LT4586B - Pakeisti benzenesulfonamidų dariniai - ciklooksigenazės-2 inhibitorių provaistai - Google Patents
Pakeisti benzenesulfonamidų dariniai - ciklooksigenazės-2 inhibitorių provaistai Download PDFInfo
- Publication number
- LT4586B LT4586B LT98-142A LT98142A LT4586B LT 4586 B LT4586 B LT 4586B LT 98142 A LT98142 A LT 98142A LT 4586 B LT4586 B LT 4586B
- Authority
- LT
- Lithuania
- Prior art keywords
- phenyl
- sulfonyl
- methyl
- phenylisoxazol
- acetamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63151496A | 1996-04-12 | 1996-04-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
LT98142A LT98142A (en) | 1999-07-26 |
LT4586B true LT4586B (lt) | 1999-12-27 |
Family
ID=24531540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT98-142A LT4586B (lt) | 1996-04-12 | 1998-10-09 | Pakeisti benzenesulfonamidų dariniai - ciklooksigenazės-2 inhibitorių provaistai |
Country Status (40)
Country | Link |
---|---|
US (4) | US5932598A (es) |
EP (2) | EP1288206B1 (es) |
JP (2) | JP3382624B2 (es) |
KR (1) | KR100387658B1 (es) |
CN (1) | CN1098256C (es) |
AP (1) | AP1009A (es) |
AT (2) | ATE233743T1 (es) |
AU (1) | AU734275C (es) |
BG (2) | BG64531B1 (es) |
BR (2) | BR9708574A (es) |
CA (1) | CA2249009C (es) |
CU (1) | CU23116A3 (es) |
CZ (1) | CZ297430B6 (es) |
DE (2) | DE69719496T2 (es) |
DK (2) | DK0892791T3 (es) |
EA (1) | EA003319B1 (es) |
EE (1) | EE03685B1 (es) |
ES (2) | ES2311571T3 (es) |
GE (1) | GEP20032998B (es) |
HK (1) | HK1019741A1 (es) |
HU (1) | HU225473B1 (es) |
IL (3) | IL153738A (es) |
IS (2) | IS2156B (es) |
LT (1) | LT4586B (es) |
LV (1) | LV12239B (es) |
ME (1) | ME00768B (es) |
NO (1) | NO314184B1 (es) |
NZ (1) | NZ331542A (es) |
OA (1) | OA11015A (es) |
PL (1) | PL195955B1 (es) |
PT (2) | PT1288206E (es) |
RO (1) | RO121338B1 (es) |
RS (1) | RS50019B (es) |
SI (2) | SI22713B (es) |
SK (1) | SK285353B6 (es) |
TR (1) | TR199802049T2 (es) |
TW (1) | TW585857B (es) |
UA (1) | UA47475C2 (es) |
WO (1) | WO1997038986A1 (es) |
ZA (1) | ZA973146B (es) |
Families Citing this family (279)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0828718A1 (en) | 1995-06-02 | 1998-03-18 | G.D. SEARLE & CO. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
CA2249009C (en) * | 1996-04-12 | 2003-09-16 | G.D. Searle & Co. | Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors |
US8022095B2 (en) | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
AU725697B2 (en) * | 1997-04-03 | 2000-10-19 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia |
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
US6887893B1 (en) | 1997-12-24 | 2005-05-03 | Sankyo Company, Limited | Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia |
JP2002506024A (ja) * | 1998-03-13 | 2002-02-26 | メルク エンド カムパニー インコーポレーテッド | 急性冠動脈虚血症候群および関連状態に対する併用療法および組成物 |
US6136804A (en) * | 1998-03-13 | 2000-10-24 | Merck & Co., Inc. | Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions |
AU4428899A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
AR024222A1 (es) * | 1998-10-16 | 2002-09-25 | Palau Pharma Sa | Imidazoles con actividad antiinflamatoria un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen |
AU759307B2 (en) * | 1998-11-02 | 2003-04-10 | Merck Sharp & Dohme Corp. | Method of treating migraines and pharmaceutical compositions |
WO2000029022A1 (en) * | 1998-11-12 | 2000-05-25 | Algos Pharmaceutical Corporation | Cox-2 inhibitors in combination with centrally acting analgesics |
US20030013739A1 (en) * | 1998-12-23 | 2003-01-16 | Pharmacia Corporation | Methods of using a combination of cyclooxygenase-2 selective inhibitors and thalidomide for the treatment of neoplasia |
US20030119895A1 (en) * | 1998-12-23 | 2003-06-26 | Pharmacia Corporation | Methods using a combination of a 3-heteroaryl-2-indolinone and a cyclooxygenase-2 inhibitor for the treatment of neoplasia |
US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
AU3596500A (en) * | 1999-02-19 | 2000-09-04 | Pozen, Inc. | Formulation of 5-ht agonists with cox-2 inhibitors |
US20010024664A1 (en) * | 1999-03-19 | 2001-09-27 | Obukowicz Mark G. | Selective COX-2 inhibition from edible plant extracts |
AU8026200A (en) | 1999-10-19 | 2001-04-30 | Board Of Regents, The University Of Texas System | Treatment of heart disease with cox-2 inhibitors |
NZ513960A (en) * | 1999-12-08 | 2004-02-27 | Pharmacia Corp | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
ATE323485T1 (de) * | 1999-12-22 | 2006-05-15 | Pharmacia Corp | Arzneizubereitungen mit zwei verschiedenen freisetzungsraten enthaltend einen cyclooxygenase-2 hemmer |
WO2001045703A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
IL151299A0 (en) | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
EP1259504A1 (en) * | 2000-03-03 | 2002-11-27 | Pfizer Products Inc. | Pyrazole ether derivatives as anti-inflammatory/analgesic agents |
US20070072861A1 (en) * | 2000-03-27 | 2007-03-29 | Barbara Roniker | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
ES2166710B1 (es) * | 2000-04-25 | 2004-10-16 | J. URIACH & CIA, S.A. | Nuevos compuestos heterociclicos con actividad antiinflamatoria. |
JP2003531202A (ja) * | 2000-04-25 | 2003-10-21 | ファルマシア・コーポレーション | 3,4−ジ(カルボシクリルまたはヘテロシクリル)チオフェンの位置選択的合成 |
JP2004503601A (ja) * | 2000-07-13 | 2004-02-05 | ファルマシア・コーポレーション | 眼のcox−2媒介疾患の処置及び予防におけるcox−2阻害剤の使用法 |
DE60129330T2 (de) | 2000-07-20 | 2008-04-10 | Lauras As | Verwendung von cox-2 inhibitoren als immunostimulantien zur behandlung von hiv oder aids |
US20030219461A1 (en) * | 2000-09-12 | 2003-11-27 | Britten Nancy J. | Parenteral combination therapy for infective conditions |
CA2422064A1 (en) * | 2000-09-18 | 2002-03-21 | Merck & Co., Inc. | Treatment of inflammation with a combination of a cyclooxygenase-2 inhibitor and an integrin alpha-v antagonist |
AU2002213467A1 (en) * | 2000-10-11 | 2002-04-22 | Chemocentryx, Inc. | Modulation of ccr4 function |
