 2
- 229920000249 biocompatible polymer Polymers 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000011066 ex-situ storage Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
SE FACILITAN COMPUESTOS MEJORADOS PARA LIBERAR LIQUIDO BIOCOMPATIBLE, QUE TIENEN UTILIDAD PARA LA FORMACION DE SISTEMAS DE APOYO DE LIBERACION SOSTENIDA. LOS COMPUESTOS INCLUYEN FORMULAS LIQUIDAS DE UN POLIMERO O PREPOLIMERO BIOCOMPATIBLE EN COMBINACION CON UN ELEMENTO DE LIBERACION CONTROLADO QUE INCLUYE UN AGENTE ACTIVO. ESTOS COMPUESTOS SE PUEDEN INTRODUCIR EN EL CUERPO DE UN SUJETO EN FORMA LIQUIDA PARA SOLIDIFICARSE O CURARSE IN SITU Y FORMAR UN IMPLANTE QUE LIBERA DE FORMA CONTROLADA O UN VENDAJE EN FORMA DE PELICULA. ESTOS COMPUESTOS SE PUEDEN EMPLEAR TAMBIEN PARA PRODUCIR EX SITU LOS IMPLANTES REFERIDOS. SE FACILITAN TAMBIEN LOS METODOS PARA REALIZAR IMPLANTES QUE SE LIBERAN DE FORMA CONTROLADA Y EMPLEAR LAS FORMULAS LIQUIDAS REFERIDAS EN EL TRATAMIENTO DE UN SUJETO.
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US22514094A | 1994-04-08 | 1994-04-08 |
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ES95914202T Expired - Lifetime ES2171186T3 (es) | 1994-04-08 | 1995-03-27 | Composiciones liquidas de difusion. |
ES01111735T Expired - Lifetime ES2258495T3 (es) | 1994-04-08 | 1995-03-27 | Composiciones de administracion liquida de farmacos. |
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ES01111735T Expired - Lifetime ES2258495T3 (es) | 1994-04-08 | 1995-03-27 | Composiciones de administracion liquida de farmacos. |
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ES (2) | ES2171186T3 (es) |
NZ (1) | NZ283282A (es) |
PT (1) | PT754032E (es) |
WO (1) | WO1995027481A1 (es) |
Families Citing this family (269)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0729357T3 (da) * | 1993-11-19 | 2005-06-06 | Janssen Pharmaceutica Nv | Mikroindkapslede 1,2-benzazoler |
US7833543B2 (en) * | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
US6413536B1 (en) * | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
HUP9700322A3 (en) * | 1995-06-09 | 2001-03-28 | Euro Celtique Sa | Formulations and methods for providing prolonged local anesthesia |
US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
KR0180334B1 (ko) | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
US20030077317A1 (en) * | 1996-06-25 | 2003-04-24 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
US5955096A (en) * | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
US5980948A (en) * | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
ES2158611T3 (es) * | 1996-12-20 | 2001-09-01 | Alza Corp | Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion. |
US6630168B1 (en) * | 1997-02-20 | 2003-10-07 | Biomedicines, Inc. | Gel delivery vehicles for anticellular proliferative agents |
US20060025328A1 (en) * | 1997-05-28 | 2006-02-02 | Burns Patrick J | Compositions suitable for controlled release of the hormone GnRH and its analogs |
US7303756B1 (en) | 1997-06-05 | 2007-12-04 | Bertex Pharma Gmbh | Multiphase system |
AUPO907697A0 (en) | 1997-09-09 | 1997-10-02 | Day, Robert Edward | Chemical supplementation of bone |
US6054421A (en) * | 1997-09-23 | 2000-04-25 | Scimed Life Systems, Inc. | Medical emulsion lubricant |
US6281175B1 (en) | 1997-09-23 | 2001-08-28 | Scimed Life Systems, Inc. | Medical emulsion for lubrication and delivery of drugs |
US6410057B1 (en) * | 1997-12-12 | 2002-06-25 | Samyang Corporation | Biodegradable mixed polymeric micelles for drug delivery |
US6210717B1 (en) * | 1997-12-12 | 2001-04-03 | Samyang Corporation | Biodegradable mixed polymeric micelles for gene delivery |
ES2359973T3 (es) * | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas. |
US6261547B1 (en) | 1998-04-07 | 2001-07-17 | Alcon Manufacturing, Ltd. | Gelling ophthalmic compositions containing xanthan gum |
US6174524B1 (en) | 1999-03-26 | 2001-01-16 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
US7128927B1 (en) * | 1998-04-14 | 2006-10-31 | Qlt Usa, Inc. | Emulsions for in-situ delivery systems |
US6245345B1 (en) * | 1998-07-07 | 2001-06-12 | Atrix Laboratories, Inc. | Filamentous porous films and methods for producing the same |
US6261583B1 (en) | 1998-07-28 | 2001-07-17 | Atrix Laboratories, Inc. | Moldable solid delivery system |
US7790192B2 (en) | 1998-08-14 | 2010-09-07 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US6143314A (en) * | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
US6368658B1 (en) * | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
EP1949890A3 (en) * | 1999-06-04 | 2011-05-18 | ALZA Corporation | Implantable gel compositions and method of manufacture |
HUP0201626A3 (en) * | 1999-06-04 | 2004-05-28 | Alza Corp Mountain View | Implantable gel compositions and method of manufacture |
IL146801A0 (en) | 1999-06-11 | 2002-07-25 | Pro Duct Health Inc | Gel composition for filling a breast milk duct prior to surgical excision of the duct or other breast tissue |
US6358197B1 (en) * | 1999-08-13 | 2002-03-19 | Enteric Medical Technologies, Inc. | Apparatus for forming implants in gastrointestinal tract and kit for use therewith |
US6755811B1 (en) * | 1999-08-25 | 2004-06-29 | Corazon Technologies, Inc. | Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue |
IL148915A0 (en) * | 1999-10-12 | 2002-09-12 | Yarmut Yehuda | Targeted drug activation |
CA2386822A1 (en) | 1999-11-01 | 2001-05-10 | Alcon, Inc. | Pharmaceutical compositions containing a fluoroquinolone antibiotic drug and xanthan gum |
KR100416242B1 (ko) * | 1999-12-22 | 2004-01-31 | 주식회사 삼양사 | 약물전달체용 생분해성 블록 공중합체의 액체 조성물 및이의 제조방법 |
US20010007083A1 (en) * | 1999-12-29 | 2001-07-05 | Roorda Wouter E. | Device and active component for inhibiting formation of thrombus-inflammatory cell matrix |
AU2463701A (en) | 1999-12-29 | 2001-07-09 | Nanodelivery, Inc. | Drug delivery system exhibiting permeability control |
EP1248596B1 (de) | 2000-01-11 | 2007-03-07 | Roland Bodmeier | Kit zur implantation enthaltend eine trägerphase und ein lösungsmittel |
US7097855B1 (en) | 2000-01-31 | 2006-08-29 | Massachusetts Institute Of Technology | Transdermal thermal polymerization |
MXPA02007938A (es) | 2000-02-17 | 2003-02-10 | 3M Innovative Properties Co | Sistema de suministro, composiciones y metodos, que utilizan un polimero biodegradable preformado. |
US7193007B2 (en) * | 2000-03-15 | 2007-03-20 | Yu-Ling Cheng | Environment responsive gelling copolymer |
US7160931B2 (en) * | 2000-03-15 | 2007-01-09 | Yu-Ling Cheng | Thermally reversible implant and filler |
US20030211974A1 (en) * | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
CA2406790C (en) | 2000-04-19 | 2009-07-07 | Genentech, Inc. | Sustained release formulations |
US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
US6613355B2 (en) | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
ES2225573T3 (es) | 2000-07-28 | 2005-03-16 | Alcon, Inc | Composiciones farmaceuticas que contienen tobramicina y goma xantana. |
ATE377048T1 (de) * | 2000-09-06 | 2007-11-15 | Ap Pharma Inc | Abbaubare polyacetal-polymere |
US8470359B2 (en) | 2000-11-13 | 2013-06-25 | Qlt Usa, Inc. | Sustained release polymer |
AU2002242231B2 (en) * | 2001-02-23 | 2007-09-06 | Genentech, Inc. | Erodible polymers for injection |
US20040185101A1 (en) * | 2001-03-27 | 2004-09-23 | Macromed, Incorporated. | Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof |
US6590059B2 (en) * | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
US20030152630A1 (en) * | 2001-05-11 | 2003-08-14 | Ng Steven Y. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
ES2554106T3 (es) * | 2001-06-21 | 2015-12-16 | Genentech, Inc. | Formulación de liberación sostenida |
US6592899B2 (en) * | 2001-10-03 | 2003-07-15 | Macromed Incorporated | PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water |
US20030118649A1 (en) * | 2001-10-04 | 2003-06-26 | Jinming Gao | Drug delivery devices and methods |
JP2005519873A (ja) * | 2001-11-14 | 2005-07-07 | アルザ・コーポレーション | カテーテル注入可能なデポー組成物およびそれらの使用 |
US20070196415A1 (en) * | 2002-11-14 | 2007-08-23 | Guohua Chen | Depot compositions with multiple drug release rate controls and uses thereof |
CN1703197A (zh) * | 2001-11-14 | 2005-11-30 | 阿尔扎有限公司 | 可注射的长效组合物和其使用 |
US6524606B1 (en) * | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
US6537985B1 (en) * | 2001-11-30 | 2003-03-25 | Phoenix Scientific, Inc. | Antibiotic formulation and a method of making this formulation |
WO2003080629A2 (en) | 2002-02-25 | 2003-10-02 | Guilford Pharmaceuticals, Inc. | Phosphorus-containing compounds with polymeric chains, and methods of making and using the same |
EP1344538A1 (en) | 2002-03-14 | 2003-09-17 | Degradable Solutions AG | Porous biodegradable implant material and method for its fabrication |
