BRPI0512832A - composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para usar um composto - Google Patents
composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para usar um compostoInfo
- Publication number
- BRPI0512832A BRPI0512832A BRPI0512832-3A BRPI0512832A BRPI0512832A BR PI0512832 A BRPI0512832 A BR PI0512832A BR PI0512832 A BRPI0512832 A BR PI0512832A BR PI0512832 A BRPI0512832 A BR PI0512832A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- stereoisomer
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
COMPOSTO OU UM SAL OU ESTEREOISÈMERO FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA, E, MéTODO PARA USAR UM COMPOSTO. A presente invenção se refere a pirazóis tricíclicos de acordo com Fórmula (I) que são úteis para tratar doenças de proliferação celular, para tratar distúrbios associados com atividade de cinesina KSP, e para inibir cinesina KSP. A invenção também se refere a composições que compreendem estes compostos, e métodos de usar elas para tratar câncer em mamíferos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58480804P | 2004-07-01 | 2004-07-01 | |
US60090104P | 2004-08-12 | 2004-08-12 | |
PCT/US2005/022730 WO2006007491A1 (en) | 2004-07-01 | 2005-06-27 | Mitotic kinesin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0512832A true BRPI0512832A (pt) | 2008-04-08 |
Family
ID=35149059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0512832-3A BRPI0512832A (pt) | 2004-07-01 | 2005-06-27 | composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para usar um composto |
Country Status (15)
Country | Link |
---|---|
US (1) | US7632833B2 (pt) |
EP (1) | EP1765830B1 (pt) |
JP (1) | JP2008505085A (pt) |
KR (1) | KR20070039885A (pt) |
CN (1) | CN1980938B (pt) |
AT (1) | ATE482218T1 (pt) |
AU (1) | AU2005262373B2 (pt) |
BR (1) | BRPI0512832A (pt) |
CA (1) | CA2571807A1 (pt) |
DE (1) | DE602005023730D1 (pt) |
IL (1) | IL180328A0 (pt) |
MX (1) | MXPA06015275A (pt) |
NO (1) | NO20070589L (pt) |
RU (1) | RU2007103816A (pt) |
WO (1) | WO2006007491A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2220061B1 (en) | 2007-10-19 | 2016-02-17 | Merck Sharp & Dohme Corp. | Spiro-condensed 1, 3, 4-thiadiazole derivatives for inhibiting ksp kinesin activity |
SI2483278T1 (sl) * | 2009-09-28 | 2014-03-31 | F. Hoffmann-La Roche Ag | Inhibitorske spojine benzoksazepina pi3k in njihova uporaba pri zdravljenju raka |
US20140087309A1 (en) * | 2011-04-01 | 2014-03-27 | The Research Foundation Of State University Of New York | Olefin-triggered acid amplifiers |
US20140193752A1 (en) * | 2011-04-01 | 2014-07-10 | The Research Foundation Of State University Of New York | Stabilized acid amplifiers |
CA2864331C (en) | 2012-02-14 | 2018-10-09 | Children's Hospital Medical Center | Use of small molecule inhibitors targeting the interaction between rac gtpase and p67(phox) |
WO2014176268A1 (en) * | 2013-04-22 | 2014-10-30 | Abbvie Inc. | Thiazoles and uses thereof |
PL3419979T3 (pl) * | 2016-02-23 | 2020-06-29 | Pfizer Inc. | Związki 6,7-dihydro-5h-pirazolo[5,1-b][1,3]oksazyno-2- karboksyamidowe |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990003378A1 (en) | 1988-09-22 | 1990-04-05 | E.I. Du Pont De Nemours And Company | Substituted indazole arthropodicides |
PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
US5719147A (en) | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
US5604260A (en) | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
CA2293952A1 (en) | 1993-01-15 | 1994-07-21 | David B. Reitz | Preparation of esters and analogs thereof |
US5409944A (en) | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
US5380738A (en) | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
GB9602877D0 (en) | 1996-02-13 | 1996-04-10 | Merck Frosst Canada Inc | 3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors |
US5436265A (en) | 1993-11-12 | 1995-07-25 | Merck Frosst Canada, Inc. | 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents |
US5344991A (en) | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
US5393790A (en) | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