AU2002229074A1 (en) * | 2000-12-15 | 2002-06-24 | Pharmacia Corporation | Selective cox-2 inhibition from plant extracts |
JP2004517838A (ja) * | 2000-12-15 | 2004-06-17 | ファルマシア・コーポレーション | 非食用植物抽出物による選択的cox−2阻害 |
WO2002060378A2 (en) | 2000-12-21 | 2002-08-08 | Nitromed, Inc. | Substituted aryl compounds as cyclooxygenase-2 selective inhibitors, compositions and methods of use |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
EP1363669A2 (en) * | 2001-02-02 | 2003-11-26 | Pharmacia Corporation | Method of using a cyclooxygenase-2 inhibitor and sex steroids as a combination therapy for the treatment and prevention of dismenorrhea |
AU2002306868A1 (en) * | 2001-03-28 | 2002-10-15 | Pharmacia Corporation | Therapeutic combinations for cardiovascular and inflammatory indications |
PE20021017A1 (es) * | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
ITMI20010733A1 (it) | 2001-04-05 | 2002-10-05 | Recordati Chem Pharm | Uso di inibitori dell'isoenzina cox-2 per il trattamento dell'incontinenza urinaria |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
WO2002094264A1 (en) * | 2001-05-23 | 2002-11-28 | Tularik Inc. | Ccr4 antagonists |
US20030153801A1 (en) * | 2001-05-29 | 2003-08-14 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and radiation for inhibition or prevention of cardiovascular disease |
MXPA03010991A (es) * | 2001-05-31 | 2004-02-27 | Pharmacia Corp | Composicion permeable a la piel que comprende inhibidor de ciclooxigenasa-a selectivo y alcohol monohidrico. |
US20060167074A1 (en) * | 2001-06-19 | 2006-07-27 | Norbert Muller | Methods and compositions for the treatment of psychiatric disorders |
DE10129320A1 (de) * | 2001-06-19 | 2003-04-10 | Norbert Mueller | Verwendung von COX-2 Inhibitoren zur Behandlung von Schizophrenie, wahnhaften Störungen, affektiven Störungen oder Ticstörungen |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
US20040067992A1 (en) * | 2001-08-10 | 2004-04-08 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a carbonic anhydrase inhibitor for the treatment of neoplasia |
JP2005501083A (ja) * | 2001-08-10 | 2005-01-13 | ファルマシア・コーポレーション | 炭酸脱水酵素阻害剤 |
US20050101563A1 (en) * | 2001-08-14 | 2005-05-12 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation |
US20030114416A1 (en) * | 2001-08-14 | 2003-06-19 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
CA2459879A1 (en) * | 2001-09-10 | 2003-03-20 | Sugen, Inc. | 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene)-2-indolinone derivatives as kinase inhibitors |
EP1436285A4 (en) * | 2001-09-18 | 2004-12-15 | Onconova Therapeutics Inc | METHOD FOR PRODUCING 1,5-DIARYL-3-SUBSTITUTED PYRAZOLES |
US20030236308A1 (en) * | 2001-09-18 | 2003-12-25 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and acetaminophen for treatment and prevention of inflammation, inflammation-mediated disorders and pain |
WO2003024400A2 (en) | 2001-09-18 | 2003-03-27 | Onconova Therapeutics, Inc. | Process for the preparation of 1,5-diarylpyrazoles |
US20030114483A1 (en) * | 2001-09-18 | 2003-06-19 | Pharmacia Corporation | Compositions of chromene cyclooxygenase-2 selective inhibitors and acetaminophen for treatment and prevention of inflammation, inflammation-mediated disorders and pain |
EP1427706B1 (en) * | 2001-09-19 | 2007-05-30 | Pharmacia Corporation | Substituted pyrazolo compounds for the treatment of inflammation |
EP1438300A1 (en) * | 2001-10-02 | 2004-07-21 | Pharmacia Corporation | Method for preparing benzenesulfonyl compounds |
AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
WO2003031404A2 (en) * | 2001-10-12 | 2003-04-17 | Onconova Therapeutics, Inc. | Processes for the preparation of substituted isoxazoles and 2-isoxazolines |
US20030162824A1 (en) * | 2001-11-12 | 2003-08-28 | Krul Elaine S. | Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor |
RU2004114552A (ru) * | 2001-11-13 | 2005-02-20 | Фармация Корпорейшн (Us) | Пероральная дозированная форма сульфонамидного пролекарства |
EP1551812B1 (en) | 2001-12-06 | 2009-03-04 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
AU2002353147A1 (en) * | 2001-12-13 | 2003-06-30 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
US20040126438A1 (en) * | 2001-12-13 | 2004-07-01 | Obukowicz Mark G. | Selective cox-2 inhibition from plant extracts |
US20040062823A1 (en) * | 2001-12-13 | 2004-04-01 | Obukowicz Mark G. | Selective cox-2 inhibition from non-edible plant extracts |
US20030211163A1 (en) * | 2002-01-10 | 2003-11-13 | Chong Kong Teck | Combination antiviral therapy |
US20030212138A1 (en) * | 2002-01-14 | 2003-11-13 | Pharmacia Corporation | Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor |
US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
TW200403072A (en) * | 2002-01-23 | 2004-03-01 | Upjohn Co | Combination therapy for the treatment of bacterial infections |
WO2004026235A2 (en) * | 2002-09-20 | 2004-04-01 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
EP1915992A1 (en) | 2002-02-19 | 2008-04-30 | Pharmacia Corporation | Use of cyclooxygenase inhibitors and antimuscarinic agents for the treatment of incontinence |
JP4906233B2 (ja) * | 2002-03-01 | 2012-03-28 | ユニバーシティー オブ サウス フロリダ | 少なくとも1種の有効薬剤成分を含有する多構成要素固相 |
JP2005529084A (ja) * | 2002-03-15 | 2005-09-29 | ファルマシア・コーポレーション | 結晶性パレコキシブナトリウム |
US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
WO2003084917A1 (en) | 2002-04-08 | 2003-10-16 | Glaxo Group Limited | (2-((2-alkoxy) -phenyl) -cyclopent-1-enyl) aromatic carbo and heterocyclic acid and derivatives |
BR0309337A (pt) * | 2002-04-18 | 2005-02-15 | Pharmacia Corp | Monoterapia para o tratamento de doença de parkinson com inibidores de ciclooxigenase-2 (cox2) |
MXPA04009352A (es) * | 2002-04-18 | 2005-01-25 | Pharmacia Corp | Terapia de combinacion para el tratamiento de la enfermedad de parkinson con inhibidores de ciclooxigenasa-2 (cox2). |
