BRPI1008308A2 - processo para produzir um composto - Google Patents
processo para produzir um compostoInfo
- Publication number
- BRPI1008308A2 BRPI1008308A2 BRPI1008308A BRPI1008308A BRPI1008308A2 BR PI1008308 A2 BRPI1008308 A2 BR PI1008308A2 BR PI1008308 A BRPI1008308 A BR PI1008308A BR PI1008308 A BRPI1008308 A BR PI1008308A BR PI1008308 A2 BRPI1008308 A2 BR PI1008308A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- produce
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009046003 | 2009-02-27 | ||
| JP2009-046003 | 2009-02-27 | ||
| JP2009-153770 | 2009-06-29 | ||
| JP2009153770 | 2009-06-29 | ||
| PCT/JP2010/053043 WO2010098428A1 (ja) | 2009-02-27 | 2010-02-26 | 遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI1008308A2 true BRPI1008308A2 (pt) | 2016-02-23 |
| BRPI1008308B1 BRPI1008308B1 (pt) | 2020-03-31 |
| BRPI1008308B8 BRPI1008308B8 (pt) | 2021-05-25 |
Family
ID=42665632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1008308A BRPI1008308B8 (pt) | 2009-02-27 | 2010-02-26 | processo para produzir um composto |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8952174B2 (pt) |
| EP (2) | EP2404908B1 (pt) |
| JP (1) | JP5312570B2 (pt) |
| KR (1) | KR101639834B1 (pt) |
| CN (1) | CN102333765B (pt) |
| AU (1) | AU2010218748B2 (pt) |
| BR (1) | BRPI1008308B8 (pt) |
| CA (1) | CA2752485C (pt) |
| DK (1) | DK2404908T3 (pt) |
| ES (1) | ES2459722T3 (pt) |
| HK (1) | HK1162501A1 (pt) |
| IL (1) | IL214302A (pt) |
| MX (1) | MX2011008348A (pt) |
| PL (1) | PL2404908T3 (pt) |
| PT (1) | PT2404908E (pt) |
| RU (1) | RU2510393C9 (pt) |
| SG (1) | SG173884A1 (pt) |
| TW (1) | TWI466874B (pt) |
| WO (1) | WO2010098428A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2589977T3 (es) * | 2010-08-27 | 2016-11-17 | Teijin Pharma Limited | Método para la producción de derivados heterocíclicos sustituidos con fenilos mediante medios de método de acoplamiento utilizando un compuesto de palladio |
| CN102234253B (zh) * | 2011-06-02 | 2013-07-03 | 重庆莱美药业股份有限公司 | 一种制备非布索坦中间体的方法 |
| CN103910694B (zh) * | 2012-12-29 | 2016-08-24 | 广东东阳光药业有限公司 | 一种2-芳基腈噻唑衍生物的制备方法 |
| AU2015260294A1 (en) * | 2014-05-13 | 2017-01-05 | Teijin Pharma Limited | Novel crystalline polymorph of pyridine derivative, and method for producing same |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| CN110066258A (zh) * | 2018-01-23 | 2019-07-30 | 湘北威尔曼制药股份有限公司 | 噻唑-5-甲酸衍生物及其制备方法与应用 |
| CN109293597B (zh) * | 2018-10-29 | 2022-05-10 | 安徽省庆云医药股份有限公司 | 一种非布索坦的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4346094A (en) | 1980-09-22 | 1982-08-24 | Eli Lilly And Company | 3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels |
| US4495195A (en) | 1982-11-01 | 1985-01-22 | Eli Lilly And Company | Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use |
| JP2591632B2 (ja) | 1987-12-18 | 1997-03-19 | 株式会社トプコン | 真空吸引装置 |
| CA2073981C (en) | 1990-11-30 | 2002-01-08 | Shiro Kondo | 2-arylthiazole derivatives and pharmaceutical composition thereof |
| JP3399559B2 (ja) | 1992-08-12 | 2003-04-21 | 帝人株式会社 | ２−フェニル複素環式化合物 |
| JP3113110B2 (ja) | 1993-01-19 | 2000-11-27 | 帝人株式会社 | イソキサゾールおよびイソチアゾール誘導体 |
| JP3169735B2 (ja) | 1993-04-08 | 2001-05-28 | 帝人株式会社 | （アルコキシシアノフェニル）チアゾール誘導体の製造方法 |
| JP2706037B2 (ja) | 1993-04-13 | 1998-01-28 | 帝人株式会社 | シアノ化合物およびその製造方法 |
| JP2834971B2 (ja) | 1993-05-25 | 1998-12-14 | 帝人株式会社 | ２−（４−アルコキシ−３−シアノフェニル）チアゾール誘導体の製造法およびその新規製造中間体 |
| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JPH10139770A (ja) | 1996-11-08 | 1998-05-26 | Teijin Ltd | ２−（３−シアノフェニル）チアゾール誘導体の製造法 |
| JPH10310578A (ja) | 1996-11-13 | 1998-11-24 | Yoshitomi Pharmaceut Ind Ltd | ３−フェニルピラゾール化合物 |
| JP3440196B2 (ja) | 1997-08-13 | 2003-08-25 | 帝人株式会社 | チオベンズアミド誘導体の製造方法 |
| US6458819B1 (en) | 2000-02-23 | 2002-10-01 | Alteon, Inc. | Thiazolium compounds and treatments of disorders associated with protein aging |
| WO2002051849A1 (fr) | 2000-12-26 | 2002-07-04 | Daiichi Pharmaceutical Co., Ltd. | Inhibiteurs cdk4 |
| AR038703A1 (es) * | 2002-02-28 | 2005-01-26 | Novartis Ag | Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3 |
| EP2562158A1 (en) * | 2003-02-10 | 2013-02-27 | Vertex Pharmaceuticals Incorporated | Processes for the preparation of n-heteroaryl-N-aryl-amines by reacting an N-aryl carbamic acid ester with a halo-heteroaryl and analogous processes |
| EP1664006A2 (en) | 2003-09-06 | 2006-06-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| WO2005075435A1 (en) | 2004-01-30 | 2005-08-18 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| KR20070045272A (ko) * | 2004-08-27 | 2007-05-02 | 아스텔라스세이야쿠 가부시키가이샤 | 2-페닐피리딘 유도체 |
| US7816558B2 (en) * | 2005-10-07 | 2010-10-19 | Astellas Pharma Inc. | Triarylcarboxylic acid derivative |
| WO2007097403A1 (ja) * | 2006-02-24 | 2007-08-30 | Astellas Pharma Inc. | 消化管潰瘍治療又は予防薬 |
| JP2012096999A (ja) | 2009-02-27 | 2012-05-24 | Nagoya Univ | ニッケル触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法 |
| ES2589977T3 (es) | 2010-08-27 | 2016-11-17 | Teijin Pharma Limited | Método para la producción de derivados heterocíclicos sustituidos con fenilos mediante medios de método de acoplamiento utilizando un compuesto de palladio |
-
2010
- 2010-02-26 ES ES10746307.7T patent/ES2459722T3/es active Active
- 2010-02-26 DK DK10746307.7T patent/DK2404908T3/da active
- 2010-02-26 SG SG2011062122A patent/SG173884A1/en unknown
- 2010-02-26 US US13/148,820 patent/US8952174B2/en active Active
- 2010-02-26 BR BRPI1008308A patent/BRPI1008308B8/pt active IP Right Grant
- 2010-02-26 MX MX2011008348A patent/MX2011008348A/es active IP Right Grant
- 2010-02-26 RU RU2011139307/04A patent/RU2510393C9/ru active
- 2010-02-26 EP EP10746307.7A patent/EP2404908B1/en active Active
- 2010-02-26 PL PL10746307T patent/PL2404908T3/pl unknown
- 2010-02-26 CN CN201080009880.9A patent/CN102333765B/zh active Active
- 2010-02-26 EP EP14163761.1A patent/EP2754658A1/en not_active Withdrawn
- 2010-02-26 TW TW99105657A patent/TWI466874B/zh active
- 2010-02-26 JP JP2011501659A patent/JP5312570B2/ja active Active
- 2010-02-26 PT PT107463077T patent/PT2404908E/pt unknown
- 2010-02-26 CA CA2752485A patent/CA2752485C/en active Active
- 2010-02-26 AU AU2010218748A patent/AU2010218748B2/en active Active
- 2010-02-26 KR KR1020117019476A patent/KR101639834B1/ko active IP Right Grant
- 2010-02-26 WO PCT/JP2010/053043 patent/WO2010098428A1/ja active Application Filing
-
2011
- 2011-07-26 IL IL214302A patent/IL214302A/en active IP Right Grant
-
2012
- 2012-03-26 HK HK12102980.4A patent/HK1162501A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL214302A0 (en) | 2011-09-27 |
| AU2010218748B2 (en) | 2015-03-26 |
| EP2404908A1 (en) | 2012-01-11 |
| CN102333765B (zh) | 2015-01-14 |
| KR101639834B1 (ko) | 2016-07-14 |
| CA2752485A1 (en) | 2010-09-02 |
| AU2010218748A1 (en) | 2011-08-11 |
| HK1162501A1 (en) | 2012-08-31 |
| EP2754658A1 (en) | 2014-07-16 |
| BRPI1008308B1 (pt) | 2020-03-31 |
| US8952174B2 (en) | 2015-02-10 |
| TWI466874B (zh) | 2015-01-01 |
| RU2510393C9 (ru) | 2014-08-27 |
| PL2404908T3 (pl) | 2014-12-31 |
| PT2404908E (pt) | 2014-06-23 |
| RU2510393C2 (ru) | 2014-03-27 |
| MX2011008348A (es) | 2011-09-01 |
| US20110313169A1 (en) | 2011-12-22 |
| KR20110120896A (ko) | 2011-11-04 |
| TW201041859A (en) | 2010-12-01 |
| DK2404908T3 (da) | 2014-04-28 |
| BRPI1008308B8 (pt) | 2021-05-25 |
| WO2010098428A1 (ja) | 2010-09-02 |
| ES2459722T3 (es) | 2014-05-12 |
| SG173884A1 (en) | 2011-10-28 |
| JPWO2010098428A1 (ja) | 2012-09-06 |
| EP2404908A4 (en) | 2012-08-15 |
| RU2011139307A (ru) | 2013-04-10 |
| IL214302A (en) | 2014-09-30 |
| JP5312570B2 (ja) | 2013-10-09 |
| EP2404908B1 (en) | 2014-04-09 |
| CN102333765A (zh) | 2012-01-25 |
| CA2752485C (en) | 2017-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/03/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/02/2010 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
| B15V | Prolongation of time limit allowed | ||
| B25A | Requested transfer of rights approved |
Owner name: TEIJIN LIMITED (JP) |