PL2404908T3 - Sposób wytwarzania podstawionej fenylem pochodnej heterocyklicznej przez sprzężenie z użyciem katalizatora metalu przejściowego - Google Patents
Sposób wytwarzania podstawionej fenylem pochodnej heterocyklicznej przez sprzężenie z użyciem katalizatora metalu przejściowegoInfo
- Publication number
- PL2404908T3 PL2404908T3 PL10746307T PL10746307T PL2404908T3 PL 2404908 T3 PL2404908 T3 PL 2404908T3 PL 10746307 T PL10746307 T PL 10746307T PL 10746307 T PL10746307 T PL 10746307T PL 2404908 T3 PL2404908 T3 PL 2404908T3
- Authority
- PL
- Poland
- Prior art keywords
- coupling
- transition metal
- metal catalyst
- substituted heterocyclic
- heterocyclic derivative
- Prior art date
Links
- 239000003054 catalyst Substances 0.000 title 1
- 230000008878 coupling Effects 0.000 title 1
- 238000010168 coupling process Methods 0.000 title 1
- 238000005859 coupling reaction Methods 0.000 title 1
- 125000000623 heterocyclic group Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229910052723 transition metal Inorganic materials 0.000 title 1
- 150000003624 transition metals Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009046003 | 2009-02-27 | ||
| JP2009153770 | 2009-06-29 | ||
| EP10746307.7A EP2404908B1 (en) | 2009-02-27 | 2010-02-26 | Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst |
| PCT/JP2010/053043 WO2010098428A1 (ja) | 2009-02-27 | 2010-02-26 | 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2404908T3 true PL2404908T3 (pl) | 2014-12-31 |
Family
ID=42665632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10746307T PL2404908T3 (pl) | 2009-02-27 | 2010-02-26 | Sposób wytwarzania podstawionej fenylem pochodnej heterocyklicznej przez sprzężenie z użyciem katalizatora metalu przejściowego |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8952174B2 (pl) |
| EP (2) | EP2754658A1 (pl) |
| JP (1) | JP5312570B2 (pl) |
| KR (1) | KR101639834B1 (pl) |
| CN (1) | CN102333765B (pl) |
| AU (1) | AU2010218748B2 (pl) |
| BR (1) | BRPI1008308B8 (pl) |
| CA (1) | CA2752485C (pl) |
| DK (1) | DK2404908T3 (pl) |
| ES (1) | ES2459722T3 (pl) |
| IL (1) | IL214302A (pl) |
| MX (1) | MX2011008348A (pl) |
| PL (1) | PL2404908T3 (pl) |
| PT (1) | PT2404908E (pl) |
| RU (1) | RU2510393C9 (pl) |
| SG (1) | SG173884A1 (pl) |
| TW (1) | TWI466874B (pl) |
| WO (1) | WO2010098428A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG187843A1 (en) * | 2010-08-27 | 2013-03-28 | Teijin Pharma Ltd | Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound |
| CN102234253B (zh) * | 2011-06-02 | 2013-07-03 | 重庆莱美药业股份有限公司 | 一种制备非布索坦中间体的方法 |
| CN103910694B (zh) * | 2012-12-29 | 2016-08-24 | 广东东阳光药业有限公司 | 一种2-芳基腈噻唑衍生物的制备方法 |
| JP6289619B2 (ja) * | 2014-05-13 | 2018-03-07 | 帝人ファーマ株式会社 | ピリジン誘導体の新規な結晶多形体およびその製造方法 |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| CN110066258A (zh) * | 2018-01-23 | 2019-07-30 | 湘北威尔曼制药股份有限公司 | 噻唑-5-甲酸衍生物及其制备方法与应用 |
| CN109293597B (zh) * | 2018-10-29 | 2022-05-10 | 安徽省庆云医药股份有限公司 | 一种非布索坦的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346094A (en) | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| US4495195A (en) | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| JP2591632B2 (ja) | 1987-12-18 | 1997-03-19 | 株式会社トプコン | 真空吸引装置 |
| DE122008000051I1 (de) | 1990-11-30 | 2009-02-05 | Teijin Ltd | 2-arylthiazolderivat sowie dieses enthaltendes arzneimittel |
| JP3399559B2 (ja) | 1992-08-12 | 2003-04-21 | 帝人株式会社 | ２−フェニル複素環式化合物 |
| JP3113110B2 (ja) | 1993-01-19 | 2000-11-27 | 帝人株式会社 | イソキサゾールおよびイソチアゾール誘導体 |
| JP3169735B2 (ja) | 1993-04-08 | 2001-05-28 | 帝人株式会社 | （アルコキシシアノフェニル）チアゾール誘導体の製造方法 |
| JP2706037B2 (ja) | 1993-04-13 | 1998-01-28 | 帝人株式会社 | シアノ化合物およびその製造方法 |
| JP2834971B2 (ja) | 1993-05-25 | 1998-12-14 | 帝人株式会社 | ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法およびその新規製造中間体 |
| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JPH10139770A (ja) | 1996-11-08 | 1998-05-26 | Teijin Ltd | ２−（３−シアノフェニル）チアゾール誘導体の製造法 |
| JPH10310578A (ja) | 1996-11-13 | 1998-11-24 | Yoshitomi Pharmaceut Ind Ltd | ３−フェニルピラゾール化合物 |
| JP3440196B2 (ja) | 1997-08-13 | 2003-08-25 | 帝人株式会社 | チオベンズアミド誘導体の製造方法 |
| AU780205B2 (en) | 2000-02-23 | 2005-03-10 | Alteon Inc. | Thiazolium compounds and treatments of disorders associated with protein aging |
| WO2002051849A1 (en) | 2000-12-26 | 2002-07-04 | Daiichi Pharmaceutical Co., Ltd. | Cdk4 inhibitors |
| AR038703A1 (es) * | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| CA2755297A1 (en) * | 2003-02-10 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Processes for the preparation of n-heteroaryl-n-aryl-amines by reacting an n-aryl carbamic acid ester with a halo-heteroaryl and analogous processes |
| MXPA06002567A (es) | 2003-09-06 | 2006-09-04 | Vertex Pharma | Moduladores de transportadores con casete de union de atp. |
| JP4960708B2 (ja) | 2004-01-30 | 2012-06-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｐ結合カセットトランスポーターのモジュレーター |
| ES2331579T3 (es) | 2004-08-27 | 2010-01-08 | Astellas Pharma Inc. | Derivado de 2-fenilpiridina. |
| US7816558B2 (en) * | 2005-10-07 | 2010-10-19 | Astellas Pharma Inc. | Triarylcarboxylic acid derivative |
| ATE555810T1 (de) | 2006-02-24 | 2012-05-15 | Astellas Pharma Inc | Mittel zur behandlung oder prävention von verdauungsgeschwüren |
| JP2012096999A (ja) * | 2009-02-27 | 2012-05-24 | Nagoya Univ | ニッケル触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
| SG187843A1 (en) * | 2010-08-27 | 2013-03-28 | Teijin Pharma Ltd | Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound |
-
2010
- 2010-02-26 PL PL10746307T patent/PL2404908T3/pl unknown
- 2010-02-26 AU AU2010218748A patent/AU2010218748B2/en not_active Ceased
- 2010-02-26 PT PT107463077T patent/PT2404908E/pt unknown
- 2010-02-26 EP EP14163761.1A patent/EP2754658A1/en not_active Withdrawn
- 2010-02-26 BR BRPI1008308A patent/BRPI1008308B8/pt not_active IP Right Cessation
- 2010-02-26 JP JP2011501659A patent/JP5312570B2/ja active Active
- 2010-02-26 SG SG2011062122A patent/SG173884A1/en unknown
- 2010-02-26 WO PCT/JP2010/053043 patent/WO2010098428A1/ja not_active Ceased
- 2010-02-26 CN CN201080009880.9A patent/CN102333765B/zh not_active Expired - Fee Related
- 2010-02-26 ES ES10746307.7T patent/ES2459722T3/es active Active
- 2010-02-26 TW TW99105657A patent/TWI466874B/zh not_active IP Right Cessation
- 2010-02-26 DK DK10746307.7T patent/DK2404908T3/da active
- 2010-02-26 KR KR1020117019476A patent/KR101639834B1/ko not_active Expired - Fee Related
- 2010-02-26 CA CA2752485A patent/CA2752485C/en active Active
- 2010-02-26 RU RU2011139307/04A patent/RU2510393C9/ru active
- 2010-02-26 US US13/148,820 patent/US8952174B2/en active Active
- 2010-02-26 EP EP10746307.7A patent/EP2404908B1/en active Active
- 2010-02-26 MX MX2011008348A patent/MX2011008348A/es active IP Right Grant
-
2011
- 2011-07-26 IL IL214302A patent/IL214302A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2752485C (en) | 2017-01-03 |
| JP5312570B2 (ja) | 2013-10-09 |
| WO2010098428A1 (ja) | 2010-09-02 |
| JPWO2010098428A1 (ja) | 2012-09-06 |
| SG173884A1 (en) | 2011-10-28 |
| EP2404908A4 (en) | 2012-08-15 |
| MX2011008348A (es) | 2011-09-01 |
| KR101639834B1 (ko) | 2016-07-14 |
| RU2510393C2 (ru) | 2014-03-27 |
| CN102333765A (zh) | 2012-01-25 |
| EP2754658A1 (en) | 2014-07-16 |
| BRPI1008308B1 (pt) | 2020-03-31 |
| ES2459722T3 (es) | 2014-05-12 |
| RU2011139307A (ru) | 2013-04-10 |
| HK1162501A1 (en) | 2012-08-31 |
| EP2404908B1 (en) | 2014-04-09 |
| KR20110120896A (ko) | 2011-11-04 |
| US8952174B2 (en) | 2015-02-10 |
| BRPI1008308A2 (pt) | 2016-02-23 |
| EP2404908A1 (en) | 2012-01-11 |
| IL214302A (en) | 2014-09-30 |
| CN102333765B (zh) | 2015-01-14 |
| RU2510393C9 (ru) | 2014-08-27 |
| CA2752485A1 (en) | 2010-09-02 |
| PT2404908E (pt) | 2014-06-23 |
| DK2404908T3 (da) | 2014-04-28 |
| AU2010218748B2 (en) | 2015-03-26 |
| BRPI1008308B8 (pt) | 2021-05-25 |
| US20110313169A1 (en) | 2011-12-22 |
| AU2010218748A1 (en) | 2011-08-11 |
| TWI466874B (zh) | 2015-01-01 |
| TW201041859A (en) | 2010-12-01 |
| IL214302A0 (en) | 2011-09-27 |
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