CU20170014A7 - Conjugados de fármacos con anticuerpos anti-cdh6 - Google Patents

Conjugados de fármacos con anticuerpos anti-cdh6

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Publication number
CU20170014A7
CU20170014A7 CUP2017000014A CU20170014A CU20170014A7 CU 20170014 A7 CU20170014 A7 CU 20170014A7 CU P2017000014 A CUP2017000014 A CU P2017000014A CU 20170014 A CU20170014 A CU 20170014A CU 20170014 A7 CU20170014 A7 CU 20170014A7
Authority
CU
Cuba
Prior art keywords
conjugates
drugs
antibodies
cdh6 antibodies
cdh6
Prior art date
Application number
CUP2017000014A
Other languages
English (en)
Inventor
Carl Uli Bialucha
Scott Collins
Clemens Dürr
Tiancen Hu
Mary Jo Janatpour
Matthew John Meyer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20170014A7 publication Critical patent/CU20170014A7/es

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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6869Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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Abstract

La presente invención se refiere a anticuerpos anti-CDH6, fragmentos de anticuerpos, conjugados de fármacos con anticuerpos, y sus usos para el tratamiento del cáncer.
CUP2017000014A 2014-08-12 2017-02-10 Conjugados de fármacos con anticuerpos anti-cdh6 CU20170014A7 (es)

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CN106659790A (zh) 2017-05-10
PE20170903A1 (es) 2017-07-12
WO2016024195A1 (en) 2016-02-18
MA40513A (fr) 2017-06-21
CL2017000170A1 (es) 2017-07-14
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US20170224836A1 (en) 2017-08-10
UY36266A (es) 2016-04-01
EP3180360A1 (en) 2017-06-21
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US9982045B2 (en) 2018-05-29
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DOP2017000045A (es) 2017-05-15
US10238748B2 (en) 2019-03-26
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