WO2009028629A1 - 複素環化合物およびその用途 - Google Patents

複素環化合物およびその用途 Download PDF

Info

Publication number
WO2009028629A1
WO2009028629A1 PCT/JP2008/065454 JP2008065454W WO2009028629A1 WO 2009028629 A1 WO2009028629 A1 WO 2009028629A1 JP 2008065454 W JP2008065454 W JP 2008065454W WO 2009028629 A1 WO2009028629 A1 WO 2009028629A1
Authority
WO
WIPO (PCT)
Prior art keywords
heterocyclic compound
formula
disclosed
substituents
iii
Prior art date
Application number
PCT/JP2008/065454
Other languages
English (en)
French (fr)
Inventor
Masaaki Hirose
Masanori Okaniwa
Yoko Hayashi
Terufumi Takagi
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Priority to EP08828528.3A priority Critical patent/EP2184285B1/en
Priority to JP2009530185A priority patent/JP5350247B2/ja
Priority to US12/675,663 priority patent/US8344135B2/en
Priority to TW097145882A priority patent/TW201004620A/zh
Priority to PE2008002012A priority patent/PE20091259A1/es
Priority to ARP080105279A priority patent/AR069567A1/es
Publication of WO2009028629A1 publication Critical patent/WO2009028629A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

　本発明は、強力なＲａｆ阻害活性を示す下式複素環化合物を提供する。式（ＩＩＩ） 〔式中、各置換基の定義は本文中と同意義を示す。〕で表される化合物またはその塩。
PCT/JP2008/065454 2007-08-29 2008-08-28 複素環化合物およびその用途 WO2009028629A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP08828528.3A EP2184285B1 (en) 2007-08-29 2008-08-28 Heterocyclic compound and use thereof
JP2009530185A JP5350247B2 (ja) 2007-08-29 2008-08-28 複素環化合物およびその用途
US12/675,663 US8344135B2 (en) 2007-08-29 2008-08-28 Heterocyclic compound and use thereof
TW097145882A TW201004620A (en) 2008-07-18 2008-11-27 Heterocyclic compound and use thereof
PE2008002012A PE20091259A1 (es) 2008-07-18 2008-12-03 Compuestos heterociclicos como inhibidores de raf quinasa
ARP080105279A AR069567A1 (es) 2008-07-18 2008-12-04 Compuestos heterociclicos que tienen una fuerte actividad inhibidora de raf y son utiles para el tratamiento preventivo y similares del cancer y sus usos

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-223284 2007-08-29
JP2007223284 2007-08-29
JP2008187953 2008-07-18
JP2008-187953 2008-07-18

Publications (1)

Publication Number Publication Date
WO2009028629A1 true WO2009028629A1 (ja) 2009-03-05

Family

ID=40387343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065454 WO2009028629A1 (ja) 2007-08-29 2008-08-28 複素環化合物およびその用途

Country Status (4)

Country Link
US (1) US8344135B2 (ja)
EP (1) EP2184285B1 (ja)
JP (1) JP5350247B2 (ja)
WO (1) WO2009028629A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010064611A1 (ja) * 2008-12-01 2010-06-10 武田薬品工業株式会社 複素環化合物およびその用途
US8143258B2 (en) 2008-12-02 2012-03-27 Takeda Pharmaceutical Company Limited Benzothiazole compounds useful for Raf inhibition
US8304557B2 (en) 2007-06-05 2012-11-06 Takeda Pharmaceutical Company Limited Fused heterocycle derivatives and use thereof
US8324395B2 (en) 2007-08-23 2012-12-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8445509B2 (en) 2008-05-08 2013-05-21 Takeda Pharmaceutical Company Limited Fused heterocyclic derivatives and use thereof
US8501936B2 (en) 2009-06-05 2013-08-06 Cephalon, Inc. Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
JP2016520617A (ja) * 2013-05-30 2016-07-14 カラ ファーマシューティカルズ インコーポレイテッド 新規の化合物及びその使用
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0510378B1 (pt) 2004-04-30 2018-12-11 Blackberry Ltd Método de manusear transferências de dados em um dispositivo móvel , mídia lida porcomputador e aparelho de transferência de dados
AR072657A1 (es) * 2008-02-29 2010-09-15 Genentech Inc Compuestos inhibidores de raf y metodos para su uso
US20110003809A1 (en) * 2008-02-29 2011-01-06 Array Biopharma Inc. Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
CA2716949A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
PE20091561A1 (es) * 2008-02-29 2009-10-30 Array Biopharma Inc Compuestos inhibidores de raf y metodos para su uso
KR20130031296A (ko) 2010-05-21 2013-03-28 케밀리아 에이비 신규한 피리미딘 유도체
EP3333259B1 (en) * 2010-06-09 2021-02-24 Dana Farber Cancer Institute, Inc. A mek1 mutation conferring resistance to raf and mek inhibitors
DK2688883T3 (en) 2011-03-24 2016-09-05 Noviga Res Ab pyrimidine
WO2012148792A1 (en) * 2011-04-26 2012-11-01 Merck Sharp & Dohme Corp. Heterocyclic compounds as b-raf inhibitors for treatment of cancer
US9161226B2 (en) 2011-10-17 2015-10-13 Blackberry Limited Associating services to perimeters
US9497220B2 (en) 2011-10-17 2016-11-15 Blackberry Limited Dynamically generating perimeters
US9613219B2 (en) 2011-11-10 2017-04-04 Blackberry Limited Managing cross perimeter access
US8799227B2 (en) 2011-11-11 2014-08-05 Blackberry Limited Presenting metadata from multiple perimeters
US9369466B2 (en) 2012-06-21 2016-06-14 Blackberry Limited Managing use of network resources
GB2508792A (en) * 2012-09-11 2014-06-18 Rec Modules Pte Ltd Back contact solar cell cell interconnection arrangements
US20140280698A1 (en) * 2013-03-13 2014-09-18 Qnx Software Systems Limited Processing a Link on a Device
WO2016086026A1 (en) 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
CN105884628B (zh) * 2016-06-06 2018-06-29 上海工程技术大学 2,4-二叔丁基-5-氨基酚的制备方法
US20230391768A2 (en) * 2018-11-07 2023-12-07 Dana-Farber Cancer Institute, Inc. Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
US20230148448A9 (en) * 2018-11-07 2023-05-11 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
AU2021267373A1 (en) 2020-05-06 2022-12-08 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
EP4430042A1 (en) 2021-11-09 2024-09-18 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN114805120A (zh) * 2022-05-23 2022-07-29 江苏瑞达环保科技有限公司 一种间氰甲基苯甲酸甲酯的合成工艺
WO2024081748A2 (en) * 2022-10-12 2024-04-18 Maze Therapeutics, Inc. Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044156A2 (en) * 2000-11-29 2002-06-06 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
WO2003082272A1 (en) * 2002-03-29 2003-10-09 Chiron Corporation Substituted benzazoles and use thereof as raf kinase inhibitors
WO2005032548A1 (en) * 2003-09-29 2005-04-14 Chiron Corporation Substituted benzazoles and use thereof as inhibitors of raf kinase
WO2007030377A1 (en) * 2005-08-30 2007-03-15 Novartis Ag Substituted benzimidazoles as kinase inhibitors

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US21048A (en) * 1858-07-27 holzer
US4096264A (en) 1975-12-09 1978-06-20 Merck & Co., Inc. Certain substituted imidazo [1,2-a] pyridines
US4177274A (en) 1975-12-09 1979-12-04 Merck & Co., Inc. Substituted imidazo [1,2-a] pyridines
US4237300A (en) 1975-12-09 1980-12-02 Merck & Co., Inc. Certain 6-substituted-2-pyridinamines
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
HUP0004024A3 (en) * 1997-09-26 2001-10-29 Zentaris Gmbh Azabenzimidazole-based compounds, process for their preparation and pharmaceutical composition thereof
CA2359244C (en) 1999-01-13 2013-10-08 Bayer Corporation .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
DE60103136T2 (de) 2000-03-06 2004-10-28 Smithkline Beecham Plc, Brentford Imidazolderivate als Raf-Kinase Inhibitoren
GB0005357D0 (en) 2000-03-06 2000-04-26 Smithkline Beecham Plc Compounds
WO2002024680A1 (en) 2000-09-21 2002-03-28 Smithkline Beecham P.L.C. Imidazole derivatives as raf kinase inhibitors
GB0112348D0 (en) 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
GB0121494D0 (en) 2001-09-05 2001-10-24 Smithkline Beecham Plc Compounds
US7375105B2 (en) 2001-09-05 2008-05-20 Smithkline Beecham P.L.C. Pyridine substituted furan derivatives as Raf kinase inhibitors
WO2003022837A1 (en) 2001-09-05 2003-03-20 Smithkline Beecham P.L.C. Heterocycle-carboxamide derivatives as raf kinase inhibitors
GB0121488D0 (en) 2001-09-05 2001-10-24 Smithkline Beecham Plc Compounds
EP1751124A4 (en) 2004-05-07 2010-04-14 Exelixis Inc RAF MODULATORS AND METHODS OF USE
WO2006071035A1 (en) * 2004-12-31 2006-07-06 Lg Life Sciences, Ltd. Novel ([1,3]thiazolo[5,4-b]pyridin-2-yl)-2-carboxamide derivatives
WO2006076376A1 (en) 2005-01-11 2006-07-20 Medicinova, Inc. Topical treatment of solid tumors and ocular neovascularization
US7759342B2 (en) * 2005-01-13 2010-07-20 Signal Pharmaceuticals, Llc Methods of treatment and prevention using haloaryl substituted aminopurines
KR20070052207A (ko) 2005-11-16 2007-05-21 주식회사 엘지생명과학 신규한 ｋｄｒ 억제제
CL2008001626A1 (es) * 2007-06-05 2009-06-05 Takeda Pharmaceuticals Co Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer.
WO2009025358A1 (ja) 2007-08-23 2009-02-26 Takeda Pharmaceutical Company Limited 複素環化合物およびその用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044156A2 (en) * 2000-11-29 2002-06-06 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
WO2003082272A1 (en) * 2002-03-29 2003-10-09 Chiron Corporation Substituted benzazoles and use thereof as raf kinase inhibitors
WO2005032548A1 (en) * 2003-09-29 2005-04-14 Chiron Corporation Substituted benzazoles and use thereof as inhibitors of raf kinase
WO2007030377A1 (en) * 2005-08-30 2007-03-15 Novartis Ag Substituted benzimidazoles as kinase inhibitors

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8304557B2 (en) 2007-06-05 2012-11-06 Takeda Pharmaceutical Company Limited Fused heterocycle derivatives and use thereof
US8324395B2 (en) 2007-08-23 2012-12-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8445509B2 (en) 2008-05-08 2013-05-21 Takeda Pharmaceutical Company Limited Fused heterocyclic derivatives and use thereof
WO2010064611A1 (ja) * 2008-12-01 2010-06-10 武田薬品工業株式会社 複素環化合物およびその用途
US8143258B2 (en) 2008-12-02 2012-03-27 Takeda Pharmaceutical Company Limited Benzothiazole compounds useful for Raf inhibition
US8497274B2 (en) 2008-12-02 2013-07-30 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8501936B2 (en) 2009-06-05 2013-08-06 Cephalon, Inc. Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
US8633173B2 (en) 2009-06-05 2014-01-21 Cephalon, Inc Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
JP2016520617A (ja) * 2013-05-30 2016-07-14 カラ ファーマシューティカルズ インコーポレイテッド 新規の化合物及びその使用
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors

Also Published As

Publication number Publication date
US20100249119A1 (en) 2010-09-30
US8344135B2 (en) 2013-01-01
JPWO2009028629A1 (ja) 2010-12-02
EP2184285A4 (en) 2011-07-20
EP2184285B1 (en) 2015-11-04
JP5350247B2 (ja) 2013-11-27
EP2184285A1 (en) 2010-05-12

Similar Documents

Publication Publication Date Title
WO2009028629A1 (ja) 複素環化合物およびその用途
WO2009025358A1 (ja) 複素環化合物およびその用途
WO2009028655A1 (ja) 複素環化合物およびその用途
WO2009030469A8 (en) Fungicidal 2-alkylthio-2-quinolinyloxy-acetamide deritvatives
WO2008130021A3 (en) Heterocyclic hydrazide compound and pesticidal use of the same
WO2009049716A3 (en) Novel fungicides
WO2008110355A8 (en) Quinoline derivatives as fungicides
WO2009048101A1 (ja) アミド化合物
WO2009019015A8 (en) Novel herbicides
WO2009087098A3 (en) Quinoline derivatives and their use as fungicides
MY150989A (en) Benzothiazole compounds useful for raf inhibition
WO2008102908A1 (ja) ハロアルキルスルホンアニリド誘導体
WO2006058700A8 (en) Acetamide compounds as fungicides
WO2009024342A3 (en) Novel microbiocides
EP1953145A4 (en) HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY OF 11-HYDROXYSTEROID DEHYDROGENASE TYPE I
TW200637837A (en) Fungicides
WO2010063700A3 (en) Novel pyrazole-4 -n-alkoxycarboxamides as microbiocides
WO2009060835A1 (ja) 新規ユビキリン結合性小分子
WO2006039250A3 (en) Chemokine-binding heterocyclic compound salts, and methods of use thereof
WO2009019005A8 (en) Tricyclic bridged cyclopentanedione derivatives as herbicides
WO2008153159A1 (ja) アミン化合物及びその医薬用途
WO2009007115A8 (en) Tropane derivatives useful as pesticides
WO2008151828A3 (en) Novel microbiocides
WO2009030467A3 (en) Saturated and insaturated bi- or tricyclic aryloxyacetamide derivatives and their use as fungicides
WO2009127718A3 (en) Novel microbiocides

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08828528

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2009530185

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12675663

Country of ref document: US

Ref document number: 2008828528

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE