BR112017001588A2 - conjugados de anticorpo/fármaco anti-cdh6 - Google Patents

conjugados de anticorpo/fármaco anti-cdh6

Info

Publication number
BR112017001588A2
BR112017001588A2 BR112017001588A BR112017001588A BR112017001588A2 BR 112017001588 A2 BR112017001588 A2 BR 112017001588A2 BR 112017001588 A BR112017001588 A BR 112017001588A BR 112017001588 A BR112017001588 A BR 112017001588A BR 112017001588 A2 BR112017001588 A2 BR 112017001588A2
Authority
BR
Brazil
Prior art keywords
drug conjugates
cdh6 antibody
antibody
cdh6
relates
Prior art date
Application number
BR112017001588A
Other languages
English (en)
Inventor
Uli Bialucha Carl
Dürr Clemens
Jo Janatpour Mary
John Meyer Matthew
Collins Scott
Hu Tiancen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112017001588A2 publication Critical patent/BR112017001588A2/pt

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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Abstract

a presente invenção se refere a anticorpos anti-cdh6, fragmentos de anticorpo, conjugados de anticorpo/fármaco e seus usos para o tratamento de câncer.
BR112017001588A 2014-08-12 2015-08-07 conjugados de anticorpo/fármaco anti-cdh6 BR112017001588A2 (pt)

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PE20170903A1 (es) 2017-07-12
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AP2017009719A0 (en) 2017-01-31
MA40513A (fr) 2017-06-21
UY36266A (es) 2016-04-01
ECSP17011657A (es) 2018-03-31
SG11201700254QA (en) 2017-02-27
US20170224836A1 (en) 2017-08-10
TW201613643A (en) 2016-04-16
MX2017001946A (es) 2017-06-19
AU2015302959B2 (en) 2018-09-20
US20160046711A1 (en) 2016-02-18
EP3180360A1 (en) 2017-06-21
PH12017500002A1 (en) 2017-05-15
NI201700016A (es) 2017-03-08
JP2017524364A (ja) 2017-08-31
US10238748B2 (en) 2019-03-26
CL2017000170A1 (es) 2017-07-14
DOP2017000045A (es) 2017-05-15
CO2017001191A2 (es) 2017-04-28
US9982045B2 (en) 2018-05-29
KR20170040249A (ko) 2017-04-12
EA201790334A1 (ru) 2017-06-30
CU20170014A7 (es) 2017-04-05
CN106659790A (zh) 2017-05-10
AU2015302959A1 (en) 2017-02-02
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CA2954599A1 (en) 2016-02-18
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