MX353203B - Metodo para producir un derivado heterociclico fenilo sustituido por medio del metodo de acoplamiento utilizando un compuesto paladio. - Google Patents
Metodo para producir un derivado heterociclico fenilo sustituido por medio del metodo de acoplamiento utilizando un compuesto paladio.Info
- Publication number
- MX353203B MX353203B MX2013001768A MX2013001768A MX353203B MX 353203 B MX353203 B MX 353203B MX 2013001768 A MX2013001768 A MX 2013001768A MX 2013001768 A MX2013001768 A MX 2013001768A MX 353203 B MX353203 B MX 353203B
- Authority
- MX
- Mexico
- Prior art keywords
- palladium compound
- substituted heterocyclic
- heterocyclic derivative
- formula
- producing phenyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención proporciona un método para producir un inhibidor de xantina oxidasa, que es un agente terapéutico para la hiperuricemia, o intermediarios del mismo, el método que es eficiente y que utiliza un procedimiento corto. La presente invención es un método de acoplamiento novedoso para obtener un compuesto representado por la fórmula (3) provocando una reacción de acoplamiento entre un compuesto representado por la fórmula (1) y un compuesto representado por la fórmula (2), en la presencia de un compuesto de paladio, un ligando obtenido por la coordinación en un compuesto de paladio, una base, un ácido carboxílico de C1-C40, y por lo menos una clase de aditivo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010190760 | 2010-08-27 | ||
| PCT/JP2011/069250 WO2012026565A1 (ja) | 2010-08-27 | 2011-08-26 | パラジウム化合物を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013001768A MX2013001768A (es) | 2013-03-22 |
| MX353203B true MX353203B (es) | 2018-01-05 |
Family
ID=45723554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013001768A MX353203B (es) | 2010-08-27 | 2011-08-26 | Metodo para producir un derivado heterociclico fenilo sustituido por medio del metodo de acoplamiento utilizando un compuesto paladio. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8916714B2 (es) |
| EP (1) | EP2610248B1 (es) |
| JP (1) | JP5654601B2 (es) |
| KR (1) | KR101800054B1 (es) |
| CN (1) | CN103068807B (es) |
| AU (1) | AU2011294204B2 (es) |
| BR (1) | BR112013003992B1 (es) |
| CA (1) | CA2807543C (es) |
| DK (1) | DK2610248T3 (es) |
| ES (1) | ES2589977T3 (es) |
| HK (1) | HK1179960A1 (es) |
| HU (1) | HUE030166T2 (es) |
| IL (1) | IL224923A (es) |
| MX (1) | MX353203B (es) |
| PL (1) | PL2610248T3 (es) |
| PT (1) | PT2610248T (es) |
| RU (1) | RU2563459C2 (es) |
| SG (1) | SG187843A1 (es) |
| TW (1) | TWI554505B (es) |
| WO (1) | WO2012026565A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5312570B2 (ja) | 2009-02-27 | 2013-10-09 | 帝人ファーマ株式会社 | 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
| RU2016148736A (ru) * | 2014-05-13 | 2018-06-14 | Тейдзин Фарма Лимитед | Новые кристаллические полиморфы производного пиридина и способ их получения |
| CN110156698B (zh) * | 2019-06-06 | 2020-10-13 | 沈阳海诺威医药科技有限公司 | 2-苯基-1，6-二氢嘧啶-5-甲酸衍生物的制备方法和用途 |
| CN110683926B (zh) * | 2019-09-29 | 2022-11-04 | 北京大学深圳研究生院 | 羧酸芳基酯类化合物的制备方法 |
| CN110698431B (zh) * | 2019-11-20 | 2022-07-01 | 陕西师范大学 | 一种1,2-苯并噻嗪类化合物的合成方法 |
| CN113731406B (zh) * | 2021-10-12 | 2023-07-28 | 南京工业大学 | 一种提高钯碳活性加氢脱除保护基的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346094A (en) | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| US4495195A (en) | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| DE122008000051I1 (de) | 1990-11-30 | 2009-02-05 | Teijin Ltd | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
| JP3399559B2 (ja) | 1992-08-12 | 2003-04-21 | 帝人株式会社 | ２−フェニル複素環式化合物 |
| JP3113110B2 (ja) | 1993-01-19 | 2000-11-27 | 帝人株式会社 | イソキサゾールおよびイソチアゾール誘導体 |
| JP3169735B2 (ja) | 1993-04-08 | 2001-05-28 | 帝人株式会社 | （アルコキシシアノフェニル）チアゾール誘導体の製造方法 |
| JP2706037B2 (ja) | 1993-04-13 | 1998-01-28 | 帝人株式会社 | シアノ化合物およびその製造方法 |
| JP2834971B2 (ja) | 1993-05-25 | 1998-12-14 | 帝人株式会社 | ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法およびその新規製造中間体 |
| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JPH10139770A (ja) | 1996-11-08 | 1998-05-26 | Teijin Ltd | ２−（３−シアノフェニル）チアゾール誘導体の製造法 |
| JPH10310578A (ja) | 1996-11-13 | 1998-11-24 | Yoshitomi Pharmaceut Ind Ltd | ３−フェニルピラゾール化合物 |
| JP3440196B2 (ja) | 1997-08-13 | 2003-08-25 | 帝人株式会社 | チオベンズアミド誘導体の製造方法 |
| JP2003523388A (ja) | 2000-02-23 | 2003-08-05 | アルテオン インコーポレーテッド | チアゾリウム化合物及びタンパク質老化に関連する障害の治療 |
| WO2002051849A1 (fr) | 2000-12-26 | 2002-07-04 | Daiichi Pharmaceutical Co., Ltd. | Inhibiteurs cdk4 |
| WO2004069394A2 (en) | 2003-02-03 | 2004-08-19 | The Trustees Of Columbia University In The City Of New York | Synthetic method for direct arylation of heterocyclic arenes |
| MXPA05008450A (es) * | 2003-02-10 | 2005-10-18 | Vertex Pharma | Procesos para la preparacion de n-heteroaril-n-aril-aminas mediante reaccion de un ester de acido n-aril-carbamico con un halo-heteroarilo y procesos analogos. |
| RU2006111093A (ru) | 2003-09-06 | 2007-10-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы атр-связывающих кассетных транспортеров |
| BRPI0507278A (pt) | 2004-01-30 | 2007-06-26 | Vertex Pharma | moduladores dos transportadores do cassete de ligação ao atp |
| GB0402262D0 (en) * | 2004-02-02 | 2004-03-10 | Novartis Ag | Process for the manufacture of organic compounds |
| EP1992361B1 (en) | 2006-02-24 | 2012-05-02 | Astellas Pharma Inc. | Remedy or preventive for digestive ulcer |
| JP5312570B2 (ja) * | 2009-02-27 | 2013-10-09 | 帝人ファーマ株式会社 | 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
-
2011
- 2011-08-26 EP EP11820025.2A patent/EP2610248B1/en active Active
- 2011-08-26 CN CN201180041695.2A patent/CN103068807B/zh active Active
- 2011-08-26 RU RU2013113576/04A patent/RU2563459C2/ru active
- 2011-08-26 PL PL11820025.2T patent/PL2610248T3/pl unknown
- 2011-08-26 WO PCT/JP2011/069250 patent/WO2012026565A1/ja active Application Filing
- 2011-08-26 JP JP2012530728A patent/JP5654601B2/ja active Active
- 2011-08-26 AU AU2011294204A patent/AU2011294204B2/en active Active
- 2011-08-26 US US13/818,538 patent/US8916714B2/en active Active
- 2011-08-26 DK DK11820025.2T patent/DK2610248T3/en active
- 2011-08-26 HU HUE11820025A patent/HUE030166T2/en unknown
- 2011-08-26 SG SG2013010954A patent/SG187843A1/en unknown
- 2011-08-26 BR BR112013003992-2A patent/BR112013003992B1/pt active IP Right Grant
- 2011-08-26 KR KR1020137007451A patent/KR101800054B1/ko active IP Right Grant
- 2011-08-26 MX MX2013001768A patent/MX353203B/es active IP Right Grant
- 2011-08-26 TW TW100130694A patent/TWI554505B/zh active
- 2011-08-26 ES ES11820025.2T patent/ES2589977T3/es active Active
- 2011-08-26 CA CA2807543A patent/CA2807543C/en active Active
- 2011-08-26 PT PT118200252T patent/PT2610248T/pt unknown
-
2013
- 2013-02-26 IL IL224923A patent/IL224923A/en active IP Right Grant
- 2013-06-19 HK HK13107170.2A patent/HK1179960A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011294204B2 (en) | 2015-07-23 |
| ES2589977T3 (es) | 2016-11-17 |
| US8916714B2 (en) | 2014-12-23 |
| DK2610248T3 (en) | 2016-07-25 |
| MX2013001768A (es) | 2013-03-22 |
| US20130158272A1 (en) | 2013-06-20 |
| CN103068807B (zh) | 2016-05-25 |
| CA2807543C (en) | 2018-08-28 |
| PT2610248T (pt) | 2016-08-23 |
| EP2610248B1 (en) | 2016-06-08 |
| IL224923A (en) | 2017-07-31 |
| EP2610248A4 (en) | 2013-10-16 |
| KR101800054B1 (ko) | 2017-11-21 |
| TW201305122A (zh) | 2013-02-01 |
| AU2011294204A1 (en) | 2013-03-21 |
| HUE030166T2 (en) | 2017-05-29 |
| BR112013003992B1 (pt) | 2021-07-20 |
| CN103068807A (zh) | 2013-04-24 |
| PL2610248T3 (pl) | 2016-12-30 |
| RU2563459C2 (ru) | 2015-09-20 |
| JPWO2012026565A1 (ja) | 2013-10-28 |
| WO2012026565A1 (ja) | 2012-03-01 |
| EP2610248A1 (en) | 2013-07-03 |
| RU2013113576A (ru) | 2014-10-10 |
| HK1179960A1 (zh) | 2013-10-11 |
| KR20130138219A (ko) | 2013-12-18 |
| SG187843A1 (en) | 2013-03-28 |
| JP5654601B2 (ja) | 2015-01-14 |
| CA2807543A1 (en) | 2012-03-01 |
| BR112013003992A2 (pt) | 2016-07-12 |
| TWI554505B (zh) | 2016-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |