WO2008143262A1 - 複素環化合物およびその用途 - Google Patents

複素環化合物およびその用途 Download PDF

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Publication number
WO2008143262A1
WO2008143262A1 PCT/JP2008/059286 JP2008059286W WO2008143262A1 WO 2008143262 A1 WO2008143262 A1 WO 2008143262A1 JP 2008059286 W JP2008059286 W JP 2008059286W WO 2008143262 A1 WO2008143262 A1 WO 2008143262A1
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WIPO (PCT)
Prior art keywords
disease
heterocyclic compound
compound
disclosed
hyperlipemia
Prior art date
Application number
PCT/JP2008/059286
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English (en)
French (fr)
Inventor
Takanobu Kuroita
Hideyuki Igawa
Hiroki Sakamoto
Kouhei Asano
Minoru Sasaki
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Priority to US12/451,602 priority Critical patent/US8501750B2/en
Priority to JP2009515248A priority patent/JPWO2008143262A1/ja
Priority to EP08764423A priority patent/EP2151440A4/en
Publication of WO2008143262A1 publication Critical patent/WO2008143262A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61P7/06—Antianaemics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

　本発明は、高血圧症、心臓病、動脈硬化、腎疾患、脳卒中などの循環器系疾患および／または高脂血症、ならびに肥満症、糖尿病などの代謝性疾患、脳梗塞などの中枢神経障害、痴呆症、うつ病などの精神疾患などの予防・治療に有用であり、かつ優れた薬理作用、物理化学的性質などを有する化合物を提供することを目的とする。 　一般式（Ｉ）： [式中の各記号は、明細書記載のとおり]で表される化合物またはその塩。
PCT/JP2008/059286 2007-05-21 2008-05-20 複素環化合物およびその用途 WO2008143262A1 (ja)

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US9453026B2 (en) 2011-11-11 2016-09-27 Gilead Apollo, Inc. ACC inhibitors and uses thereof
JP2018538246A (ja) * 2015-10-26 2018-12-27 ギリアド アポロ， エルエルシー Ａｃｃ阻害剤およびその使用
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JP7265681B2 (ja) 2019-12-05 2023-04-26 ▲ザン▼州片仔▲ファン▼薬業股▲フン▼有限公司 Ａｃｃ１及びａｃｃ２阻害剤としての結晶形及びその製造方法並びに使用

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