US7273616B2 (en) * | 2002-05-10 | 2007-09-25 | The Trustees Of Columbia University In The City Of New York | Genetically engineered cell lines and systems for propagating Varicella zoster virus and methods of use thereof |
JP2006500377A (ja) * | 2002-06-21 | 2006-01-05 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 改善された溶解性を有する医薬組成物 |
MXPA05000011A (es) * | 2002-06-26 | 2005-04-08 | Pharmacia Corp | Formulacion parenteral liquida estable de parecoxib. |
US7087630B2 (en) | 2002-06-27 | 2006-08-08 | Nitromed, Inc. | Cyclooxygenase 2 selective inhibitors, compositions and methods of use |
AU2003279622A1 (en) | 2002-06-28 | 2004-01-19 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
CA2491479A1 (en) * | 2002-07-02 | 2004-01-15 | Pharmacia Corporation | Use of cyclooxygenase-2 selective inhibitors and thrombolytic agents for the treatment or prevention of a vaso-occlusive event |
EP3584235A3 (en) * | 2002-08-12 | 2020-04-22 | Brigham and Women's Hospital | Resolvins: biotemplates for novel therapeutic interventions |
US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
KR100484525B1 (ko) * | 2002-10-15 | 2005-04-20 | 씨제이 주식회사 | 이소티아졸 유도체, 그 제조방법 및 약제학적 조성물 |
US20040082543A1 (en) * | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
US20040092566A1 (en) * | 2002-11-12 | 2004-05-13 | Graneto Matthew J. | Celecoxib prodrug |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
US20050020658A1 (en) * | 2002-11-21 | 2005-01-27 | Katsuyuki Inoo | Selective cyclooxygenase-2 inhibitor patch |
US20040126415A1 (en) * | 2002-11-21 | 2004-07-01 | Lu Guang Wei | Dermal delivery of a water-soluble selective cyclooxygenase-2 inhibitor |
US20040127531A1 (en) * | 2002-11-21 | 2004-07-01 | Lu Guang Wei | Adhesive coated sheet for dermal delivery of a selective cyclooxygenase-2 inhibitor |
RU2331438C2 (ru) | 2002-12-13 | 2008-08-20 | Уорнер-Ламберт Компани Ллс | Альфа-2-дельта лиганд для лечения симптомов нижних мочевыводящих путей |
US20040235925A1 (en) * | 2002-12-17 | 2004-11-25 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
US20080153894A1 (en) * | 2002-12-19 | 2008-06-26 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis |
PL377427A1 (pl) * | 2002-12-19 | 2006-02-06 | Pharmacia Corporation | Sposoby i kompozycje do leczenia infekcji wirusem opryszczki z zastosowaniem inhibitorów selektywnych względem cyklooksygenazy-2 lub inhibitorów cyklooksygenazy-2 w połączeniu ze środkami przeciwwirusowymi |
WO2004058354A1 (en) * | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and selective serotonin reuptake inhibitors for the treatment or prevention of a vaso-occlusive event |
ES2215474B1 (es) | 2002-12-24 | 2005-12-16 | J. URIACH & CIA S.A. | Nuevos derivados de fosforamida. |
DK1575566T3 (da) | 2002-12-26 | 2012-03-26 | Pozen Inc | Flerlagsdoseringsformer indeholdende naproxen og triptaner |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
WO2004060367A1 (en) * | 2002-12-30 | 2004-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Imidazole and triazole derivatives useful as selective cox-1 inhibitors |
US20050026902A1 (en) * | 2003-01-31 | 2005-02-03 | Timothy Maziasz | Methods and compositions for the treatment or prevention of human immunodeficiency virus and related conditions using cyclooxygenase-2 selective inhibitors and antiviral agents |
US20040176378A1 (en) * | 2003-02-12 | 2004-09-09 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an amphetamine for the treatment of reduced blood flow to the central nervous system |
WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
US20040214753A1 (en) * | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
PT1608407E (pt) * | 2003-03-20 | 2006-12-29 | Pharmacia Corp | Formulação dispersível de um agente anti-inflamatório |
US20050004098A1 (en) * | 2003-03-20 | 2005-01-06 | Britten Nancy Jean | Dispersible formulation of an anti-inflammatory agent |
US20050009931A1 (en) * | 2003-03-20 | 2005-01-13 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
US20040214861A1 (en) * | 2003-03-28 | 2004-10-28 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitors and 5-HT1B1D antagonists for the treatment and prevention of migraine |
US20050143431A1 (en) * | 2003-04-04 | 2005-06-30 | Hetero Drugs Limited | Novel crystalline forms of parecoxib sodium |
CN1794989A (zh) * | 2003-04-14 | 2006-06-28 | 药物研发有限责任公司 | 用于治疗糖尿病的n-(((((1,3-噻唑-2-基)氨基)羰基)苯基)磺酰基)苯丙氨酸衍生物及相关化合物 |
WO2004093814A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a sodium channel blocker |
WO2004093896A1 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage |
WO2004093813A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
US20040229803A1 (en) * | 2003-04-22 | 2004-11-18 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of pain, inflammation or inflammation mediated disorders |
WO2004093816A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent |
US20040224940A1 (en) * | 2003-04-22 | 2004-11-11 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a sodium ion channel blocker for the treatment of central nervous system damage |
EA200501710A1 (ru) | 2003-04-30 | 2006-06-30 | ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи | Замещённые карбоновые кислоты |
US20040220167A1 (en) * | 2003-05-02 | 2004-11-04 | Nasrollah Samiy | Methods of treating neuralgic pain |
PT1534305E (pt) | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
WO2004100895A2 (en) * | 2003-05-13 | 2004-11-25 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a peroxisome proliferator activated receptor agonist for the treatment of ischemic mediated central nervous system disorders |
US20050026919A1 (en) * | 2003-05-14 | 2005-02-03 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a cholinergic agent for the treatment of reduced blood flow or trauma to the central nervous system |
US20050159419A1 (en) * | 2003-05-14 | 2005-07-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a central nervous system stimulant for the treatment of central nervous system damage |
WO2004103357A1 (en) * | 2003-05-14 | 2004-12-02 | Pharmacia Corporation | Compositions for the treatment of reduced blood flow |
JP2006528695A (ja) * | 2003-05-14 | 2006-12-21 | ファルマシア・コーポレーション | 血流量の減少又は中枢神経系の外傷を治療するためのベンゼンスルホンアミド又はメチルスルホニルベンゼン系シクロオキシゲナーゼ−2選択的阻害剤及びコリン作動性作用物質の組成物 |
WO2004110456A1 (en) * | 2003-05-27 | 2004-12-23 | Pharmacia Corporation | Fcompositions of a cyclooxygenase-2 selective inhibitor, a xanthine compound and an alcohol for the treatment of ischemic mediated central nervous system disorders or injury |
US20060160776A1 (en) * | 2003-05-28 | 2006-07-20 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a cannabinoid agent for the treatment of central nervous system damage |
UA82698C2 (uk) | 2003-05-30 | 2008-05-12 | Ранбакси Лабораториз Лимитед | Заміщені похідні піролу та їх використання в якості інгібіторів hmg-co |
US20050054646A1 (en) * | 2003-06-09 | 2005-03-10 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an antioxidant agent for the treatment of central nervous system disorders |
US20050065154A1 (en) * | 2003-06-24 | 2005-03-24 | Pharmacia Corporation | Treatment of migraine accompanied by nausea with a combination of cyclooxygenase-2 selective inhibitors and anti-nausea agents |
US20050101597A1 (en) * | 2003-07-10 | 2005-05-12 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitior and a non-NMDA glutamate modulator for the treatment of central nervous system damage |
WO2005007156A1 (en) * | 2003-07-10 | 2005-01-27 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an angiotensin ii receptor antagonist for the treatment of central nervous system damage |
WO2005018541A2 (en) * | 2003-07-11 | 2005-03-03 | Pharmacia Corporation | Cox-2 inhibitor and serotonin modulator for treating cns damage |
WO2005016249A2 (en) * | 2003-07-11 | 2005-02-24 | Pharmacia Corporation | Compositions of a chromene or phenyl acetic acid cyclooxygenase-2 selective inhibitor and an ace inhibitor for the treatment of central nervous system damage |
US20050014729A1 (en) * | 2003-07-16 | 2005-01-20 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
US20050075341A1 (en) * | 2003-07-17 | 2005-04-07 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and an IKK inhibitor for the treatment of ischemic mediated central nervous system disorders or injury |
JPWO2005012268A1 (ja) * | 2003-07-30 | 2006-09-14 | 塩野義製薬株式会社 | イソオキサゾール環を有するスルホンアミド誘導体 |
CA2536173A1 (en) * | 2003-08-20 | 2005-03-03 | Nitromed, Inc. | Nitrosated and nitrosylated cardiovascular compounds, compositions and methods of use |
US20050119262A1 (en) * | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
CA2536340A1 (en) * | 2003-08-22 | 2005-03-03 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin modulating agent for the treatment of neoplasia |
WO2005018564A2 (en) * | 2003-08-22 | 2005-03-03 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage |
US20050130971A1 (en) * | 2003-08-22 | 2005-06-16 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury |
WO2005020910A2 (en) * | 2003-08-27 | 2005-03-10 | Pharmacia Corporation | Cyclooxygenase-2 selective inhibitor and corticotropin releasing factor antagonist compositions for treating ischemic mediated cns disorders or injuries |
JP2007504136A (ja) * | 2003-08-28 | 2007-03-01 | ニトロメッド インコーポレーティッド | ニトロソ化およびニトロシル化利尿化合物、組成物、ならびに使用方法 |
US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
US20050113409A1 (en) * | 2003-09-03 | 2005-05-26 | Pharmacia Corporation | Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith |
WO2005037193A2 (en) * | 2003-10-03 | 2005-04-28 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor administered under hypothermic conditions for the treatment of ischemic mediated central nervous system disorders or injury |
BRPI0415939A (pt) * | 2003-11-12 | 2007-01-02 | Pharmacia & Upjohn Co Llc | composições de um inibidor seletivo da ciclooxigenase-2 e um agente de modulação do fator neurotrófico para o tratamento de distúrbios mediados pelo sistema nervoso central |
EP1708700A1 (en) * | 2003-12-24 | 2006-10-11 | Pharmacia Corporation | Metal salts of parecoxib as prodrugs of the cox-2 inhibitor valdecoxib for the treatment of inflammation, pain and/or fever |
EP1708718A1 (en) | 2004-01-22 | 2006-10-11 | Pfizer Limited | Triazole derivatives which inhibit vasopressin antagonistic activity |
WO2005105025A1 (en) * | 2004-04-14 | 2005-11-10 | Boston University | Methods and compositions for preventing or treating periodontal diseases |
EP1742932A1 (en) * | 2004-04-28 | 2007-01-17 | Pfizer Limited | 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor |
BRPI0512832A (pt) | 2004-07-01 | 2008-04-08 | Merck & Co Inc | composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para usar um composto |
ES2257929B1 (es) * | 2004-07-16 | 2007-05-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de pirazolina, procedimiento para su obtencion y utilizacion de los mismos como agentes terapeuticos. |
MX2007000749A (es) * | 2004-07-22 | 2007-03-28 | Pharmacia Corp | Composiciones para el tratamiento de inflamacion y dolor usando una combinacion de un aine y un antagonista del receptor de ltb4. |
US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
EP1814535A4 (en) * | 2004-11-08 | 2008-06-04 | Nitromed Inc | NITROSED AND NITROSYLATED COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING EYE DISEASES |
US20100137378A1 (en) | 2004-12-23 | 2010-06-03 | Glaxo Group Limited | Pyridine Compounds For The Treatment Of Prostaglandin Mediated Diseases |
US20080306041A1 (en) * | 2005-01-21 | 2008-12-11 | Garvey David S | Cardiovascular Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use |
