|
US4769320A
(en)
|
1982-07-27 |
1988-09-06 |
New England Medical Center Hospitals, Inc. |
Immunoassay means and methods useful in human native prothrombin and human abnormal prothorombin determinations
|
|
ES8404858A1
(es)
|
1982-04-12 |
1984-05-16 |
Hybritech Inc |
Un procedimiento para la purificacion de un anticuerpo.
|
|
US4689299A
(en)
|
1982-09-30 |
1987-08-25 |
University Of Rochester |
Human monoclonal antibodies against bacterial toxins
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6132803A
(ja)
|
1984-07-25 |
1986-02-15 |
Electric Power Dev Co Ltd |
架空線への光フアイバケ−ブル巻付機
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
JPH06104071B2
(ja)
|
1986-08-24 |
1994-12-21 |
財団法人化学及血清療法研究所 |
第▲ix▼因子コンホメ−シヨン特異性モノクロ−ナル抗体
|
|
US4801687A
(en)
|
1986-10-27 |
1989-01-31 |
Bioprobe International, Inc. |
Monoclonal antibody purification process using protein A
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
|
US5770701A
(en)
|
1987-10-30 |
1998-06-23 |
American Cyanamid Company |
Process for preparing targeted forms of methyltrithio antitumor agents
|
|
US5606040A
(en)
|
1987-10-30 |
1997-02-25 |
American Cyanamid Company |
Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
|
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5202253A
(en)
|
1988-12-30 |
1993-04-13 |
Oklahoma Medical Research Foundation |
Monoclonal antibody specific for protein C and antibody purification method
|
|
CA2006684C
(en)
|
1988-12-30 |
1996-12-17 |
Charles T. Esmon |
Monoclonal antibody against protein c
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
CA2026147C
(en)
|
1989-10-25 |
2006-02-07 |
Ravi J. Chari |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
|
JPH0636741B2
(ja)
|
1989-11-08 |
1994-05-18 |
帝人株式会社 |
ヒト・プロテインcの分離方法
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
CA2075927A1
(en)
|
1990-02-16 |
1991-08-17 |
Victor A. Raso |
Hybrid reagents capable of selectively releasing molecules into cells
|
|
US5130129A
(en)
|
1990-03-06 |
1992-07-14 |
The Regents Of The University Of California |
Method for enhancing antibody transport through capillary barriers
|
|
JP2909971B2
(ja)
|
1990-06-06 |
1999-06-23 |
三菱電機ホーム機器株式会社 |
布団乾燥機用シート付マット
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
GB9022547D0
(en)
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Purified immunoglobulin
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
DE122009000019I1
(de)
|
1991-04-25 |
2009-07-16 |
Chugai Seiyaku K K 5 1 |
Rekombinierte humane antikörper gegen den humanen interleukin-6 rezeptor
|
|
DE122004000008I1
(de)
|
1991-06-14 |
2005-06-09 |
Genentech Inc |
Humanisierter Heregulin Antikörper.
|
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
|
JPH06104071A
(ja)
|
1991-08-30 |
1994-04-15 |
Jasco Corp |
発熱体セラミックス溶接加工方法
|
|
WO1993006217A1
(en)
|
1991-09-19 |
1993-04-01 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
|
|
FI941572A7
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
JPH08500962A
(ja)
|
1992-02-06 |
1996-02-06 |
クリエイティブ バイオモレキュルズ,インコーポレイテッド |
癌マーカー用生物合成結合蛋白質
|
|
GB9203459D0
(en)
|
1992-02-19 |
1992-04-08 |
Scotgen Ltd |
Antibodies with germ-line variable regions
|
|
AU4116793A
(en)
|
1992-04-24 |
1993-11-29 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
JP2650574B2
(ja)
|
1992-07-10 |
1997-09-03 |
株式会社島津製作所 |
磁場型質量分析装置
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
EP1005870B1
(en)
|
1992-11-13 |
2009-01-21 |
Biogen Idec Inc. |
Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US7393682B1
(en)
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
|
EP0690873B1
(en)
|
1993-03-19 |
2003-06-11 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-8
|
|
JPH08511423A
(ja)
|
1993-06-10 |
1996-12-03 |
ジェネティック セラピー,インコーポレイテッド |
血友病治療のためのアデノウイルスベクター
|
|
EP0714409A1
(en)
|
1993-06-16 |
1996-06-05 |
Celltech Therapeutics Limited |
Antibodies
|
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
|
JPH07177572A
(ja)
|
1993-12-20 |
1995-07-14 |
Matsushita Electric Ind Co Ltd |
コードレス電話の留守番方法
|
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
TW416960B
(en)
|
1994-07-13 |
2001-01-01 |
Chugai Pharmaceutical Co Ltd |
Reshaped human antibody to human interleukin-8
|
|
AU701342B2
(en)
|
1994-07-13 |
1999-01-28 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human interleukin-8
|
|
US6048972A
(en)
|
1994-07-13 |
2000-04-11 |
Chugai Pharmaceutical Co., Ltd. |
Recombinant materials for producing humanized anti-IL-8 antibodies
|
|
JP3865418B2
(ja)
*
|
1994-07-13 |
2007-01-10 |
中外製薬株式会社 |
ヒトインターロイキン−8に対する再構成ヒト抗体
|
|
CN1156460A
(zh)
*
|
1994-07-13 |
1997-08-06 |
中外制药株式会社 |
抗人白细胞介素-8的重构人抗体
|
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
|
ATE552012T1
(de)
|
1994-10-07 |
2012-04-15 |
Chugai Pharmaceutical Co Ltd |
Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoff
|
|
EP0791359A4
(en)
|
1994-10-21 |
2002-09-11 |
Chugai Pharmaceutical Co Ltd |
MEDICINE AGAINST IL-6 PRODUCTION IN DISEASES
|
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
US5830478A
(en)
|
1995-06-07 |
1998-11-03 |
Boston Biomedical Research Institute |
Method for delivering functional domains of diphtheria toxin to a cellular target
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
US5783186A
(en)
|
1995-12-05 |
1998-07-21 |
Amgen Inc. |
Antibody-induced apoptosis
|
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
|
AU728657B2
(en)
|
1996-03-18 |
2001-01-18 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
ZA976326B
(en)
|
1996-07-19 |
1998-02-03 |
Amgen Inc |
Analogs of cationic proteins.
|
|
CA2262405A1
(en)
|
1996-08-02 |
1998-02-12 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
US7247302B1
(en)
|
1996-08-02 |
2007-07-24 |
Bristol-Myers Squibb Company |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
|
US6025158A
(en)
|
1997-02-21 |
2000-02-15 |
Genentech, Inc. |
Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US20070059302A1
(en)
|
1997-04-07 |
2007-03-15 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
ES2183351T3
(es)
|
1997-04-17 |
2003-03-16 |
Amgen Inc |
Composicones que comprenden conjugados de proteina ob humana activa estable con una cadena fc de inmunoglobulinas y metodos.
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
CN1068524C
(zh)
|
1997-06-23 |
2001-07-18 |
叶庆炜 |
一种治疗顽症牛皮癣的药物
|
|
ES2244066T3
(es)
|
1997-06-24 |
2005-12-01 |
Genentech, Inc. |
Procedimiento y composiciones de glicoproteinas galactosiladas.
|
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
|
WO1999018212A1
(fr)
|
1997-10-03 |
1999-04-15 |
Chugai Seiyaku Kabushiki Kaisha |
Anticorps humain naturel
|
|
ATE419009T1
(de)
|
1997-10-31 |
2009-01-15 |
Genentech Inc |
Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen
|
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
|
ES2375931T3
(es)
|
1997-12-05 |
2012-03-07 |
The Scripps Research Institute |
Humanización de anticuerpo murino.
