NZ583844A - Maytansinoid conjugates linked via a non-cleavable linker - Google Patents

Maytansinoid conjugates linked via a non-cleavable linker

Info

Publication number
NZ583844A
NZ583844A NZ583844A NZ58384404A NZ583844A NZ 583844 A NZ583844 A NZ 583844A NZ 583844 A NZ583844 A NZ 583844A NZ 58384404 A NZ58384404 A NZ 58384404A NZ 583844 A NZ583844 A NZ 583844A
Authority
NZ
New Zealand
Prior art keywords
antibody
ester
cell
maytansinoid
dml
Prior art date
Application number
NZ583844A
Other languages
English (en)
Inventor
Rita Steeves
Ravi Chari
Hongsheng Xie
Yelena Kovtun
Robert Lutz
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34467962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ583844(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of NZ583844A publication Critical patent/NZ583844A/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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NZ583844A 2003-10-10 2004-10-12 Maytansinoid conjugates linked via a non-cleavable linker NZ583844A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US10/960,602 US8088387B2 (en) 2003-10-10 2004-10-08 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

Publications (1)

Publication Number Publication Date
NZ583844A true NZ583844A (en) 2011-06-30

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ID=34467962

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ583844A NZ583844A (en) 2003-10-10 2004-10-12 Maytansinoid conjugates linked via a non-cleavable linker
NZ545195A NZ545195A (en) 2003-10-10 2004-10-12 Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates

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CN107198778A (zh) 2017-09-26
PL1689846T3 (pl) 2013-07-31
JP2016135786A (ja) 2016-07-28
CA3237922A1 (en) 2005-04-28
EP1689846A2 (en) 2006-08-16
LU92336I2 (fr) 2014-02-17
NZ545195A (en) 2010-07-30
KR101476082B1 (ko) 2014-12-23
AU2004282491A1 (en) 2005-04-28
EP2596804A2 (en) 2013-05-29
KR20060130552A (ko) 2006-12-19
EP2596804A3 (en) 2013-09-18
WO2005037992A2 (en) 2005-04-28
HK1244452A1 (zh) 2018-08-10
JP2017200934A (ja) 2017-11-09
JP2024059792A (ja) 2024-05-01
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CA3139478A1 (en) 2005-04-28
US8563509B2 (en) 2013-10-22
AU2010212291A1 (en) 2010-09-02
LU92336I9 (enExample) 2019-01-16
EA010508B1 (ru) 2008-10-30
BRPI0415448A (pt) 2006-12-05
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JP2012006928A (ja) 2012-01-12
IL246605A (en) 2017-08-31
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CN108578710B (zh) 2021-11-19
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IL235253B (en) 2018-04-30
US20120226025A1 (en) 2012-09-06
BRPI0415448A8 (pt) 2019-08-13
JP5718745B2 (ja) 2015-05-13
US20080114153A1 (en) 2008-05-15
KR20130102649A (ko) 2013-09-17
US8198417B2 (en) 2012-06-12
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JP2014177463A (ja) 2014-09-25
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WO2005037992A3 (en) 2009-04-23
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US7989598B2 (en) 2011-08-02
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IL173625A0 (en) 2006-07-05
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US10844135B2 (en) 2020-11-24
CA2542128C (en) 2022-01-11
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US20050169933A1 (en) 2005-08-04
US8685920B2 (en) 2014-04-01
KR20140033003A (ko) 2014-03-17
US20140154804A1 (en) 2014-06-05
FR13C0068I1 (enExample) 2014-01-17
KR101573124B1 (ko) 2015-12-01
SI1689846T1 (en) 2013-06-28
EP2612682A2 (en) 2013-07-10
DK1689846T3 (da) 2013-05-06
JP5926759B2 (ja) 2016-05-25
ECSP066461A (es) 2007-05-30
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IL173625A (en) 2016-07-31
CN108578710A (zh) 2018-09-28
AU2010212291B2 (en) 2012-05-24
EA200600752A1 (ru) 2007-08-31
BE2013C075I2 (enExample) 2023-12-18
JP2019142864A (ja) 2019-08-29
EP2596803A2 (en) 2013-05-29
US20110281856A1 (en) 2011-11-17
US20210261683A1 (en) 2021-08-26
CN103223174A (zh) 2013-07-31
US20080171865A1 (en) 2008-07-17
EP2612682A3 (en) 2013-09-25
US8163888B2 (en) 2012-04-24
US8088387B2 (en) 2012-01-03
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