US5633272A (en) | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
US6020343A (en) | 1995-10-13 | 2000-02-01 | Merck Frosst Canada, Inc. | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors |
CA2249009C (en) | 1996-04-12 | 2003-09-16 | G.D. Searle & Co. | Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors |
US5861419A (en) | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
DE19805117A1 (de) | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
DE19905278A1 (de) | 1999-02-09 | 2000-08-10 | Bayer Ag | Oxazolidinone und ihre Verwendung als antibakterielle Mittel |
JP4597519B2 (ja) * | 2001-12-06 | 2010-12-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 有糸分裂キネシン阻害薬 |
DE60329990D1 (de) | 2002-03-08 | 2009-12-24 | Merck & Co Inc | Mitotische kinesin-hemmer |
-
2005
- 2005-06-27 BR BRPI0512832-3A patent/BRPI0512832A/pt not_active Application Discontinuation
- 2005-06-27 KR KR1020067027736A patent/KR20070039885A/ko not_active Application Discontinuation
- 2005-06-27 EP EP05786157A patent/EP1765830B1/en active Active
- 2005-06-27 US US11/630,231 patent/US7632833B2/en not_active Expired - Fee Related
- 2005-06-27 CA CA002571807A patent/CA2571807A1/en not_active Abandoned
- 2005-06-27 RU RU2007103816/04A patent/RU2007103816A/ru unknown
- 2005-06-27 AT AT05786157T patent/ATE482218T1/de not_active IP Right Cessation
- 2005-06-27 JP JP2007519334A patent/JP2008505085A/ja active Pending
- 2005-06-27 CN CN2005800225786A patent/CN1980938B/zh not_active Expired - Fee Related
- 2005-06-27 DE DE602005023730T patent/DE602005023730D1/de active Active
- 2005-06-27 MX MXPA06015275A patent/MXPA06015275A/es unknown
- 2005-06-27 WO PCT/US2005/022730 patent/WO2006007491A1/en active Application Filing
- 2005-06-27 AU AU2005262373A patent/AU2005262373B2/en not_active Ceased
-
2006
- 2006-12-25 IL IL180328A patent/IL180328A0/en unknown
-
2007
- 2007-01-31 NO NO20070589A patent/NO20070589L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008505085A (ja) | 2008-02-21 |
ATE482218T1 (de) | 2010-10-15 |
DE602005023730D1 (de) | 2010-11-04 |
WO2006007491A1 (en) | 2006-01-19 |
IL180328A0 (en) | 2007-07-04 |
AU2005262373A1 (en) | 2006-01-19 |
EP1765830B1 (en) | 2010-09-22 |
AU2005262373B2 (en) | 2011-03-17 |
MXPA06015275A (es) | 2007-03-15 |
EP1765830A1 (en) | 2007-03-28 |
CN1980938B (zh) | 2010-11-03 |
KR20070039885A (ko) | 2007-04-13 |
US7632833B2 (en) | 2009-12-15 |
CN1980938A (zh) | 2007-06-13 |
US20080287414A1 (en) | 2008-11-20 |
RU2007103816A (ru) | 2008-08-10 |
CA2571807A1 (en) | 2006-01-19 |
NO20070589L (no) | 2007-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE446094T1 (de) | Mitotische kinesin-hemmer | |
ATE448207T1 (de) | Mitotische kinesin-hemmer | |
HRP20090195T1 (en) | Mitotic kinesin inhibitors | |
ATE424388T1 (de) | Mitotische kinesinhemmer | |
ATE447577T1 (de) | Mitotische kinesin-hemmer | |
DE60312516D1 (de) | Inhibitoren von mitotischem kinesin | |
WO2006068933A3 (en) | Mitotic kinesin inhibitors | |
WO2005017190A3 (en) | Mitotic kinesin inhibitors | |
WO2005018547A3 (en) | Mitotic kinesin inhibitors | |
ATE419249T1 (de) | Inhibitoren von mitotischem kinesin | |
WO2006086358A3 (en) | Mitotic kinesin inhibitors | |
WO2006031348A3 (en) | Mitotic kinesin inhibitors | |
WO2005065183A3 (en) | Mitotic kinesin inhibitors | |
WO2006078598A3 (en) | Mitotic kinesin inhibitors | |
BRPI0512832A (pt) | composto ou um sal ou estereoisÈmero farmaceuticamente aceitável do mesmo, composição farmacêutica, e, método para usar um composto | |
WO2006007496A3 (en) | Mitotic kinesin inhibitors | |
WO2006007501A3 (en) | Mitotic kinesin inhibitors | |
WO2006101761A3 (en) | Mitotic kinesin inhibitors | |
WO2006023440A3 (en) | Mitotic kinesin inhibitors | |
ATE426605T1 (de) | Inhibitoren von mitotischem kinesin | |
WO2005060654A3 (en) | Mitotic kinesin inhibitors | |
WO2005092011A3 (en) | Mitotic kinesin inhibitors | |
WO2004087050A3 (en) | Mitotic kinesin inhibitors | |
WO2006007497A3 (en) | Prodrugs of mitotic kinesin inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |