WO2009009117A3 - Chemoenzymatic processes for preparation of levetiracetam - Google Patents
Chemoenzymatic processes for preparation of levetiracetam Download PDFInfo
- Publication number
- WO2009009117A3 WO2009009117A3 PCT/US2008/008503 US2008008503W WO2009009117A3 WO 2009009117 A3 WO2009009117 A3 WO 2009009117A3 US 2008008503 W US2008008503 W US 2008008503W WO 2009009117 A3 WO2009009117 A3 WO 2009009117A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- levetiracetam
- preparation
- processes
- polypeptides
- nitrile hydratase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01084—Nitrile hydratase (4.2.1.84)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Compounds and processes for preparing intermediates in the synthesis of levetiracetam and precursors of levetiracetam and related compounds are provided. Also provided are processes for the preparation of levetiracetam or a pharmaceutically acceptable salt thereof. Modified nitrile hydratase polypeptides and uses thereof also are provided. Among the modified nitrile hydratase polypeptides provided are those that have altered activities, including altered enantioselectivity.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95920907P | 2007-07-11 | 2007-07-11 | |
US60/959,209 | 2007-07-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009009117A2 WO2009009117A2 (en) | 2009-01-15 |
WO2009009117A3 true WO2009009117A3 (en) | 2009-04-02 |
Family
ID=40204620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/008503 WO2009009117A2 (en) | 2007-07-11 | 2008-07-11 | Chemoenzymatic processes for preparation of levetiracetam |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2009009117A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011020025A1 (en) * | 2009-08-14 | 2011-02-17 | Loyola University Of Chicago | Composition for catalytic amide production and uses thereof |
AU2015203199B2 (en) * | 2011-06-07 | 2017-10-26 | Mitsubishi Chemical Corporation | Improved nitrile hydratase |
JP5929910B2 (en) * | 2011-06-07 | 2016-06-08 | 三菱レイヨン株式会社 | Improved nitrile hydratase |
AU2015270032B2 (en) * | 2014-06-06 | 2018-11-29 | Mitsubishi Chemical Corporation | Improved nitrile hydratase |
CN107075457B (en) * | 2014-09-30 | 2021-03-26 | 巴斯夫欧洲公司 | Method for culturing microorganism having nitrile hydratase activity |
CN107881163A (en) * | 2017-09-29 | 2018-04-06 | 浙江大学 | A kind of heat-resisting nitrile hydratase, engineering bacteria and its application in catalysis nitrile compound hydration reaction generation acid amides |
CN108872213B (en) * | 2018-05-08 | 2020-12-29 | 中国航发北京航空材料研究院 | Method for measuring high-content nickel element in Au82Ni alloy |
US20230183177A1 (en) | 2020-04-24 | 2023-06-15 | Pharmazell Gmbh | Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds |
CN113106130B (en) * | 2020-06-23 | 2023-03-14 | 核芯生物医药科技(杭州)有限公司 | Application of nitrile hydratase derived from staphylococcus aggregatus in preparation of amide pyrazine compounds |
US11400074B1 (en) * | 2021-02-01 | 2022-08-02 | Divi's Laboratories Ltd. | Enzymatic process for the preparation of (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl]butyric acid and its conversion into brivaracetam |
CN113511994B (en) * | 2021-08-16 | 2023-03-21 | 江苏八巨药业有限公司 | Preparation method of levetiracetam |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307926A2 (en) * | 1987-09-18 | 1989-03-22 | YAMADA, Hideaki | Process for biological production of amides |
US20040224395A1 (en) * | 2003-05-08 | 2004-11-11 | Bramucci Michael G. | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids |
WO2004101768A2 (en) * | 2003-05-08 | 2004-11-25 | E.I. Dupont De Nemours And Company | Recombinant comamonas testosreroni 5-mgam-4d amids and carboxylic acid production |
WO2005090595A2 (en) * | 2004-03-20 | 2005-09-29 | Brain Biotechnology Research And Information Network Ag | Nitrile hydratases from metagenome libraries |
-
2008
- 2008-07-11 WO PCT/US2008/008503 patent/WO2009009117A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0307926A2 (en) * | 1987-09-18 | 1989-03-22 | YAMADA, Hideaki | Process for biological production of amides |
US20040224395A1 (en) * | 2003-05-08 | 2004-11-11 | Bramucci Michael G. | Preparation of (E)- and (Z)-2-methyl-2-butenoic acids |
WO2004101768A2 (en) * | 2003-05-08 | 2004-11-25 | E.I. Dupont De Nemours And Company | Recombinant comamonas testosreroni 5-mgam-4d amids and carboxylic acid production |
WO2005090595A2 (en) * | 2004-03-20 | 2005-09-29 | Brain Biotechnology Research And Information Network Ag | Nitrile hydratases from metagenome libraries |
Non-Patent Citations (2)
Title |
---|
BRADY D ET AL: "Characterisation of nitrilase and nitrile hydratase biocatalytic systems", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER VERLAG, BERLIN, DE, vol. 64, no. 1, 1 March 2004 (2004-03-01), pages 76 - 85, XP002333496, ISSN: 0175-7598 * |
DATABASE UniProt 1 June 2003 (2003-06-01), KANEKO T ET AL: "Nitrile hydratase subunit alpha", XP002510381, retrieved from EBI accession no. Q89LP5_BRAJA Database accession no. Q89LP5 * |
Also Published As
Publication number | Publication date |
---|---|
WO2009009117A2 (en) | 2009-01-15 |
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