BR112022021426A2 - Anticorpo biespecífico anti-cd73/anti-pd-1, molécula de ácido nucleico isolada, vetor, célula hospedeira, método para preparar o anticorpo biespecífico anti-cd73/anti-pd-1, conjugado, kit, usos do anticorpo biespecífico anti-cd73/anti-pd-1, composição farmacêutica, método in vitro, linhagem celular de hibridoma e anticorpo monoclonal anti-cd73 - Google Patents
Anticorpo biespecífico anti-cd73/anti-pd-1, molécula de ácido nucleico isolada, vetor, célula hospedeira, método para preparar o anticorpo biespecífico anti-cd73/anti-pd-1, conjugado, kit, usos do anticorpo biespecífico anti-cd73/anti-pd-1, composição farmacêutica, método in vitro, linhagem celular de hibridoma e anticorpo monoclonal anti-cd73Info
- Publication number
- BR112022021426A2 BR112022021426A2 BR112022021426A BR112022021426A BR112022021426A2 BR 112022021426 A2 BR112022021426 A2 BR 112022021426A2 BR 112022021426 A BR112022021426 A BR 112022021426A BR 112022021426 A BR112022021426 A BR 112022021426A BR 112022021426 A2 BR112022021426 A2 BR 112022021426A2
- Authority
- BR
- Brazil
- Prior art keywords
- bispecific antibody
- antibody
- pharmaceutical composition
- conjugate
- kit
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 title abstract 2
- 210000004408 hybridoma Anatomy 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
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Abstract
ANTICORPO BIESPECÍFICO ANTI-CD73/ANTI-PD-1, MOLÉCULA DE ÁCIDO NUCLEICO ISOLADA, VETOR, CÉLULA HOSPEDEIRA, MÉTODO PARA PREPARAR O ANTICORPO BIESPECÍFICO ANTI-CD73/ANTI-PD-1, CONJUGADO, KIT, USOS DO ANTICORPO BIESPECÍFICO ANTI-CD73/ANTI-PD-1, COMPOSIÇÃO FARMACÊUTICA, MÉTODO IN VITRO, LINHAGEM CELULAR DE HIBRIDOMA E ANTICORPO MONOCLONAL ANTI-CD73. São fornecidos um anticorpo biespecífico anti-CD73-anti-PD-1, uma composição farmacêutica do mesmo e um uso do mesmo.
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CN202010324783 | 2020-04-22 | ||
CN202110270671 | 2021-03-12 | ||
PCT/CN2021/089059 WO2021213475A1 (zh) | 2020-04-22 | 2021-04-22 | 抗cd73-抗pd-1双特异性抗体及其用途 |
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EP (1) | EP4141033A4 (pt) |
JP (1) | JP2023522730A (pt) |
KR (1) | KR20230004726A (pt) |
CN (1) | CN113527501A (pt) |
AU (1) | AU2021261803A1 (pt) |
BR (1) | BR112022021426A2 (pt) |
CA (1) | CA3176321A1 (pt) |
IL (1) | IL297432A (pt) |
MX (1) | MX2022013311A (pt) |
WO (1) | WO2021213475A1 (pt) |
ZA (1) | ZA202211405B (pt) |
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US20240018254A1 (en) * | 2020-10-23 | 2024-01-18 | Akeso Biopharma, Inc | Anti-cd73 antibody and use thereof |
CN115073588B (zh) * | 2021-03-12 | 2024-06-18 | 中山康方生物医药有限公司 | 提高含有免疫球蛋白Fc片段的药物的安全性的方法 |
WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
WO2023246247A1 (zh) * | 2022-06-22 | 2023-12-28 | 中山康方生物医药有限公司 | 药物组合物及其用途 |
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
CA2802344C (en) * | 2010-06-18 | 2023-06-13 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
JP6755866B2 (ja) * | 2014-11-10 | 2020-09-16 | メディミューン リミテッド | Cd73特異的結合分子及びその使用 |
GB2538120A (en) | 2014-11-11 | 2016-11-09 | Medimmune Ltd | Therapeutic combinations comprising anti-CD73 antibodies and uses thereof |
HUE050596T2 (hu) * | 2014-11-21 | 2020-12-28 | Bristol Myers Squibb Co | Antitestek CD73 ellen és azok felhasználásai |
SG10201912150TA (en) * | 2015-10-06 | 2020-02-27 | Alector Llc | Anti-trem2 antibodies and methods of use thereof |
AU2016381964B2 (en) * | 2015-12-30 | 2024-02-15 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
US20190284293A1 (en) * | 2016-03-04 | 2019-09-19 | Bristol-Myers Squibb Company | Combination therapy with anti-cd73 antibodies |
CA3026050A1 (en) * | 2016-08-05 | 2018-02-08 | Chugai Seiyaku Kabushiki Kaisha | Composition for prophylaxis or treatment of il-8 related diseases |
CN106967172B (zh) * | 2016-08-23 | 2019-01-08 | 康方药业有限公司 | 抗ctla4-抗pd-1 双功能抗体、其药物组合物及其用途 |
CN106977602B (zh) * | 2016-08-23 | 2018-09-25 | 中山康方生物医药有限公司 | 一种抗pd1单克隆抗体、其药物组合物及其用途 |
US20210008206A1 (en) * | 2017-11-06 | 2021-01-14 | Corvus Pharmaceuticals, Inc. | Adenosine pathway inhibitors for cancer treatment |
AU2019231172B2 (en) * | 2018-03-09 | 2023-08-24 | Phanes Therapeutics, Inc. | Anti-CD73 antibodies and uses thereof |
CN112218657A (zh) * | 2018-04-12 | 2021-01-12 | 百时美施贵宝公司 | Cd73拮抗剂抗体和pd-1/pd-l1轴拮抗剂抗体的抗癌组合疗法 |
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- 2021-04-22 IL IL297432A patent/IL297432A/en unknown
- 2021-04-22 JP JP2022564073A patent/JP2023522730A/ja active Pending
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IL297432A (en) | 2022-12-01 |
WO2021213475A1 (zh) | 2021-10-28 |
KR20230004726A (ko) | 2023-01-06 |
ZA202211405B (en) | 2024-02-28 |
EP4141033A1 (en) | 2023-03-01 |
AU2021261803A1 (en) | 2023-01-05 |
US20230151111A1 (en) | 2023-05-18 |
EP4141033A4 (en) | 2024-05-29 |
MX2022013311A (es) | 2022-11-14 |
CA3176321A1 (en) | 2021-10-28 |
CN113527501A (zh) | 2021-10-22 |
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