CA2597422A1 (en) * | 2005-02-16 | 2007-08-02 | Nitromed, Inc. | Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use |
US7521435B2 (en) * | 2005-02-18 | 2009-04-21 | Pharma Diagnostics, N.V. | Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same |
CA2597463A1 (en) * | 2005-02-28 | 2006-09-08 | Nitromed, Inc. | Cardiovascular compounds comprising nitric oxide enhancing groups, compositions and methods of use |
AU2006238930B2 (en) | 2005-04-26 | 2010-12-23 | Pfizer Inc. | P-cadherin antibodies |
US20060251702A1 (en) * | 2005-05-05 | 2006-11-09 | Cook Biotech Incorporated | Implantable materials and methods for inhibiting tissue adhesion formation |
US8362075B2 (en) | 2005-05-17 | 2013-01-29 | Merck Sharp & Dohme Corp. | Cyclohexyl sulphones for treatment of cancer |
US20080234252A1 (en) * | 2005-05-18 | 2008-09-25 | Pfizer Inc | Compounds Useful in Therapy |
EP1883614A4 (en) * | 2005-05-23 | 2010-04-14 | Nicox Sa | ORGANIC NITRIC OXIDES IMPROVING SALTS FROM NON-SUBSTITUTE INFLAMMATORY COMPOUNDS AND COMPOSITIONS AND USES THEREOF |
HUP0500730A2 (en) * | 2005-07-29 | 2007-02-28 | Richter Gedeon Vegyuszeti Gyar | 1,2-diaryl-heterocyclic compounds, their preparation, pharmaceutical compositions comprising thereof and their use |
WO2007016677A2 (en) | 2005-08-02 | 2007-02-08 | Nitromed, Inc. | Nitric oxide enhancing antimicrobial compounds, compositions and methods of use |
TWI387592B (zh) * | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
ES2546069T3 (es) | 2005-09-07 | 2015-09-18 | Amgen Fremont Inc. | Anticuerpos monoclonales humanos para quinasa-1 de tipo receptor de activina (ALK-1) |
WO2007041440A2 (en) * | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
CA2624933A1 (en) * | 2005-10-04 | 2007-04-12 | Nitromed, Inc. | Methods for treating respiratory disorders |
US8026377B2 (en) | 2005-11-08 | 2011-09-27 | Ranbaxy Laboratories, Limited | Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt |
WO2007059311A2 (en) * | 2005-11-16 | 2007-05-24 | Nitromed, Inc. | Furoxan compounds, compositions and methods of use |
WO2007061783A1 (en) * | 2005-11-18 | 2007-05-31 | Trustees Of Boston University | Treatment and prevention of bone loss using resolvins |
EP1968584A2 (en) * | 2005-12-20 | 2008-09-17 | Nitromed, Inc. | Nitric oxide enhancing glutamic acid compounds, compositions and methods of use |
EP1971340A2 (en) * | 2005-12-22 | 2008-09-24 | Nitromed, Inc. | Nitric oxide enhancing pyruvate compounds, compositions and methods of use |
NL2000351C2 (nl) | 2005-12-22 | 2007-09-11 | Pfizer Prod Inc | Estrogeen-modulatoren. |
WO2007087246A2 (en) | 2006-01-24 | 2007-08-02 | Merck & Co., Inc. | Jak2 tyrosine kinase inhibition |
GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
WO2007126609A1 (en) * | 2006-03-29 | 2007-11-08 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
SI2010528T1 (en) | 2006-04-19 | 2018-02-28 | Novartis Ag | 6-O-substituted benzoxazole and benzothiazole compounds and procedures for inhibiting CSF-1R signaling |
EP2027087A2 (en) | 2006-05-18 | 2009-02-25 | MannKind Corporation | Intracellular kinase inhibitors |
WO2008033931A1 (en) * | 2006-09-13 | 2008-03-20 | The Institutes For Pharmaceutical Discovery, Llc | Para-xylylene carboxylic acids and isothiazolones useful as protein tyrosine phosphatases (ptps) in particular ptp-ib |
WO2008039327A2 (en) | 2006-09-22 | 2008-04-03 | Merck & Co., Inc. | Method of treatment using fatty acid synthesis inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
CN101600458A (zh) | 2006-12-22 | 2009-12-09 | 瑞蔻达蒂爱尔兰有限公司 | 采用α2δ配体和NSAID的下泌尿道疾病的联合治疗 |
PL2336120T3 (pl) | 2007-01-10 | 2014-12-31 | Msd Italia Srl | Kombinacje zawierające indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy) (PARP) |
KR100843351B1 (ko) * | 2007-01-30 | 2008-07-03 | 한국과학기술연구원 | 중추신경계 질환 치료제로 유효한n-벤질-n-(2-디메틸아미노-에틸)-벤젠술폰아미드 화합물 |
MX2009009304A (es) | 2007-03-01 | 2009-11-18 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso. |
GB0704407D0 (en) | 2007-03-07 | 2007-04-18 | Glaxo Group Ltd | Compounds |
CA2685967A1 (en) | 2007-05-21 | 2008-11-21 | Novartis Ag | Csf-1r inhibitors, compositions, and methods of use |
CA2690191C (en) | 2007-06-27 | 2015-07-28 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
JP2010533205A (ja) | 2007-07-12 | 2010-10-21 | トラガラ ファーマシューティカルズ,インク. | 癌、腫瘍、および腫瘍関連障害を治療するための方法および組成物 |
US7943658B2 (en) | 2007-07-23 | 2011-05-17 | Bristol-Myers Squibb Company | Indole indane amide compounds useful as CB2 agonists and method |
MX2010002712A (es) | 2007-09-10 | 2010-06-09 | Calcimedica Inc | Compuestos que modulan calcio intracelular. |
WO2009111354A2 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
GB0813144D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
BRPI0917719A2 (pt) | 2008-08-27 | 2019-11-19 | Calcimedica Inc | compostos que modulam cálcio intracelular |
EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
GB0903493D0 (en) | 2009-02-27 | 2009-04-08 | Vantia Ltd | New compounds |
JP5212177B2 (ja) * | 2009-02-27 | 2013-06-19 | 東レ株式会社 | γ−ケトアセタール化合物及びピロール誘導体の製造方法 |
KR101069175B1 (ko) | 2009-04-19 | 2011-09-30 | 중앙대학교 산학협력단 | 신규 아미노설포닐아릴이소옥사졸계 화합물 및 이를 포함하는 다약제내성 억제용 약제학적 조성물 |
WO2011012622A1 (en) | 2009-07-30 | 2011-02-03 | Glaxo Group Limited | Benzoxazinone derivatives for the treatment of glytl mediated disorders |
WO2011023753A1 (en) | 2009-08-27 | 2011-03-03 | Glaxo Group Limited | Benzoxazine derivatives as glycine transport inhibitors |
PE20121172A1 (es) | 2009-10-14 | 2012-09-05 | Merck Sharp & Dohme | Piperidinas sustituidas con actividad en la hdm2 |
GB201000685D0 (en) | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
CN101805290A (zh) * | 2010-04-01 | 2010-08-18 | 中国人民解放军第四军医大学 | 氨基磺酰吡唑类化合物及其用途 |
CA2797533A1 (en) | 2010-04-27 | 2011-11-10 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
AU2011248877B9 (en) | 2010-04-27 | 2015-11-05 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
GB201007789D0 (en) | 2010-05-10 | 2010-06-23 | Glaxo Group Ltd | Novel Compound |
GB201007791D0 (en) | 2010-05-10 | 2010-06-23 | Glaxo Group Ltd | Novel compounds |
EP2571860A1 (en) | 2010-05-21 | 2013-03-27 | Pfizer Inc | 2-phenyl benzoylamides |
US8999957B2 (en) | 2010-06-24 | 2015-04-07 | Merck Sharp & Dohme Corp. | Heterocyclic compounds as ERK inhibitors |
US9115132B2 (en) | 2010-07-09 | 2015-08-25 | Convergence Pharmaceuticals Limited | Tetrazole compounds as calcium channel blockers |
CA2805265A1 (en) | 2010-08-02 | 2012-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
CA2807307C (en) | 2010-08-17 | 2021-02-09 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
JP5934212B2 (ja) * | 2010-08-20 | 2016-06-15 | アラーガン、インコーポレイテッドAllergan,Incorporated | 複数のプロスタグランジン受容体に作用し、一般的な抗炎症反応を生じる化合物 |
EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
AU2011293201B2 (en) | 2010-08-27 | 2015-11-05 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
US8946216B2 (en) | 2010-09-01 | 2015-02-03 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
EP2632472B1 (en) | 2010-10-29 | 2017-12-13 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina) |
US9351965B2 (en) | 2010-12-21 | 2016-05-31 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as ERK inhibitors |
WO2012098400A1 (en) | 2011-01-19 | 2012-07-26 | Convergence Pharmaceuticals Limited | Piperazine derivatives as cav2.2 calcium channel blockers |
JP2014513923A (ja) | 2011-03-04 | 2014-06-19 | ファイザー・インク | Edn3様ペプチドおよびその使用 |
IN2013MN02170A (es) | 2011-04-21 | 2015-06-12 | Piramal Entpr Ltd | |
WO2013063214A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
EP2773207B1 (en) | 2011-10-31 | 2018-03-07 | Merck Sharp & Dohme Corp. | Aminopyrimidinones as interleukin receptor-associated kinase inhibitors |
US9562015B2 (en) | 2011-11-17 | 2017-02-07 | The Regents Of The University Of Colorado, A Body | Methods and compositions for enhanced drug delivery to the eye and extended delivery formulations |
GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
EP2844261B1 (en) | 2012-05-02 | 2018-10-17 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
WO2014052563A2 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
MX363243B (es) | 2012-11-28 | 2019-03-14 | Merck Sharp & Dohme | Composiciones para tratar cáncer y usos de dichas composiciones. |
BR112015013611A2 (pt) | 2012-12-20 | 2017-11-14 | Merck Sharp & Dohme | composto, e, composição farmacêutica |
EP2951180B1 (en) | 2013-01-30 | 2018-05-02 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
NZ712479A (en) * | 2013-03-15 | 2019-01-25 | Univ Southern California | Methods, compounds, and compositions for the treatment of angiotensin-related diseases |
WO2015006181A1 (en) | 2013-07-11 | 2015-01-15 | Merck Sharp & Dohme Corp. | Substituted amidopyrazole inhibitors of interleukin receptor-associated kinases (irak-4) |
EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
CN104418818B (zh) * | 2013-09-04 | 2017-01-11 | 天津汉瑞药业有限公司 | 帕瑞昔布钠无水化合物 |
WO2015054283A1 (en) | 2013-10-08 | 2015-04-16 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
CN105085425B (zh) * | 2014-05-23 | 2018-01-30 | 昆药集团股份有限公司 | 一种制备帕瑞昔布的方法 |
JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
GB201417497D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
GB201417500D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
GB201417499D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
CN104557754A (zh) * | 2015-01-04 | 2015-04-29 | 成都克莱蒙医药科技有限公司 | 一种帕瑞昔布钠杂质的合成方法 |
US10329294B2 (en) | 2015-03-12 | 2019-06-25 | Merck Sharp & Dohme Corp. | Pyrazolopyrimidine inhibitors of IRAK4 activity |
WO2016144844A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Carboxamide inhibitors of irak4 activity |
WO2016144849A1 (en) | 2015-03-12 | 2016-09-15 | Merck Sharp & Dohme Corp. | Thienopyrazine inhibitors of irak4 activity |
ES2957583T3 (es) * | 2015-07-31 | 2024-01-22 | Univ Johns Hopkins | Profármacos de análogos de la glutamina |
US9598361B1 (en) * | 2016-04-12 | 2017-03-21 | King Saud University | Amino substituted acetamide derivative |
WO2019094311A1 (en) | 2017-11-08 | 2019-05-16 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
CN108164521B (zh) * | 2018-03-02 | 2020-11-13 | 成都新恒创药业有限公司 | 一种帕瑞昔布钠降解杂质及其制备、检测方法和应用 |
CN108299331A (zh) * | 2018-03-02 | 2018-07-20 | 成都新恒创药业有限公司 | 一种帕瑞昔布钠光降解杂质及其制备、检测方法和应用 |
US20210277009A1 (en) | 2018-08-07 | 2021-09-09 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
CN110305071A (zh) * | 2019-07-23 | 2019-10-08 | 成都通德药业有限公司 | 一种帕瑞昔布钠中间体帕瑞昔布的合成方法 |
KR20220123229A (ko) | 2019-12-17 | 2022-09-06 | 머크 샤프 앤드 돔 엘엘씨 | Prmt5 억제제 |
IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases |
CN115784991A (zh) * | 2022-11-22 | 2023-03-14 | 合肥医工医药股份有限公司 | N-(苯磺酰基)酰胺衍生物及其制备方法和用途 |
Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US538738A (en) | 1895-05-07 | Measuring-faucet | ||
US3984431A (en) | 1972-03-15 | 1976-10-05 | Claude Gueremy | Derivatives of pyrazole-5-acetic acid |
US4146721A (en) | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
US5051518A (en) | 1987-05-29 | 1991-09-24 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides |
JPH05323522A (ja) | 1992-05-20 | 1993-12-07 | Fuji Photo Film Co Ltd | 黒白ハロゲン化銀写真感光材料の処理方法 |
WO1994013635A1 (en) | 1992-12-11 | 1994-06-23 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
WO1994015932A1 (en) | 1993-01-15 | 1994-07-21 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5338749A (en) | 1989-02-10 | 1994-08-16 | Basf Aktiengesellschaft | Diaryl-substituted heterocyclic compounds, their preparation and drigs and cosmetics obtained therefrom |
US5344991A (en) | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
WO1994020480A1 (en) | 1993-03-12 | 1994-09-15 | Merck Frosst Canada Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
WO1994026731A1 (en) | 1993-05-13 | 1994-11-24 | Merck Frosst Canada Inc. | 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase |
WO1994027980A1 (en) | 1993-05-21 | 1994-12-08 | G.D. Searle & Co. | Substituted oxazolyl compounds for the treatment of inflammation |
WO1995000501A2 (en) | 1993-06-24 | 1995-01-05 | Merck Frosst Canada Inc. | Phenyl heterocycles as cyclooxygenase-2 inhibitors |
US5387592A (en) | 1991-06-25 | 1995-02-07 | Imperial Chemical Industries Plc | Substituted benzoxazole, benzthiazole, and benzimidazole derivatives as angiotensin II antagonists |
US5389635A (en) | 1992-04-06 | 1995-02-14 | E. I. Du Pont De Nemours And Company | 4- or 5-heterocyclic substituted imadazoles as angiotensin-II antagonists |
US5393790A (en) | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
US5401765A (en) | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
WO1995015316A1 (en) | 1993-11-30 | 1995-06-08 | G. D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
US5434178A (en) | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
US5486534A (en) | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
JPH1045374A (ja) | 1996-08-01 | 1998-02-17 | Nittetsu Mining Co Ltd | ドラム缶吊り上げ装置 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB911204A (en) | 1960-07-28 | 1962-11-21 | Unilever Ltd | Bleaching compositions |
DE3321082C2 (de) | 1982-06-10 | 1996-08-22 | Kao Corp | Bleich-Reinigungsmittel |
JPS59145300A (ja) | 1983-02-07 | 1984-08-20 | 日本パ−オキサイド株式会社 | 漂白洗剤 |
JPS6015500A (ja) | 1983-07-08 | 1985-01-26 | ライオン株式会社 | 高嵩密度洗剤組成物 |
JPS60118606A (ja) | 1983-11-28 | 1985-06-26 | Mitsubishi Gas Chem Co Inc | 安定化された過炭酸ナトリウム粒状物 |
JP2590124B2 (ja) * | 1987-08-12 | 1997-03-12 | 国際試薬株式会社 | 水溶性テトラゾリウム化合物およびその化合物を用いる還元性物質の測定方法 |
JPS6445374U (es) | 1987-09-10 | 1989-03-20 | ||
JPH04277724A (ja) * | 1991-03-06 | 1992-10-02 | Sumitomo Electric Ind Ltd | 有機非線形光学材料 |
US5334991A (en) | 1992-05-15 | 1994-08-02 | Reflection Technology | Dual image head-mounted display |
ES2133740T3 (es) * | 1994-02-10 | 1999-09-16 | Searle & Co | Espiro-compuestos sustituidos para el tratamiento de la inflamacion. |
US5556019A (en) * | 1994-07-25 | 1996-09-17 | Sealed Air Corporation | Bag separator and dispenser |
US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
JP2636819B2 (ja) * | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
JP3181190B2 (ja) * | 1994-12-20 | 2001-07-03 | 日本たばこ産業株式会社 | オキサゾール誘導体 |
US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
CA2249009C (en) * | 1996-04-12 | 2003-09-16 | G.D. Searle & Co. | Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors |
US20030105144A1 (en) * | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
-
1997
- 1997-04-11 CA CA002249009A patent/CA2249009C/en not_active Expired - Lifetime
- 1997-04-11 ES ES02025005T patent/ES2311571T3/es not_active Expired - Lifetime
- 1997-04-11 DE DE69719496T patent/DE69719496T2/de not_active Expired - Lifetime
- 1997-04-11 PT PT02025005T patent/PT1288206E/pt unknown
- 1997-04-11 ME MEP-1998-443A patent/ME00768B/me unknown
- 1997-04-11 PT PT97921092T patent/PT892791E/pt unknown
- 1997-04-11 EE EE9800351A patent/EE03685B1/xx active Protection Beyond IP Right Term
- 1997-04-11 KR KR10-1998-0708126A patent/KR100387658B1/ko not_active IP Right Cessation
- 1997-04-11 DE DE69739003T patent/DE69739003D1/de not_active Expired - Lifetime
- 1997-04-11 SI SI9720101A patent/SI22713B/sl active Search and Examination
- 1997-04-11 BR BR9708574A patent/BR9708574A/pt active Search and Examination
- 1997-04-11 AU AU27227/97A patent/AU734275C/en not_active Ceased
- 1997-04-11 IL IL153738A patent/IL153738A/en not_active IP Right Cessation
- 1997-04-11 NZ NZ331542A patent/NZ331542A/xx not_active IP Right Cessation
- 1997-04-11 EP EP02025005A patent/EP1288206B1/en not_active Expired - Lifetime
- 1997-04-11 GE GEAP19974523A patent/GEP20032998B/en unknown
- 1997-04-11 JP JP53713997A patent/JP3382624B2/ja not_active Expired - Lifetime
- 1997-04-11 ES ES97921092T patent/ES2194195T3/es not_active Expired - Lifetime
- 1997-04-11 IL IL12584997A patent/IL125849A/xx not_active IP Right Cessation
- 1997-04-11 AT AT97921092T patent/ATE233743T1/de active
- 1997-04-11 DK DK97921092T patent/DK0892791T3/da active
- 1997-04-11 SK SK1242-98A patent/SK285353B6/sk not_active IP Right Cessation
- 1997-04-11 HU HU9901807A patent/HU225473B1/hu unknown
- 1997-04-11 RO RO98-01469A patent/RO121338B1/ro unknown
- 1997-04-11 PL PL97329276A patent/PL195955B1/pl unknown
- 1997-04-11 TR TR1998/02049T patent/TR199802049T2/xx unknown
- 1997-04-11 AT AT02025005T patent/ATE408607T1/de active
- 1997-04-11 SI SI9720035A patent/SI9720035B/sl active Search and Examination
- 1997-04-11 CN CN97193747A patent/CN1098256C/zh not_active Expired - Lifetime
- 1997-04-11 WO PCT/US1997/005497 patent/WO1997038986A1/en active IP Right Grant
- 1997-04-11 EP EP97921092A patent/EP0892791B1/en not_active Expired - Lifetime
- 1997-04-11 EA EA199800919A patent/EA003319B1/ru not_active IP Right Cessation
- 1997-04-11 AP APAP/P/1998/001355A patent/AP1009A/en active
- 1997-04-11 DK DK02025005T patent/DK1288206T3/da active
- 1997-04-11 CZ CZ0271098A patent/CZ297430B6/cs not_active IP Right Cessation
- 1997-04-14 ZA ZA9703146A patent/ZA973146B/xx unknown
- 1997-05-02 BR BR1100403-7A patent/BR1100403A/pt active IP Right Grant
- 1997-05-26 TW TW086107093A patent/TW585857B/zh not_active IP Right Cessation
- 1997-10-09 RS YUP-443/98A patent/RS50019B/sr unknown
- 1997-11-04 UA UA98115994A patent/UA47475C2/uk unknown
-
1998
- 1998-01-12 US US09/005,610 patent/US5932598A/en not_active Expired - Lifetime
- 1998-10-09 LT LT98-142A patent/LT4586B/lt not_active IP Right Cessation
- 1998-10-09 NO NO19984727A patent/NO314184B1/no not_active IP Right Cessation
