MX2018010427A - Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. - Google Patents

Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion.

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Publication number
MX2018010427A
MX2018010427A MX2018010427A MX2018010427A MX2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A MX 2018010427 A MX2018010427 A MX 2018010427A
Authority
MX
Mexico
Prior art keywords
methods
solid forms
production
acc inhibitor
thienopyrimidinedione
Prior art date
Application number
MX2018010427A
Other languages
English (en)
Inventor
C Harriman Geraldine
Morrison Henry
Alexander Katy
C Amedio John Jr
Calimsiz Selcuk
Geier Michael
Hu Sijun
P Lawson Jon
Sabourin Kyle
Varghese Vimal
Arvind Varia Kunal
Yang Xiaowei
E Scott Mark
Wang Xiaotian
Original Assignee
Gilead Apollo Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Apollo Llc filed Critical Gilead Apollo Llc
Publication of MX2018010427A publication Critical patent/MX2018010427A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)

Abstract

La presente invención proporciona formas sólidas de compuestos útiles como inhibidores de la acetil CoA carboxilasa (ACC), sus composiciones, sus métodos de producción y métodos de uso de los mismos en el tratamiento de enfermedades mediadas por la ACC.
MX2018010427A 2016-03-02 2017-03-01 Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion. MX2018010427A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662302755P 2016-03-02 2016-03-02
US201662303237P 2016-03-03 2016-03-03
PCT/US2017/020271 WO2017151816A1 (en) 2016-03-02 2017-03-01 Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof

Publications (1)

Publication Number Publication Date
MX2018010427A true MX2018010427A (es) 2019-03-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018010427A MX2018010427A (es) 2016-03-02 2017-03-01 Formas solidas de un inhibidor de tienopirimidindiona acetil coa carboxilasa y metodos para su produccion.

Country Status (13)

Country Link
US (4) US10183951B2 (es)
EP (2) EP4364795A2 (es)
JP (3) JP6944462B2 (es)
KR (2) KR102622161B1 (es)
CN (2) CN108699078A (es)
AU (3) AU2017226267B2 (es)
BR (1) BR112018067408A2 (es)
CA (4) CA3172549A1 (es)
IL (1) IL261255A (es)
MX (1) MX2018010427A (es)
SG (1) SG11201807077RA (es)
TW (2) TWI818828B (es)
WO (1) WO2017151816A1 (es)

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CA3015526C (en) 2022-10-04
CA3220447A1 (en) 2017-09-08
TW202400605A (zh) 2024-01-01
US10183951B2 (en) 2019-01-22
US20200148699A1 (en) 2020-05-14
WO2017151816A1 (en) 2017-09-08
AU2017226267B2 (en) 2021-06-24
US20190225623A1 (en) 2019-07-25
AU2021209149A1 (en) 2021-08-19
US11104687B2 (en) 2021-08-31
CN108699078A (zh) 2018-10-23
JP2021185206A (ja) 2021-12-09
AU2023206094A1 (en) 2023-08-10
KR20230035692A (ko) 2023-03-14
EP3423456C0 (en) 2023-12-27
AU2021209149B2 (en) 2023-04-20
CA3172549A1 (en) 2017-09-08
AU2017226267A1 (en) 2018-09-06
CA3015526A1 (en) 2017-09-08
CA3155220A1 (en) 2017-09-08
US20170267690A1 (en) 2017-09-21
JP2023010977A (ja) 2023-01-20
JP7356564B2 (ja) 2023-10-04
IL261255A (en) 2018-10-31
TWI788281B (zh) 2023-01-01
US10487090B2 (en) 2019-11-26
JP2019507160A (ja) 2019-03-14
TWI818828B (zh) 2023-10-11
US20220064181A1 (en) 2022-03-03
JP7184988B2 (ja) 2022-12-06
SG11201807077RA (en) 2018-09-27
TW202330543A (zh) 2023-08-01
EP3423456A1 (en) 2019-01-09
KR102622161B1 (ko) 2024-01-09
US11912718B2 (en) 2024-02-27
CN112920200A (zh) 2021-06-08
KR20180114937A (ko) 2018-10-19
EP4364795A2 (en) 2024-05-08
JP6944462B2 (ja) 2021-10-06
TW201738247A (zh) 2017-11-01
EP3423456B1 (en) 2023-12-27
CA3155220C (en) 2024-01-16
BR112018067408A2 (pt) 2018-12-26

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