|
|
US6458355B1
(en)
|
1998-01-22 |
2002-10-01 |
Genentech, Inc. |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
|
|
US6355683B1
(en)
|
1998-09-11 |
2002-03-12 |
Ilexus Pty Limited |
Fc receptor modulators and uses thereof
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
DE69937291T2
(de)
|
1998-04-02 |
2008-07-10 |
Genentech, Inc., South San Francisco |
Antikörpervarianten und fragmente davon
|
|
AU752730B2
(en)
|
1998-04-03 |
2002-09-26 |
Chugai Seiyaku Kabushiki Kaisha |
Humanized antibody against human tissue factor (TF) and process for constructing humanized antibody
|
|
PT2180007E
(pt)
|
1998-04-20 |
2013-11-25 |
Roche Glycart Ag |
Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
WO2000009560A2
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
|
US6475718B2
(en)
|
1998-09-08 |
2002-11-05 |
Schering Aktiengesellschaft |
Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
|
|
RU2236222C2
(ru)
|
1998-09-11 |
2004-09-20 |
Айлексус Пти Лимитед |
Модуляторы fc-рецептора и их применение
|
|
JP2002531466A
(ja)
|
1998-12-01 |
2002-09-24 |
プロテイン デザイン ラブス, インコーポレイテッド |
γ−インターフェロンに対するヒト化抗体
|
|
KR101155191B1
(ko)
|
1999-01-15 |
2012-06-13 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US6972125B2
(en)
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
|
AU2006225302B2
(en)
|
1999-03-25 |
2010-08-12 |
AbbVie Deutschland GmbH & Co. KG |
Human antibodies that bind human IL-12 and methods for producing
|
|
ES2568899T3
(es)
|
1999-04-09 |
2016-05-05 |
Kyowa Hakko Kirin Co., Ltd. |
Procedimiento para controlar la actividad de una molécula inmunofuncional
|
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
|
ES2248127T3
(es)
|
1999-10-04 |
2006-03-16 |
Medicago Inc. |
Metodo para regular la transcripcion de genes foraneos en presencia de nigtrogeno.
|
|
AU7950400A
(en)
|
1999-10-19 |
2001-04-30 |
Kyowa Hakko Kogyo Co. Ltd. |
Process for producing polypeptide
|
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
|
US20030180714A1
(en)
|
1999-12-15 |
2003-09-25 |
Genentech, Inc. |
Shotgun scanning
|
|
PT1242438E
(pt)
|
1999-12-29 |
2007-02-28 |
Immunogen Inc |
Agentes citotóxicos compreendendo dixorrubicinas e daunorrubicinas modificadas e seu uso terapêutico
|
|
SI1266006T1
(sl)
|
2000-03-22 |
2006-06-30 |
Octagene Gmbh |
Proizvodnja rekombinantnih muteinov krvnega koagulacijskega faktorja VIII v humanih celicnih linijah
|
|
SI2857516T1
(sl)
|
2000-04-11 |
2017-09-29 |
Genentech, Inc. |
Multivalentna protitelesa in njihove uporabe
|
|
FR2807767B1
(fr)
|
2000-04-12 |
2005-01-14 |
Lab Francais Du Fractionnement |
Anticorps monoclonaux anti-d
|
|
AU6627201A
(en)
|
2000-05-03 |
2001-11-12 |
Mbt Munich Biotechnology Gmbh |
Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
|
|
DK1294769T3
(da)
|
2000-06-16 |
2011-04-26 |
Human Genome Sciences Inc |
Antistoffer der immunspecifikt binder til BLyS
|
|
AU2011244851A1
(en)
|
2000-07-27 |
2011-11-24 |
The John Hopkins University School Of Medicine |
Promyostatin peptides and methods of using same
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
|
EP1331266B1
(en)
|
2000-10-06 |
2017-01-04 |
Kyowa Hakko Kirin Co., Ltd. |
Cells producing antibody compositions
|
|
CA2424379C
(en)
|
2000-10-10 |
2013-10-01 |
Tanox, Inc. |
Inhibition of complement c5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
ES2405944T3
(es)
|
2000-11-30 |
2013-06-04 |
Medarex, Inc. |
Ácidos nucleicos que codifican las secuencias de inmunoglobulina humana reorganizadas a partir de ratones transcromoscómicos transgénicos
zadas
|
|
DK1355919T3
(da)
|
2000-12-12 |
2011-03-14 |
Medimmune Llc |
Molekyler med længere halveringstider, sammensætninger og anvendelser deraf
|
|
US20040002450A1
(en)
|
2000-12-29 |
2004-01-01 |
Janette Lazarovits |
Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
|
|
US20040001822A1
(en)
|
2000-12-29 |
2004-01-01 |
Avigdor Levanon |
Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
|
|
US20040001839A1
(en)
|
2000-12-29 |
2004-01-01 |
Avigdor Levanon |
Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
|
|
EE200300509A
(et)
|
2001-04-13 |
2004-08-16 |
Biogen, Inc. |
Antikehad VLA-1 vastu
|
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
|
CN101240022B
(zh)
|
2001-06-22 |
2012-07-18 |
中外制药株式会社 |
含有抗磷脂酰肌醇蛋白聚糖3抗体的细胞生长抑制剂
|
|
US20040161741A1
(en)
|
2001-06-30 |
2004-08-19 |
Elazar Rabani |
Novel compositions and processes for analyte detection, quantification and amplification
|
|
NZ603111A
(en)
|
2001-08-03 |
2014-05-30 |
Roche Glycart Ag |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
|
BRPI0211953B8
(pt)
|
2001-08-17 |
2021-05-25 |
Genentech Inc |
anticorpo monoclonal ou fragmento de ligação a antígeno que se liga a c5 e c5a sem a prevenção da formação de c5b, linhagem celular, composição farmacêutica, bem como método in vitro para inibir a atividade de c5a e método de diagnóstico in vitro
|
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
ES2326964T3
(es)
|
2001-10-25 |
2009-10-22 |
Genentech, Inc. |
Composiciones de glicoproteina.
|
|
DK1562968T3
(da)
|
2001-11-14 |
2013-10-28 |
Janssen Biotech Inc |
Anti-il-6-antistoffer, sammensætninger, fremgangsmåder og anvendelser
|
|
US7771951B2
(en)
|
2001-12-03 |
2010-08-10 |
Amgen Fremont Inc. |
Antibody categorization based on binding characteristics
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
BR0307548A
(pt)
|
2002-02-11 |
2006-01-17 |
Genentech Inc |
Método de produção de uma variante de anticorpo, variante de anticorpo, composição, ácido nucléico isolado, vetor, célula hospedeira, processo para a produção de uma variante de anticorpo e método de determinação do coeficiente de associação de antìgeno de um anticorpo
|
|
AR038568A1
(es)
|
2002-02-20 |
2005-01-19 |
Hoffmann La Roche |
Anticuerpos anti-a beta y su uso
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
|
US20080199471A1
(en)
|
2002-03-01 |
2008-08-21 |
Bernett Matthew J |
Optimized cd40 antibodies and methods of using the same
|
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
EP1500400A4
(en)
|
2002-04-09 |
2006-10-11 |
Kyowa Hakko Kogyo Kk |
MEDICAMENT CONTAINING ANTIBODY COMPOSITION
|
|
BR0309145A
(pt)
|
2002-04-09 |
2005-02-01 |
Kyowa Hakko Kogyo Kk |
Células das quais o genoma é modificado
|
|
AU2003236020B2
(en)
|
2002-04-09 |
2009-03-19 |
Kyowa Hakko Kirin Co., Ltd. |
Cell with depression or deletion of the activity of protein participating in GDP-fucose transport
|
|
JPWO2003085118A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物の製造方法
|
|
JPWO2003085119A1
(ja)
|
2002-04-09 |
2005-08-11 |
協和醗酵工業株式会社 |
抗体組成物のFcγ受容体IIIaに対する結合活性を高める方法
|
|
US20050031613A1
(en)
|
2002-04-09 |
2005-02-10 |
Kazuyasu Nakamura |
Therapeutic agent for patients having human FcgammaRIIIa
|
|
EP1509770B1
(en)
|
2002-05-31 |
2014-07-09 |
GE Healthcare Bio-Sciences AB |
Method of coupling binding agents to a substrate surface
|
|
CA2488441C
(en)
|
2002-06-03 |
2015-01-27 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
DE60326839D1
(de)
|
2002-06-12 |
2009-05-07 |
Genencor Int |
Verfahren zur verbesserung einer bindungseigenschaft eines moleküls
|
|
US20060141456A1
(en)
|
2002-06-12 |
2006-06-29 |
Cynthia Edwards |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
|
ITMI20021527A1
(it)
|
2002-07-11 |
2004-01-12 |
Consiglio Nazionale Ricerche |
Anticorpi anti componente c5 del complemento e loro uso
|
|
US8193318B2
(en)
|
2002-08-14 |
2012-06-05 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
|
WO2004016740A2
(en)
|
2002-08-15 |
2004-02-26 |
Epitomics, Inc. |
Humanized rabbit antibodies
|
|
DE60331778D1
(de)
|
2002-09-16 |
2010-04-29 |
Univ Johns Hopkins |
Metalloproteaseaktivierung von myostatin und verfahren zur modulation der myostatinaktivität
|
|
KR100980065B1
(ko)
|
2002-09-27 |
2010-09-03 |
젠코어 인코포레이티드 |
최적화된 Fc 변이체 및 그의 제조 방법
|
|
RU2390527C2
(ru)
|
2002-09-27 |
2010-05-27 |
Ксенкор, Инк. |
АНТИТЕЛО, СОДЕРЖАЩЕЕ Fc-ВАРИАНТНУЮ ЧАСТЬ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ АНТИТЕЛО, И СПОСОБ ЛЕЧЕНИЯ МЛЕКОПИТАЮЩЕГО
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
AU2003286467B2
(en)
|
2002-10-15 |
2009-10-01 |
Abbvie Biotherapeutics Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
AR047392A1
(es)
|
2002-10-22 |
2006-01-18 |
Wyeth Corp |
Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
|
|
US7282568B2
(en)
|
2002-12-16 |
2007-10-16 |
Medarex, Inc. |
Human monoclonal antibodies against interleukin 8 (IL-8)
|
|
DE60332957D1
(de)
|
2002-12-16 |
2010-07-22 |
Genentech Inc |
Immunoglobulinvarianten und deren verwendungen
|
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
WO2004065416A2
(en)
|
2003-01-16 |
2004-08-05 |
Genentech, Inc. |
Synthetic antibody phage libraries
|
|
EP1608684A2
(en)
|
2003-02-07 |
2005-12-28 |
Protein Design Labs, Inc. |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
|
KR20060026004A
(ko)
|
2003-02-28 |
2006-03-22 |
안티제닉스 아이엔씨 |
당단백질 및 항원성 분자의 올리고머화를 조장하는 렉틴의용도
|
|
EP1601697B1
(en)
|
2003-02-28 |
2007-05-30 |
Lonza Biologics plc |
Antibody purification by Protein A and ion exchange chromatography
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
KR100973564B1
(ko)
|
2003-05-02 |
2010-08-03 |
젠코어 인코포레이티드 |
최적화된 Fc 변이체 및 그의 제조 방법
|
|
US9051373B2
(en)
|
2003-05-02 |
2015-06-09 |
Xencor, Inc. |
Optimized Fc variants
|
|
RU2322261C2
(ru)
|
2003-06-02 |
2008-04-20 |
Уайт |
Применение ингибиторов миостатика (gdf8) в сочетании с кортикостероидами для лечения нервно-мышечных заболеваний
|
|
CA2528434A1
(en)
|
2003-06-05 |
2005-01-06 |
Genentech, Inc. |
Combination therapy for b cell disorders
|
|
WO2005023193A2
(en)
*
|
2003-09-04 |
2005-03-17 |
Interleukin Genetics, Inc. |
Methods of treating endometriosis
|
|
JP2007504245A
(ja)
|
2003-09-05 |
2007-03-01 |
ジェネンテック・インコーポレーテッド |
変更したエフェクター機能を有する抗体
|
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
|
EP1688439A4
(en)
|
2003-10-08 |
2007-12-19 |
Kyowa Hakko Kogyo Kk |
COMPOSITION OF CONDENSED PROTEINS
|
|
US20070134759A1
(en)
|
2003-10-09 |
2007-06-14 |
Harue Nishiya |
Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase
|
|
AU2003271174A1
(en)
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
|
WO2005037867A1
(en)
|
2003-10-15 |
2005-04-28 |
Pdl Biopharma, Inc. |
ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG
|
|
WO2005049649A1
(en)
|
2003-11-05 |
2005-06-02 |
Ares Trading S.A. |
Process for the purification of il-18 binding protein
|
|
JP4653109B2
(ja)
|
2003-11-05 |
2011-03-16 |
ロシュ グリクアート アクチェンゲゼルシャフト |
高められたFcレセプター結合親和性及びエフェクター機能をもつCD20抗体
|
|
SG149815A1
(en)
|
2003-11-06 |
2009-02-27 |
Seattle Genetics Inc |
Monomethylvaline compounds capable of conjugation to ligands
|
|
WO2005047327A2
(en)
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
|
EP1701979A2
(en)
|
2003-12-03 |
2006-09-20 |
Xencor, Inc. |
Optimized antibodies that target the epidermal growth factor receptor
|
|
JPWO2005053742A1
(ja)
|
2003-12-04 |
2007-06-28 |
協和醗酵工業株式会社 |
抗体組成物を含有する医薬
|
|
EP2221315A1
(en)
|
2003-12-04 |
2010-08-25 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
|
NZ547157A
(en)
|
2003-12-10 |
2009-07-31 |
Medarex Inc |
Interferon Alpha Antibodies and their uses
|
|
EP1697520A2
(en)
|
2003-12-22 |
2006-09-06 |
Xencor, Inc. |
Fc polypeptides with novel fc ligand binding sites
|
|
WO2005066204A2
(en)
|
2003-12-31 |
2005-07-21 |
Schering-Plough Ltd. |
Neutralizing epitope-based growth enhancing vaccine
|
|
PE20051053A1
(es)
|
2004-01-09 |
2005-12-12 |
Pfizer |
ANTICUERPOS CONTRA MAdCAM
|
|
US20070116710A1
(en)
|
2004-02-03 |
2007-05-24 |
Leonard Bell |
Methods of treating hemolytic anemia
|
|
US20050169921A1
(en)
|
2004-02-03 |
2005-08-04 |
Leonard Bell |
Method of treating hemolytic disease
|
|
JP2008505054A
(ja)
|
2004-02-11 |
2008-02-21 |
ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー |
Il−6アンタゴニストで骨関節炎を治療する方法
|
|
AU2005227896B2
(en)
|
2004-03-23 |
2008-11-13 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
|
US20050260711A1
(en)
|
2004-03-30 |
2005-11-24 |
Deepshikha Datta |
Modulating pH-sensitive binding using non-natural amino acids
|
|
KR101245983B1
(ko)
|
2004-03-31 |
2013-06-28 |
제넨테크, 인크. |
인간화 항-tgf-베타 항체
|
|
US7785903B2
(en)
|
2004-04-09 |
2010-08-31 |
Genentech, Inc. |
Variable domain library and uses
|
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
PL1737891T3
(pl)
|
2004-04-13 |
2013-08-30 |
Hoffmann La Roche |
Przeciwciała przeciw selektynie p
|
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
|
AU2005247301B2
(en)
|
2004-04-16 |
2011-08-18 |
Macrogenics, Inc. |
FCγRIIB-specific antibodies and methods of use thereof
|
|
KR100620554B1
(ko)
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
NZ582684A
(en)
|
2004-06-18 |
2011-05-27 |
Ambrx Inc |
Use of an antibody or binding fragment thereof comprising a non naturally encoded amino acid coupled to a linker
|
|
EP1773391A4
(en)
|
2004-06-25 |
2009-01-21 |
Medimmune Inc |
INCREASING THE PRODUCTION OF RECOMBINANT ANTIBODIES IN MAMMALIAN CELLS BY MUTAGENESIS ON THE SITE
|
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
|
EP2940043A1
(en)
|
2004-07-15 |
2015-11-04 |
Xencor, Inc. |
Optimized fc variants
|
|
PL1776384T3
(pl)
|
2004-08-04 |
2013-10-31 |
Mentrik Biotech Llc |
WARIANTY REGIONÓW Fc
|
|
EP1778726A4
(en)
|
2004-08-16 |
2009-03-18 |
Medimmune Inc |
INTEGRIN ANTAGONISTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-ASSAYED CYTOTOXICITY ACTIVITY
|
|
ZA200701715B
(en)
|
2004-08-19 |
2008-07-30 |
Genentech Inc |
Polypeptide variants with altered effector function
|
|
US7572456B2
(en)
|
2004-09-13 |
2009-08-11 |
Macrogenics, Inc. |
Humanized antibodies against West Nile Virus and therapeutic and prophylactic uses thereof
|
|
WO2006030200A1
(en)
|
2004-09-14 |
2006-03-23 |
National Institute For Biological Standards And Control |
Vaccine
|
|
TWI380996B
(zh)
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ox40l抗體
|
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
|
TR201808537T4
(tr)
|
2004-09-23 |
2018-07-23 |
Genentech Inc |
Sistein değiştirilmiş antikorlar ve konjugatlar.
|
|
MX2007003320A
(es)
|
2004-09-24 |
2007-05-18 |
Amgen Inc |
Moleculas fc modificadas.
