EA199800919A1 - Производные замещенного бензосульфонамида-лекарства ингибиторов сох-2 - Google Patents
Производные замещенного бензосульфонамида-лекарства ингибиторов сох-2Info
- Publication number
- EA199800919A1 EA199800919A1 EA199800919A EA199800919A EA199800919A1 EA 199800919 A1 EA199800919 A1 EA 199800919A1 EA 199800919 A EA199800919 A EA 199800919A EA 199800919 A EA199800919 A EA 199800919A EA 199800919 A1 EA199800919 A1 EA 199800919A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- heterocyclyl
- cycloalkenyl
- aryl
- inhibitors
- Prior art date
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- Otolaryngology (AREA)
Abstract
В настоящем изобретении описаны ингибиторы СОХ-2 формулы (I)полезные в лечении воспаления и связанных с ним расстройств, в формуле А представляет собой заместитель в кольце, выбранный из частично ненасыщенного гетероциклила, гетероарила, циклоалкенила и арила, где А необязательно замещен, в доступном для замещения положении одним или более радикалами, выбранными из алкилкарбоксила, формила, галогена, алкила, галоалкила, оксо, циано, нитро, карбоксила, алкокси, аминокарбонила, алкоксикарбонила, карбоксиалкила, цианоалкила, гидроксиалкила, галоалкилсульфонилокси, алкоксиалкилоксиалкила, карбоксиалкоксиалкила, циклоалкилалкила, алкенила, алкинила, гетероциклилокси, алкилтио, циклоалкила, арила, гетероциклила, циклоалкенила, аралкила, гетероциклила, алкилтиоалкила, арилкарбонила, аралкилкарбонила, аралкенила, алкоксиалкила, арилтиоалкила, арилоксиалкила, аралкилтиоалкила, аралкоксиалкила, алкоксикарбонила, аминокарбонилалкила, алкиламинокарбонила, N-ариламинокарбонила, N-алкил-N-ариламинокарбонила, алкиламинокарбонилалкила, алкиламино, N-ариламино, N-аралкиламино, N-алкил-N-аралкиламино, N-алкил-N-ариламино, аминоалкила, алкиламиноалкила, N-ариламиноалкила, N-аралкиламиноалкила, N-алкил-N-аралкиламиноалкила, N-алкил-N-ариламиноалкила, арилокси, аралкокси, арилтио, аралкилтио, алкилсульфинила, алкилсульфонила, аминосульфонила, алкиламиносульфонила, N-ариламиносульфонила, арилсульфонила и N-алкил-N-ариламиносульфонила; в которой Rвыбирают из гетероциклила, циклоалкила, циклоалкенила и арила, где Rнеобязательно замещен, в доступном для замещения положении, одним или более радикалами, выбранными из алкила, галоалкила, циано, карбоксила,
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Application Number | Priority Date | Filing Date | Title |
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US63151496A | 1996-04-12 | 1996-04-12 | |
PCT/US1997/005497 WO1997038986A1 (en) | 1996-04-12 | 1997-04-11 | Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors |
Publications (2)
Publication Number | Publication Date |
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EA199800919A1 true EA199800919A1 (ru) | 1999-04-29 |
EA003319B1 EA003319B1 (ru) | 2003-04-24 |
Family
ID=24531540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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EA199800919A EA003319B1 (ru) | 1996-04-12 | 1997-04-11 | Производные замещенного бензолсульфонамида - пролекарства ингибиторов cox-2 |
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US (4) | US5932598A (ru) |
EP (2) | EP0892791B1 (ru) |
JP (2) | JP3382624B2 (ru) |
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AT (2) | ATE408607T1 (ru) |
AU (1) | AU734275C (ru) |
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CZ (1) | CZ297430B6 (ru) |
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EA (1) | EA003319B1 (ru) |
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ES (2) | ES2194195T3 (ru) |
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