NZ576851A - Boronic acids and esters as inhibitors of fatty acid amide hydrolase - Google Patents
Boronic acids and esters as inhibitors of fatty acid amide hydrolaseInfo
- Publication number
- NZ576851A NZ576851A NZ576851A NZ57685107A NZ576851A NZ 576851 A NZ576851 A NZ 576851A NZ 576851 A NZ576851 A NZ 576851A NZ 57685107 A NZ57685107 A NZ 57685107A NZ 576851 A NZ576851 A NZ 576851A
- Authority
- NZ
- New Zealand
- Prior art keywords
- disorder
- acid
- conditions
- phenylboronic acid
- esters
- Prior art date
Links
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 title 1
- 125000005620 boronic acid group Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 abstract 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 abstract 2
- HNMYSSCCYZGAFK-UHFFFAOYSA-N (4-benzylsulfonylphenyl)boronic acid Chemical compound C1=CC(B(O)O)=CC=C1S(=O)(=O)CC1=CC=CC=C1 HNMYSSCCYZGAFK-UHFFFAOYSA-N 0.000 abstract 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000005695 Ammonium acetate Substances 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 102100027297 Fatty acid 2-hydroxylase Human genes 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 101000937693 Homo sapiens Fatty acid 2-hydroxylase Proteins 0.000 abstract 1
- 101000918494 Homo sapiens Fatty-acid amide hydrolase 1 Proteins 0.000 abstract 1
- 208000016285 Movement disease Diseases 0.000 abstract 1
- WDPDXLNTUAMJTH-UHFFFAOYSA-N [3-[3-(trifluoromethyl)phenyl]phenyl]methylboronic acid Chemical compound OB(O)CC1=CC=CC(C=2C=C(C=CC=2)C(F)(F)F)=C1 WDPDXLNTUAMJTH-UHFFFAOYSA-N 0.000 abstract 1
- NVVIPBQBVPAHJK-UHFFFAOYSA-N [4-(3-fluorophenoxy)-2-phenylmethoxycarbonylphenyl]boronic acid Chemical compound C1=C(C(=O)OCC=2C=CC=CC=2)C(B(O)O)=CC=C1OC1=CC=CC(F)=C1 NVVIPBQBVPAHJK-UHFFFAOYSA-N 0.000 abstract 1
- VGUKNUREMQVJPS-UHFFFAOYSA-N [4-(phenylsulfanylmethyl)phenyl]boronic acid Chemical compound C1=CC(B(O)O)=CC=C1CSC1=CC=CC=C1 VGUKNUREMQVJPS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229940043376 ammonium acetate Drugs 0.000 abstract 1
- 235000019257 ammonium acetate Nutrition 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 150000001543 aryl boronic acids Chemical class 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000004634 feeding behavior Effects 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004112 neuroprotection Effects 0.000 abstract 1
- 238000006400 oxidative hydrolysis reaction Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 208000020685 sleep-wake disease Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85052006P | 2006-10-10 | 2006-10-10 | |
| PCT/US2007/021626 WO2008063300A2 (en) | 2006-10-10 | 2007-10-10 | Boronic acids and esters as inhibitors of fatty acid amide hydrolase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ576851A true NZ576851A (en) | 2012-09-28 |
Family
ID=39323893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ576851A NZ576851A (en) | 2006-10-10 | 2007-10-10 | Boronic acids and esters as inhibitors of fatty acid amide hydrolase |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US7947663B2 (https=) |
| EP (4) | EP2399584A1 (https=) |
| JP (2) | JP5641600B2 (https=) |
| KR (2) | KR20150038363A (https=) |
| CN (2) | CN104230971B (https=) |
| AR (1) | AR063165A1 (https=) |
| AT (1) | ATE524188T1 (https=) |
| AU (1) | AU2007322268B2 (https=) |
| BR (1) | BRPI0719218A2 (https=) |
| CA (1) | CA2666224C (https=) |
| CL (1) | CL2007002910A1 (https=) |
| DK (1) | DK2073816T3 (https=) |
| ES (1) | ES2373697T3 (https=) |
| IL (2) | IL197932A (https=) |
| JO (1) | JO3598B1 (https=) |
| MX (1) | MX2009003727A (https=) |
| NO (1) | NO342439B1 (https=) |
| NZ (1) | NZ576851A (https=) |
| PE (1) | PE20081172A1 (https=) |
| PH (1) | PH12012500765A1 (https=) |
| PT (1) | PT2073816E (https=) |
| RU (1) | RU2492174C2 (https=) |
| SG (3) | SG175608A1 (https=) |
| TW (1) | TWI451870B (https=) |
| UA (1) | UA101601C2 (https=) |
| WO (1) | WO2008063300A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| DK2076508T3 (da) | 2006-10-18 | 2011-02-21 | Pfizer Prod Inc | Biaryl-ether-urinstof-forbindelser |
| TW201000107A (en) * | 2008-04-09 | 2010-01-01 | Infinity Pharmaceuticals Inc | Inhibitors of fatty acid amide hydrolase |
| JP5657566B2 (ja) * | 2008-12-24 | 2015-01-21 | バイアル ポルテラ アンド シーエイ エス エイＢＩＡＬ−Ｐｏｒｔｅｌａ ＆ Ｃａ， Ｓ．Ａ． | 医薬品 |
| US20100222381A1 (en) | 2009-02-27 | 2010-09-02 | Hariprasad Vankayalapati | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors |
| CA2757622A1 (en) * | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| WO2010118155A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| US9062116B2 (en) | 2009-04-23 | 2015-06-23 | Infinity Pharmaceuticals, Inc. | Anti-fatty acid amide hydrolase-2 antibodies and uses thereof |
| US8927551B2 (en) | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US9149465B2 (en) | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| AR076687A1 (es) * | 2009-05-18 | 2011-06-29 | Infinity Pharmaceuticals Inc | Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen |
| US8765735B2 (en) | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| WO2011085216A2 (en) | 2010-01-08 | 2011-07-14 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating parkinson's disease and restless legs syndrome |
| MX361692B (es) * | 2010-02-03 | 2018-12-13 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de ácido graso. |
| WO2011123719A2 (en) | 2010-03-31 | 2011-10-06 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating abdominal, visceral and pelvic pain |
| EP2575823A1 (en) * | 2010-05-31 | 2013-04-10 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | 3-substituted vinylboronates and uses thereof |
| JP5719028B2 (ja) | 2010-10-06 | 2015-05-13 | グラクソスミスクライン エルエルシー | Ｐｉ３キナーゼ阻害剤としてのベンズイミダゾール誘導体 |
| WO2012112670A1 (en) * | 2011-02-16 | 2012-08-23 | Albert Einstein College Of Medicine Of Yeshiva University | Novel lipogenic inhibitors and uses thereof |
| WO2013049332A1 (en) * | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
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