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
|
CA2585043A1
(en)
|
2004-10-22 |
2007-01-04 |
Medimmune, Inc. |
High affinity antibodies against hmgb1 and methods of use thereof
|
|
US20060115485A1
(en)
|
2004-10-29 |
2006-06-01 |
Medimmune, Inc. |
Methods of preventing and treating RSV infections and related conditions
|
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
|
US7632497B2
(en)
|
2004-11-10 |
2009-12-15 |
Macrogenics, Inc. |
Engineering Fc Antibody regions to confer effector function
|
|
US20070135620A1
(en)
|
2004-11-12 |
2007-06-14 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
EP2314618A3
(en)
|
2004-11-12 |
2011-10-19 |
Xencor Inc. |
Fc variants with altered binding to FcRn
|
|
US8329186B2
(en)
|
2004-12-20 |
2012-12-11 |
Isu Abxis Co., Ltd |
Treatment of inflammation using BST2 inhibitor
|
|
US20090061485A1
(en)
|
2004-12-22 |
2009-03-05 |
Chugai Seiyaku Kabushiki Kaisha |
Method of Producing an Antibody Using a Cell in Which the Function of Fucose Transporter Is Inhibited
|
|
ES2343426T3
(es)
|
2004-12-23 |
2010-07-30 |
Novo Nordisk A/S |
Ligandos de afinidad de union a anticuerpos.
|
|
US20090087478A1
(en)
|
2004-12-27 |
2009-04-02 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally Deliverable and Anti-Toxin Antibodies and Methods for Making and Using Them
|
|
EP2028193B1
(en)
|
2005-01-05 |
2012-03-07 |
f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. |
Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
|
|
AU2006204791A1
(en)
|
2005-01-12 |
2006-07-20 |
Xencor, Inc |
Antibodies and Fc fusion proteins with altered immunogenicity
|
|
GB0502358D0
(en)
|
2005-02-04 |
2005-03-16 |
Novartis Ag |
Organic compounds
|
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
|
US20060263357A1
(en)
|
2005-05-05 |
2006-11-23 |
Tedder Thomas F |
Anti-CD19 antibody therapy for autoimmune disease
|
|
JP5153613B2
(ja)
|
2005-03-18 |
2013-02-27 |
メディミューン,エルエルシー |
抗体のフレームワーク・シャッフル
|
|
AU2006230413B8
(en)
|
2005-03-31 |
2011-01-20 |
Xencor, Inc |
Fc variants with optimized properties
|
|
DK3050963T3
(da)
|
2005-03-31 |
2019-12-09 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåde til fremstilling af polypeptid ved regulering af arrangement
|
|
DK2824183T3
(da)
|
2005-04-08 |
2020-09-28 |
Chugai Pharmaceutical Co Ltd |
Fremgangsmåde til fremstilling af bispecifikke antistoffer
|
|
JP4909988B2
(ja)
|
2005-04-20 |
2012-04-04 |
アムジエン・フレモント・インコーポレイテツド |
インターロイキン‐8に対する高親和性の完全ヒトモノクローナル抗体、およびそのような抗体のエピトープ
|
|
TW200724548A
(en)
|
2005-04-25 |
2007-07-01 |
Pfizer |
Antibodies to myostatin
|
|
US8163881B2
(en)
|
2005-05-31 |
2012-04-24 |
The Board Of Regents Of The University Of Texas System |
Immunoglobulin molecules with improved characteristics
|
|
AU2006268227A1
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc |
Optimized anti-Ep-CAM antibodies
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
PL2407486T3
(pl)
|
2005-08-19 |
2018-05-30 |
Wyeth Llc |
Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8
|
|
JP2009504787A
(ja)
|
2005-08-19 |
2009-02-05 |
シーラス コーポレイション |
抗体によって媒介される免疫応答の増強
|
|
DK1931709T3
(en)
|
2005-10-03 |
2017-03-13 |
Xencor Inc |
FC VARIETIES WITH OPTIMIZED FC RECEPTOR BINDING PROPERTIES
|
|
JP5052517B2
(ja)
|
2005-10-06 |
2012-10-17 |
イーライ リリー アンド カンパニー |
抗ミオスタチン抗体
|
|
JP4860703B2
(ja)
|
2005-10-06 |
2012-01-25 |
ゼンコー・インコーポレイテッド |
最適化された抗cd30抗体
|
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
|
CA2625619A1
(en)
|
2005-10-14 |
2007-04-26 |
Medimmune, Inc. |
Cell display of antibody libraries
|
|
US8679490B2
(en)
|
2005-11-07 |
2014-03-25 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
|
|
AR057579A1
(es)
|
2005-11-23 |
2007-12-05 |
Merck & Co Inc |
Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
|
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
|
US20080311122A1
(en)
|
2005-11-28 |
2008-12-18 |
Medimmune, Llc |
Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof
|
|
WO2007064919A2
(en)
|
2005-12-02 |
2007-06-07 |
Genentech, Inc. |
Binding polypeptides with restricted diversity sequences
|
|
MY181173A
(en)
|
2005-12-12 |
2020-12-21 |
Ac Immune Sa |
Therapeutic vaccine
|
|
JP5193881B2
(ja)
|
2005-12-29 |
2013-05-08 |
セントカー・インコーポレーテツド |
ヒト抗il−23抗体、組成物、方法および用途
|
|
AU2007212147A1
(en)
|
2006-02-03 |
2007-08-16 |
Medimmune, Llc |
Protein formulations
|
|
US20070190056A1
(en)
|
2006-02-07 |
2007-08-16 |
Ravi Kambadur |
Muscle regeneration compositions and uses therefor
|
|
WO2007097361A1
(ja)
|
2006-02-21 |
2007-08-30 |
Protenova Co., Ltd. |
イムノグロブリン親和性リガンド
|
|
JP4179517B2
(ja)
|
2006-02-21 |
2008-11-12 |
プロテノバ株式会社 |
イムノグロブリン親和性リガンド
|
|
EP1988882B1
(en)
|
2006-03-02 |
2014-12-17 |
Alexion Pharmaceuticals, Inc. |
Prolongation of survival of an allograft by inhibiting complement activity
|
|
SG172686A1
(en)
|
2006-03-08 |
2011-07-28 |
Archemix Corp |
Complement binding aptamers and anti-c5 agents useful in the treatment of ocular disorders
|
|
CA3022097C
(en)
|
2006-03-15 |
2020-10-27 |
Alexion Pharmaceuticals, Inc. |
Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement
|
|
KR101516823B1
(ko)
|
2006-03-17 |
2015-05-07 |
바이오겐 아이덱 엠에이 인코포레이티드 |
안정화된 폴리펩티드 조성물
|
|
EA200802061A1
(ru)
|
2006-03-28 |
2009-04-28 |
Байоджен Айдек Эмэй Инк. |
Антитело или его фрагмент, специфично связывающееся с рецептором 1 инсулиноподобного фактора роста (igf-r1) (варианты), композиция на его основе, полинуклеотид, кодирующий вариабельную область антитела (варианты), содержащие полинуклеотид композиция (варианты) и вектор, содержащая вектор клетка-хозяин (варианты), способ продуцирования антитела или его фрагмента (варианты) и способ лечения гиперпролиферативного заболевания у животного организма