KR100496353B1 (ko) * | 2002-04-15 | 2005-06-20 | 서울산업대학교 산학협력단 | 약물방출 능을 가진 생분해성 고분자를 이용한 조직공학용생분해성 고분자 지지체 및 그의 제조 방법 |
US7432245B2 (en) * | 2002-06-07 | 2008-10-07 | Abbott Laboratories Inc. | Pharmaceutical formulation comprising a peptide angiogenesis inhibitor |
US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
TWI353854B (en) | 2002-06-25 | 2011-12-11 | Alza Corp | Short duration depot formulations |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
US20070184089A1 (en) * | 2002-07-15 | 2007-08-09 | Alcon, Inc. | Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use |
BR0312635A (pt) * | 2002-07-15 | 2005-04-19 | Alcon Inc | Composições de implante farmacêutico lipofìlico não polimérico para uso intraocular |
DK1539101T3 (da) | 2002-07-31 | 2009-04-27 | Alza Corp | Injicerbare, multi-modale polymere depotsammens tninger og anvendelser deraf |
ES2319400T3 (es) * | 2002-07-31 | 2009-05-07 | Durect Corporation | Composiciones deposito inyectables y empleo de las mismas. |
AU2003295409B2 (en) * | 2002-11-06 | 2010-02-11 | Durect Corporation | Controlled release depot formulations |
US7045589B2 (en) * | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
ATE482695T1 (de) * | 2002-12-13 | 2010-10-15 | Durect Corp | Orale darreichungsform mit flüssigen hochviskosen trägersystemen |
AU2004219595A1 (en) * | 2003-03-11 | 2004-09-23 | Qlt Usa Inc. | Formulations for cell- schedule dependent anticancer agents |
DE10312346A1 (de) * | 2003-03-20 | 2004-09-30 | Bayer Healthcare Ag | Kontrolliertes Freisetzungssystem |
US20040215335A1 (en) * | 2003-04-25 | 2004-10-28 | Brin David S. | Methods and apparatus for treatment of aneurysmal tissue |
US20070184084A1 (en) * | 2003-05-30 | 2007-08-09 | Guohua Chen | Implantable elastomeric caprolactone depot compositions and uses thereof |
EP1643968A1 (en) * | 2003-05-30 | 2006-04-12 | ALZA Corporation | Implantable elastomeric depot compositions, uses thereof and method of manufacturing |
US7331979B2 (en) * | 2003-06-04 | 2008-02-19 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9289195B2 (en) * | 2003-06-04 | 2016-03-22 | Access Closure, Inc. | Auto-retraction apparatus and methods for sealing a vascular puncture |
ES2646813T3 (es) * | 2003-06-19 | 2017-12-18 | Coloplast A/S | Un dispositivo para el cuidado de heridas |
TWI377958B (en) | 2003-06-26 | 2012-12-01 | Control Delivery Sys Inc | In-situ gelling drug delivery system |
JP5628467B2 (ja) * | 2003-06-26 | 2014-11-19 | シヴィダ・ユーエス・インコーポレイテッドPsivida Us, Inc. | 生体分解性徐放性ドラッグデリバリーシステム |
US20050009910A1 (en) * | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
US20070224278A1 (en) * | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20050250737A1 (en) * | 2003-11-12 | 2005-11-10 | Allergan, Inc. | Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods |
US20050101582A1 (en) * | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
US20050281879A1 (en) * | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
US20050245876A1 (en) * | 2003-12-24 | 2005-11-03 | Accessclosure, Inc. | Apparatus and methods for facilitating access through a puncture including sealing compound therein |
US20050149117A1 (en) * | 2003-12-24 | 2005-07-07 | Farhad Khosravi | Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis |
US20070060950A1 (en) * | 2003-12-24 | 2007-03-15 | Farhad Khosravi | Apparatus and methods for delivering sealing materials during a percutaneous procedure to facilitate hemostasis |
JP2007517042A (ja) * | 2003-12-30 | 2007-06-28 | デュレクト コーポレーション | 活性物質、好ましくはgnrhの制御放出のための、好ましくはpegおよびplgの混合物を含有するポリマーインプラント |
WO2005067890A2 (en) | 2004-01-13 | 2005-07-28 | Vasogenix Pharmaceuticals, Inc. | Controlled release cgrp delivery composition for cardiovascular and renal indications |
CA2552758A1 (en) * | 2004-01-13 | 2005-08-04 | Vasogenix Pharmaceuticals, Inc. | Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same |
CA2552757A1 (en) * | 2004-01-13 | 2005-08-04 | Vasogenix Pharmaceuticals, Inc. | Methods of using cgrp for cardiovascular and renal indications |
JP2007518804A (ja) | 2004-01-20 | 2007-07-12 | アラーガン、インコーポレイテッド | トリアムシノロンアセトニドおよびヒアルロン酸を好ましく含有する眼局所治療用組成物 |
US8048086B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
US8052669B2 (en) | 2004-02-25 | 2011-11-08 | Femasys Inc. | Methods and devices for delivery of compositions to conduits |
US8048101B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
US9238127B2 (en) | 2004-02-25 | 2016-01-19 | Femasys Inc. | Methods and devices for delivering to conduit |
CA2558200A1 (en) * | 2004-03-02 | 2005-09-15 | Nanotherapeutics, Inc. | Compositions for repairing bone and methods for preparing and using such compositions |
US8147865B2 (en) * | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
US8163030B2 (en) | 2004-05-06 | 2012-04-24 | Degradable Solutions Ag | Biocompatible bone implant compositions and methods for repairing a bone defect |
NZ551990A (en) * | 2004-06-04 | 2011-01-28 | Camurus Ab | Liquid depot formulations |
EP1604693A1 (en) | 2004-06-09 | 2005-12-14 | Scil Technology GmbH | In situ forming scaffold, its manufacturing and use |
JP2008505978A (ja) | 2004-07-12 | 2008-02-28 | アラーガン、インコーポレイテッド | 眼病用組成物および眼病治療法 |
DK1629844T4 (da) | 2004-07-13 | 2012-05-29 | Bayer Schering Pharma Oy | Retarderet indgivelsessystem med kontrolleret initialudbrud |
PT1781264E (pt) | 2004-08-04 | 2013-10-16 | Evonik Corp | Métodos para o fabrico de dispositivis de administração e dispositivos para a mesma |
US8980300B2 (en) | 2004-08-05 | 2015-03-17 | Advanced Cardiovascular Systems, Inc. | Plasticizers for coating compositions |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
WO2006026504A2 (en) * | 2004-08-27 | 2006-03-09 | Spherics, Inc. | Mucoadhesive oral formulations of high permeability, high solubility drugs |
US8348971B2 (en) * | 2004-08-27 | 2013-01-08 | Accessclosure, Inc. | Apparatus and methods for facilitating hemostasis within a vascular puncture |
US20060045902A1 (en) * | 2004-09-01 | 2006-03-02 | Serbousek Jon C | Polymeric wrap for in vivo delivery of osteoinductive formulations |
US20060057184A1 (en) * | 2004-09-16 | 2006-03-16 | Nycz Jeffrey H | Process to treat avascular necrosis (AVN) with osteoinductive materials |
LT2767292T (lt) * | 2004-09-17 | 2016-12-12 | Durect Corporation | Palaikomosios vietinės anestezijos mišinys su saib |
US20080038316A1 (en) * | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
AU2005294382A1 (en) * | 2004-10-04 | 2006-04-20 | Qlt Usa, Inc. | Ocular delivery of polymeric delivery formulations |
US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
CA2583911A1 (en) * | 2004-10-28 | 2006-05-11 | Microchips, Inc. | Orthopedic and dental implant devices providing controlled drug delivery |
US8262693B2 (en) | 2004-11-05 | 2012-09-11 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
JP5244394B2 (ja) * | 2004-11-10 | 2013-07-24 | トルマー セラピューティクス, インコーポレイテッド. | 安定化されたポリマー送達系 |
US8263105B2 (en) * | 2004-12-01 | 2012-09-11 | Tyco Healthcare Group Lp | Biomaterial drug delivery and surface modification compositions |
CA2526541C (en) * | 2004-12-01 | 2013-09-03 | Tyco Healthcare Group Lp | Novel biomaterial drug delivery and surface modification compositions |
WO2006071208A1 (en) * | 2004-12-23 | 2006-07-06 | Durect Corporation | Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of a gnrh |
US20060142234A1 (en) * | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
US8137664B2 (en) * | 2005-02-02 | 2012-03-20 | Sdgi Holdings, Inc. | Method and kit for repairing a defect in bone |
CN101370634A (zh) * | 2005-02-16 | 2009-02-18 | 亚历山大·R·瓦卡若 | 供植入与药物传递的再吸收中空装置 |
CA2498623A1 (en) * | 2005-02-18 | 2006-08-18 | Qlt Inc. | Treatment of onychomycosis |
US20060189958A1 (en) * | 2005-02-21 | 2006-08-24 | Talton James D | Inverted cannula for use in reconstituting dry material in syringes |
US8002742B2 (en) * | 2005-04-22 | 2011-08-23 | Accessclosure, Inc. | Apparatus and methods for sealing a puncture in tissue |
US7806856B2 (en) * | 2005-04-22 | 2010-10-05 | Accessclosure, Inc. | Apparatus and method for temporary hemostasis |
WO2007001624A2 (en) * | 2005-06-28 | 2007-01-04 | Microchips, Inc. | Medical and dental implant devices for controlled drug delivery |
US20070005130A1 (en) * | 2005-06-29 | 2007-01-04 | Thierry Glauser | Biodegradable polymer for coating |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
EP1919561A1 (en) | 2005-08-08 | 2008-05-14 | Cytyc Corporation | Tumescent skin spacing method |
US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
EP1984009B1 (en) * | 2006-01-18 | 2012-10-24 | Qps, Llc | Pharmaceutical compositions with enhanced stability |
US20070212307A1 (en) * | 2006-02-10 | 2007-09-13 | Daniel Wermeling | Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same |
US8658210B2 (en) | 2006-04-17 | 2014-02-25 | Advanced Cardiovascular Systems, Inc. | Polyesteramide platform for site specific drug delivery |
US20070265329A1 (en) * | 2006-05-12 | 2007-11-15 | Devang Shah T | Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) |
US20070264339A1 (en) * | 2006-05-12 | 2007-11-15 | Ap Pharma, Inc. | Base-stabilized polyorthoester formulations |
US20070264338A1 (en) * | 2006-05-12 | 2007-11-15 | Shah Devang T | Base-stabilized polyorthoester formulations |
WO2008008363A1 (en) | 2006-07-11 | 2008-01-17 | Qps, Llc | Pharmaceutical compositions for sustained release delivery of peptides |
US8685430B1 (en) | 2006-07-14 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Tailored aliphatic polyesters for stent coatings |
US8936780B2 (en) * | 2006-08-30 | 2015-01-20 | Advanced Cardiovascular Systems, Inc. | Stimuli responsive polyester amide particles |
US8617204B2 (en) * | 2006-09-13 | 2013-12-31 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US8076448B2 (en) | 2006-10-11 | 2011-12-13 | Tolmar Therapeutics, Inc. | Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction |
DK2117521T3 (da) | 2006-11-03 | 2012-09-03 | Durect Corp | Transdermale indgivelsessystemer omfattende bupivacain |
ES2755374T3 (es) | 2007-02-15 | 2020-04-22 | Tolmar Therapeutics Inc | Poli(lactida/glicolida) de descarga lenta y métodos para producir polímeros |
ES2372652T3 (es) | 2007-05-23 | 2012-01-25 | Amcol International Corporation | Filosilicatos estratificados, que interactúan con el colesterol y métodos para reducir la hipercolesterolemia en un mamífero. |
TW200846031A (en) * | 2007-05-25 | 2008-12-01 | Shu-Yi Lin | Drug delivery system and the preparing method thereof |
CN101801415B (zh) | 2007-05-25 | 2015-09-23 | Rb医药品有限公司 | 利培酮化合物的持续递送制剂 |
US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
US7993367B2 (en) * | 2007-09-28 | 2011-08-09 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
EP2203129A4 (en) * | 2007-10-15 | 2011-11-23 | Univ Wake Forest Health Sciences | METHODS AND COMPOSITIONS FOR PRINTING NANOTUBE COMPOSITES OF BIOLOGICALLY COMPATIBLE AUTOLOGOUS TISSUE |
EP2209426A4 (en) * | 2007-11-02 | 2015-04-22 | Incept Llc | APPARATUS AND METHODS FOR CLOSING VASCULAR PERFORATION |
WO2009064442A1 (en) * | 2007-11-13 | 2009-05-22 | Brookwood Pharmaceuticals, Inc. | Viscous terpolymers as drug delivery platform |
AU2008335809A1 (en) * | 2007-12-06 | 2009-06-18 | Durect Corporation | Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition |
US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
JP2008120838A (ja) * | 2008-02-21 | 2008-05-29 | Medgel Corp | 配位結合を利用した薬物−高分子複合体製剤の調製方法 |
US8029533B2 (en) | 2008-04-04 | 2011-10-04 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US9364206B2 (en) | 2008-04-04 | 2016-06-14 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
CA2721927C (en) | 2008-04-21 | 2014-01-28 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
CN102026623B (zh) | 2008-05-14 | 2013-08-14 | 奥德纳米有限公司 | 用于治疗耳部病症的控制释放皮质类固醇组合物和方法 |
US9486531B2 (en) | 2008-06-03 | 2016-11-08 | Indivior Uk Limited | Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system |
CN102112107A (zh) * | 2008-06-03 | 2011-06-29 | 托马医疗科技公司 | 具有改进的释放动力学特征的控制释放共聚物制剂 |
CA2730760A1 (en) * | 2008-07-16 | 2010-01-21 | Surmodics Pharmaceuticals, Inc. | Process for preparing microparticles containing bioactive peptides |
US20100016808A1 (en) * | 2008-07-17 | 2010-01-21 | Bioform Medical, Inc. | Thin-Walled Delivery System |
US20100120811A1 (en) | 2008-07-17 | 2010-05-13 | Peter Hanson | Long-acting injectable analgesic formulations for animals |
US10092580B2 (en) | 2008-07-21 | 2018-10-09 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
US8784870B2 (en) * | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
US10070888B2 (en) | 2008-10-03 | 2018-09-11 | Femasys, Inc. | Methods and devices for sonographic imaging |
US9554826B2 (en) | 2008-10-03 | 2017-01-31 | Femasys, Inc. | Contrast agent injection system for sonographic imaging |
US9161903B2 (en) * | 2008-10-31 | 2015-10-20 | Warsaw Orthopedic, Inc. | Flowable composition that hardens on delivery to a target tissue site beneath the skin |
US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
JP2012508618A (ja) | 2008-11-12 | 2012-04-12 | アクセスクロージャー,インク. | 脈管穿刺を閉鎖する装置及び方法 |
DE102008059201A1 (de) | 2008-11-27 | 2010-06-02 | GÖPFERICH, Achim, Prof. Dr. | In situ präzipitierende Arzneistofflösungen |
JP2012512163A (ja) * | 2008-12-11 | 2012-05-31 | エーピー ファーマ, インコーポレイテッド | ポリオルトエステルおよびそれらの製剤の安定性を高めるための方法 |
US9480643B2 (en) | 2008-12-23 | 2016-11-01 | Surmodics Pharmaceuticals, Inc. | Implantable composites and implants comprising same |
US8974808B2 (en) | 2008-12-23 | 2015-03-10 | Surmodics, Inc. | Elastic implantable composites and implants comprising same |
US9415197B2 (en) * | 2008-12-23 | 2016-08-16 | Surmodics, Inc. | Implantable suction cup composites and implants comprising same |
US8951546B2 (en) * | 2008-12-23 | 2015-02-10 | Surmodics Pharmaceuticals, Inc. | Flexible implantable composites and implants comprising same |
US20100168807A1 (en) * | 2008-12-23 | 2010-07-01 | Burton Kevin W | Bioactive terpolymer compositions and methods of making and using same |
WO2010102066A1 (en) | 2009-03-05 | 2010-09-10 | Bend Research, Inc. | Dextran polymer powder for inhalation administration of pharmaceuticals |
AU2010246115A1 (en) * | 2009-05-04 | 2011-12-08 | Incept. Llc | Biomaterials for track and puncture closure |
AU2009347929A1 (en) * | 2009-06-12 | 2012-01-19 | Amrita Vishwa Vidyapeetham University | Targeted nano-photomedicines for photodynamic therapy of cancer |
US20110027331A1 (en) * | 2009-07-29 | 2011-02-03 | Warsaw Orthopedic, Inc. | An implantable drug depot having a reversible phase transition material for treatment of pain and/or inflammation |
EA201290506A1 (ru) * | 2009-12-16 | 2013-03-29 | Брихэм Энд Уимен'З Хоспитал, Инк. | Частицы для доставки множества агентов |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
GB2481018B (en) | 2010-06-08 | 2015-03-18 | Rb Pharmaceuticals Ltd | Injectable flowable composition comprising buprenorphine |
GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
WO2011161531A1 (en) | 2010-06-24 | 2011-12-29 | Torrent Pharmaceuticals Limited | Pharmaceutical composition containing goserelin for in-situ implant |
WO2012030822A1 (en) | 2010-08-30 | 2012-03-08 | Surmodics Pharmaceuticals, Inc. | Process for reducing moisture in a biodegradable implant device |
US8815294B2 (en) | 2010-09-03 | 2014-08-26 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives and a carrier material |
KR20130124302A (ko) * | 2010-09-29 | 2013-11-13 | 가부시키가이샤 구라레 | 아크릴아미드 유도체, 고분자 화합물 및 포토레지스트 조성물 |
KR101411349B1 (ko) * | 2010-12-24 | 2014-06-25 | 주식회사 삼양바이오팜 | 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물 |
PL3257498T3 (pl) | 2010-12-29 | 2020-02-28 | Medincell | Biodegradowalne kompozycje do dostarczania leków |
US9820728B2 (en) | 2011-01-19 | 2017-11-21 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
ES2870965T3 (es) | 2011-01-19 | 2021-10-28 | Access Closure Inc | Procedimientos para sellar una punción vascular |
US8936635B2 (en) | 2011-03-23 | 2015-01-20 | Palmetto Pharmaceuticals Llc | Bioresorbable nitric oxide agonist prodrug scaffolds for vascular stents |
US9060938B2 (en) | 2011-05-10 | 2015-06-23 | Bend Research, Inc. | Pharmaceutical compositions of active agents and cationic dextran polymer derivatives |
US9386968B2 (en) | 2011-05-11 | 2016-07-12 | Access Closure, Inc. | Apparatus and methods for sealing a vascular puncture |
US20130095160A1 (en) * | 2011-09-12 | 2013-04-18 | Gautam S. GHATNEKAR | Resorbable polystatin biomaterials |
HUE055562T2 (hu) | 2011-11-23 | 2021-11-29 | Therapeuticsmd Inc | Természetes kombinációjú hormon helyettesítõ kiszerelések, és terápiák ezekkel |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
HUE050904T2 (hu) * | 2012-01-23 | 2021-01-28 | Allergan Inc | Idõben fokozatos felszabadítású biológiailag lebontható vagy biológiailag erodeálódó mikrogömbök vagy mikrorészecskék, melyek egy megszilárduló depó-képzõ injekciós gyógyszerben vannak szuszpendálva |
US9757105B2 (en) | 2012-03-23 | 2017-09-12 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US8721680B2 (en) | 2012-03-23 | 2014-05-13 | Accessclosure, Inc. | Apparatus and methods for sealing a vascular puncture |
US8906003B2 (en) | 2012-06-05 | 2014-12-09 | Cook Medical Technologies Llc | Erodible embolization material for targeted tumor cryoablation |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
AU2013294915C1 (en) | 2012-07-26 | 2019-11-21 | Camurus Ab | Opioid formulations |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
TW201521769A (zh) | 2013-03-15 | 2015-06-16 | Durect Corp | 具有流變改質劑以減少溶解變異性之組成物 |
WO2015029615A1 (ja) * | 2013-08-26 | 2015-03-05 | 独立行政法人科学技術振興機構 | 接着剤 |
CA2921816A1 (en) | 2013-08-27 | 2015-03-05 | Otonomy, Inc. | Treatment of pediatric otic disorders |
KR20160065968A (ko) * | 2013-10-08 | 2016-06-09 | 훼링 비.브이. | Pgss에 의해 제조되는 gnrh를 포함하는 미립자 |
JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
AU2015284048A1 (en) | 2014-07-03 | 2017-02-16 | Otonomy, Inc. | Sterilization of ciprofloxacin composition |
US11382909B2 (en) | 2014-09-05 | 2022-07-12 | Sydnexis, Inc. | Ophthalmic composition |
US20160106804A1 (en) | 2014-10-15 | 2016-04-21 | Yuhua Li | Pharmaceutical composition with improved stability |
CA2965895C (en) | 2014-11-07 | 2019-08-06 | Indivior Uk Limited | The use of sustained-release buprenorphine formulations for the treatment of pain or opioid use disorders |
WO2016196367A1 (en) | 2015-05-29 | 2016-12-08 | Sydnexis, Inc. | D2o stabilized pharmaceutical formulations |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
CA2993645A1 (en) | 2015-07-28 | 2017-02-02 | Otonomy, Inc. | Trkb or trkc agonist compositions and methods for the treatment of otic conditions |
WO2017085561A1 (en) | 2015-11-16 | 2017-05-26 | Medincell | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
WO2017100576A1 (en) | 2015-12-11 | 2017-06-15 | Otonomy, Inc. | Ciprofloxacin otic composition and kits and method for using same |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
JP7034148B2 (ja) * | 2016-06-10 | 2022-03-11 | ニルバナ サイエンシーズ インク. | 波長範囲が狭い蛍光発光のヒドロポルフィリンビーズ |
WO2018053173A1 (en) | 2016-09-16 | 2018-03-22 | Otonomy, Inc. | Otic gel formulations for treating otitis externa |
HUE058207T2 (hu) | 2017-01-31 | 2022-07-28 | Veru Inc | Készítmények és módszerek gonadotropin felszabadító hormon (GNRH) antagonisták elnyújtott idejû felszabadítására |
US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
WO2019104191A1 (en) | 2017-11-21 | 2019-05-31 | Sydnexis, Inc. | Ophthalmic composition and delivery device thereof |
BR112020011774A2 (pt) | 2017-12-18 | 2020-11-17 | Foresee Pharmaceuticals Co., Ltd. | composições farmacêuticas com duração de liberação selecionada |
JP7497289B2 (ja) | 2018-01-09 | 2024-06-10 | ドンペ ファーマシューティシ エス.ピー.エー. | 成長因子耳用製剤 |
WO2019154895A1 (en) | 2018-02-08 | 2019-08-15 | Strekin Ag | Gel formulation for preventing or treating hearing loss |
EP3946547A4 (en) | 2019-03-26 | 2023-01-18 | Pocket Naloxone Corp. | DEVICES AND METHODS FOR DELIVERING PHARMACEUTICAL COMPOSITIONS |
WO2020240417A1 (en) | 2019-05-27 | 2020-12-03 | Tolmar International Limited | Leuprolide acetate compositions and methods of using the same to treat breast cancer |
BR112022013784A2 (pt) | 2020-01-13 | 2022-10-11 | Durect Corp | Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
WO2022154463A1 (ko) * | 2021-01-15 | 2022-07-21 | 랩인큐브 주식회사 | 금속유기 복합입자 및 금속유기 복합입자를 포함하는 조성물 |
US11278709B1 (en) | 2021-03-12 | 2022-03-22 | Pocket Naloxone Corp. | Drug delivery device and methods for using same |
WO2024168022A2 (en) | 2023-02-10 | 2024-08-15 | Tolmar, Inc. | Degarelix polymeric formulations |
WO2024168024A1 (en) | 2023-02-10 | 2024-08-15 | Tolmar, Inc. | Degarelix organic solvent formulations |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2155658A (en) * | 1936-01-08 | 1939-04-25 | Chemische Forschungs Gmbh | Surgical and medical preparations |
US3887699A (en) * | 1969-03-24 | 1975-06-03 | Seymour Yolles | Biodegradable polymeric article for dispensing drugs |
US4450150A (en) * | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
CA1125698A (en) * | 1978-03-09 | 1982-06-15 | Masaru Yoshida | Process for preparing a polymer composition |
US4265247A (en) * | 1979-11-07 | 1981-05-05 | Research Corporation | Malic acid polymers |
US4408023A (en) * | 1980-11-12 | 1983-10-04 | Tyndale Plains-Hunter, Ltd. | Polyurethane diacrylate compositions useful for contact lenses and the like |
DE3045135A1 (de) * | 1980-11-29 | 1982-06-09 | Sandoz-Patent-GmbH, 7850 Lörrach | Pharmazeutische kompositionen enthaltende bioabbaubare polymere |
US4721613A (en) * | 1982-12-13 | 1988-01-26 | Alza Corporation | Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use |
US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
US4631188A (en) * | 1983-08-31 | 1986-12-23 | S.K.Y. Polymers, Ltd. (Kingston Technologies) | Injectable physiologically-acceptable polymeric composition |
US4685883A (en) * | 1983-09-12 | 1987-08-11 | Jernberg Gary R | Local delivery of chemotherapeutic agents for the treatment of periodontal disease |
US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
EP0163696B1 (en) * | 1983-11-14 | 1992-11-25 | Columbia Laboratories, Inc. | Use of a bioadhesive |
GB8416234D0 (en) * | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
US5049386A (en) * | 1985-01-07 | 1991-09-17 | Syntex (U.S.A.) Inc. | N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
JPS62223112A (ja) * | 1986-03-25 | 1987-10-01 | Rooto Seiyaku Kk | 歯周病治療剤 |
US4780320A (en) * | 1986-04-29 | 1988-10-25 | Pharmetrix Corp. | Controlled release drug delivery system for the periodontal pocket |
US4919939A (en) * | 1986-04-29 | 1990-04-24 | Pharmetrix Corporation | Periodontal disease treatment system |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US5227157A (en) * | 1986-10-14 | 1993-07-13 | Board Of Regents, The University Of Texas System | Delivery of therapeutic agents |
US4981696A (en) * | 1986-12-22 | 1991-01-01 | E. I. Du Pont De Nemours And Company | Polylactide compositions |
JPH0819004B2 (ja) * | 1986-12-26 | 1996-02-28 | 日清製粉株式会社 | 徐放性医薬製剤 |
US4861627A (en) * | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
US5013553A (en) * | 1987-06-30 | 1991-05-07 | Vipont Pharmaceutical, Inc. | Drug delivery devices |
US4912141A (en) * | 1987-07-28 | 1990-03-27 | Kronman Joseph H | Fibrous and cartilaginous tissue replacement |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
IT1226800B (it) * | 1988-09-16 | 1991-02-19 | Prodotti Formenti | Composizioni farmaceutiche orali contenenti sali di destrorfano. |
US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5324520A (en) * | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5077049A (en) * | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
US5271961A (en) * | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
US5188837A (en) * | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
NZ239370A (en) * | 1990-08-22 | 1994-04-27 | Merck & Co Inc | Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone |
US5238714A (en) * | 1990-10-02 | 1993-08-24 | Board Of Regents, The University Of Texas System | Efficient microcapsule preparation and method of use |
US5149543A (en) * | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
JPH04173746A (ja) * | 1990-11-07 | 1992-06-22 | Unitika Ltd | 徐放性機能を有する薬剤・ポリマー複合体 |
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5326568A (en) * | 1991-05-03 | 1994-07-05 | Giampapa Vincent C | Method of tissue-specific delivery |
US5176907A (en) * | 1991-08-13 | 1993-01-05 | The Johns Hopkins University School Of Medicine | Biocompatible and biodegradable poly (phosphoester-urethanes) |
AU2605592A (en) * | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
EP0560014A1 (en) * | 1992-03-12 | 1993-09-15 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
JP2651320B2 (ja) * | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
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1995
- 1995-03-27 ES ES95914202T patent/ES2171186T3/es not_active Expired - Lifetime
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- 1995-03-27 EP EP95914202A patent/EP0754032B1/en not_active Expired - Lifetime
- 1995-03-27 AT AT95914202T patent/ATE209907T1/de active
- 1995-03-27 JP JP52635895A patent/JP4259610B2/ja not_active Expired - Fee Related
- 1995-03-27 DK DK01111735T patent/DK1125577T3/da active
- 1995-03-27 DK DK95914202T patent/DK0754032T3/da active
- 1995-03-27 AT AT01111735T patent/ATE317690T1/de active
- 1995-03-27 DE DE69524398T patent/DE69524398T2/de not_active Expired - Lifetime
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- 1995-03-27 KR KR1019960705687A patent/KR100374098B1/ko not_active IP Right Cessation
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- 1995-03-27 EP EP01111735A patent/EP1125577B1/en not_active Expired - Lifetime
- 1995-03-27 WO PCT/US1995/003792 patent/WO1995027481A1/en active IP Right Grant
- 1995-03-27 CA CA002187353A patent/CA2187353C/en not_active Expired - Lifetime
- 1995-03-27 ES ES01111735T patent/ES2258495T3/es not_active Expired - Lifetime
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1997
- 1997-06-09 US US08/871,492 patent/US5744153A/en not_active Expired - Lifetime
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- 2008-09-18 JP JP2008239734A patent/JP4974987B2/ja not_active Expired - Lifetime
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