NZ598686A - Rapid establishment and/or termination of substantial steady-state drug delivery - Google Patents
Rapid establishment and/or termination of substantial steady-state drug deliveryInfo
- Publication number
- NZ598686A NZ598686A NZ598686A NZ59868610A NZ598686A NZ 598686 A NZ598686 A NZ 598686A NZ 598686 A NZ598686 A NZ 598686A NZ 59868610 A NZ59868610 A NZ 59868610A NZ 598686 A NZ598686 A NZ 598686A
- Authority
- NZ
- New Zealand
- Prior art keywords
- mcg
- day
- exenatide
- reservoir
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices ; Anti-rape devices
- A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
- A61F5/0013—Implantable devices or invasive measures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Nursing (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medical Informatics (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ624569A NZ624569A (en) | 2009-09-28 | 2010-09-21 | Rapid establishment and/or termination of substantial steady-state drug delivery |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27772409P | 2009-09-28 | 2009-09-28 | |
| US35811210P | 2010-06-24 | 2010-06-24 | |
| PCT/US2010/002591 WO2011037623A1 (en) | 2009-09-28 | 2010-09-21 | Rapid establishment and/or termination of substantial steady-state drug delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ598686A true NZ598686A (en) | 2014-05-30 |
Family
ID=43780643
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ598686A NZ598686A (en) | 2009-09-28 | 2010-09-21 | Rapid establishment and/or termination of substantial steady-state drug delivery |
| NZ747990A NZ747990A (en) | 2009-09-28 | 2010-09-21 | Rapid establishment and/or termination of substantial steady-state drug delivery |
| NZ624569A NZ624569A (en) | 2009-09-28 | 2010-09-21 | Rapid establishment and/or termination of substantial steady-state drug delivery |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ747990A NZ747990A (en) | 2009-09-28 | 2010-09-21 | Rapid establishment and/or termination of substantial steady-state drug delivery |
| NZ624569A NZ624569A (en) | 2009-09-28 | 2010-09-21 | Rapid establishment and/or termination of substantial steady-state drug delivery |
Country Status (23)
| Country | Link |
|---|---|
| US (5) | US8298561B2 (enExample) |
| EP (3) | EP3323423B1 (enExample) |
| JP (6) | JP5718925B2 (enExample) |
| KR (4) | KR101823699B1 (enExample) |
| CN (3) | CN104323981B (enExample) |
| AU (5) | AU2010298733B2 (enExample) |
| CA (1) | CA2775676C (enExample) |
| CY (1) | CY1119649T1 (enExample) |
| DK (1) | DK2462246T3 (enExample) |
| ES (1) | ES2650667T3 (enExample) |
| HR (1) | HRP20171801T1 (enExample) |
| HU (1) | HUE035862T2 (enExample) |
| IL (4) | IL218648A (enExample) |
| LT (1) | LT2462246T (enExample) |
| MX (3) | MX352878B (enExample) |
| NO (1) | NO2462246T3 (enExample) |
| NZ (3) | NZ598686A (enExample) |
| PL (1) | PL2462246T3 (enExample) |
| PT (1) | PT2462246T (enExample) |
| RU (3) | RU2547990C2 (enExample) |
| SI (1) | SI2462246T1 (enExample) |
| SM (1) | SMT201700583T1 (enExample) |
| WO (1) | WO2011037623A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| NZ572003A (en) | 2006-05-30 | 2010-07-30 | Intarcia Therapeutics Inc | Two-piece, internal-channel osmotic delivery system flow modulator with spiral fluid channel |
| DK2049081T3 (da) | 2006-08-09 | 2013-02-25 | Intarcia Therapeutics Inc | Osmotiske leveringssystemer og stempelarrangementer |
| PL2157967T3 (pl) | 2007-04-23 | 2013-06-28 | Intarcia Therapeutics Inc | Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| NZ598686A (en) | 2009-09-28 | 2014-05-30 | Intarcia Therapeutics Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
| KR101861389B1 (ko) | 2010-06-04 | 2018-05-28 | 바이엘 헬쓰케어 엘엘씨 | 활성 전달 진행상황 모니터 |
| BR112012031359A2 (pt) | 2010-06-04 | 2016-10-25 | Medrad Inc | sistema e método de planejamento e monitoramento da utilização de doses múltiplas de radiofármacos em injetores de radiofármacos |
| US20120208755A1 (en) * | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| AU2012261799B2 (en) | 2011-06-03 | 2017-03-23 | Bayer Healthcare, Llc | System and method for rapid quantitative dynamic molecular imaging scans |
| CN112599225A (zh) | 2011-11-17 | 2021-04-02 | 拜耳医药保健有限公司 | 用于确定在医疗过程中使用的方案的方案拟定客户端 |
| CN104258378A (zh) * | 2014-09-12 | 2015-01-07 | 深圳市健元医药科技有限公司 | 一种glp-1类似物注射用缓释植入剂及其制备 |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| AU2016270984B2 (en) | 2015-06-03 | 2021-02-25 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| US20170231790A1 (en) * | 2016-02-17 | 2017-08-17 | Abbott Cardiovascular Systems Inc. | Bioresorbable scaffold delivery system with improved distal integrity |
| MA53353A (fr) | 2016-05-16 | 2021-06-09 | Intarcia Therapeutics Inc | Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| US10406336B2 (en) * | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| SG11201903462UA (en) | 2016-10-20 | 2019-05-30 | Peptron Inc | Methods of delivering a neuroprotective polypeptide to the central nervous system |
| CN110225762A (zh) * | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
| WO2018165462A1 (en) * | 2017-03-08 | 2018-09-13 | Intarcia Therapeutics, Inc | Apparatus and methods for administration of a nauseogenic compound from a drug delivery device |
| JP7234149B2 (ja) | 2017-07-07 | 2023-03-07 | バイエル・ヘルスケア・エルエルシー | 注入システム間でデータをピア交換するためのシステム、方法、及び、コンピュータプログラムプロダクト |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
| CN109589491B (zh) * | 2019-01-29 | 2024-01-09 | 上海安翰医疗技术有限公司 | 自动给药装置 |
| US10828432B1 (en) * | 2019-06-24 | 2020-11-10 | De Motu Cordis Pty Ltd | Respiratory delivery device and method |
| CN116251192A (zh) * | 2020-01-16 | 2023-06-13 | 上海仁会生物制药股份有限公司 | Glp-1给药方案 |
| AU2021400738A1 (en) * | 2020-12-17 | 2023-07-13 | I2O Therapeutics, Inc. | Long acting glucagon like polypeptide-1 (glp-1) receptor agonists and methods of use |
| WO2022202881A1 (ja) | 2021-03-25 | 2022-09-29 | テルモ株式会社 | 持続投与装置 |
| WO2023080251A1 (ja) * | 2021-11-08 | 2023-05-11 | テルモ株式会社 | 医療器具 |
| WO2023085144A1 (ja) * | 2021-11-10 | 2023-05-19 | テルモ株式会社 | 投与装置 |
| WO2023100571A1 (ja) * | 2021-11-30 | 2023-06-08 | テルモ株式会社 | 医療器具および医療デバイス |
| JPWO2023181995A1 (enExample) | 2022-03-25 | 2023-09-28 | ||
| JPWO2023181997A1 (enExample) * | 2022-03-25 | 2023-09-28 |
Family Cites Families (703)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR640907A (fr) | 1927-06-25 | 1928-07-24 | Limitateur de débit automatique | |
| US2168437A (en) | 1935-04-10 | 1939-08-08 | Kenneth O Buercklin | Injection device |
| US2110208A (en) | 1937-02-12 | 1938-03-08 | U S Standard Products Company | Antigen preparations |
| US2531724A (en) | 1948-09-20 | 1950-11-28 | Edmund D Cevasco | Infant bath mat |
| US3025991A (en) | 1960-05-23 | 1962-03-20 | Carron Products Co | Bottle stopper |
| NL280825A (enExample) | 1962-07-11 | |||
| GB1049104A (en) | 1963-05-11 | 1966-11-23 | Prodotti Antibiotici Spa | Pharmaceutical compositions for oral or parenteral administration comprising tetracycline antibiotics |
| US3122162A (en) | 1963-06-20 | 1964-02-25 | Asa D Sands | Flow control device |
| BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| US3632768A (en) | 1969-10-02 | 1972-01-04 | Upjohn Co | Therapeutic composition and method for treating infections with actinospectacin |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US4034756A (en) | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
| US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
| US3732865A (en) | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US4211771A (en) | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| JPS523342B2 (enExample) | 1972-01-26 | 1977-01-27 | ||
| BE795516A (fr) | 1972-02-17 | 1973-08-16 | Ciba Geigy | Preparations de peptides huileuses et injectables et procede pour leur preparation |
| US3797492A (en) | 1972-12-27 | 1974-03-19 | Alza Corp | Device for dispensing product with directional guidance member |
| US3995632A (en) | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
| GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
| DE2528516A1 (de) | 1974-07-05 | 1976-01-22 | Sandoz Ag | Neue galenische zubereitung |
| JPS523653A (en) | 1975-06-27 | 1977-01-12 | Fuji Photo Film Co Ltd | Process for producing fine polymer particles |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4078060A (en) | 1976-05-10 | 1978-03-07 | Richardson-Merrell Inc. | Method of inducing an estrogenic response |
| US4111203A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| US4203439A (en) | 1976-11-22 | 1980-05-20 | Alza Corporation | Osmotic system with volume amplifier for increasing amount of agent delivered therefrom |
| US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4111201A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for delivering selected beneficial agents having varying degrees of solubility |
| USD258837S (en) | 1977-10-17 | 1981-04-07 | Gambro Dialysatoren Gmbh And Co. Kg | Dialyzer cartridge |
| USD259458S (en) | 1978-06-09 | 1981-06-09 | Fuller Charles R | Support pad for an infant |
| US4243030A (en) | 1978-08-18 | 1981-01-06 | Massachusetts Institute Of Technology | Implantable programmed microinfusion apparatus |
| US4305927A (en) | 1979-02-05 | 1981-12-15 | Alza Corporation | Method for the management of intraocular pressure |
| US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
| US4310516A (en) | 1980-02-01 | 1982-01-12 | Block Drug Company Inc. | Cosmetic and pharmaceutical vehicle thickened with solid emulsifier |
| US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
| AU546785B2 (en) | 1980-07-23 | 1985-09-19 | Commonwealth Of Australia, The | Open-loop controlled infusion of diabetics |
| US4350271A (en) | 1980-08-22 | 1982-09-21 | Alza Corporation | Water absorbing fluid dispenser |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US4376118A (en) | 1980-10-06 | 1983-03-08 | Miles Laboratories, Inc. | Stable nonaqueous solution of tetracycline salt |
| PH19942A (en) | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
| US4340054A (en) | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
| US4444498A (en) | 1981-02-27 | 1984-04-24 | Bentley Laboratories | Apparatus and method for measuring blood oxygen saturation |
| US4455145A (en) | 1981-07-10 | 1984-06-19 | Alza Corporation | Dispensing device with internal drive |
| AU561343B2 (en) | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| EP0079143A3 (en) | 1981-10-20 | 1984-11-21 | Adnovum Ag | Pseudoplastic gel transfer |
| EP0080879B1 (en) | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Pharmaceutical composition containing interferon in stable state |
| US5004689A (en) | 1982-02-22 | 1991-04-02 | Biogen, Massachusetts | DNA sequences, recombinant DNA molecules and processes for producing human gamma interferon-like polypeptides in high yields |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4455143A (en) | 1982-03-22 | 1984-06-19 | Alza Corporation | Osmotic device for dispensing two different medications |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3220116A1 (de) | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung |
| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4753651A (en) | 1982-08-30 | 1988-06-28 | Alza Corporation | Self-driven pump |
| US4966843A (en) | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
| US4552561A (en) | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
| US4673405A (en) | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
| US4639244A (en) | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| DE3320583A1 (de) | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung |
| JPS6058915A (ja) | 1983-09-12 | 1985-04-05 | Fujisawa Pharmaceut Co Ltd | 薬物含有脂質小胞体製剤 |
| US4594108A (en) | 1983-09-19 | 1986-06-10 | The Dow Chemical Company | Highly pseudoplastic polymer solutions |
| US5385738A (en) | 1983-10-14 | 1995-01-31 | Sumitomo Pharmaceuticals Company, Ltd. | Sustained-release injection |
| US4840896A (en) | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
| US5639639A (en) | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| MX9203641A (es) | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
| US4855238A (en) | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| US4851228A (en) | 1984-06-20 | 1989-07-25 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic |
| US5120832A (en) | 1984-08-27 | 1992-06-09 | Genentech, Inc. | Distinct family of human leukocyte interferons |
| US5231176A (en) | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
| US4927687A (en) | 1984-10-01 | 1990-05-22 | Biotek, Inc. | Sustained release transdermal drug delivery composition |
| US5411951A (en) | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| FI90990C (fi) | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi |
| US4655462A (en) | 1985-01-07 | 1987-04-07 | Peter J. Balsells | Canted coiled spring and seal |
| JPS61189230A (ja) | 1985-02-19 | 1986-08-22 | Nippon Kayaku Co Ltd | エトポシド製剤 |
| US4609374A (en) | 1985-04-22 | 1986-09-02 | Alza Corporation | Osmotic device comprising means for governing initial time of agent release therefrom |
| US4885166A (en) | 1985-06-11 | 1989-12-05 | Ciba-Geigy Corporation | Hybrid interferons |
| US4845196A (en) | 1985-06-24 | 1989-07-04 | G. D. Searle & Co. | Modified interferon gammas |
| US4847079A (en) | 1985-07-29 | 1989-07-11 | Schering Corporation | Biologically stable interferon compositions comprising thimerosal |
| IE59361B1 (en) | 1986-01-24 | 1994-02-09 | Akzo Nv | Pharmaceutical preparation for obtaining a highly viscous hydrogel or suspension |
| DE3607835A1 (de) | 1986-03-10 | 1987-09-24 | Boehringer Ingelheim Int | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4737437A (en) | 1986-03-27 | 1988-04-12 | East Shore Chemical Co. | Light sensitive diazo compound, composition and method of making the composition |
| US5614492A (en) | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US7138486B2 (en) | 1986-05-05 | 2006-11-21 | The General Hospital Corporation | Insulinotropic hormone derivatives and uses thereof |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US6849708B1 (en) | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US4755180A (en) | 1986-06-16 | 1988-07-05 | Alza Corporation | Dosage form comprising solubility regulating member |
| DE3636123A1 (de) | 1986-10-23 | 1988-05-05 | Rentschler Arzneimittel | Arzneizubereitungen zur oralen verabreichung, die als einzeldosis 10 bis 240 mg dihydropyridin enthalten |
| ZA878295B (en) | 1986-11-06 | 1988-05-03 | Amarillo Cell Culture Co. Inc. | Treatment of immuno-resistant disease |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| DE3642096A1 (de) | 1986-12-10 | 1988-06-16 | Boehringer Ingelheim Int | Pferde-(gamma)-interferon |
| US5371089A (en) | 1987-02-26 | 1994-12-06 | Senetek, Plc | Method and composition for ameliorating the adverse effects of aging |
| US5278151A (en) | 1987-04-02 | 1994-01-11 | Ocular Research Of Boston, Inc. | Dry eye treatment solution |
| JPH0720866B2 (ja) | 1987-05-15 | 1995-03-08 | 三生製薬株式会社 | エペリゾン又はトルペリゾン或いはそれらの塩類含有経皮適用製剤 |
| US4940465A (en) | 1987-05-27 | 1990-07-10 | Felix Theeuwes | Dispenser comprising displaceable matrix with solid state properties |
| US4892778A (en) | 1987-05-27 | 1990-01-09 | Alza Corporation | Juxtaposed laminated arrangement |
| US5938654A (en) | 1987-06-25 | 1999-08-17 | Alza Corporation | Osmotic device for delayed delivery of agent |
| US4874388A (en) | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
| US5023088A (en) | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
| US4915949A (en) | 1987-07-13 | 1990-04-10 | Alza Corporation | Dispenser with movable matrix comprising a plurality of tiny pills |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| DE19975054I2 (de) | 1987-08-08 | 2000-04-13 | Akzo Nobel Nv | Kontrazeptives Implantat |
| US4915954A (en) | 1987-09-03 | 1990-04-10 | Alza Corporation | Dosage form for delivering a drug at two different rates |
| US5756450A (en) | 1987-09-15 | 1998-05-26 | Novartis Corporation | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms |
| US4886668A (en) | 1987-09-24 | 1989-12-12 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic pump |
| GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| WO1989003678A1 (en) | 1987-10-30 | 1989-05-05 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
| US4917895A (en) | 1987-11-02 | 1990-04-17 | Alza Corporation | Transdermal drug delivery device |
| US5160122A (en) | 1990-03-20 | 1992-11-03 | Peter J. Balsells | Coil spring with an elastomer having a hollow coil cross section |
| US5072070A (en) | 1989-12-01 | 1991-12-10 | Peter J. Balsells | Device for sealing electromagnetic waves |
| US5079388A (en) | 1989-12-01 | 1992-01-07 | Peter J. Balsells | Gasket for sealing electromagnetic waves |
| US4915366A (en) | 1988-04-25 | 1990-04-10 | Peter J. Balsells | Outside back angle canted coil spring |
| ATE94955T1 (de) | 1988-04-25 | 1993-10-15 | Peter J Balsells | In sich geschlossene ringfoermige schraubenfeder mit aeusserem, rueckwaertigem neigungswinkel. |
| US4934666A (en) | 1988-04-25 | 1990-06-19 | Peter J. Balsells | Coiled spring electromagnetic shielding gasket |
| US5203849A (en) | 1990-03-20 | 1993-04-20 | Balsells Peter J | Canted coil spring in length filled with an elastomer |
| US4964204A (en) | 1988-04-25 | 1990-10-23 | Peter J. Balsells | Method for making a garter-type axially-resilient coil spring |
| US4893795A (en) | 1988-08-15 | 1990-01-16 | Peter J. Balsells | Radially loaded canted coiled spring with turn angle |
| US4907788A (en) | 1988-04-25 | 1990-03-13 | Peter J. Balsells | Dual concentric canted-coil spring apparatus |
| US4830344A (en) | 1988-04-25 | 1989-05-16 | Peter J. Balsells | Canted-coil spring with turn angle and seal |
| US4961253A (en) | 1988-04-25 | 1990-10-09 | Peter J. Balsells | Manufacturing method for canted-coil spring with turn angle and seal |
| US4826144A (en) | 1988-04-25 | 1989-05-02 | Peter J. Balsells | Inside back angle canted coil spring |
| US5117066A (en) | 1988-04-25 | 1992-05-26 | Peter J. Balsells | Retaining and locking electromagnetic gasket |
| US4876781A (en) | 1988-04-25 | 1989-10-31 | Peter J. Balsells | Method of making a garter-type axially resilient coiled spring |
| US4974821A (en) | 1988-04-25 | 1990-12-04 | Peter J. Balsells | Canted-coil spring with major axis radial loading |
| US5108078A (en) | 1988-04-25 | 1992-04-28 | Peter J. Balsells | Canted-coil spring loaded while in a cavity |
| US5006346A (en) | 1988-04-28 | 1991-04-09 | Alza Corporation | Delivery system |
| US5160743A (en) | 1988-04-28 | 1992-11-03 | Alza Corporation | Annealed composition for pharmaceutically acceptable drug |
| US4931285A (en) | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
| US5024842A (en) | 1988-04-28 | 1991-06-18 | Alza Corporation | Annealed coats |
| JP2827287B2 (ja) | 1988-07-05 | 1998-11-25 | 武田薬品工業株式会社 | 水溶性薬物含有徐放型マイクロカプセル |
| JP2794022B2 (ja) | 1988-11-11 | 1998-09-03 | 三生製薬株式会社 | ブナゾシン或いはその塩類含有経皮適用製剤 |
| US5034229A (en) | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| US5110596A (en) | 1988-12-13 | 1992-05-05 | Alza Corporation | Delivery system comprising means for delivering agent to livestock |
| US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
| US5728088A (en) * | 1988-12-13 | 1998-03-17 | Alza Corporation | Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals |
| US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| US4969884A (en) | 1988-12-28 | 1990-11-13 | Alza Corporation | Osmotically driven syringe |
| US5234424A (en) | 1988-12-28 | 1993-08-10 | Alza Corporation | Osmotically driven syringe |
| US4976966A (en) | 1988-12-29 | 1990-12-11 | Alza Corporation | Delayed release osmotically driven fluid dispenser |
| IL92344A0 (en) | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
| US5288479A (en) | 1989-01-17 | 1994-02-22 | Sterling Drug, Inc. | Extrudable elastic oral pharmaceutical gel compositions and metered dose dispensers containing them and method of making and method of use thereof |
| US5906816A (en) | 1995-03-16 | 1999-05-25 | University Of Florida | Method for treatment of autoimmune diseases |
| US5705363A (en) | 1989-03-02 | 1998-01-06 | The Women's Research Institute | Recombinant production of human interferon τ polypeptides and nucleic acids |
| US5219572A (en) | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
| DE69005800T2 (de) | 1989-05-01 | 1994-05-19 | Alkermes Inc | Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen. |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| WO1990013361A1 (en) | 1989-05-04 | 1990-11-15 | Southern Research Institute | Improved encapsulation process and products therefrom |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5126142A (en) | 1989-07-18 | 1992-06-30 | Alza Corporation | Dispenser comprising ionophore |
| US5225205A (en) | 1989-07-28 | 1993-07-06 | Debiopharm S.A. | Pharmaceutical composition in the form of microparticles |
| US5439688A (en) | 1989-07-28 | 1995-08-08 | Debio Recherche Pharmaceutique S.A. | Process for preparing a pharmaceutical composition |
| FI920856A0 (fi) | 1989-08-28 | 1992-02-26 | Pharmaceutical Delivery System | Bioeroderbar polymerer foer kontrollerad frigoerelse av terapeutiska aemnen. |
| US5112614A (en) | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| US5290558A (en) | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| SE465950B (sv) | 1989-10-23 | 1991-11-25 | Medinvent Sa | Kombination av ett aggregat partikelformat, kristallint eller frystorkat laekemedel med en pseudoplastisk gel foer beredning av ett injicerbart preparat samt foerfarande foer dess framstaellning |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| ES2046039T3 (es) | 1989-11-13 | 1994-01-16 | Becton Dickinson France | Frasco de almacenamiento que contiene un componente de una solucion medicamentosa. |
| JPH03236317A (ja) | 1989-12-06 | 1991-10-22 | Sansei Seiyaku Kk | ドパミン誘導体含有経皮用製剤 |
| US5030216A (en) | 1989-12-15 | 1991-07-09 | Alza Corporation | Osmotically driven syringe |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| USD326718S (en) | 1989-12-26 | 1992-06-02 | Minnesota Mining And Manufacturing Co. | Blood sensor cassette |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5213809A (en) | 1990-01-24 | 1993-05-25 | Alza Corporation | Delivery system comprising means for controlling internal pressure |
| US5223266A (en) | 1990-01-24 | 1993-06-29 | Alza Corporation | Long-term delivery device with early startup |
| US5126147A (en) | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| US5478564A (en) | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
| US5122128A (en) | 1990-03-15 | 1992-06-16 | Alza Corporation | Orifice insert for a ruminal bolus |
| US5120306A (en) | 1990-03-21 | 1992-06-09 | Gosselin Leon F | Direct delivery of anti-inflammatories to the proximal small bowel |
| US5207752A (en) | 1990-03-30 | 1993-05-04 | Alza Corporation | Iontophoretic drug delivery system with two-stage delivery profile |
| US5213810A (en) | 1990-03-30 | 1993-05-25 | American Cyanamid Company | Stable compositions for parenteral administration and method of making same |
| US5324280A (en) | 1990-04-02 | 1994-06-28 | Alza Corporation | Osmotic dosage system for delivering a formulation comprising liquid carrier and drug |
| US5091188A (en) | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5290271A (en) | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
| US5374620A (en) | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
| US5234693A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234692A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5180591A (en) | 1990-07-11 | 1993-01-19 | Alza Corporation | Delivery device with a protective sleeve |
| US5234695A (en) | 1990-07-24 | 1993-08-10 | Eastman Kodak Company | Water dispersible vitamin E composition |
| USD329278S (en) | 1990-10-01 | 1992-09-08 | Gallup Allen I | Infant's bathing support |
| US5300302A (en) | 1990-10-04 | 1994-04-05 | Nestec S.A. | Pharmaceutical composition in gel form in a dispensing package |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| US5122377A (en) | 1990-11-19 | 1992-06-16 | A.H. Robins, Company, Incorporated | Oral delivery system for veterinary drugs |
| IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| US5161806A (en) | 1990-12-17 | 1992-11-10 | Peter J. Balsells | Spring-loaded, hollow, elliptical ring seal |
| GB9027422D0 (en) | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| PT99989A (pt) | 1991-01-09 | 1994-05-31 | Alza Corp | Dispositivos biodegradaveis e composicoes para libertacao difusivel de agentes |
| US5443459A (en) | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
| NL9100160A (nl) | 1991-01-30 | 1992-08-17 | Texas Instruments Holland | Injector. |
| US5861166A (en) | 1991-03-12 | 1999-01-19 | Alza Corporation | Delivery device providing beneficial agent stability |
| JPH06507416A (ja) | 1991-05-07 | 1994-08-25 | ダイナジェン・インコーポレーテッド | 禁煙のための調節された持続的放出伝達システム |
| US5113938A (en) | 1991-05-07 | 1992-05-19 | Clayton Charley H | Whipstock |
| US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| EP0520119A1 (de) | 1991-06-17 | 1992-12-30 | Spirig Ag Pharmazeutische Präparate | Neue orale Diclofenaczubereitung |
| US5252338A (en) | 1991-06-27 | 1993-10-12 | Alza Corporation | Therapy delayed |
| US5190765A (en) | 1991-06-27 | 1993-03-02 | Alza Corporation | Therapy delayed |
| HU222501B1 (hu) | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására |
| DE4122217C2 (de) | 1991-07-04 | 1997-02-13 | Merz & Co Gmbh & Co | Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern |
| US5288214A (en) | 1991-09-30 | 1994-02-22 | Toshio Fukuda | Micropump |
| YU87892A (sh) | 1991-10-01 | 1995-12-04 | Eli Lilly And Company Lilly Corporate Center | Injektibilne formulacije produženog otpuštanja i postupci za njihovo dobijanje i primenu |
| EP0664118B1 (en) | 1991-10-04 | 1999-08-25 | Yoshitomi Pharmaceutical Industries, Ltd. | Sustained-release tablet |
| NZ244682A (en) | 1991-10-10 | 1993-12-23 | Alza Corp | Osmotically driven controlled delivery device characterised in that a |
| US5288502A (en) | 1991-10-16 | 1994-02-22 | The University Of Texas System | Preparation and uses of multi-phase microspheres |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5236707A (en) | 1991-11-08 | 1993-08-17 | Dallas Biotherapeutics, Inc. | Stabilization of human interferon |
| DE4137649C2 (de) | 1991-11-15 | 1997-11-20 | Gerhard Dingler | Bauelement |
| WO1993009763A1 (en) | 1991-11-15 | 1993-05-27 | Isp Investments Inc. | Pharmaceutical tablet with pvp having an enhanced drug dissolution rate |
| US5200195A (en) | 1991-12-06 | 1993-04-06 | Alza Corporation | Process for improving dosage form delivery kinetics |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5223265A (en) | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
| US5658593A (en) | 1992-01-16 | 1997-08-19 | Coletica | Injectable compositions containing collagen microcapsules |
| US5676942A (en) | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5209746A (en) | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| JP3267972B2 (ja) | 1992-02-28 | 2002-03-25 | コラーゲン コーポレイション | 高濃度均質化コラーゲン組成物 |
| US5221278A (en) | 1992-03-12 | 1993-06-22 | Alza Corporation | Osmotically driven delivery device with expandable orifice for pulsatile delivery effect |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| AU3941493A (en) | 1992-03-30 | 1993-11-08 | Alza Corporation | Viscous suspensions of controlled-release drug particles |
| US5571525A (en) | 1992-03-30 | 1996-11-05 | Alza Corporation | Erosion rate modifier for use in bioerodible drug delivery devices and method of use |
| US6197346B1 (en) | 1992-04-24 | 2001-03-06 | Brown Universtiy Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| FR2690622B1 (fr) | 1992-04-29 | 1995-01-20 | Chronotec | Système de pompe à perfusion ambulatoire programmable. |
| US5314685A (en) | 1992-05-11 | 1994-05-24 | Agouron Pharmaceuticals, Inc. | Anhydrous formulations for administering lipophilic agents |
| US5711968A (en) | 1994-07-25 | 1998-01-27 | Alkermes Controlled Therapeutics, Inc. | Composition and method for the controlled release of metal cation-stabilized interferon |
| JP2651320B2 (ja) | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
| US5413672A (en) | 1992-07-22 | 1995-05-09 | Ngk Insulators, Ltd. | Method of etching sendust and method of pattern-etching sendust and chromium films |
| US5512293A (en) | 1992-07-23 | 1996-04-30 | Alza Corporation | Oral sustained release drug delivery device |
| US5609885A (en) | 1992-09-15 | 1997-03-11 | Alza Corporation | Osmotic membrane and delivery device |
| GB9223146D0 (en) | 1992-11-05 | 1992-12-16 | Scherer Corp R P | Vented capsule |
| DE69224386T2 (de) | 1992-11-06 | 1998-06-18 | Texas Instruments Inc | Vorrichtung zum subkutanen Einführen einer Nadel |
| DK0669128T3 (da) | 1992-11-17 | 2000-06-19 | Yoshitomi Pharmaceutical | Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme |
| USD342855S (en) | 1992-11-20 | 1994-01-04 | Butler Ii George D | Combined infant cushion and cover |
| US5260069A (en) | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| SE9203594D0 (sv) | 1992-11-30 | 1992-11-30 | Christer Nystroem | Laekemedel i dispersa system |
| DE69329295T2 (de) | 1992-12-02 | 2001-03-15 | Alkermes Controlled Therapeutics, Inc. | Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung |
| TW333456B (en) | 1992-12-07 | 1998-06-11 | Takeda Pharm Ind Co Ltd | A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide. |
| US5589167A (en) | 1993-02-23 | 1996-12-31 | Genentech, Inc. | Excipient stabilization of polypeptides treated with organic solvents |
| US5368588A (en) | 1993-02-26 | 1994-11-29 | Bettinger; David S. | Parenteral fluid medication reservoir pump |
| US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| AU6410494A (en) | 1993-03-17 | 1994-10-11 | Alza Corporation | Device for the transdermal administration of alprazolam |
| US5514110A (en) | 1993-03-22 | 1996-05-07 | Teh; Eutiquio L. | Automatic flow control device |
| US6284727B1 (en) | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
| NZ250844A (en) | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
| TW404844B (en) | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
| NZ247516A (en) | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US5639477A (en) | 1993-06-23 | 1997-06-17 | Alza Corporation | Ruminal drug delivery device |
| WO1995001167A2 (en) | 1993-06-25 | 1995-01-12 | Alza Corporation | Incorporating poly-n-vinyl amide in a transdermal system |
| KR100325972B1 (ko) | 1993-08-09 | 2002-07-27 | 바이오메져 인코퍼레이티드 | 치료성펩타이드유도체 |
| US5498255A (en) | 1993-08-17 | 1996-03-12 | Alza Corporation | Osmotic device for protracted pulsatile delivery of agent |
| US5385887A (en) | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
| JP2700141B2 (ja) | 1993-09-17 | 1998-01-19 | 富士化学工業株式会社 | リン酸水素カルシウム及びその製法並びにそれを用いた賦形剤 |
| ATE183926T1 (de) | 1993-09-29 | 1999-09-15 | Alza Corp | Hautpermeabilitaetserhöher bestehend aus monoglycerid/laktat estern |
| US6913767B1 (en) | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
| SK282231B6 (sk) | 1993-11-19 | 2001-12-03 | Janssen Pharmaceutica N. V. | Farmaceutický prostriedok na liečenie psychotických porúch |
| US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
| ATE212830T1 (de) | 1993-11-19 | 2002-02-15 | Alkermes Inc | Herstellung biologisch abbaubarer, einen biologisch aktiven stoff enthaltender, mikropartikel |
| JPH07196479A (ja) | 1994-01-04 | 1995-08-01 | Unitika Ltd | マイクロカプセルの製造法 |
| USD358644S (en) | 1994-01-18 | 1995-05-23 | Bio Medic Data Systems, Inc. | Transponder implanter |
| US6241734B1 (en) | 1998-08-14 | 2001-06-05 | Kyphon, Inc. | Systems and methods for placing materials into bone |
| US5540665A (en) | 1994-01-31 | 1996-07-30 | Alza Corporation | Gas driven dispensing device and gas generating engine therefor |
| DE69528355T2 (de) | 1994-02-04 | 2003-05-15 | Lipocore Holding Ab Stockholm | Doppelschicht-zusammensetzungen aus digalactosyldiacylglycerol enthaltendem galactolipid |
| US5697975A (en) | 1994-02-09 | 1997-12-16 | The University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic for tinnitus |
| US5458888A (en) | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| ATE227133T1 (de) | 1994-03-07 | 2002-11-15 | Imperial College | Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber |
| ZA953078B (en) | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| DE69431533T2 (de) | 1994-06-13 | 2003-10-02 | Alza Corp., Palo Alto | Dosierungsform zur verabreichung von flüssige arzneimittel formulierung |
| NL9401150A (nl) | 1994-07-12 | 1996-02-01 | Nederland Ptt | Werkwijze voor het aan een ontvangzijde aanbieden van een van een zendzijde afkomstig eerste aantal videosignalen, alsmede systeem, alsmede zender, alsmede netwerk, en alsmede ontvanger. |
| WO1996002232A1 (en) | 1994-07-13 | 1996-02-01 | Alza Corporation | Composition and method for enhancing transdermal electrotransport agent delivery |
| US5633011A (en) | 1994-08-04 | 1997-05-27 | Alza Corporation | Progesterone replacement therapy |
| US5574008A (en) | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| DK0788351T3 (da) | 1994-11-10 | 2003-05-26 | Univ Kentucky Res Found | Implanterbar, genopfyldelig anordning til hastighedsreguleret lægemiddeladministration direkte til en indre del af kroppen |
| US5595759A (en) | 1994-11-10 | 1997-01-21 | Alza Corporation | Process for providing therapeutic composition |
| US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
| FR2731150B1 (fr) | 1995-03-03 | 1997-04-18 | Oreal | Utilisation de composes amphiphiles en tant qu'agent epaississant de milieux non aqueux |
| US5595751A (en) | 1995-03-06 | 1997-01-21 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/or amido groups |
| US5844017A (en) | 1995-03-06 | 1998-12-01 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters containing amines and/or amido groups |
| US5597579A (en) | 1995-03-06 | 1997-01-28 | Ethicon, Inc. | Blends of absorbable polyoxaamides |
| US5962023A (en) | 1995-03-06 | 1999-10-05 | Ethicon, Inc. | Hydrogels containing absorbable polyoxaamides |
| US5464929A (en) | 1995-03-06 | 1995-11-07 | Ethicon, Inc. | Absorbable polyoxaesters |
| US6403655B1 (en) | 1995-03-06 | 2002-06-11 | Ethicon, Inc. | Method of preventing adhesions with absorbable polyoxaesters |
| US6100346A (en) | 1995-03-06 | 2000-08-08 | Ethicon, Inc. | Copolymers of polyoxaamides |
| US5618552A (en) | 1995-03-06 | 1997-04-08 | Ethicon, Inc. | Absorbable polyoxaesters |
| US5607687A (en) | 1995-03-06 | 1997-03-04 | Ethicon, Inc. | Polymer blends containing absorbable polyoxaesters |
| US5648088A (en) | 1995-03-06 | 1997-07-15 | Ethicon, Inc. | Blends of absorbable polyoxaesters containing amines and/or amide groups |
| US5859150A (en) | 1995-03-06 | 1999-01-12 | Ethicon, Inc. | Prepolymers of absorbable polyoxaesters |
| US5700583A (en) | 1995-03-06 | 1997-12-23 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters containing amines or amido groups |
| US5698213A (en) | 1995-03-06 | 1997-12-16 | Ethicon, Inc. | Hydrogels of absorbable polyoxaesters |
| US6147168A (en) | 1995-03-06 | 2000-11-14 | Ethicon, Inc. | Copolymers of absorbable polyoxaesters |
| IL113100A0 (en) | 1995-03-23 | 1995-06-29 | Schatz Anat | Infant's mattress |
| US5542682A (en) | 1995-03-27 | 1996-08-06 | American Variseal | Slant coil spring and seal |
| US5736159A (en) | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
| JP3470198B2 (ja) | 1995-05-02 | 2003-11-25 | 大正製薬株式会社 | 経口投与用組成物 |
| US5939286A (en) | 1995-05-10 | 1999-08-17 | University Of Florida | Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them |
| US5922253A (en) | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
| US5882676A (en) | 1995-05-26 | 1999-03-16 | Alza Corporation | Skin permeation enhancer compositions using acyl lactylates |
| US5718922A (en) | 1995-05-31 | 1998-02-17 | Schepens Eye Research Institute, Inc. | Intravitreal microsphere drug delivery and method of preparation |
| MX9709193A (es) | 1995-06-06 | 1998-03-31 | Hoffmann La Roche | Monogliceridos y un inhibidor de proteinasa que comprende la composicion farmaceutica. |
| US6129761A (en) | 1995-06-07 | 2000-10-10 | Reprogenesis, Inc. | Injectable hydrogel compositions |
| US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| US6572879B1 (en) | 1995-06-07 | 2003-06-03 | Alza Corporation | Formulations for transdermal delivery of pergolide |
| IL122432A (en) | 1995-06-07 | 2000-07-16 | Cygnus Therapeutic Systems | Transdermal patch for preventing ovulation |
| US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
| US5690952A (en) | 1995-06-07 | 1997-11-25 | Judy A. Magruder et al. | Implantable system for delivery of fluid-sensitive agents to animals |
| US5782396A (en) | 1995-08-28 | 1998-07-21 | United States Surgical Corporation | Surgical stapler |
| US5906830A (en) | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
| US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| GB9521125D0 (en) | 1995-10-16 | 1995-12-20 | Unilever Plc | Cosmetic composition |
| SE505146C2 (sv) | 1995-10-19 | 1997-06-30 | Biogram Ab | Partiklar för fördröjd frisättning |
| US5766620A (en) | 1995-10-23 | 1998-06-16 | Theratech, Inc. | Buccal delivery of glucagon-like insulinotropic peptides |
| GB9521805D0 (en) | 1995-10-25 | 1996-01-03 | Cortecs Ltd | Solubilisation methods |
| ES2192221T3 (es) | 1995-10-30 | 2003-10-01 | Oleoyl Estrone Developments S | Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso. |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| CA2329474C (en) | 1995-11-02 | 2002-02-26 | Schering Corporation | Continuous low-dose cytokine infusion therapy |
| CA2192773C (en) | 1995-12-15 | 2008-09-23 | Hiroaki Okada | Production of sustained-release preparation for injection |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| AUPN723395A0 (en) | 1995-12-19 | 1996-01-18 | Macnaught Medical Pty Limited | Lubrication methods |
| US5980945A (en) | 1996-01-16 | 1999-11-09 | Societe De Conseils De Recherches Et D'applications Scientifique S.A. | Sustained release drug formulations |
| DE69624087T2 (de) | 1996-01-31 | 2003-06-05 | Sumitomo Bakelite Co. Ltd., Tokio/Tokyo | Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung |
| DE69720190T2 (de) | 1996-02-02 | 2003-12-11 | Alza Corp | Implantierbares system mit verzögerter freisetzung von leuprolid |
| US6156331A (en) | 1996-02-02 | 2000-12-05 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US6132420A (en) | 1996-02-02 | 2000-10-17 | Alza Corporation | Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems |
| WO1997028181A2 (en) | 1996-02-02 | 1997-08-07 | Rhomed Incorporated | Post-labeling stabilization of radiolabeled proteins and peptides |
| US6261584B1 (en) | 1996-02-02 | 2001-07-17 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US6395292B2 (en) | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6245349B1 (en) | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
| KR100611130B1 (ko) | 1996-03-01 | 2006-11-30 | 노보 노르디스크 에이/에스 | 식욕억제펩티드로이루어진약학적조성물의사용 |
| JPH09241153A (ja) | 1996-03-04 | 1997-09-16 | Q P Corp | 静脈注射用脂肪乳剤 |
| CN1084747C (zh) | 1996-03-08 | 2002-05-15 | 曾尼卡有限公司 | 作为神经活性剂的吡咯并苯并氮杂䓬衍生物 |
| EP0904373A1 (en) | 1996-03-14 | 1999-03-31 | The Immune Response Corporation | Targeted delivery of genes encoding interferon |
| US5703200A (en) | 1996-03-15 | 1997-12-30 | Ethicon, Inc. | Absorbable copolymers and blends of 6,6-dialkyl-1,4-dioxepan-2-one and its cyclic dimer |
| EP0889722B1 (en) | 1996-03-28 | 2002-11-20 | Takeda Chemical Industries, Ltd. | Sustained-release preparation and its production |
| US5660858A (en) | 1996-04-03 | 1997-08-26 | Research Triangle Pharmaceuticals | Cyclosporin emulsions |
| US6204022B1 (en) | 1996-04-12 | 2001-03-20 | Pepgen Corporation And University Of Florida | Low-toxicity human interferon-alpha analogs |
| US6074673A (en) | 1996-04-22 | 2000-06-13 | Guillen; Manuel | Slow-release, self-absorbing, drug delivery system |
| US5976109A (en) | 1996-04-30 | 1999-11-02 | Medtronic, Inc. | Apparatus for drug infusion implanted within a living body |
| US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| TW487572B (en) | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
| CA2259469A1 (en) | 1996-06-05 | 1997-12-11 | Ashmont Holdings Limited | Injectable compositions |
| CN1183158C (zh) | 1996-06-05 | 2005-01-05 | 罗赫诊断器材股份有限公司 | Exendin类似物,其制备方法及含有它们的药物制剂 |
| DE29610419U1 (de) | 1996-06-14 | 1996-10-24 | Filtertek, S.A., Plailly | Schwerkraftinfusionsvorrichtung für medizinische Infusionen |
| GB9613858D0 (en) | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
| AU737664B2 (en) | 1996-07-03 | 2001-08-30 | Alza Corporation | Non-aqueous protic peptide formulations |
| US5932547A (en) | 1996-07-03 | 1999-08-03 | Alza Corporation | Non-aqueous polar aprotic peptide formulations |
| US5916582A (en) | 1996-07-03 | 1999-06-29 | Alza Corporation | Aqueous formulations of peptides |
| ES2259746T3 (es) | 1996-07-15 | 2006-10-16 | Alza Corporation | Nuevas formulaciones para la administracion transdermica de fluoxetina. |
| AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
| AU4063697A (en) | 1996-08-08 | 1998-02-25 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
| AU3981097A (en) | 1996-08-21 | 1998-03-06 | Alkermes Controlled Therapeutics, Inc. | Controlled release microparticles with a hydrophobic material |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6195647B1 (en) * | 1996-09-26 | 2001-02-27 | The Nasdaq Stock Market, Inc. | On-line transaction processing system for security trading |
| US5984890A (en) | 1996-09-27 | 1999-11-16 | American Home Products Corporation | Medical device for the placement of solid materials |
| IN184589B (enExample) | 1996-10-16 | 2000-09-09 | Alza Corp | |
| US6004578A (en) | 1996-10-24 | 1999-12-21 | Alza Corporation | Permeation enhances for transdermal drug delivery compositions, devices and methods |
| US5817129A (en) | 1996-10-31 | 1998-10-06 | Ethicon, Inc. | Process and apparatus for coating surgical sutures |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| DE19646392A1 (de) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US5928666A (en) | 1996-11-12 | 1999-07-27 | Cygnus Inc. | Crystalline form of estradiol and pharmaceutical formulations comprising same |
| EP1066081B1 (en) | 1996-11-15 | 2003-07-16 | ALZA Corporation | Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems |
| IL130532A0 (en) | 1996-12-20 | 2000-06-01 | Alza Corp | Gel composition and methods |
| GB9626513D0 (en) | 1996-12-20 | 1997-02-05 | Bioglan Ireland R & D Ltd | A pharmaceutical composition |
| ATE304864T1 (de) | 1997-01-07 | 2005-10-15 | Amylin Pharmaceuticals Inc | Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme |
| JP2001511128A (ja) | 1997-01-28 | 2001-08-07 | ファルマシア・アンド・アップジョン・カンパニー | 水不溶性ポルフィリンの脂質錯体の凍結乾燥物 |
| US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| ZA981610B (en) | 1997-03-24 | 1999-08-26 | Alza Corp | Self adjustable exit port. |
| US5874388A (en) | 1997-04-02 | 1999-02-23 | Dow Corning Corporation | Lubricant composition for disc brake caliper pin and a disc brake asembly containing the lubricant |
| US6127520A (en) | 1997-04-15 | 2000-10-03 | Regents Of The University Of Michigan | Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles |
| JP2001524958A (ja) | 1997-04-17 | 2001-12-04 | ジーエス ディベロップメント アクティエボラーグ | 新規な液晶をベースとする生物接着性薬剤送出系 |
| AR012448A1 (es) | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
| US6638502B1 (en) | 1997-04-28 | 2003-10-28 | Gencell Sas | Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors |
| US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
| US6113947A (en) | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| US6663899B2 (en) | 1997-06-13 | 2003-12-16 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| SI9700186B (sl) | 1997-07-14 | 2006-10-31 | Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. | Nova farmacevtska oblika z nadzorovanim sproscanjem zdravilnih ucinkovin |
| MY125849A (en) | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
| MY125870A (en) | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| US7157555B1 (en) | 1997-08-08 | 2007-01-02 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| GB9718986D0 (en) | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
| US6023802A (en) | 1997-09-10 | 2000-02-15 | King; Susan Melton | Infant sleeper |
| US6172046B1 (en) | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| PL195212B1 (pl) | 1997-09-29 | 2007-08-31 | Nektar Therapeutics | Preparat bioaktywny w postaci proszku i sposób jego wytwarzania |
| JPH11100353A (ja) | 1997-09-29 | 1999-04-13 | Esupo Kk | 精製・脱臭液状エステルワックスとその組成物 |
| US6133429A (en) | 1997-10-03 | 2000-10-17 | Becton Dickinson And Company | Chromophores useful for the preparation of novel tandem conjugates |
| USD399821S (en) | 1997-11-07 | 1998-10-20 | Motorola, Inc. | Front section of a battery charger |
| WO1999025728A1 (en) | 1997-11-14 | 1999-05-27 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| AU761577C (en) | 1997-12-08 | 2004-02-05 | Genentech Inc. | Human interferon-epsilon: a type I interferon |
| US6368612B1 (en) | 1997-12-12 | 2002-04-09 | Biohybrid Technologies Llc | Devices for cloaking transplanted cells |
| DE69807748T2 (de) | 1997-12-22 | 2003-01-02 | Alza Corp., Palo Alto | Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe |
| ATE329648T1 (de) | 1997-12-29 | 2006-07-15 | Alza Corp | Vorrichtung zum implantieren von subkutanen implantaten |
| EP1300173B1 (en) | 1997-12-29 | 2006-06-14 | Alza Corporation | Implanter device for subcutaneous implants |
| EP1041968B1 (en) | 1997-12-29 | 2004-03-03 | Alza Corporation | Osmotic delivery system with membrane plug retention mechanism |
| PT1736145E (pt) | 1997-12-30 | 2012-03-16 | Intarcia Therapeutics Inc | Sistema de entrega de agente benéfico com obturador de membrana |
| US20040024068A1 (en) | 1998-01-23 | 2004-02-05 | Trustees Of Tufts College | Antimicrobial compounds |
| IT1298575B1 (it) | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di |
| US6017545A (en) | 1998-02-10 | 2000-01-25 | Modi; Pankaj | Mixed micellar delivery system and method of preparation |
| ATE366115T1 (de) | 1998-02-13 | 2007-07-15 | Amylin Pharmaceuticals Inc | Inotropische und diuretische effekte von exendin und glp-1 |
| US6703359B1 (en) | 1998-02-13 | 2004-03-09 | Amylin Pharmaceuticals, Inc. | Inotropic and diuretic effects of exendin and GLP-1 |
| USD408917S (en) | 1998-02-26 | 1999-04-27 | Minnesota Mining And Manufacturing Company | Membrane support structure of a flow through cell for blood gas measurement |
| US6224577B1 (en) | 1998-03-02 | 2001-05-01 | Medrad, Inc. | Syringes and plungers for use therein |
| US6056718A (en) | 1998-03-04 | 2000-05-02 | Minimed Inc. | Medication infusion set |
| US6245357B1 (en) | 1998-03-06 | 2001-06-12 | Alza Corporation | Extended release dosage form |
| US6183461B1 (en) | 1998-03-11 | 2001-02-06 | Situs Corporation | Method for delivering a medication |
| US20020136848A1 (en) | 1998-03-12 | 2002-09-26 | Fumio Yoshii | Lactone-containing resin composition, molded object thereof, and film |
| US6029361A (en) | 1998-03-25 | 2000-02-29 | Ultratech Stepper, Inc. | Air-guage nozzle probe structure for microlithographic image focusing |
| US6074660A (en) | 1998-04-20 | 2000-06-13 | Ethicon, Inc. | Absorbable polyoxaesters containing amines and/ or amido groups |
| TW586944B (en) | 1998-05-29 | 2004-05-11 | Sumitomo Pharma | Controlled release agent having a multi-layer structure |
| US8626302B2 (en) | 1998-06-03 | 2014-01-07 | Spr Therapeutics, Llc | Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain |
| EA004538B1 (ru) | 1998-06-12 | 2004-06-24 | Амилин Фармасьютикалс, Инк. | ГЛЮКАГОНОПОДОБНЫЙ ПЕПТИД-1, УЛУЧШАЮЩИЙ ОТВЕТ β-КЛЕТОК НА ГЛЮКОЗУ У СУБЪЕКТОВ С НАРУШЕНИЕМ ТОЛЕРАНТНОСТИ К ГЛЮКОЗЕ |
| JP2002520120A (ja) | 1998-07-17 | 2002-07-09 | スカイファーマ インコーポレーテッド | 封入物質の制御放出のための生分解性組成物 |
| US7390637B2 (en) | 1998-07-21 | 2008-06-24 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US6472512B1 (en) | 1998-07-21 | 2002-10-29 | Human Genome Sciences, Inc. | Keratinocyte derived interferon |
| US6270700B1 (en) | 1998-07-23 | 2001-08-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Encapsulation of water soluble peptides |
| USD415073S (en) | 1998-08-17 | 1999-10-12 | ScooterBug, Inc. | Stroller |
| US6720407B1 (en) | 1998-08-28 | 2004-04-13 | Eli Lilly And Company | Method for administering insulinotropic peptides |
| US6551613B1 (en) | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
| US6174547B1 (en) | 1999-07-14 | 2001-01-16 | Alza Corporation | Dosage form comprising liquid formulation |
| KR100620292B1 (ko) | 1998-09-09 | 2006-09-13 | 알자 코포레이션 | 액체 제형물을 포함하는 제형 |
| US6248112B1 (en) | 1998-09-30 | 2001-06-19 | C. R. Bard, Inc. | Implant delivery system |
| US6284725B1 (en) | 1998-10-08 | 2001-09-04 | Bionebraska, Inc. | Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue |
| RU2246295C2 (ru) | 1998-11-02 | 2005-02-20 | Элзэ Копэрейшн | Лекарственная форма c постоянной скоростью высвобождения лекарственного вещества, ядро лекарственной формы и способ обеспечения облегченного высвобождения лекарственного вещества из лекарственной формы |
| WO2000029206A1 (en) | 1998-11-13 | 2000-05-25 | Sensor Technologies Inc. | Monodisperse preparations useful with implanted devices |
| US20030060425A1 (en) | 1998-11-24 | 2003-03-27 | Ahlem Clarence N. | Immune modulation method using steroid compounds |
| PL202367B1 (pl) | 1998-12-07 | 2009-06-30 | Sod Conseils Rech Applic | Związki stanowiące analogi GLP-1, kompozycje zawierające te związki oraz zastosowanie tych związków |
| CA2354472C (en) | 1998-12-17 | 2009-02-24 | Alza Corporation | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
| EP1140018B1 (en) | 1998-12-23 | 2003-10-08 | Amgen Inc. | Polyol/oil suspensions for the sustained release of proteins |
| DE69906132T2 (de) | 1998-12-31 | 2003-12-18 | Alza Corp., Mountain View | Osmotisches verabreichungsystem mit raumsparenden kolben |
| US6433144B1 (en) | 1999-01-12 | 2002-08-13 | Viragen, Inc. | Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods |
| EP1140144A4 (en) | 1998-12-31 | 2002-10-30 | Viragen Inc | METHODS AND COMPOSITION OF EXTREMELY PURIFIED NATURAL MIXTURES OF TYPE I INTERFERONS DERIVED FROM LEUCOCYTES |
| WO2000040273A2 (en) | 1999-01-08 | 2000-07-13 | Vical Incorporated | Treatment of viral diseases using an interferon omega expressing polynucleotide |
| US6703225B1 (en) | 1999-01-12 | 2004-03-09 | Sumitomo Pharmaceuticals Company, Limited | Interferon-α |
| US7399489B2 (en) | 1999-01-14 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Exendin analog formulations |
| EP1143989B1 (en) | 1999-01-14 | 2006-12-13 | Amylin Pharmaceuticals, Inc. | Exendins for glucagon suppression |
| BRPI0007820B8 (pt) | 1999-01-14 | 2021-05-25 | Amylin Pharmaceuticals Llc | formulações farmacêuticas agonistas de exendina e seus usos |
| ATE322889T1 (de) | 1999-02-08 | 2006-04-15 | Alza Corp | Stabile nicht wässerige einphasige visköse vehikeln und formulierungen die diese vehikeln verwenden |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| US6541021B1 (en) | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| CA2367131C (en) | 1999-04-05 | 2007-07-03 | Solomon S. Steiner | Methods for fine powder formation |
| GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
| JP2002542202A (ja) | 1999-04-19 | 2002-12-10 | シェリング・コーポレーション | 抗酸化剤を伴ったリバビリンを含有するｈｃｖ組み合わせ治療薬 |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
| AU4917900A (en) | 1999-05-07 | 2000-11-21 | Pharmasol Gmbh | Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same |
| DE60006100T2 (de) | 1999-05-17 | 2004-07-01 | Conjuchem, Inc., Montreal | Lang wirkende insulinotrope peptide |
| US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6514500B1 (en) | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| US20030059376A1 (en) | 1999-06-04 | 2003-03-27 | Libbey Miles A. | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
| NZ530701A (en) | 1999-06-04 | 2005-09-30 | Alza Corp | Implantable gel compositions comprising compressed particles including the active agent in a bioerodible gel |
| AU5936400A (en) | 1999-06-04 | 2000-12-28 | Delrx Pharmaceutical Corporation | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
| US20010040326A1 (en) | 1999-06-14 | 2001-11-15 | Lord Corporation | Resilient member with deformed element and method of forming same |
| US6833256B1 (en) | 1999-06-22 | 2004-12-21 | University Of Maryland | Interferon tau mutants and methods for making them |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| USD445975S1 (en) | 1999-08-27 | 2001-07-31 | Black & Decker, Inc. | Base unit for a hand held vacuum cleaner |
| SE9903236D0 (sv) | 1999-09-10 | 1999-09-10 | Astra Ab | Method to obtain microparticles |
| US6458387B1 (en) | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
| US6284283B1 (en) | 1999-10-21 | 2001-09-04 | Alkermes Controlled Therapeutics, Inc. | Method of producing sub-micron particles of biologically active agents and uses thereof |
| US6436091B1 (en) | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| WO2001043528A2 (en) | 1999-12-17 | 2001-06-21 | Durect Corporation | Devices and methods in intracerebrospinal delivery of morphine-6-glucuronide |
| ES2248156T3 (es) | 1999-12-21 | 2006-03-16 | Alza Corporation | Valvula para dispositivos osmoticos. |
| US6498193B2 (en) * | 1999-12-22 | 2002-12-24 | Trustees Of Dartmouth College | Treatment for complications of type 2 diabetes |
| US6283949B1 (en) | 1999-12-27 | 2001-09-04 | Advanced Cardiovascular Systems, Inc. | Refillable implantable drug delivery pump |
| US6572890B2 (en) | 2000-01-13 | 2003-06-03 | Osmotica Corp. | Osmotic device containing venlafaxine and an anti-psychotic agent |
| US6472060B1 (en) | 2000-01-19 | 2002-10-29 | Seco Tools Ab | Coated body with nanocrystalline CVD coating for enhanced edge toughness and reduced friction |
| US6844321B2 (en) | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
| US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
| US6464688B1 (en) | 2000-02-15 | 2002-10-15 | Microsolutions, Inc. | Osmotic pump delivery system with flexible drug compartment |
| US6471688B1 (en) | 2000-02-15 | 2002-10-29 | Microsolutions, Inc. | Osmotic pump drug delivery systems and methods |
| MXPA02009031A (es) | 2000-03-14 | 2004-08-19 | Amylin Pharmaceuticals Inc | Efectos del peptido-1(7-36) tipo glucagon en la motilidad antro-piloro.duodenal. |
| US20030211974A1 (en) | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
| TWI250874B (en) | 2000-03-24 | 2006-03-11 | Nat Health Research Institutes | Pharmaceutical compositions for preventing or treating disorders associated with bacterial or viral infection |
| WO2001078683A2 (en) | 2000-04-19 | 2001-10-25 | Genentech, Inc. | Sustained release formulations comprising growth hormone |
| CA2407074A1 (en) | 2000-04-21 | 2001-11-01 | Jukka Hartikka | Compositions and methods for in vivo delivery of polynucleotide-based therapeutics |
| US6996503B2 (en) | 2000-04-27 | 2006-02-07 | El-Con System Co., Ltd. | System and method for take-off of materials using two-dimensional CAD interface |
| US6706689B2 (en) | 2000-05-19 | 2004-03-16 | Amylin Pharmaceuticals, Inc. | Treatment of acute coronary syndrome with GLP-1 |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| KR100847615B1 (ko) | 2000-06-16 | 2008-07-21 | 일라이 릴리 앤드 캄파니 | 글루카곤-유사 펩티드-1 유사체 |
| US6479065B2 (en) | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US6547250B1 (en) | 2000-08-21 | 2003-04-15 | Westport Research Inc. | Seal assembly with two sealing mechanisms for providing static and dynamic sealing |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| WO2002028366A2 (en) | 2000-10-06 | 2002-04-11 | Durect Corporation | Devices and methods for management of inflammation |
| AU2587002A (en) | 2000-11-03 | 2002-05-15 | Biomedicines Inc | Method for short-term and long-term drug dosimetry |
| WO2002067895A2 (en) | 2000-11-16 | 2002-09-06 | Durect Corporation | Implant dosage form and use thereof for the delivery of a cholesterol lowering agent |
| AU2002219793A1 (en) | 2000-11-29 | 2002-06-11 | Durect Corporation | Devices and methods for controlled delivery from a drug delivery device |
| US20020165286A1 (en) | 2000-12-08 | 2002-11-07 | Hanne Hedeman | Dermal anti-inflammatory composition |
| AU2002228608A1 (en) | 2000-12-13 | 2002-06-24 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| US7259233B2 (en) | 2000-12-13 | 2007-08-21 | Eli Lilly And Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| RU2275207C2 (ru) | 2000-12-14 | 2006-04-27 | Амилин Фармасьютикалз, Инк. | Способ снижения доступности питательного вещества, способ подавления аппетита |
| EP1343480B2 (en) | 2000-12-21 | 2016-02-17 | Alrise Biosystems GmbH | Induced phase transition method for the production of microparticles containing hydrophobic active agents |
| USD472896S1 (en) | 2000-12-23 | 2003-04-08 | Andreas Peiker | Telephone support |
| IN188924B (enExample) | 2001-03-01 | 2002-11-23 | Bharat Serums & Vaccines Ltd | |
| EP1379197A4 (en) | 2001-03-23 | 2009-06-03 | Durect Corp | DISPOSAL OF MEDICINAL PRODUCTS OF DELAYED RELEASE DEVICES IMPLANTED IN MYOKARD TISSUE OR PER ICARDROOM |
| US6632217B2 (en) | 2001-04-19 | 2003-10-14 | Microsolutions, Inc. | Implantable osmotic pump |
| JP2005506956A (ja) | 2001-06-01 | 2005-03-10 | イーライ・リリー・アンド・カンパニー | 長時間作用性ｇｌｐ−１製剤 |
| US6514517B2 (en) | 2001-06-20 | 2003-02-04 | Ethicon, Inc. | Antimicrobial coatings for medical devices |
| IL159048A0 (en) | 2001-06-21 | 2004-05-12 | Genentech Inc | Sustained release formulation |
| ES2284871T3 (es) | 2001-06-22 | 2007-11-16 | Pfizer Products Inc. | Composiciones farmaceuticas que contienen una dispersion solida de farmaco poco soluble y un polimero potenciador de la solubilidad. |
| US7163688B2 (en) | 2001-06-22 | 2007-01-16 | Alza Corporation | Osmotic implant with membrane and membrane retention means |
| AU2002322289A1 (en) | 2001-06-22 | 2003-01-08 | Johns Hopkins University School Of Medicine | Biodegradable polymer coompositions |
| US20030138403A1 (en) | 2001-06-29 | 2003-07-24 | Maxygen Aps | Interferon formulations |
| HUP0401156A2 (hu) | 2001-07-20 | 2004-12-28 | Intermune, Inc. | Májfibrózis kezelésére szolgáló módszerek |
| AU2002317599B2 (en) | 2001-07-31 | 2008-04-03 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | GLP-1 exendin-4 peptide analogs and uses thereof |
| BR0212080A (pt) | 2001-08-23 | 2006-04-04 | Lilly Co Eli | composto de glp-1, método de estimulação de receptor de glp-1 em um indivìduo necessitando de tal estimulação, e, uso de um composto de glp-1 |
| GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
| US20030064095A1 (en) | 2001-09-14 | 2003-04-03 | Imedd, Inc. | Microfabricated nanopore device for sustained release of therapeutic agent |
| AU2002327596A1 (en) | 2001-09-17 | 2003-04-01 | Durect Corporation | Device and method for accurate delivery of an active agent |
| BR0212985A (pt) | 2001-09-24 | 2005-08-30 | Imp College Innovations Ltd | Uso de pyy ou de um agonista do mesmo na preparação de medicamentos para tratamento de distúrbios associados com excesso de peso |
| MXPA04003238A (es) | 2001-10-05 | 2004-07-08 | Intermune Inc | Metodo para tratar la infeccion de virus de hepatitis con una configuracion de suministro de interferon multifasica. |
| US7041646B2 (en) | 2001-10-05 | 2006-05-09 | Bayer Pharmaceuticals Corporation | Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists |
| EP1441679B8 (en) | 2001-10-24 | 2018-05-30 | MED-EL Elektromedizinische Geräte GmbH | Implantable fluid delivery apparatuses and implantable electrode |
| US20040142902A1 (en) | 2001-11-08 | 2004-07-22 | Struijker- Boudier Harry A.J. | Implant dosage form and use thereof for the delivery of a cholosterol lowering agent |
| JP2005516041A (ja) | 2001-11-09 | 2005-06-02 | インターシア・セラピューティクス・インコーポレイテッド | オメガインターフェロンを用いる疾患の治療方法 |
| NZ533436A (en) | 2001-11-14 | 2007-10-26 | Alza Corp | Catheter injectable depot compositons and uses thereof |
| JP5170935B2 (ja) | 2001-11-14 | 2013-03-27 | デュレクト コーポレーション | 注入可能なデポー組成物 |
| CN1703197A (zh) | 2001-11-14 | 2005-11-30 | 阿尔扎有限公司 | 可注射的长效组合物和其使用 |
| DE10159217A1 (de) | 2001-11-27 | 2003-06-05 | Schering Ag | 17alpha-Alkyl-17ß-oxy-estratriene und Zwischenprodukte zu deren Herstellung, Verwendung der 17alpha-Alkyl-17ß-oxy-estratriene zur Herstellung von Arzneimitteln sowie pharmazeutische Präparate |
| US20030108608A1 (en) | 2001-12-12 | 2003-06-12 | Erik Laridon | Thermoplastic articles comprising silver-containing antimicrobials and high amounts of carboxylic acid salts for increased surface-available silver |
| KR20040090961A (ko) | 2001-12-19 | 2004-10-27 | 알자 코포레이션 | 치료제의 조절된 방출을 위한 제제 및 투여 형태 |
| AU2002364586A1 (en) | 2001-12-21 | 2003-07-30 | Delta Biotechnology Limited | Albumin fusion proteins |
| US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
| US7105489B2 (en) | 2002-01-22 | 2006-09-12 | Amylin Pharmaceuticals, Inc. | Methods and compositions for treating polycystic ovary syndrome |
| AU2003217367B2 (en) | 2002-02-08 | 2005-09-08 | Alkermes Controlled Therapeutics, Inc. | Polymer-based compositions for sustained release |
| ATE494010T1 (de) | 2002-02-27 | 2011-01-15 | Pharmain Corp | Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung |
| US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
| GB0204722D0 (en) | 2002-02-28 | 2002-04-17 | Norferm Da | Method |
| GB2386066A (en) | 2002-02-28 | 2003-09-10 | Norbrook Lab Ltd | Long-acting parasiticidal composition with improved bioavailability comprising a salicylanilide, a further anti-parasitic compound & a polymeric species |
| JP2005528353A (ja) * | 2002-03-14 | 2005-09-22 | フォーブス メディ−テック インコーポレーテッド | 糖尿病に関連する症状及び糖尿病の合併症を包含する糖尿病の治療方法 |
| AU2003221888B2 (en) | 2002-04-11 | 2008-11-06 | Medimmune, Llc | Preservation of bioactive materials by spray drying |
| NZ536965A (en) | 2002-05-31 | 2007-02-23 | Titan Pharmaceuticals Inc | Nonerodible polymeric matrix with buprenorphine encapsulated for the treatment of opiate addiction and pain |
| WO2003105803A1 (en) | 2002-06-17 | 2003-12-24 | Alza Corporation | Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| DE60317225T2 (de) | 2002-06-26 | 2008-05-29 | Intarcia Therapeutics, Inc., Emeryville | Minimal nachgiebiger volumen-effizienter kolben für osmotische medikamentenabgabesysteme |
| US7177526B2 (en) | 2002-06-28 | 2007-02-13 | Intel Corporation | System and method for improving audio during post-production of video recordings |
| US8252303B2 (en) | 2002-07-31 | 2012-08-28 | Durect Corporation | Injectable depot compositions and uses thereof |
| CN1684663A (zh) | 2002-07-31 | 2005-10-19 | 阿尔萨公司 | 可注射的多模式聚合物储库组合物以及其用途 |
| US20080260838A1 (en) | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| US20060084922A1 (en) | 2002-09-04 | 2006-04-20 | Ruark Botha | Device for securing a blood vessel cannula to a body |
| AU2003286472A1 (en) | 2002-10-17 | 2004-05-04 | Alkermes Controlled Therapeutics, Inc. Ii | Microencapsulation and sustained release of biologically active polypeptides |
| EP1567127A4 (en) | 2002-10-17 | 2007-02-21 | Alkermes Inc | METHOD FOR MODIFYING THE RELEASE PROFILE OF COMPRESSED RELATED COMPOSITION COMPOSITIONS |
| US20040209801A1 (en) | 2002-10-22 | 2004-10-21 | Brand Stephen J. | Treatment of diabetes |
| PL377333A1 (pl) | 2002-11-06 | 2006-01-23 | Alza Corporation | Preparaty depot o kontrolowanym uwalnianiu |
| US6969702B2 (en) | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| US7014636B2 (en) | 2002-11-21 | 2006-03-21 | Alza Corporation | Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel |
| US7790681B2 (en) | 2002-12-17 | 2010-09-07 | Amylin Pharmaceuticals, Inc. | Treatment of cardiac arrhythmias with GLP-1 receptor ligands |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| JP2006512370A (ja) | 2002-12-19 | 2006-04-13 | アルザ・コーポレーション | 安定な非水性単相ゲル、および植込み型デバイスから送達するためのその配合物 |
| GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
| JP2004238392A (ja) | 2003-01-14 | 2004-08-26 | Nipro Corp | 安定化された蛋白質性製剤 |
| WO2004075349A2 (en) | 2003-02-18 | 2004-09-02 | Medconx, Inc. | Male medical device electrical connector with engineered friction fit |
| EP1610765B1 (en) | 2003-03-31 | 2008-08-13 | ALZA Corporation | Non-aqueous single phase vehicles and formulations utilizing such vehicles |
| US20050010196A1 (en) | 2003-03-31 | 2005-01-13 | Fereira Pamela J. | Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems |
| CN100548411C (zh) | 2003-03-31 | 2009-10-14 | 精达制药公司 | 设置有内部压力释放部件的渗透泵 |
| WO2004101017A2 (de) | 2003-05-16 | 2004-11-25 | Blue Membranes Gmbh | Biokompatibel beschichtete medizinische implantate |
| WO2004103342A2 (en) | 2003-05-16 | 2004-12-02 | Alkermes Controlled Therapeutics, Inc. | Injectable sustained release compositions |
| KR20060023140A (ko) | 2003-05-30 | 2006-03-13 | 알자 코포레이션 | 이식성 탄성중합체 데포 조성물, 이의 용도 및 이의제조방법 |
| ES2425221T3 (es) | 2003-05-30 | 2013-10-14 | Amylin Pharmaceuticals, Llc | Nuevos métodos y composiciones para suministro por vía transmucosa potenciado de péptidos y proteínas |
| KR101308912B1 (ko) | 2003-06-03 | 2013-09-23 | 노보 노르디스크 에이/에스 | 안정화된 약학적 펩티드 조성물 |
| US8491571B2 (en) | 2003-06-12 | 2013-07-23 | Cordis Corporation | Orifice device having multiple channels with varying flow rates for drug delivery |
| US7454765B2 (en) | 2003-07-09 | 2008-11-18 | Samsung Electronics Co., Ltd. | Optical disc drive |
| US7205409B2 (en) | 2003-09-04 | 2007-04-17 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
| US9005244B2 (en) | 2003-09-30 | 2015-04-14 | Ethicon, Inc. | Tissue approximation device |
| KR20060097008A (ko) | 2003-09-30 | 2006-09-13 | 알자 코포레이션 | 상승하는 방출 프로파일을 제공하는 삼투압으로 구동되는활성제 전달 장치 |
| EP1686968A2 (en) | 2003-10-31 | 2006-08-09 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
| CA2545027A1 (en) | 2003-11-06 | 2005-05-26 | Alza Corporation | Modular imbibition rate reducer for use with implantable osmotic pump |
| US20050118206A1 (en) | 2003-11-14 | 2005-06-02 | Luk Andrew S. | Surfactant-based gel as an injectable, sustained drug delivery vehicle |
| US20050106214A1 (en) | 2003-11-14 | 2005-05-19 | Guohua Chen | Excipients in drug delivery vehicles |
| US20050281879A1 (en) | 2003-11-14 | 2005-12-22 | Guohua Chen | Excipients in drug delivery vehicles |
| US7780973B2 (en) | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
| US20050216087A1 (en) | 2004-01-05 | 2005-09-29 | St. Francis Medical Technologies, Inc. | Disk repair structures for positioning disk repair material |
| US20050175701A1 (en) | 2004-02-10 | 2005-08-11 | Alza Corporation | Capillary moderator for osmotic delivery system |
| CN102174115B (zh) | 2004-02-11 | 2014-05-14 | 安米林药品有限责任公司 | 具有可选择特性的杂合多肽 |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
| JP5030292B2 (ja) | 2004-04-15 | 2012-09-19 | アミリン・ファーマシューティカルズ，インコーポレイテッド | ポリマーを基にした持続放出性装置 |
| WO2005112977A2 (en) | 2004-04-23 | 2005-12-01 | Pharmain, Ltd. | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
| CN1997756A (zh) * | 2004-05-04 | 2007-07-11 | 杰耐萨斯药品公司 | 单倍型标记和利用其确定对于治疗的反应的方法 |
| US20050266087A1 (en) | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| US20090042781A1 (en) | 2004-06-28 | 2009-02-12 | Novo Nordisk A/S | Methods for Treating Diabetes |
| US7772182B2 (en) | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
| BRPI0514297A (pt) * | 2004-08-12 | 2008-06-10 | Quest Pharmaceutical Services | composições farmacêuticas para liberação controlada de compostos biologicamente ativos |
| GB2434189B (en) | 2004-08-18 | 2009-04-01 | Waters Investments Ltd | Defined leak path for high pressure seal |
| US8268791B2 (en) * | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
| EP1791643B1 (en) * | 2004-09-01 | 2009-03-11 | Microchips, Inc. | Multi-cap reservoir devices for controlled release or exposure of reservoir contents |
| US20060094693A1 (en) | 2004-09-21 | 2006-05-04 | Point Therapeutics, Inc. | Methods and compositions for treating glucose-associated conditions, metabolic syndrome, dyslipidemias and other conditions |
| KR101506925B1 (ko) | 2004-10-01 | 2015-03-30 | 램스코르 인코포레이티드 | 편리하게 이식가능한 서방형 약물 조성물 |
| US20080038316A1 (en) * | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| EP2939686A1 (en) * | 2004-10-08 | 2015-11-04 | Clinuvel Pharmaceuticals Limited | Compositions and methods for inducing melanogenesis in a subject |
| US7442682B2 (en) | 2004-10-19 | 2008-10-28 | Nitto Denko Corporation | Transepithelial delivery of peptides with incretin hormone activities |
| DK1814590T4 (da) | 2004-11-01 | 2014-02-24 | Amylin Pharmaceuticals Llc | Behandling af obesitet og beslægtede sygdomme. |
| US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| US7575579B2 (en) | 2004-11-18 | 2009-08-18 | Union Surgical, Llc | Drill guide tissue protector |
| US20060142234A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| US20060141040A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| US7393827B2 (en) | 2004-12-30 | 2008-07-01 | Diakine Therapeutics, Inc. | Pharmaceutical compositions and methods for restoring β-cell mass and function |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| USD587374S1 (en) | 2005-01-14 | 2009-02-24 | Edwards Lifesciences Corporation | Sensor case |
| CN101141994B (zh) | 2005-01-24 | 2010-10-13 | 欧加农股份有限公司 | 用于插入植入物的操作器 |
| AU2006208131A1 (en) * | 2005-01-25 | 2006-08-03 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
| WO2006084139A2 (en) | 2005-02-03 | 2006-08-10 | Intarcia Therapeutics, Inc. | An implantable interferon-containing device |
| US20060216242A1 (en) | 2005-02-03 | 2006-09-28 | Rohloff Catherine M | Suspending vehicles and pharmaceutical suspensions for drug dosage forms |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| US20070032420A1 (en) | 2005-02-09 | 2007-02-08 | Entelos, Inc. | Treating diabetes with glucagon-like peptide-1 secretagogues |
| US20090286723A1 (en) | 2005-02-11 | 2009-11-19 | Amylin Pharmaceuticals, Inc. | Hybrid Polypeptides with Selectable Properties |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| BRPI0606992A2 (pt) | 2005-02-11 | 2009-07-28 | Amylin Pharmaceuticals Inc | análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis |
| JP4413851B2 (ja) * | 2005-02-16 | 2010-02-10 | 旭有機材工業株式会社 | 積層鋳型用レジンコーテッドサンド |
| GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| US7671023B2 (en) | 2005-03-31 | 2010-03-02 | Amylin Pharmaceuticals, Inc. | Amylin agonist for treating depression, anxiety disorder and schizophrenia |
| AU2006235183B2 (en) * | 2005-04-08 | 2011-02-10 | Amylin Pharmaceuticals, Llc | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
| EP1874339A1 (en) | 2005-04-21 | 2008-01-09 | Gastrotech Pharma A/S | Pharmaceutical preparations of a glp-1 molecule and an anti-emetic drug |
| US7569050B2 (en) | 2005-05-06 | 2009-08-04 | Medtronic Minimed, Inc. | Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion |
| WO2006131730A1 (en) | 2005-06-06 | 2006-12-14 | Camurus Ab | Glp-1 analogue formulations |
| US20060280795A1 (en) | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
| US9447781B2 (en) | 2005-07-22 | 2016-09-20 | University Of Utah Research Foundation | Osmotically driven dispense pump and related components for use in high pressure applications |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US8389472B2 (en) * | 2005-08-19 | 2013-03-05 | Amylin Pharmaceuticals, Llc | Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease |
| DK3524261T5 (da) | 2005-08-19 | 2024-09-02 | Amylin Pharmaceuticals Llc | Exendin til anvendelse til behandling af diabetes og reduktion af kropsvægt |
| ES2586236T3 (es) | 2005-11-04 | 2016-10-13 | Glaxosmithkline Llc | Procedimientos para administrar agentes hipoglucémicos |
| US8039432B2 (en) | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
| WO2007062531A1 (en) * | 2005-12-02 | 2007-06-07 | Waratah Pharmaceuticals, Inc. | Combination treatments with gastrin agonists for diabetes and related diseases |
| WO2007075534A2 (en) | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Polymer conjugates of glp-1 |
| US20090209460A1 (en) | 2005-12-16 | 2009-08-20 | Amylin Pharmaceuticals, Inc. | Compositions and methods for treating obesity and related metabolic disorders |
| RU2427383C2 (ru) * | 2006-01-18 | 2011-08-27 | КьюПиЭс, ЭлЭлСи | Фармацевтические композиции с повышенной стабильностью |
| JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ，リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
| RU2008147398A (ru) | 2006-05-02 | 2010-06-10 | Актогеникс Н.В. (Be) | Доставка пептидов, связанных с ожирением, через кишечник посредством микроорганизмов |
| WO2007133778A2 (en) | 2006-05-12 | 2007-11-22 | Amylin Pharmaceuticals, Inc. | Methods to restore glycemic control |
| NZ572003A (en) | 2006-05-30 | 2010-07-30 | Intarcia Therapeutics Inc | Two-piece, internal-channel osmotic delivery system flow modulator with spiral fluid channel |
| TW200815045A (en) * | 2006-06-29 | 2008-04-01 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of ropinirole and methods of use thereof |
| GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
| KR101466933B1 (ko) | 2006-07-11 | 2014-12-01 | 큐피에스 엘엘씨 | 펩타이드의 지속 방출 전달을 위한 의약 조성물 |
| US8501693B2 (en) | 2006-08-04 | 2013-08-06 | Amylin Pharmaceuticals, Llc | Use of exendins and exendin agonists and GLP-1 receptor agonists for altering the concentration of fibrinogen |
| DK2049081T3 (da) | 2006-08-09 | 2013-02-25 | Intarcia Therapeutics Inc | Osmotiske leveringssystemer og stempelarrangementer |
| KR20090087441A (ko) | 2006-10-05 | 2009-08-17 | 파나세아 바이오테크 리미티드 | 새로운 형태의 주입형 데포 조성물 및 이를 위한 조제방법 |
| WO2008061355A1 (en) | 2006-11-24 | 2008-05-29 | Matregen Corp. | Glp-1 depot systems, and methods of manufacture and uses thereof |
| TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
| RU2477286C2 (ru) | 2007-01-05 | 2013-03-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | АНАЛОГИ ГЛЮКАГОНА, ОБЛАДАЮЩИЕ ПОВЫШЕННОЙ РАСТВОРИМОСТЬЮ В БУФЕРАХ С ФИЗИОЛОГИЧЕСКИМ ЗНАЧЕНИЕМ pH |
| USD555589S1 (en) | 2007-01-23 | 2007-11-20 | Intec, Inc. | Battery charger and game controller cradle |
| US20090022727A1 (en) | 2007-01-26 | 2009-01-22 | Alza Corp. | Injectable, nonaqueous suspension with high concentration of therapeutic agent |
| US20080208194A1 (en) | 2007-02-13 | 2008-08-28 | Christine Bickenbach | Double cut shaver |
| US8262667B1 (en) | 2007-02-23 | 2012-09-11 | Holmed Corporation | Multi-diameter implant forceps |
| PL2157967T3 (pl) | 2007-04-23 | 2013-06-28 | Intarcia Therapeutics Inc | Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania |
| US8236760B2 (en) | 2007-04-27 | 2012-08-07 | Cedars-Sinsai Medical Center | Use of GLP-1 receptor agonists for the treatment of short bowel syndrome |
| AU2009212367B2 (en) * | 2008-02-08 | 2013-08-01 | Foresee Pharmaceuticals Co., Ltd. | Composition for sustained release delivery of proteins or peptides |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| WO2009102969A1 (en) | 2008-02-14 | 2009-08-20 | Enteromedics, Inc. | Treatment of excess weight by neural downregulation in combination with compositions |
| EP2259791A2 (en) | 2008-03-05 | 2010-12-15 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Glp-1 receptor agonists and related active pharmaceutical ingredients for treatment of cancer |
| US20090234392A1 (en) | 2008-03-13 | 2009-09-17 | Depuy Spine, Inc. | Method for inserting a spinal fixation element using implants having guide tabs |
| JP5792057B2 (ja) | 2008-04-01 | 2015-10-07 | モサメディックス・ビー．ブイ．ＭｏｓａＭｅｄｉｘ Ｂ．Ｖ． | 創傷治癒における瘢痕形成を低減するための組成物および方法 |
| CN105031811B (zh) * | 2008-04-04 | 2017-09-08 | 安特罗麦迪克斯公司 | 用于葡萄糖调节的方法和系统 |
| ES2552646T3 (es) | 2008-05-21 | 2015-12-01 | Amylin Pharmaceuticals, Inc. | Exendinas para disminuir el colesterol y los triglicéridos |
| US20100105627A1 (en) * | 2008-09-17 | 2010-04-29 | Paul Salama | Pharmaceutical compositions and related methods of delivery |
| US9078900B2 (en) | 2008-09-30 | 2015-07-14 | Braeburn Pharmaceuticals Bvba Sprl | Implantable device for the delivery of risperidone and methods of use thereof |
| EP2349200A1 (en) | 2008-10-15 | 2011-08-03 | Intarcia Therapeutics, Inc | Highly concentrated drug particles, formulations, suspensions and uses thereof |
| WO2010068467A1 (en) | 2008-11-25 | 2010-06-17 | Attenuex Technologies, Inc. | Implant with high vapor pressure medium |
| US20100298840A1 (en) | 2009-05-22 | 2010-11-25 | Schwartz Lyman D | Phimosis Treatment Device and Method |
| USD638478S1 (en) | 2009-07-06 | 2011-05-24 | Performance Designed Products Llc | Video game controller accessory |
| US20110022165A1 (en) | 2009-07-23 | 2011-01-27 | Edwards Lifesciences Corporation | Introducer for prosthetic heart valve |
| US9358064B2 (en) | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
| USD789539S1 (en) | 2015-07-09 | 2017-06-13 | Spinal Surgical Strategies, Llc | Fusion cage |
| NZ598686A (en) | 2009-09-28 | 2014-05-30 | Intarcia Therapeutics Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
| CN102686607B (zh) | 2009-12-16 | 2014-10-29 | 诺沃—诺迪斯克有限公司 | 双酰化glp-1衍生物 |
| AR079344A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
| AR079345A1 (es) | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina |
| MX366325B (es) | 2010-05-05 | 2019-07-05 | Boehringer Ingelheim Int | Terapia de combinacion. |
| US8263554B2 (en) | 2010-06-09 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | Methods of using GLP-1 receptor agonists to treat pancreatitis |
| USD669589S1 (en) | 2010-08-31 | 2012-10-23 | Koninklijke Philips Electronics N.V. | Blood system cartridge |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US9944687B2 (en) | 2011-07-04 | 2018-04-17 | Imperial Innovations Limited | Compounds and their effects on feeding behaviour |
| TWD149032S (zh) | 2011-10-04 | 2012-09-01 | 虹光精密工業股份有限公司 | 手持式掃描器底座 |
| CN104302236A (zh) | 2012-04-19 | 2015-01-21 | 瑞福德有限公司 | 用于去除皮肤下植入物的工具 |
| AU2013268517A1 (en) | 2012-05-29 | 2015-01-22 | National University Corporation Kochi University | Artery visualization device and artery imaging device |
| US20140058425A1 (en) | 2012-08-27 | 2014-02-27 | Amir Porat | Manually operated surgical devices with operative portions formed of a see-through material |
| US9332995B2 (en) | 2012-09-25 | 2016-05-10 | Russo Inventions, Llc | Bone-harvesting tool |
| US9241722B2 (en) | 2012-10-08 | 2016-01-26 | Warsaw Orthopedic, Inc. | Surgical pin guide and methods of use |
| WO2014078832A1 (en) | 2012-11-19 | 2014-05-22 | Endo Pharmaceuticals Solutions Inc. | Implantable drug delivery compositions and methods of treatment thereof |
| USD731630S1 (en) | 2014-04-08 | 2015-06-09 | Bootz Manufacturing Company | Shower pan |
| USD724740S1 (en) | 2014-06-05 | 2015-03-17 | Deka Products Limited Partnership | Enclosure for a peritoneal dialysis device |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| AU2016270984B2 (en) | 2015-06-03 | 2021-02-25 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
| USD789540S1 (en) | 2016-01-29 | 2017-06-13 | Veterinary Implants Direct, Llc. | Orthopedic plate |
| US9931133B2 (en) | 2016-03-24 | 2018-04-03 | A.M. Surgical, Inc. | Compact endoscopic surgical device and method of use thereof |
| MA53353A (fr) | 2016-05-16 | 2021-06-09 | Intarcia Therapeutics Inc | Polypeptides sélectifs pour le récepteur du glucagon et méthodes pour leur utilisation |
| CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
-
2010
- 2010-09-21 NZ NZ598686A patent/NZ598686A/en not_active IP Right Cessation
- 2010-09-21 DK DK10819152.9T patent/DK2462246T3/da active
- 2010-09-21 ES ES10819152.9T patent/ES2650667T3/es active Active
- 2010-09-21 JP JP2012530862A patent/JP5718925B2/ja active Active
- 2010-09-21 KR KR1020127007802A patent/KR101823699B1/ko active Active
- 2010-09-21 LT LTEP10819152.9T patent/LT2462246T/lt unknown
- 2010-09-21 EP EP17186130.5A patent/EP3323423B1/en active Active
- 2010-09-21 KR KR1020147036345A patent/KR20150006083A/ko not_active Ceased
- 2010-09-21 EP EP10819152.9A patent/EP2462246B1/en active Active
- 2010-09-21 CN CN201410482045.7A patent/CN104323981B/zh not_active Expired - Fee Related
- 2010-09-21 SI SI201031593T patent/SI2462246T1/en unknown
- 2010-09-21 RU RU2012110926/14A patent/RU2547990C2/ru active
- 2010-09-21 MX MX2012003680A patent/MX352878B/es active IP Right Grant
- 2010-09-21 SM SM20170583T patent/SMT201700583T1/it unknown
- 2010-09-21 CN CN201080042868.8A patent/CN102686741B/zh not_active Expired - Fee Related
- 2010-09-21 MX MX2017004990A patent/MX378797B/es unknown
- 2010-09-21 AU AU2010298733A patent/AU2010298733B2/en not_active Ceased
- 2010-09-21 PL PL10819152T patent/PL2462246T3/pl unknown
- 2010-09-21 CA CA2775676A patent/CA2775676C/en active Active
- 2010-09-21 RU RU2015107870A patent/RU2753280C2/ru active
- 2010-09-21 US US12/924,175 patent/US8298561B2/en active Active
- 2010-09-21 WO PCT/US2010/002591 patent/WO2011037623A1/en not_active Ceased
- 2010-09-21 HR HRP20171801TT patent/HRP20171801T1/hr unknown
- 2010-09-21 PT PT108191529T patent/PT2462246T/pt unknown
- 2010-09-21 EP EP20179817.0A patent/EP3735944A1/en not_active Withdrawn
- 2010-09-21 KR KR1020197023817A patent/KR102148624B1/ko not_active Expired - Fee Related
- 2010-09-21 KR KR1020197003513A patent/KR102093612B1/ko active Active
- 2010-09-21 NO NO10819152A patent/NO2462246T3/no unknown
- 2010-09-21 NZ NZ747990A patent/NZ747990A/en not_active IP Right Cessation
- 2010-09-21 NZ NZ624569A patent/NZ624569A/en not_active IP Right Cessation
- 2010-09-21 HU HUE10819152A patent/HUE035862T2/en unknown
- 2010-09-21 CN CN201710980889.8A patent/CN107638562B/zh not_active Expired - Fee Related
-
2012
- 2012-03-15 IL IL218648A patent/IL218648A/en active IP Right Grant
- 2012-03-27 MX MX2021000241A patent/MX2021000241A/es unknown
- 2012-10-04 US US13/645,422 patent/US20130030417A1/en not_active Abandoned
-
2014
- 2014-09-04 RU RU2014136091A patent/RU2703471C2/ru active
- 2014-10-10 JP JP2014209225A patent/JP6502643B2/ja active Active
-
2016
- 2016-08-12 AU AU2016213867A patent/AU2016213867B2/en not_active Ceased
- 2016-08-22 US US15/242,732 patent/US10231923B2/en active Active
- 2016-12-07 JP JP2016237525A patent/JP6517777B2/ja active Active
-
2017
- 2017-08-14 IL IL253982A patent/IL253982B/en active IP Right Grant
- 2017-11-22 CY CY20171101224T patent/CY1119649T1/el unknown
-
2018
- 2018-03-05 AU AU2018201551A patent/AU2018201551B2/en not_active Ceased
- 2018-07-06 US US16/029,232 patent/US10869830B2/en not_active Expired - Fee Related
- 2018-07-12 JP JP2018132384A patent/JP2018168195A/ja active Pending
-
2019
- 2019-04-28 IL IL266254A patent/IL266254B/en unknown
- 2019-10-24 JP JP2019193440A patent/JP6835933B2/ja active Active
- 2019-10-31 AU AU2019257489A patent/AU2019257489B2/en not_active Ceased
-
2020
- 2020-12-14 US US17/121,359 patent/US12042557B2/en active Active
-
2021
- 2021-02-04 JP JP2021016605A patent/JP7187592B2/ja active Active
- 2021-09-09 IL IL286217A patent/IL286217B2/en unknown
-
2022
- 2022-04-20 AU AU2022202622A patent/AU2022202622A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ598686A (en) | Rapid establishment and/or termination of substantial steady-state drug delivery | |
| Yang et al. | Phase‐transition microneedle patches for efficient and accurate transdermal delivery of insulin | |
| JP2015024174A5 (enExample) | ||
| AU2007266475B2 (en) | Two-piece, internal-channel osmotic delivery system flow modulator | |
| MX349176B (es) | Suministro transdermico de farmaco empleando un osmolito y un agente vasoactivo. | |
| EA201270379A1 (ru) | Имплантируемое устройство для контролируемой доставки лекарства | |
| WO2009104175A3 (en) | Use of electrospun microtubes for drug delivery | |
| EP2422798A3 (en) | Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation | |
| CN105744983A (zh) | 用于缓释在增溶剂中的低水溶性治疗剂的装置和方法 | |
| EA201591560A1 (ru) | Инъекционная композиция с контролируемым высвобождением, содержащая жидкий носитель с высокой вязкостью | |
| JP2010517621A (ja) | 治療用ハイブリッド移植型デバイス | |
| RU2016120644A (ru) | Элюирующая матрица и ее применения | |
| CN112312946A (zh) | 具有抑制氧气渗透的医疗递送设备 | |
| CN104203220A (zh) | 缓慢释放治疗剂的装置和方法 | |
| EP3277234A1 (fr) | Dispositif de distribution de liquide hors d'un flacon de conditionnement stérile | |
| KR102610991B1 (ko) | 경피 약물 전달을 위한 마이크로니들 패치 시스템 | |
| RU2017129375A (ru) | Интестинальный гель на основе леводопы и карбидопы и способы его применения | |
| WO2013112734A1 (en) | Sustained drug delivery from solid implants with nanochannel membranes | |
| HRP20151321T1 (hr) | Epalrestat ili njegov derivat u oblicima s prilagođenim otpuštanjem te postupci uporabe istih | |
| NZ731923A (en) | Rapid establishment and/or termination of substantial steady-state drug delivery | |
| EP3285836B1 (de) | Primärpackmittel und verfahren zur herstellung eines primärpackmittels | |
| KR102494543B1 (ko) | Ｈｐｖ 백신 전달용 용해성 미세바늘 패치 | |
| RU2011137413A (ru) | Применение кардиотрофина-1 для лечения метаболических заболеваний | |
| KR20170043429A (ko) | 자성성분을 함유하는 용해성 마이크로니들 패치 | |
| RU2021122069A (ru) | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2015 BY COMPUTER PACKAGES INC Effective date: 20141218 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2016 BY COMPUTER PACKAGES INC Effective date: 20150901 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2017 BY COMPUTER PACKAGES INC Effective date: 20160831 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2018 BY COMPUTER PACKAGES INC Effective date: 20170831 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2019 BY COMPUTER PACKAGES INC Effective date: 20180831 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2020 BY COMPUTER PACKAGES INC Effective date: 20190831 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2021 BY COMPUTER PACKAGES INC Effective date: 20200901 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2022 BY COMPUTER PACKAGES INC Effective date: 20210830 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2023 BY COMPUTER PACKAGES INC Effective date: 20220830 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 21 SEP 2024 BY COMPUTER PACKAGES INC Effective date: 20230830 |
|
| LAPS | Patent lapsed |