NO20070589L - Mitotiske kinesin-inhibitorer. - Google Patents

Mitotiske kinesin-inhibitorer.

Info

Publication number
NO20070589L
NO20070589L NO20070589A NO20070589A NO20070589L NO 20070589 L NO20070589 L NO 20070589L NO 20070589 A NO20070589 A NO 20070589A NO 20070589 A NO20070589 A NO 20070589A NO 20070589 L NO20070589 L NO 20070589L
Authority
NO
Norway
Prior art keywords
mitotic kinesin
kinesin inhibitors
relates
ksp kinesin
treating
Prior art date
Application number
NO20070589A
Other languages
English (en)
Inventor
Jeffrey Bergmann
Mark E Fraley
Edward S Tasber
Paul J Colemann
Robert M Garbaccio
George D Hartmen
Chunze Li
Lou Anne Neilson
Christy M Olson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO20070589L publication Critical patent/NO20070589L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Foreliggende oppfinnelse gjelder trisykliske pyrazoler ifølge formel (I) som er anvendbare for behandling av cellulære, proliferative sykdommer, for behandling av forstyrrelser forbundet med KSP-kinesinaktivitet og for inhibering av KSP-kinesin. Oppfinnelsen gjelder også preparater som omfatter disse forbindelsene og fremgangsmåter for anvendelse av dem for behandling av kreft i pattedyr.
NO20070589A 2004-07-01 2007-01-31 Mitotiske kinesin-inhibitorer. NO20070589L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58480804P 2004-07-01 2004-07-01
US60090104P 2004-08-12 2004-08-12
PCT/US2005/022730 WO2006007491A1 (en) 2004-07-01 2005-06-27 Mitotic kinesin inhibitors

Publications (1)

Publication Number Publication Date
NO20070589L true NO20070589L (no) 2007-03-22

Family

ID=35149059

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070589A NO20070589L (no) 2004-07-01 2007-01-31 Mitotiske kinesin-inhibitorer.

Country Status (15)

Country Link
US (1) US7632833B2 (no)
EP (1) EP1765830B1 (no)
JP (1) JP2008505085A (no)
KR (1) KR20070039885A (no)
CN (1) CN1980938B (no)
AT (1) ATE482218T1 (no)
AU (1) AU2005262373B2 (no)
BR (1) BRPI0512832A (no)
CA (1) CA2571807A1 (no)
DE (1) DE602005023730D1 (no)
IL (1) IL180328A0 (no)
MX (1) MXPA06015275A (no)
NO (1) NO20070589L (no)
RU (1) RU2007103816A (no)
WO (1) WO2006007491A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0818605A2 (pt) 2007-10-19 2015-04-22 Schering Corp Derivados de 1,3,4-tiadiazl espiro-condensados para inibir a atividade de ksp cinesima
NZ597833A (en) * 2009-09-28 2014-01-31 Hoffmann La Roche Benzoxazepin pi3k inhibitor compounds and methods of use
US20140087309A1 (en) * 2011-04-01 2014-03-27 The Research Foundation Of State University Of New York Olefin-triggered acid amplifiers
JP2014511849A (ja) * 2011-04-01 2014-05-19 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク 安定化された酸増幅剤
US9453022B2 (en) 2012-02-14 2016-09-27 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox)
CA2909938A1 (en) * 2013-04-22 2014-10-30 Abbvie Inc. Thiazoles and uses thereof
CN108699080B (zh) * 2016-02-23 2021-05-14 辉瑞公司 6,7-二氢-5H-吡唑并[5,1-b][1,3]噁嗪-2-甲酰胺化合物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04501108A (ja) 1988-09-22 1992-02-27 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 置換インダゾール殺節足動物剤
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
US5719147A (en) 1992-06-29 1998-02-17 Merck & Co., Inc. Morpholine and thiomorpholine tachykinin receptor antagonists
US5604260A (en) 1992-12-11 1997-02-18 Merck Frosst Canada Inc. 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
ATE160345T1 (de) 1993-01-15 1997-12-15 Searle & Co 3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel
US5409944A (en) 1993-03-12 1995-04-25 Merck Frosst Canada, Inc. Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
GB9602877D0 (en) 1996-02-13 1996-04-10 Merck Frosst Canada Inc 3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
US5436265A (en) 1993-11-12 1995-07-25 Merck Frosst Canada, Inc. 1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
US5344991A (en) 1993-10-29 1994-09-06 G.D. Searle & Co. 1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5393790A (en) 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
US5633272A (en) 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US6020343A (en) 1995-10-13 2000-02-01 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
EP0892791B1 (en) 1996-04-12 2003-03-05 G.D. Searle & Co. N-[[4-(5-METHYL-3-PHENYLISOXAZOL-4-YL]PHENYL]SULFONYLPROPYLAMIDE and its SODIUMSALT AS PRODRUGS OF COX-2 INHIBITORS
US5861419A (en) 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
DE19805117A1 (de) 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
DE19905278A1 (de) 1999-02-09 2000-08-10 Bayer Ag Oxazolidinone und ihre Verwendung als antibakterielle Mittel
CA2467722A1 (en) * 2001-12-06 2003-06-19 Merck & Co., Inc. Thienopyrimidinone derivatives as mitotic kinesin inhibitors
AU2003249597B2 (en) 2002-03-08 2007-06-28 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors

Also Published As

Publication number Publication date
US20080287414A1 (en) 2008-11-20
CA2571807A1 (en) 2006-01-19
BRPI0512832A (pt) 2008-04-08
IL180328A0 (en) 2007-07-04
AU2005262373A1 (en) 2006-01-19
MXPA06015275A (es) 2007-03-15
EP1765830B1 (en) 2010-09-22
KR20070039885A (ko) 2007-04-13
AU2005262373B2 (en) 2011-03-17
ATE482218T1 (de) 2010-10-15
CN1980938A (zh) 2007-06-13
CN1980938B (zh) 2010-11-03
JP2008505085A (ja) 2008-02-21
WO2006007491A1 (en) 2006-01-19
RU2007103816A (ru) 2008-08-10
US7632833B2 (en) 2009-12-15
EP1765830A1 (en) 2007-03-28
DE602005023730D1 (de) 2010-11-04

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