MX353713B - Composiciones de administracion dermica y metodos. - Google Patents
Composiciones de administracion dermica y metodos.Info
- Publication number
- MX353713B MX353713B MX2014005294A MX2014005294A MX353713B MX 353713 B MX353713 B MX 353713B MX 2014005294 A MX2014005294 A MX 2014005294A MX 2014005294 A MX2014005294 A MX 2014005294A MX 353713 B MX353713 B MX 353713B
- Authority
- MX
- Mexico
- Prior art keywords
- progestin
- methods
- estrogen
- disclosed
- delivery compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se divulga una composición para administración transdérmica de una progestina para una terapia de hormona de progestina. También se divulga un dispositivo de administración transdérmica que comprende la composición. Para la terapia de hormona únicamente de progestina, la composición contiene un anti-oxidante y no contiene un estrógeno. Para la terapia que implica una progestina y un estrógeno, la composición contiene la progestina, el estrógeno y un anti-oxidante adicional. También se describen métodos de mejora de la estabilidad de las composiciones que contienen progestina que comprenden agentes oxidativos. Los métodos comprenden incluir uno o más anti-oxidantes en las composiciones.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161555546P | 2011-11-04 | 2011-11-04 | |
US201261645778P | 2012-05-11 | 2012-05-11 | |
PCT/US2012/063314 WO2013067346A1 (en) | 2011-11-04 | 2012-11-02 | Dermal delivery compositions and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014005294A MX2014005294A (es) | 2014-09-22 |
MX353713B true MX353713B (es) | 2018-01-24 |
Family
ID=47278507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014005294A MX353713B (es) | 2011-11-04 | 2012-11-02 | Composiciones de administracion dermica y metodos. |
Country Status (16)
Country | Link |
---|---|
US (3) | US9364487B2 (es) |
EP (1) | EP2773333B1 (es) |
JP (1) | JP6316749B2 (es) |
KR (1) | KR20140088199A (es) |
CN (1) | CN103957899A (es) |
AU (1) | AU2012332254B2 (es) |
BR (1) | BR112014010670A2 (es) |
CA (1) | CA2854164C (es) |
EA (1) | EA026664B1 (es) |
ES (1) | ES2762460T3 (es) |
HK (2) | HK1200317A1 (es) |
IL (1) | IL232258A0 (es) |
IN (1) | IN2014DN03247A (es) |
MX (1) | MX353713B (es) |
WO (1) | WO2013067346A1 (es) |
ZA (1) | ZA201402988B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
PT2782584T (pt) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Preparações e terapias de substituição para hormonoterapias naturais combinadas |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
GB2521632B (en) * | 2013-12-23 | 2020-12-16 | Linscott Goode Steven | Vermin control compositions |
JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
US10098894B2 (en) | 2014-07-29 | 2018-10-16 | Therapeuticsmd, Inc. | Transdermal cream |
US9844558B1 (en) | 2015-04-30 | 2017-12-19 | Amag Pharmaceuticals, Inc. | Methods of reducing risk of preterm birth |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017059070A1 (en) | 2015-09-29 | 2017-04-06 | Amag Pharmaceuticals, Inc. | Crystalline and amorphous form of 17-a- hydroxyprogesterone caproate |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
US20200330371A1 (en) * | 2017-10-30 | 2020-10-22 | Teikoku Seiyaku Co., Ltd. | Transdermally administrable preparation |
RU2020117569A (ru) * | 2017-10-30 | 2021-12-01 | Какен Фармасьютикал Ко., Лтд. | Препарат для местного применения для лечения трихофитического онихомикоза |
BR112021005253A2 (pt) * | 2018-09-19 | 2021-06-15 | Isp Investments Llc | composição de polímero estável a peróxido e processo para sua preparação e aplicações da mesma |
CN113455506A (zh) * | 2021-06-29 | 2021-10-01 | 无锡宏霸医疗科技有限公司 | 一种适用于日化产品的水相除臭去味剂及其制备方法 |
CN114259498B (zh) * | 2021-12-02 | 2023-04-28 | 南通联亚药业股份有限公司 | 一种包含去氧孕烯和炔雌醇的药物组合物及其制备方法和应用 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5554381A (en) * | 1993-08-09 | 1996-09-10 | Cygnus, Inc. | Low flux matrix system for delivering potent drugs transdermally |
FR2739031B1 (fr) * | 1995-09-27 | 1997-11-21 | Lhd Lab Hygiene Dietetique | Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base de copolymere styrene-isoprene-styrene, procede de preparation et utilisation en therapeutique |
DE19700913C2 (de) * | 1997-01-14 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Hormonen |
IT1294748B1 (it) * | 1997-09-17 | 1999-04-12 | Permatec Tech Ag | Formulazione per un dispositivo transdermico |
GB9720470D0 (en) * | 1997-09-25 | 1997-11-26 | Ethical Pharmaceuticals South | Inhibition of crystallization in transdermal devices |
EP1197212A4 (en) * | 1999-07-01 | 2004-06-02 | Hisamitsu Pharmaceutical Co | ADHESIVE COMPOSITION FOR PERCUTANE ABSORPTION |
PT1242012E (pt) * | 1999-11-24 | 2010-03-31 | Agile Therapeutics Inc | Sistema e processo melhorado de libertação transdérmica de contraceptivo |
US7045145B1 (en) | 1999-11-24 | 2006-05-16 | Agile Therapeutics, Inc. | Transdermal contraceptive delivery system and process |
US7384650B2 (en) * | 1999-11-24 | 2008-06-10 | Agile Therapeutics, Inc. | Skin permeation enhancement composition for transdermal hormone delivery system |
EP1127567B1 (de) * | 2000-02-17 | 2010-09-01 | Basf Se | Wässrige Dispersion wasserunlöslicher organischer UV-Filtersubstanzen |
JP4422430B2 (ja) * | 2003-05-14 | 2010-02-24 | 帝國製薬株式会社 | エストロゲン及び/又はプロゲストゲン含有外用貼付剤 |
WO2006036899A2 (en) * | 2004-09-27 | 2006-04-06 | Corium International, Inc. | Transdermal systems for the delivery of estrogens and progestins |
AU2006236564B2 (en) * | 2005-04-15 | 2011-02-17 | Tolmar, Inc. | Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same |
WO2006128057A2 (en) * | 2005-05-26 | 2006-11-30 | Duramed Pharmaceuticals, Inc. | Oral dosage forms comprising progesterone and methods of making and using the same |
US10137135B2 (en) * | 2005-08-15 | 2018-11-27 | Allergan Sales, Llc | Formulations and methods for providing progestin-only contraception while minimizing adverse side effects associated therewith |
DE102006050558B4 (de) * | 2006-10-26 | 2009-03-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System enthaltend Norelgestromin zur Kontrazeption und Hormonsubstitution |
EP2086550A2 (en) * | 2006-11-29 | 2009-08-12 | Wyeth | Estrogen/ serm and estrogen/ progestin bi-layer tablets |
JP5603235B2 (ja) | 2007-07-10 | 2014-10-08 | アージャイル セラピューティクス, インコーポレイテッド | イン・サイチュシールを有する経皮送達デバイス |
US20100178323A1 (en) | 2007-07-10 | 2010-07-15 | Agis Kydonieus | Dermal Delivery Device |
US20100292660A1 (en) | 2007-07-10 | 2010-11-18 | Agis Kydonieus | Dermal delivery device with ultrasonic weld |
WO2009142699A1 (en) * | 2008-05-19 | 2009-11-26 | The Procter & Gamble Company | Treatment of heart failure in women |
US9198920B2 (en) * | 2009-03-27 | 2015-12-01 | Agile Therapeutics, Inc. | Contraceptive transdermal delivery of hormones |
-
2012
- 2012-11-02 IN IN3247DEN2014 patent/IN2014DN03247A/en unknown
- 2012-11-02 MX MX2014005294A patent/MX353713B/es active IP Right Grant
- 2012-11-02 US US13/667,632 patent/US9364487B2/en active Active
- 2012-11-02 KR KR1020147014699A patent/KR20140088199A/ko not_active Application Discontinuation
- 2012-11-02 EP EP12794803.2A patent/EP2773333B1/en active Active
- 2012-11-02 ES ES12794803T patent/ES2762460T3/es active Active
- 2012-11-02 CA CA2854164A patent/CA2854164C/en active Active
- 2012-11-02 BR BR112014010670A patent/BR112014010670A2/pt not_active IP Right Cessation
- 2012-11-02 CN CN201280054080.8A patent/CN103957899A/zh active Pending
- 2012-11-02 WO PCT/US2012/063314 patent/WO2013067346A1/en active Application Filing
- 2012-11-02 EA EA201400543A patent/EA026664B1/ru not_active IP Right Cessation
- 2012-11-02 JP JP2014540132A patent/JP6316749B2/ja active Active
- 2012-11-02 AU AU2012332254A patent/AU2012332254B2/en not_active Ceased
-
2014
- 2014-04-24 ZA ZA2014/02988A patent/ZA201402988B/en unknown
- 2014-04-27 IL IL232258A patent/IL232258A0/en unknown
-
2015
- 2015-01-22 HK HK15100698.8A patent/HK1200317A1/xx unknown
- 2015-01-26 HK HK15100858.4A patent/HK1201152A1/xx unknown
-
2016
- 2016-05-11 US US15/151,966 patent/US20160250226A1/en not_active Abandoned
-
2018
- 2018-07-25 US US16/045,338 patent/US20180325916A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2014532719A (ja) | 2014-12-08 |
WO2013067346A1 (en) | 2013-05-10 |
CA2854164A1 (en) | 2013-05-10 |
US20130116222A1 (en) | 2013-05-09 |
US20160250226A1 (en) | 2016-09-01 |
IL232258A0 (en) | 2014-06-30 |
AU2012332254B2 (en) | 2017-06-22 |
US20180325916A1 (en) | 2018-11-15 |
ES2762460T3 (es) | 2020-05-25 |
JP6316749B2 (ja) | 2018-04-25 |
CA2854164C (en) | 2021-04-13 |
EP2773333B1 (en) | 2019-10-02 |
US9364487B2 (en) | 2016-06-14 |
MX2014005294A (es) | 2014-09-22 |
EA201400543A1 (ru) | 2014-09-30 |
AU2012332254A1 (en) | 2014-05-15 |
KR20140088199A (ko) | 2014-07-09 |
ZA201402988B (en) | 2015-11-25 |
HK1200317A1 (en) | 2015-08-07 |
CN103957899A (zh) | 2014-07-30 |
EA026664B1 (ru) | 2017-05-31 |
NZ624117A (en) | 2016-02-26 |
HK1201152A1 (en) | 2015-08-28 |
EP2773333A1 (en) | 2014-09-10 |
BR112014010670A2 (pt) | 2017-05-09 |
IN2014DN03247A (es) | 2015-05-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |