PL2610248T3 - Sposób wytwarzania podstawionych fenylem pochodnych heterocyklicznych metodą sprzęgania z użyciem związku palladu - Google Patents
Sposób wytwarzania podstawionych fenylem pochodnych heterocyklicznych metodą sprzęgania z użyciem związku palladuInfo
- Publication number
- PL2610248T3 PL2610248T3 PL11820025.2T PL11820025T PL2610248T3 PL 2610248 T3 PL2610248 T3 PL 2610248T3 PL 11820025 T PL11820025 T PL 11820025T PL 2610248 T3 PL2610248 T3 PL 2610248T3
- Authority
- PL
- Poland
- Prior art keywords
- substituted heterocyclic
- palladium compound
- heterocyclic derivative
- producing phenyl
- coupling method
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/26—Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups B01J31/02 - B01J31/24
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010190760 | 2010-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2610248T3 true PL2610248T3 (pl) | 2016-12-30 |
Family
ID=45723554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11820025.2T PL2610248T3 (pl) | 2010-08-27 | 2011-08-26 | Sposób wytwarzania podstawionych fenylem pochodnych heterocyklicznych metodą sprzęgania z użyciem związku palladu |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8916714B2 (pl) |
| EP (1) | EP2610248B1 (pl) |
| JP (1) | JP5654601B2 (pl) |
| KR (1) | KR101800054B1 (pl) |
| CN (1) | CN103068807B (pl) |
| AU (1) | AU2011294204B2 (pl) |
| BR (1) | BR112013003992B1 (pl) |
| CA (1) | CA2807543C (pl) |
| DK (1) | DK2610248T3 (pl) |
| ES (1) | ES2589977T3 (pl) |
| HK (1) | HK1179960A1 (pl) |
| HU (1) | HUE030166T2 (pl) |
| IL (1) | IL224923A (pl) |
| MX (1) | MX353203B (pl) |
| PL (1) | PL2610248T3 (pl) |
| PT (1) | PT2610248T (pl) |
| RU (1) | RU2563459C2 (pl) |
| SG (1) | SG187843A1 (pl) |
| TW (1) | TWI554505B (pl) |
| WO (1) | WO2012026565A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102333765B (zh) | 2009-02-27 | 2015-01-14 | 帝人制药株式会社 | 基于使用过渡金属催化剂的偶联法的苯基取代杂环衍生物的制造方法 |
| SG11201609483YA (en) * | 2014-05-13 | 2016-12-29 | Teijin Pharma Ltd | Novel crystalline polymorphs of pyridine derivative and method for producing the same |
| CN110156698B (zh) * | 2019-06-06 | 2020-10-13 | 沈阳海诺威医药科技有限公司 | 2-苯基-1，6-二氢嘧啶-5-甲酸衍生物的制备方法和用途 |
| CN110683926B (zh) * | 2019-09-29 | 2022-11-04 | 北京大学深圳研究生院 | 羧酸芳基酯类化合物的制备方法 |
| CN110698431B (zh) * | 2019-11-20 | 2022-07-01 | 陕西师范大学 | 一种1,2-苯并噻嗪类化合物的合成方法 |
| CN113731406B (zh) * | 2021-10-12 | 2023-07-28 | 南京工业大学 | 一种提高钯碳活性加氢脱除保护基的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346094A (en) | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| US4495195A (en) | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| DE122008000051I1 (de) | 1990-11-30 | 2009-02-05 | Teijin Ltd | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
| JP3399559B2 (ja) | 1992-08-12 | 2003-04-21 | 帝人株式会社 | ２−フェニル複素環式化合物 |
| JP3113110B2 (ja) | 1993-01-19 | 2000-11-27 | 帝人株式会社 | イソキサゾールおよびイソチアゾール誘導体 |
| JP3169735B2 (ja) | 1993-04-08 | 2001-05-28 | 帝人株式会社 | （アルコキシシアノフェニル）チアゾール誘導体の製造方法 |
| JP2706037B2 (ja) | 1993-04-13 | 1998-01-28 | 帝人株式会社 | シアノ化合物およびその製造方法 |
| JP2834971B2 (ja) | 1993-05-25 | 1998-12-14 | 帝人株式会社 | ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法およびその新規製造中間体 |
| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JPH10139770A (ja) | 1996-11-08 | 1998-05-26 | Teijin Ltd | ２−（３−シアノフェニル）チアゾール誘導体の製造法 |
| JPH10310578A (ja) | 1996-11-13 | 1998-11-24 | Yoshitomi Pharmaceut Ind Ltd | ３−フェニルピラゾール化合物 |
| JP3440196B2 (ja) | 1997-08-13 | 2003-08-25 | 帝人株式会社 | チオベンズアミド誘導体の製造方法 |
| KR20030016231A (ko) | 2000-02-23 | 2003-02-26 | 알테온 인크. | 티아졸륨 화합물, 및 단백질 노화와 관련된 장애의 치료 |
| JPWO2002051849A1 (ja) | 2000-12-26 | 2004-04-22 | 第一製薬株式会社 | Ｃｄｋ４活性阻害剤 |
| WO2004069394A2 (en) * | 2003-02-03 | 2004-08-19 | The Trustees Of Columbia University In The City Of New York | Synthetic method for direct arylation of heterocyclic arenes |
| JP4675318B2 (ja) * | 2003-02-10 | 2011-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｎ−アリールカルバミン酸エステルとハロ−ヘテロアリールとを反応させることによるｎ−ヘテロアリール−ｎ−アリール−アミンの調製のためのプロセスおよび類似のプロセス |
| JP2007504255A (ja) | 2003-09-06 | 2007-03-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターの調節因子 |
| JP4960708B2 (ja) | 2004-01-30 | 2012-06-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| GB0402262D0 (en) * | 2004-02-02 | 2004-03-10 | Novartis Ag | Process for the manufacture of organic compounds |
| WO2007097403A1 (ja) * | 2006-02-24 | 2007-08-30 | Astellas Pharma Inc. | 消化管潰瘍治療又は予防薬 |
| CN102333765B (zh) * | 2009-02-27 | 2015-01-14 | 帝人制药株式会社 | 基于使用过渡金属催化剂的偶联法的苯基取代杂环衍生物的制造方法 |
-
2011
- 2011-08-26 PL PL11820025.2T patent/PL2610248T3/pl unknown
- 2011-08-26 JP JP2012530728A patent/JP5654601B2/ja active Active
- 2011-08-26 AU AU2011294204A patent/AU2011294204B2/en active Active
- 2011-08-26 SG SG2013010954A patent/SG187843A1/en unknown
- 2011-08-26 BR BR112013003992-2A patent/BR112013003992B1/pt active IP Right Grant
- 2011-08-26 HU HUE11820025A patent/HUE030166T2/en unknown
- 2011-08-26 KR KR1020137007451A patent/KR101800054B1/ko active IP Right Grant
- 2011-08-26 TW TW100130694A patent/TWI554505B/zh active
- 2011-08-26 WO PCT/JP2011/069250 patent/WO2012026565A1/ja active Application Filing
- 2011-08-26 US US13/818,538 patent/US8916714B2/en active Active
- 2011-08-26 CN CN201180041695.2A patent/CN103068807B/zh active Active
- 2011-08-26 ES ES11820025.2T patent/ES2589977T3/es active Active
- 2011-08-26 PT PT118200252T patent/PT2610248T/pt unknown
- 2011-08-26 EP EP11820025.2A patent/EP2610248B1/en active Active
- 2011-08-26 MX MX2013001768A patent/MX353203B/es active IP Right Grant
- 2011-08-26 DK DK11820025.2T patent/DK2610248T3/en active
- 2011-08-26 CA CA2807543A patent/CA2807543C/en active Active
- 2011-08-26 RU RU2013113576/04A patent/RU2563459C2/ru active
-
2013
- 2013-02-26 IL IL224923A patent/IL224923A/en active IP Right Grant
- 2013-06-19 HK HK13107170.2A patent/HK1179960A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2807543C (en) | 2018-08-28 |
| JPWO2012026565A1 (ja) | 2013-10-28 |
| JP5654601B2 (ja) | 2015-01-14 |
| EP2610248A1 (en) | 2013-07-03 |
| CA2807543A1 (en) | 2012-03-01 |
| ES2589977T3 (es) | 2016-11-17 |
| SG187843A1 (en) | 2013-03-28 |
| MX353203B (es) | 2018-01-05 |
| PT2610248T (pt) | 2016-08-23 |
| AU2011294204B2 (en) | 2015-07-23 |
| EP2610248A4 (en) | 2013-10-16 |
| RU2563459C2 (ru) | 2015-09-20 |
| CN103068807A (zh) | 2013-04-24 |
| AU2011294204A1 (en) | 2013-03-21 |
| TW201305122A (zh) | 2013-02-01 |
| TWI554505B (zh) | 2016-10-21 |
| DK2610248T3 (en) | 2016-07-25 |
| KR101800054B1 (ko) | 2017-11-21 |
| BR112013003992B1 (pt) | 2021-07-20 |
| MX2013001768A (es) | 2013-03-22 |
| WO2012026565A1 (ja) | 2012-03-01 |
| US20130158272A1 (en) | 2013-06-20 |
| RU2013113576A (ru) | 2014-10-10 |
| IL224923A (en) | 2017-07-31 |
| KR20130138219A (ko) | 2013-12-18 |
| CN103068807B (zh) | 2016-05-25 |
| BR112013003992A2 (pt) | 2016-07-12 |
| US8916714B2 (en) | 2014-12-23 |
| HUE030166T2 (en) | 2017-05-29 |
| EP2610248B1 (en) | 2016-06-08 |
| HK1179960A1 (zh) | 2013-10-11 |
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