ES2404304T3 - Conjugados de maitansinoide DM1 con anticuerpo trastuzumab, unidos mediante un conector no escindible, y su uso en el tratamiento de tumores - Google Patents

Conjugados de maitansinoide DM1 con anticuerpo trastuzumab, unidos mediante un conector no escindible, y su uso en el tratamiento de tumores Download PDF

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Publication number
ES2404304T3
ES2404304T3 ES04793896T ES04793896T ES2404304T3 ES 2404304 T3 ES2404304 T3 ES 2404304T3 ES 04793896 T ES04793896 T ES 04793896T ES 04793896 T ES04793896 T ES 04793896T ES 2404304 T3 ES2404304 T3 ES 2404304T3
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Prior art keywords
maitansinoid
conjugate
antibody
smcc
cleavable
Prior art date
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Expired - Lifetime
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ES04793896T
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English (en)
Spanish (es)
Inventor
Rita Steeves
Robert Lutz
Ravi Chari
Hongsheng Xie
Yelena Kovtun
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Immunogen Inc
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Immunogen Inc
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Application filed by Immunogen Inc filed Critical Immunogen Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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ES04793896T 2003-10-10 2004-10-12 Conjugados de maitansinoide DM1 con anticuerpo trastuzumab, unidos mediante un conector no escindible, y su uso en el tratamiento de tumores Expired - Lifetime ES2404304T3 (es)

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US7989598B2 (en) 2011-08-02
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LU92336I2 (fr) 2014-02-17
EP2596804A2 (en) 2013-05-29
JP2016135786A (ja) 2016-07-28
US20140154804A1 (en) 2014-06-05
US8563509B2 (en) 2013-10-22
US8198417B2 (en) 2012-06-12
CY1113984T1 (el) 2016-07-27
AU2004282491A1 (en) 2005-04-28
CA2542128C (en) 2022-01-11
CN103223174A (zh) 2013-07-31
EP2612682A3 (en) 2013-09-25
WO2005037992A3 (en) 2009-04-23
AU2010212291A1 (en) 2010-09-02
US10844135B2 (en) 2020-11-24
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JP2014177463A (ja) 2014-09-25
CA3139478A1 (en) 2005-04-28
US8685920B2 (en) 2014-04-01
NZ583844A (en) 2011-06-30
BE2013C075I2 (enExample) 2023-12-18
KR101476082B1 (ko) 2014-12-23
CN107198778A (zh) 2017-09-26
US8163888B2 (en) 2012-04-24
EA010508B1 (ru) 2008-10-30
JP5926759B2 (ja) 2016-05-25
JP2019011363A (ja) 2019-01-24
CN108578710A (zh) 2018-09-28
FR13C0068I1 (enExample) 2014-01-17
JP5718745B2 (ja) 2015-05-13
AU2010212291C1 (en) 2012-11-29
US20120226025A1 (en) 2012-09-06
ECSP066461A (es) 2007-05-30
US8088387B2 (en) 2012-01-03
JP2024059792A (ja) 2024-05-01
KR101573124B1 (ko) 2015-12-01
PL1689846T3 (pl) 2013-07-31
HUS1300075I1 (hu) 2014-02-28
IL246605A (en) 2017-08-31
KR20060130552A (ko) 2006-12-19
IL214788A0 (en) 2011-11-30
NZ545195A (en) 2010-07-30
US20050169933A1 (en) 2005-08-04
AU2004282491C1 (en) 2011-06-30
JP2020189854A (ja) 2020-11-26
US20170226220A1 (en) 2017-08-10
US20080171865A1 (en) 2008-07-17
CY2014002I2 (el) 2020-05-29
IL173625A0 (en) 2006-07-05
CA2542128A1 (en) 2005-04-28
KR101343676B1 (ko) 2013-12-20
WO2005037992A2 (en) 2005-04-28
US20080114153A1 (en) 2008-05-15
EP2596804A3 (en) 2013-09-18
KR20140033003A (ko) 2014-03-17
EP2596803A2 (en) 2013-05-29
US20210261683A1 (en) 2021-08-26
PT1689846E (pt) 2013-05-08
JP2007520450A (ja) 2007-07-26
NO2016001I2 (no) 2016-01-26
CN108578710B (zh) 2021-11-19
JP2019142864A (ja) 2019-08-29
EP2612682A2 (en) 2013-07-10
CY2014002I1 (el) 2020-05-29
US20080145374A1 (en) 2008-06-19
US20080171856A1 (en) 2008-07-17
EP1689846A2 (en) 2006-08-16
HK1244452A1 (zh) 2018-08-10
NO337458B1 (no) 2016-04-18
DK1689846T3 (da) 2013-05-06
US20110281856A1 (en) 2011-11-17
IL235253B (en) 2018-04-30
JP2012006928A (ja) 2012-01-12
EP1689846A4 (en) 2010-08-04
FR13C0068I2 (fr) 2014-04-11
JP2017200934A (ja) 2017-11-09
LU92336I9 (enExample) 2019-01-16
SI1689846T1 (en) 2013-06-28
CA3237922A1 (en) 2005-04-28
KR20120034800A (ko) 2012-04-12
IL173625A (en) 2016-07-31
KR20130102649A (ko) 2013-09-17
EP1689846B1 (en) 2013-03-27
NO2016001I1 (no) 2016-01-26
EP2596803A3 (en) 2013-09-11

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