- 1998-10-09 IS IS4863A patent/IS2156B/is unknown
- 1998-10-12 OA OA9800193A patent/OA11015A/en unknown
- 1998-10-12 CU CU147A patent/CU23116A3/es unknown
- 1998-10-12 LV LVP-98-215A patent/LV12239B/en unknown
- 1998-11-12 BG BG102916A patent/BG64531B1/bg unknown
- 1998-11-12 BG BG109057A patent/BG109057A/bg unknown
-
1999
- 1999-11-01 HK HK99104900A patent/HK1019741A1/xx not_active IP Right Cessation
-
2000
- 2000-09-14 US US09/661,859 patent/US6436967B1/en not_active Expired - Lifetime
-
2002
- 2002-06-24 US US10/178,697 patent/US6815460B2/en not_active Expired - Fee Related
- 2002-09-04 JP JP2002258955A patent/JP4049307B2/ja not_active Expired - Lifetime
- 2002-12-30 IL IL15373802A patent/IL153738A0/xx active IP Right Grant
-
2004
- 2004-06-02 IS IS7292A patent/IS7292A/is unknown
- 2004-09-13 US US10/939,852 patent/US7420061B2/en not_active Expired - Fee Related
Patent Citations (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US538738A (en) | 1895-05-07 | Measuring-faucet | ||
US4146721A (en) | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
US3984431A (en) | 1972-03-15 | 1976-10-05 | Claude Gueremy | Derivatives of pyrazole-5-acetic acid |
US5051518A (en) | 1987-05-29 | 1991-09-24 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-N-hydroxypropanamides |
US5338749A (en) | 1989-02-10 | 1994-08-16 | Basf Aktiengesellschaft | Diaryl-substituted heterocyclic compounds, their preparation and drigs and cosmetics obtained therefrom |
US5387592A (en) | 1991-06-25 | 1995-02-07 | Imperial Chemical Industries Plc | Substituted benzoxazole, benzthiazole, and benzimidazole derivatives as angiotensin II antagonists |
US5389635A (en) | 1992-04-06 | 1995-02-14 | E. I. Du Pont De Nemours And Company | 4- or 5-heterocyclic substituted imadazoles as angiotensin-II antagonists |
JPH05323522A (ja) | 1992-05-20 | 1993-12-07 | Fuji Photo Film Co Ltd | 黒白ハロゲン化銀写真感光材料の処理方法 |
WO1994013635A1 (en) | 1992-12-11 | 1994-06-23 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
WO1994015932A1 (en) | 1993-01-15 | 1994-07-21 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
WO1994020480A1 (en) | 1993-03-12 | 1994-09-15 | Merck Frosst Canada Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
WO1994026731A1 (en) | 1993-05-13 | 1994-11-24 | Merck Frosst Canada Inc. | 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase |
WO1994027980A1 (en) | 1993-05-21 | 1994-12-08 | G.D. Searle & Co. | Substituted oxazolyl compounds for the treatment of inflammation |
WO1995000501A2 (en) | 1993-06-24 | 1995-01-05 | Merck Frosst Canada Inc. | Phenyl heterocycles as cyclooxygenase-2 inhibitors |
US5344991A (en) | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
US5401765A (en) | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
WO1995015316A1 (en) | 1993-11-30 | 1995-06-08 | G. D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
US5434178A (en) | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
US5393790A (en) | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
US5486534A (en) | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
JPH1045374A (ja) | 1996-08-01 | 1998-02-17 | Nittetsu Mining Co Ltd | ドラム缶吊り上げ装置 |
Non-Patent Citations (3)
Title |
---|
FAID-ALLAH HM, MOKHTAR HM.: "Pyrazole derivatives with possible hypoglycemic activity", INDIAN JOURNAL OF CHEMISTRY, 1988, pages 245 |
JøRN DRUSTRUP LARSEN, HANS BUNDGAARD, VINCEN: "Prodrug forms for the sulfonamide group. II. Water-soluble amino acid derivatives of N-methylsulfonamides as possible prodrugs", INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, pages 103 |
JøRN DRUSTRUP LARSEN, HANS BUNDGAARD: "Prodrug forms for the sulfonamide group. I. Evaluation of N-acyl derivatives, N-sulfonylamidines, N-sulfonylsulfilimines and sulfonylureas as possible prodrug derivatives", INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, pages 87 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
LT4586B (lt) | Pakeisti benzenesulfonamidų dariniai - ciklooksigenazės-2 inhibitorių provaistai | |
US6809111B2 (en) | Prodrugs of COX-2 inhibitors | |
AU2003252266B2 (en) | Substituted benzenesulfonamide derivatives as prodrugs of COX-2 inhibitors | |
AU762721B2 (en) | Substituted benzenesulfonamide derivatives as prodrugs of COX -2 inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
SPCF | Filing an spc |
Free format text: PRODUCT NAME: PARECOXIBUM (DYNASTAT) (N-((4-(METIL-3-FENIL-4-IZOKSAZOL(IL)FENIL)SULFONIL)PROPANAMIDAS); REGISTRATION NO/DATE: 03/8203/2, 03/8204/2,03/8205/2, 03/8206/2 20040105 Spc suppl protection certif: PA2004001 Filing date: 20040210 Expiry date: 20170411 |
|
PD9A | Change of patent owner |
Owner name: G.D. SEARLE & CO., US Effective date: 20040519 |
|
SPCG | Grant of an spc |
Free format text: PRODUCT NAME: PARECOXIBUM (DYNASTAT) (N-((4-(METIL-3-FENIL-4-IZOKSAZOL(IL)FENIL)SULFONIL)PROPANAMIDAS); REGISTRATION NO/DATE: 03/8203/2, 03/8204/2,03/8205/2, 03/8206/2 20040105 Spc suppl protection certif: PA2004001,C4586 Filing date: 20040210 Expiry date: 20170411 Extension date: 20190126 |
|
MK9A | Expiry of a patent |
Effective date: 20170411 |
|
SPCT | Change of ownership of an spc |
Owner name: G.D. SEARLE LLC, US Free format text: PRODUCT NAME: PARECOXIBUM (DYNASTAT) (N-((4-(METIL-3-FENIL-4-IZOKSAZOL(IL)FENIL)SULFONIL)PROPANAMIDAS); REGISTRATION NO/DATE: 03/8203/2, 03/8204/2,03/8205/2, 03/8206/2 20040105 Spc suppl protection certif: PA2004001,C4586 Filing date: 20040210 Expiry date: 20170411 Extension date: 20190126 Effective date: 20170629 |
|
SPCX | Expiry of an spc |
Free format text: PRODUCT NAME: PARECOXIBUM (DYNASTAT) (N-((4-(METIL-3-FENIL-4-IZOKSAZOL(IL)FENIL)SULFONIL)PROPANAMIDAS); REGISTRATION NO/DATE: 03/8203/2, 03/8204/2,03/8205/2, 03/8206/2 20040105 Spc suppl protection certif: PA2004001,C4586 Filing date: 20040210 Expiry date: 20170411 Extension date: 20190126 |