ES2158611T3 - Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion. - Google Patents

Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion.

Info

Publication number
ES2158611T3
ES2158611T3 ES97952507T ES97952507T ES2158611T3 ES 2158611 T3 ES2158611 T3 ES 2158611T3 ES 97952507 T ES97952507 T ES 97952507T ES 97952507 T ES97952507 T ES 97952507T ES 2158611 T3 ES2158611 T3 ES 2158611T3
Authority
ES
Spain
Prior art keywords
composition
procedure
preparation
compositions
beneficial agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97952507T
Other languages
English (en)
Inventor
Kevin J Brodbeck
Theodore T Shen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21870398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2158611(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ES2158611T3 publication Critical patent/ES2158611T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)

Abstract

SE PRESENTA UNA COMPOSICION DE GEL INYECTABLE, DE EFECTO RETARDADO, QUE CONTIENE UN POLIMERO, UN SOLVENTE QUE PUEDE DISOLVER EL POLIMERO Y POR LO TANTO FORMAR UN GEL VISCOSO, UN AGENTE TERAPEUTICO, Y UN AGENTE EMULSIFICANTE EN FORMA DE UNA FASE DE GOTITAS DISPERSAS EN EL GEL VISCOSO. LA COMPOSICION DE GEL INYECTABLE DE EFECTO RETARDADO PUEDE PREPARARSE MEZCLANDO EL POLIMERO Y EL SOLVENTE DE MANERA QUE EL SOLVENTE DISUELVA EL POLIMERO Y FORME UN GEL VISCOSO. EL AGENTE TERAPEUTICO SE DISUELVE O SE DISPERSA EN EL GEL VISCOSO Y EL AGENTE EMULSIFICANTE SE MEZCLA CON EL GEL VISCOSO QUE CONTIENE EL AGENTE TERAPEUTICO. EL AGENTE EMULSIFICANTE FORMA UNA PARTE DE GOTITAS DISPERSAS EN EL GEL VISCOSO PARA SUMINISTRAR LA COMPOSICION DE GEL INYECTABLE, DE EFECTO RETARDADO. LA COMPOSICION DE GEL INYECTABLE, DE EFECTO RETARDADO PUEDE SUMINISTRAR UN AGENTE TERAPEUTICO A UN HUMANO O A UN ANIMAL CON UN PERFIL DE LIBERACION DESEADO.
ES97952507T 1996-12-20 1997-12-18 Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion. Expired - Lifetime ES2158611T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3343996P 1996-12-20 1996-12-20

Publications (1)

Publication Number Publication Date
ES2158611T3 true ES2158611T3 (es) 2001-09-01

Family

ID=21870398

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97952507T Expired - Lifetime ES2158611T3 (es) 1996-12-20 1997-12-18 Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion.
ES97952575T Expired - Lifetime ES2256898T3 (es) 1996-12-20 1997-12-18 Composicion de gel y procedimientos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97952575T Expired - Lifetime ES2256898T3 (es) 1996-12-20 1997-12-18 Composicion de gel y procedimientos.

Country Status (17)

Country Link
US (6) US6130200A (es)
EP (2) EP0959873B1 (es)
JP (4) JP2002512597A (es)
KR (1) KR100616793B1 (es)
CN (1) CN1146402C (es)
AT (2) ATE203157T1 (es)
AU (2) AU739469B2 (es)
CA (3) CA2275587C (es)
DE (2) DE69735384T2 (es)
DK (2) DK0949905T3 (es)
ES (2) ES2158611T3 (es)
GR (1) GR3036599T3 (es)
HK (2) HK1020009A1 (es)
IL (1) IL130532A0 (es)
NZ (1) NZ335851A (es)
PT (2) PT949905E (es)
WO (2) WO1998027963A2 (es)

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