|
|
EP2006381B1
(en)
|
2006-03-31 |
2016-02-03 |
Chugai Seiyaku Kabushiki Kaisha |
Method for controlling blood pharmacokinetics of antibodies
|
|
DK2009101T3
(en)
|
2006-03-31 |
2018-01-15 |
Chugai Pharmaceutical Co Ltd |
Antibody modification method for purification of a bispecific antibody
|
|
CN102887955A
(zh)
|
2006-04-05 |
2013-01-23 |
艾博特生物技术有限公司 |
抗体纯化
|
|
WO2007134050A2
(en)
|
2006-05-09 |
2007-11-22 |
Genentech, Inc. |
Binding polypeptides with optimized scaffolds
|
|
US7786270B2
(en)
|
2006-05-26 |
2010-08-31 |
Macrogenics, Inc. |
Humanized FcγRIIB-specific antibodies and methods of use thereof
|
|
AU2007255753B2
(en)
|
2006-06-08 |
2013-01-17 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive or remedy for inflammatory disease
|
|
TW200817006A
(en)
|
2006-06-23 |
2008-04-16 |
Smithkline Beecham Corp |
IL-8 receptor antagonist
|
|
EP2032159B1
(en)
|
2006-06-26 |
2015-01-07 |
MacroGenics, Inc. |
Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
|
|
AR062223A1
(es)
|
2006-08-09 |
2008-10-22 |
Glycart Biotechnology Ag |
Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
|
|
ES2402591T3
(es)
|
2006-08-14 |
2013-05-07 |
Xencor Inc. |
Anticuerpos optimizados que seleccionan como diana CD19
|
|
ES2399075T3
(es)
|
2006-08-30 |
2013-03-25 |
Genentech, Inc. |
Anticuerpos multiespecíficos
|
|
CA2661836A1
(en)
|
2006-09-05 |
2008-03-13 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
|
US8323653B2
(en)
|
2006-09-08 |
2012-12-04 |
Medimmune, Llc |
Humanized anti-CD19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
|
|
WO2008036688A2
(en)
|
2006-09-18 |
2008-03-27 |
Xencor, Inc. |
Optimized antibodies that target hm1.24
|
|
WO2008060785A2
(en)
|
2006-10-06 |
2008-05-22 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Prevention of tissue ischemia, related methods and compositions
|
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
|
WO2008121160A2
(en)
|
2006-11-21 |
2008-10-09 |
Xencor, Inc. |
Optimized antibodies that target cd5
|
|
CN100455598C
(zh)
|
2006-11-29 |
2009-01-28 |
中国抗体制药有限公司 |
功能人源化抗人cd20抗体及其应用
|
|
WO2008140603A2
(en)
|
2006-12-08 |
2008-11-20 |
Macrogenics, Inc. |
METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
|
|
US20080226635A1
(en)
|
2006-12-22 |
2008-09-18 |
Hans Koll |
Antibodies against insulin-like growth factor I receptor and uses thereof
|
|
WO2008091798A2
(en)
|
2007-01-22 |
2008-07-31 |
Xencor, Inc. |
Optimized ca9 antibodies and methods of using the same
|
|
CA2669412A1
(en)
|
2007-01-23 |
2008-07-31 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
|
WO2008098115A2
(en)
|
2007-02-07 |
2008-08-14 |
Xencor, Inc. |
Optimized igf-1r antibodies and methods of using the same
|
|
EP2087111A2
(en)
|
2007-03-19 |
2009-08-12 |
Medimmune Limited |
Polypeptide variants
|
|
EA200901211A1
(ru)
|
2007-03-22 |
2010-04-30 |
Новартис Аг |
Антигены белка с5 и их применение
|
|
US8337854B2
(en)
|
2007-04-04 |
2012-12-25 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Monoclonal antibodies against dengue and other viruses with deletion in Fc region
|
|
CL2008001071A1
(es)
|
2007-04-17 |
2009-05-22 |
Smithkline Beecham Corp |
Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
|
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
|
ES2659517T3
(es)
|
2007-05-30 |
2018-03-16 |
Xencor, Inc. |
Métodos y composiciones para inhibir células que expresan CD32B
|
|
BRPI0813287A2
(pt)
|
2007-06-25 |
2014-12-30 |
Esbatech Alcon Biomed Res Unit |
Planejamento e otimização baseados na sequência de anticorpos de cadeia única
|
|
CA2689941C
(en)
|
2007-06-25 |
2019-10-29 |
Esbatech Ag |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
|
CA2691974C
(en)
|
2007-06-29 |
2016-08-30 |
Quest Diagnostics Investments Incorporated |
Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
|
|
US20110105724A1
(en)
|
2007-08-16 |
2011-05-05 |
Stephanie Jane Clegg |
Novel compounds
|
|
JOP20080381B1
(ar)
|
2007-08-23 |
2023-03-28 |
Amgen Inc |
بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
|
|
CN101842116A
(zh)
|
2007-08-28 |
2010-09-22 |
比奥根艾迪克Ma公司 |
结合igf-1r多个表位的组合物
|
|
CA2697612A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Anti-igf-1r antibodies and uses thereof
|
|
RU2505603C2
(ru)
|
2007-09-26 |
2014-01-27 |
Чугаи Сейяку Кабусики Кайся |
Антитело против рецептора il-6
|
|
CL2008002886A1
(es)
|
2007-09-26 |
2009-12-04 |
Chugai Pharmaceutical Co Ltd |
Region constante de un anticuerpo humano; anticuerpo anti-receptor de interleucina-6 (il-6) y composicion farmaceutica que la comprende.
|
|
CA2700701C
(en)
|
2007-09-26 |
2020-12-29 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substitution in cdr
|
|
RU2010116756A
(ru)
|
2007-09-28 |
2011-11-10 |
Чугаи Сейяку Кабусики Кайся (Jp) |
Антитело против глипикана-3 с улучшенными кинетическими показателями в плазме
|
|
KR100888133B1
(ko)
|
2007-10-02 |
2009-03-13 |
에스케이에너지 주식회사 |
4종의 금속성분으로 구성된 다성분계 비스무스몰리브데이트 촉매 제조방법 및 상기촉매를 이용하여1,3-부타디엔을 제조하는 방법
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
WO2009062051A2
(en)
|
2007-11-08 |
2009-05-14 |
Pikamab, Inc. |
Methods and compositions for antibody therapy
|
|
WO2009085200A2
(en)
|
2007-12-21 |
2009-07-09 |
Amgen Inc. |
Anti-amyloid antibodies and uses thereof
|
|
KR101616758B1
(ko)
|
2007-12-26 |
2016-04-29 |
젠코어 인코포레이티드 |
FcRn에 대한 변경된 결합성을 갖는 Fc 변이체
|
|
WO2009089004A1
(en)
|
2008-01-07 |
2009-07-16 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
|
AU2009206506B2
(en)
|
2008-01-23 |
2013-01-10 |
Xencor, Inc. |
Optimized CD40 antibodies and methods of using the same
|
|
JP5373823B2
(ja)
|
2008-01-29 |
2013-12-18 |
アブリンクス エン.ヴェー. |
タンパク質及びポリペプチドを安定化する方法
|
|
AU2015227424A1
(en)
*
|
2008-04-11 |
2015-10-01 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
|
NZ717429A
(en)
|
2008-04-11 |
2018-07-27 |
Chugai Pharmaceutical Co Ltd |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
|
ES2650804T3
(es)
|
2008-04-25 |
2018-01-22 |
Dyax Corp. |
Anticuerpos contra FcRn y uso de los mismos
|
|
CA2722600C
(en)
|
2008-05-01 |
2014-01-21 |
Amgen Inc. |
Anti-hepcidin antibodies and methods of use
|
|
CN102088995B
(zh)
|
2008-05-14 |
2016-01-20 |
维多利亚农业服务控股公司 |
血管生成素和血管生成素激动剂用于治疗疾病和障碍的用途
|
|
KR20170116193A
(ko)
|
2008-06-20 |
2017-10-18 |
노파르티스 아게 |
응집이 감소된 면역글로불린
|
|
PT2328616E
(pt)
|
2008-08-05 |
2015-08-26 |
Novartis Ag |
Composições e métodos para anticorpos dirigidos à proteína c5 do complemento
|
|
ES2927192T3
(es)
|
2008-09-17 |
2022-11-03 |
Xencor Inc |
Nuevas composiciones y métodos para tratar trastornos mediados por IgE
|
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
|
JP5229888B2
(ja)
|
2008-09-30 |
2013-07-03 |
独立行政法人産業技術総合研究所 |
弱酸性域での易解離性を向上したプロテインa変異型タンパク質及び抗体捕捉剤
|
|
AU2009305113B2
(en)
|
2008-10-13 |
2015-07-16 |
Institute For Research In Biomedicine |
Dengue virus neutralizing antibodies and uses thereof
|
|
CN110317272A
(zh)
|
2008-10-14 |
2019-10-11 |
霍夫曼-拉罗奇有限公司 |
免疫球蛋白变体及其用途
|
|
AU2009313203B2
(en)
|
2008-11-10 |
2015-08-27 |
Alexion Pharmaceuticals, Inc. |
Methods and compositions for treating complement-associated disorders
|
|
JP5807300B2
(ja)
|
2008-11-18 |
2015-11-10 |
株式会社シノテスト |
試料中のc反応性蛋白質の測定方法及び測定試薬
|
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
|
AR074777A1
(es)
|
2008-12-19 |
2011-02-09 |
Glaxo Group Ltd |
Proteinas de union a antigeno
|
|
US20100292443A1
(en)
|
2009-02-26 |
2010-11-18 |
Sabbadini Roger A |
Humanized platelet activating factor antibody design using anti-lipid antibody templates
|
|
EP2826789A1
(en)
|
2009-03-19 |
2015-01-21 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
|
CN102459344A
(zh)
|
2009-05-15 |
2012-05-16 |
中外制药株式会社 |
抗axl抗体
|
|
US8609097B2
(en)
|
2009-06-10 |
2013-12-17 |
Hoffmann-La Roche Inc. |
Use of an anti-Tau pS422 antibody for the treatment of brain diseases
|
|
US8945511B2
(en)
|
2009-06-25 |
2015-02-03 |
Paul Weinberger |
Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
|
|
EP2448972A4
(en)
|
2009-06-30 |
2012-11-28 |
Res Dev Foundation |
IMMUNOGLOBULIN FC POLYPEPTIDES
|
|
GB0914691D0
(en)
|
2009-08-21 |
2009-09-30 |
Lonza Biologics Plc |
Immunoglobulin variants
|
|
US8709424B2
(en)
|
2009-09-03 |
2014-04-29 |
Merck Sharp & Dohme Corp. |
Anti-GITR antibodies
|
|
US8734798B2
(en)
|
2009-10-27 |
2014-05-27 |
Ucb Pharma S.A. |
Function modifying NAv 1.7 antibodies
|
|
CN101875696B
(zh)
|
2009-11-11 |
2012-02-08 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗体及其制备方法与应用
|
|
EP2327725A1
(en)
|
2009-11-26 |
2011-06-01 |
InflaRx GmbH |
Anti-C5a binding moieties with high blocking activity
|
|
US8362210B2
(en)
|
2010-01-19 |
2013-01-29 |
Xencor, Inc. |
Antibody variants with enhanced complement activity
|
|
CN102971342B
(zh)
|
2010-01-28 |
2016-08-03 |
Ab生物科学公司 |
亲和力降低的新抗体和制备所述抗体的方法
|
|
US20120315267A1
(en)
*
|
2010-02-09 |
2012-12-13 |
Glaxosmithkline Llc |
Novel uses
|
|
MX2012010116A
(es)
|
2010-03-01 |
2013-02-26 |
Alexion Pharma Inc |
Metodos y composiciones para el tratamiento de la enfermedad de degos.
|
|
WO2011111007A2
(en)
|
2010-03-11 |
2011-09-15 |
Rinat Neuroscience Corporation |
ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING
|
|
TW201206466A
(en)
|
2010-03-11 |
2012-02-16 |
Rinat Neuroscience Corp |
Antibodies with pH dependent antigen binding
|
|
TWI667346B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
WO2011137362A1
(en)
|
2010-04-30 |
2011-11-03 |
Rother Russell P |
Antibodies having reduced immunogenicity in a human
|
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
|
UY33421A
(es)
|
2010-06-03 |
2011-12-30 |
Glaxo Wellcome House |
Proteinas de union al antígeno humanizados
|
|
CN105585630B
(zh)
|
2010-07-29 |
2020-09-15 |
Xencor公司 |
具有修改的等电点的抗体
|
|
SG10201506405YA
(en)
|
2010-08-16 |
2015-10-29 |
Amgen Inc |
Polypeptides That Bind Myostatin, Compositions And Methods
|
|
CN103261222B
(zh)
|
2010-09-10 |
2017-07-28 |
医疗免疫有限公司 |
抗体衍生物
|
|
WO2012044831A1
(en)
|
2010-09-30 |
2012-04-05 |
Board Of Trustees Of Northern Illinois University |
Library-based methods and compositions for introducing molecular switch functionality into protein affinity reagents
|
|
CN108715614A
(zh)
|
2010-11-30 |
2018-10-30 |
中外制药株式会社 |
与多分子的抗原重复结合的抗原结合分子
|
|
MX348152B
(es)
|
2010-12-14 |
2017-06-02 |
Nat Univ Singapore |
Anticuerpo monoclonal humano con especificidad para el virus del dengue serotipo 1 proteina e y sus usos.
|
|
WO2012088247A2
(en)
|
2010-12-22 |
2012-06-28 |
Medimmune, Llc |
Anti-c5/c5a/c5adesr antibodies and fragments
|
|
US20140080153A1
(en)
|
2011-01-07 |
2014-03-20 |
Chugai Seiyaku Kabushiki Kaisha |
Method for improving physical properties of antibody
|
|
CN112812184A
(zh)
|
2011-02-25 |
2021-05-18 |
中外制药株式会社 |
FcγRIIb特异性Fc抗体
|
|
WO2012132067A1
(ja)
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
|
DK2698431T3
(da)
|
2011-03-30 |
2020-11-30 |
Chugai Pharmaceutical Co Ltd |
Opretholdelse af antigen-bindende molekyler i blodplasma og fremgangsmåde til modifikation af immunogenicitet
|
|
AU2012249454B2
(en)
|
2011-04-29 |
2016-03-24 |
Apexigen, Inc. |
Anti-CD40 antibodies and methods of use
|
|
KR101641057B1
(ko)
|
2011-05-04 |
2016-07-20 |
오메로스 코포레이션 |
Masp-2 의존적 보체 활성화를 억제하는 조성물
|
|
CA2839986A1
(en)
|
2011-06-20 |
2012-12-27 |
St. Louis University |
Targeting the neuromuscular junction for treatment
|
|
TWI687441B
(zh)
|
2011-06-30 |
2020-03-11 |
中外製藥股份有限公司 |
異源二聚化多胜肽
|
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
|
TW201945034A
(zh)
|
2011-09-30 |
2019-12-01 |
日商中外製藥股份有限公司 |
包含依離子濃度之條件對抗原之結合活性會改變之抗原結合分域、及於pH中性之條件下對FcRn有結合活性之FcRn結合分域、且誘導對標的抗原的免疫反應之抗原結合分子
|
|
SG11201401102VA
(en)
|
2011-09-30 |
2014-09-26 |
Chugai Pharmaceutical Co Ltd |
Ion concentration-dependent binding molecule library
|
|
US20150050269A1
(en)
|
2011-09-30 |
2015-02-19 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
|
|
TW201817745A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
SG11201401101XA
(en)
|
2011-09-30 |
2014-08-28 |
Chugai Pharmaceutical Co Ltd |
Antigen-binding molecule for promoting loss of antigens
|
|
US20150299313A1
(en)
|
2011-10-05 |
2015-10-22 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule for promoting clearance from plasma of antigen comprising suger chain receptor-binding domain
|
|
EP2787081A4
(en)
|
2011-11-30 |
2015-10-07 |
Chugai Pharmaceutical Co Ltd |
PHARMACEUTICAL CARRIER IN CELLS FOR THE FORMATION OF AN IMMUNOMOPLEX
|
|
US20140349321A1
(en)
|
2011-12-16 |
2014-11-27 |
Agency For Science, Technology And Research |
Binding molecules against dengue virus and uses thereof
|
|
SG11201404751UA
(en)
|
2012-02-09 |
2014-09-26 |
Chugai Pharmaceutical Co Ltd |
Modified fc region of antibody
|
|
TWI682939B
(zh)
|
2012-02-24 |
2020-01-21 |
日商中外製藥股份有限公司 |
經FcγRIIB促進抗原消失之抗原結合分子
|
|
NZ730271A
(en)
|
2012-03-16 |
2022-09-30 |
Regeneron Pharma |
Non-human animals expressing ph-sensitive immunoglobulin sequences
|
|
ES2665793T3
(es)
|
2012-03-16 |
2018-04-27 |
Regeneron Pharmaceuticals, Inc. |
Anticuerpos de cadena ligera modificada mediante ingeniería genética con histidina y roedores modificados genéticamente para la generación de los mismos
|
|
CN104302170B
(zh)
|
2012-03-16 |
2016-09-28 |
瑞泽恩制药公司 |
生产具有ph依赖性结合特性的抗原结合蛋白的小鼠
|
|
ES2651692T3
(es)
|
2012-03-29 |
2018-01-29 |
Novimmune Sa |
Anticuerpos anti-TLR4 y sus usos
|
|
WO2013151764A1
(en)
|
2012-04-02 |
2013-10-10 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for dengue virus epitopes
|
|
TWI619729B
(zh)
|
2012-04-02 |
2018-04-01 |
再生元醫藥公司 |
抗-hla-b*27抗體及其用途
|
|
JP5988659B2
(ja)
|
2012-04-09 |
2016-09-07 |
シャープ株式会社 |
送風機
|
|
WO2013166099A1
(en)
|
2012-05-01 |
2013-11-07 |
Glaxosmithkline Llc |
Novel antibodies
|
|
US9255154B2
(en)
|
2012-05-08 |
2016-02-09 |
Alderbio Holdings, Llc |
Anti-PCSK9 antibodies and use thereof
|
|
WO2013173348A1
(en)
|
2012-05-14 |
2013-11-21 |
The Usa, As Represented By The Secretary, Dept. Of Health & Human Services |
Cross-reactive antibodies against dengue virus and uses thereof
|
|
CN107759686A
(zh)
|
2012-05-30 |
2018-03-06 |
中外制药株式会社 |
靶组织特异性抗原结合分子
|
|
ES2856272T3
(es)
|
2012-05-30 |
2021-09-27 |
Chugai Pharmaceutical Co Ltd |
Molécula de unión a antígenos para eliminar antígenos agregados
|
|
EP4310191A3
(en)
|
2012-06-14 |
2024-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule containing modified fc region
|
|
SA113340642B1
(ar)
|
2012-06-15 |
2015-09-15 |
فايزر إنك |
أجسام مضادة معارضة محسنة ضد gdf-8 واستخداماتها
|
|
WO2014006217A1
(en)
|
2012-07-06 |
2014-01-09 |
Genmab B.V. |
Dimeric protein with triple mutations
|
|
BR112015002605B1
(pt)
|
2012-08-07 |
2023-03-07 |
Massachusetts Institute Of Technology |
Agente de anticorpo específico para o vírus da dengue, seu uso, kit, composição farmacêutica e método para sua produção
|
|
WO2014028354A1
(en)
|
2012-08-13 |
2014-02-20 |
Regeneron Pharmaceuticals, Inc. |
Anti-pcsk9 antibodies with ph-dependent binding characteristics
|
|
US9133269B2
(en)
|
2012-08-24 |
2015-09-15 |
Anaptysbio, Inc. |
Humanized antibodies directed against complement protein C5
|
|
EP3721900A1
(en)
|
2012-08-24 |
2020-10-14 |
Chugai Seiyaku Kabushiki Kaisha |
Fcgammariib-specific fc region variant
|
|
JP6774164B2
(ja)
|
2012-08-24 |
2020-10-21 |
中外製薬株式会社 |
マウスFcγRII特異的Fc抗体
|
|
TWI660972B
(zh)
|
2012-09-10 |
2019-06-01 |
愛爾蘭商尼歐托普生物科學公司 |
抗mcam抗體及相關使用方法
|
|
RS65556B1
(sr)
|
2012-09-13 |
2024-06-28 |
Bristol Myers Squibb Co |
Proteini domena skele na bazi fibronektina koji vezuju miostatin
|
|
TW201418707A
(zh)
|
2012-09-21 |
2014-05-16 |
Alexion Pharma Inc |
補體組分c5拮抗劑之篩選分析
|
|
MX388059B
(es)
|
2012-11-06 |
2025-03-19 |
Scholar Rock Inc |
Composiciones y metodos para modular la comunicacion celular.
|
|
CN105073133B
(zh)
|
2012-12-21 |
2021-04-20 |
Aveo制药公司 |
抗gdf15抗体
|
|
KR102249779B1
(ko)
|
2012-12-27 |
2021-05-07 |
추가이 세이야쿠 가부시키가이샤 |
헤테로이량화 폴리펩티드
|
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
|
CN105051064A
(zh)
|
2013-01-24 |
2015-11-11 |
葛兰素史克知识产权开发有限公司 |
抗TNF-α抗原结合蛋白
|
|
CA2899589C
(en)
|
2013-01-31 |
2022-02-22 |
Seoul National University R & Db Foundation |
C5 antibody and method for preventing and treating complement-related diseases
|
|
JO3532B1
(ar)
|
2013-03-13 |
2020-07-05 |
Regeneron Pharma |
الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
|
|
US9481725B2
(en)
|
2013-03-14 |
2016-11-01 |
Alderbio Holdings, Llc |
Antibodies to HGF and compositions containing
|
|
US20160031985A1
(en)
|
2013-03-15 |
2016-02-04 |
Katherine S. Bowdish |
Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use
|
|
US9321686B2
(en)
|
2013-03-15 |
2016-04-26 |
Forta Corporation |
Reinforcement fiber coating compositions, methods of making and treating, and uses for improved adhesion to asphalt and portland cement concrete
|
|
MX366425B
(es)
|
2013-03-15 |
2019-07-04 |
Affibody Ab |
Nuevos polipeptidos.
|
|
CN105452298B
(zh)
|
2013-03-15 |
2021-08-31 |
拜尔健康护理有限责任公司 |
改善药代动力学的具有跨pH范围差异结合的抗TFPI抗体变体
|
|
EP3587448B1
(en)
|
2013-03-15 |
2021-05-19 |
Xencor, Inc. |
Heterodimeric proteins
|
|
AU2014228423A1
(en)
|
2013-03-15 |
2015-11-05 |
Amgen Inc. |
Myostatin antagonism in human subjects
|
|
EP2970501A2
(en)
|
2013-03-15 |
2016-01-20 |
Amgen, Inc. |
Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9
|
|
EP2968985A2
(en)
|
2013-03-15 |
2016-01-20 |
Amgen, Inc. |
Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9
|
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
|
US20160051673A1
(en)
|
2013-03-29 |
2016-02-25 |
Alexion Pharmaceuticals, Inc. |
Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
|
|
KR102318483B1
(ko)
|
2013-04-02 |
2021-10-27 |
추가이 세이야쿠 가부시키가이샤 |
Fc영역 개변체
|
|
EP2981822B1
(en)
|
2013-05-06 |
2020-09-02 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
|
WO2014184384A1
(en)
|
2013-05-17 |
2014-11-20 |
Centre National De La Recherche Scientifique (Cnrs) |
Anti-cxcl1, cxcl7 and cxcl8 antibodies and their applications
|
|
US10111953B2
(en)
|
2013-05-30 |
2018-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
|
|
DK3004174T3
(da)
|
2013-05-31 |
2019-07-22 |
Zymeworks Inc |
Heteromultimerer med reduceret eller nedreguleret effektorfunktion
|
|
RU2727836C2
(ru)
|
2013-07-25 |
2020-07-24 |
Сайтомкс Терапьютикс, Инк. |
Мультспецифические антитела, мультспецифические активируемые антитела и способы их применения
|
|
BR112016002198A2
(pt)
|
2013-08-14 |
2017-09-12 |
Novartis Ag |
métodos de tratamento de miosite por corpos de inclusão esporádica
|
|
JP2016531910A
(ja)
|
2013-08-16 |
2016-10-13 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
移植前の臓器への補体阻害剤の投与による移植拒絶の処置
|
|
WO2015034000A1
(ja)
|
2013-09-04 |
2015-03-12 |
プロテノバ株式会社 |
イムノグロブリン結合ドメイン多量体
|
|
SG10201810825YA
(en)
|
2013-09-18 |
2019-01-30 |
Regeneron Pharma |
Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
|
|
EP2853898B1
(en)
|
2013-09-27 |
2017-01-04 |
Medizinische Hochschule Hannover |
Analysis of myostatin in serum
|
|
EA201691027A1
(ru)
|
2013-11-20 |
2016-12-30 |
Ридженерон Фармасьютикалз, Инк. |
Модуляторы aplnr и их применение
|
|
EP3080159A4
(en)
|
2013-12-13 |
2017-08-02 |
The Trustees Of The University Of Pennsylvania |
Dna antibody constructs and method of using same
|
|
US20170248609A1
(en)
|
2014-01-27 |
2017-08-31 |
Novartis Ag |
Biomarkers predictive of muscle atrophy, method and use
|
|
WO2015122995A1
(en)
|
2014-02-11 |
2015-08-20 |
Visterra, Inc. |
Antibody moleules to dengue virus and uses thereof
|
|
SG10201807826XA
(en)
|
2014-02-11 |
2018-10-30 |
Massachusetts Inst Technology |
Novel full spectrum anti-dengue antibody
|
|
JP6619745B2
(ja)
|
2014-02-20 |
2019-12-11 |
アラーガン、インコーポレイテッドAllergan,Incorporated |
補体成分c5抗体
|
|
NZ711451A
(en)
|
2014-03-07 |
2016-05-27 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
|
JP6451279B2
(ja)
|
2014-03-31 |
2019-01-16 |
信越化学工業株式会社 |
フルオロポリエーテル基含有ポリマー変性シラン、表面処理剤及び物品
|
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
|
GB201413086D0
(en)
|
2014-07-23 |
2014-09-03 |
Imp Innovations Ltd And Inst Pasteur |
Methods
|
|
US9688717B2
(en)
|
2014-09-10 |
2017-06-27 |
Purdue Research Foundation |
Raman tag
|
|
WO2016073853A1
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Anti-pro/latent-myostatin antibodies and uses thereof
|
|
WO2016073879A2
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Transforming growth factor-related antibodies and uses thereof
|
|
BR112017011411A2
(pt)
|
2014-12-08 |
2018-02-14 |
Novartis Ag |
antagonistas da miostatina ou da activina para o tratamento da sarcopenia
|
|
KR102650420B1
(ko)
|
2014-12-19 |
2024-03-21 |
추가이 세이야쿠 가부시키가이샤 |
항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
|
|
TWI617580B
(zh)
|
2014-12-19 |
2018-03-11 |
中外製藥股份有限公司 |
抗c5抗體及使用方法
|
|
WO2016117346A1
(en)
|
2015-01-22 |
2016-07-28 |
Chugai Seiyaku Kabushiki Kaisha |
A combination of two or more anti-c5 antibodies and methods of use
|
|
KR102605798B1
(ko)
*
|
2015-02-05 |
2023-11-23 |
추가이 세이야쿠 가부시키가이샤 |
이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
|
|
SG11201707592TA
(en)
|
2015-03-17 |
2017-10-30 |
Agency Science Tech & Res |
A serotype cross-reactive, dengue neutralizing antibody and uses thereof
|
|
US20190135903A1
(en)
|
2015-03-31 |
2019-05-09 |
Alexion Pharmaceuticals, Inc. |
Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients
|
|
IL255010B2
(en)
|
2015-04-15 |
2024-01-01 |
Regeneron Pharma |
Methods of increasing strength and functionality with gdf8 inhibitors
|
|
US10940126B2
(en)
|
2015-07-03 |
2021-03-09 |
Camilla Svensson |
Inhibition of IL-8 in the treatment of pain and/or bone loss
|
|
PT3922645T
(pt)
|
2015-09-15 |
2025-05-29 |
Scholar Rock Inc |
¿anticorpos anti-pró-miostatina/miostatina latente e suas utilizações
|
|
MX2018003005A
(es)
|
2015-09-18 |
2018-04-11 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos que se unen a interleucina 8 (il-8) y sus usos.
|
|
TWI747936B
(zh)
|
2015-12-18 |
2021-12-01 |
日商中外製藥股份有限公司 |
抗c5抗體及使用方法
|
|
TWI605057B
(zh)
|
2015-12-18 |
2017-11-11 |
中外製藥股份有限公司 |
抗肌抑素抗體、含變異fc區之多肽及使用方法
|
|
US10233252B2
(en)
|
2015-12-21 |
2019-03-19 |
Wisconsin Alumni Research Foundation |
pH-dependent antibodies targeting the transferrin receptor and methods of use thereof to deliver a therapeutic agent
|
|
JP7141336B2
(ja)
|
2015-12-25 |
2022-09-22 |
中外製薬株式会社 |
抗ミオスタチン抗体および使用方法
|
|
JP2019504064A
(ja)
|
2016-01-08 |
2019-02-14 |
スカラー ロック インコーポレイテッドScholar Rock,Inc. |
抗プロ/潜在型ミオスタチン抗体およびその使用方法
|
|
US20190023775A1
(en)
|
2016-01-11 |
2019-01-24 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment
|
|
GB201610162D0
(en)
|
2016-06-10 |
2016-07-27 |
Imp Innovations Ltd And Inst Pasteur |
Methods
|
|
LT3368069T
(lt)
|
2016-06-13 |
2020-12-10 |
Scholar Rock, Inc. |
Miostatino inhibitorių naudojimas, ir kombinuotas gydymas
|
|
EP4374922A3
(en)
|
2016-06-14 |
2024-08-28 |
Regeneron Pharmaceuticals, Inc. |
Anti-c5 antibodies and uses thereof
|
|
EA201990018A1
(ru)
|
2016-06-17 |
2019-08-30 |
Чугаи Сейяку Кабусики Кайся |
Антитела к с5 и способы их применения
|
|
TWI760396B
(zh)
|
2016-06-17 |
2022-04-11 |
日商中外製藥股份有限公司 |
抗肌抑素抗體及使用方法
|
|
TW202300168A
(zh)
|
2016-08-05 |
2023-01-01 |
日商中外製藥股份有限公司 |
Il-8相關疾病之治療用或預防用組成物
|
|
SG10201607778XA
(en)
|
2016-09-16 |
2018-04-27 |
Chugai Pharmaceutical Co Ltd |
Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
|
|
KR101949891B1
(ko)
|
2017-01-31 |
2019-02-19 |
추가이 세이야쿠 가부시키가이샤 |
C5-관련 질환의 치료 또는 예방용 의약 조성물 및 c5-관련 질환을 치료 또는 예방하기 위한 방법
|
|
CA3054067A1
(en)
|
2017-03-14 |
2018-09-20 |
Five Prime Therapeutics, Inc. |
Antibodies binding to vista at acidic ph
|
|
CN110446720B
(zh)
|
2017-03-16 |
2023-09-12 |
免疫医疗有限公司 |
抗par2抗体及其用途
|
|
CA3058023A1
(en)
|
2017-04-03 |
2018-10-11 |
Inflarx Gmbh |
Treatment of inflammatory diseases with inhibitors of c5a activity
|
|
KR20200132938A
(ko)
|
2018-03-15 |
2020-11-25 |
추가이 세이야쿠 가부시키가이샤 |
지카 바이러스에 대해 교차-반응성을 갖는 항-뎅기 바이러스 항체 및 사용 방법
|
|
US20210301004A1
(en)
|
2018-08-01 |
2021-09-30 |
Chugai Seiyaku Kabushiki Kaisha |
A pharmaceutical composition for use in the treatment or prevention of a c5-related disease and a method for treating or preventing a c5-related disease
|
|
AU2020273072A1
(en)
|
2019-04-10 |
2021-12-09 |
Chugai Seiyaku Kabushiki Kaisha |
Method for purifying Fc region-modified antibody
|