BRPI0417197A - sais de metais de parecoxib como pró-drogas do inibidor de cox-2 valdecoxib para tratamento de inflamação, dor e/ou febre - Google Patents

sais de metais de parecoxib como pró-drogas do inibidor de cox-2 valdecoxib para tratamento de inflamação, dor e/ou febre

Info

Publication number
BRPI0417197A
BRPI0417197A BRPI0417197-7A BRPI0417197A BRPI0417197A BR PI0417197 A BRPI0417197 A BR PI0417197A BR PI0417197 A BRPI0417197 A BR PI0417197A BR PI0417197 A BRPI0417197 A BR PI0417197A
Authority
BR
Brazil
Prior art keywords
parecoxib
anion
cox
fever
pain
Prior art date
Application number
BRPI0417197-7A
Other languages
English (en)
Inventor
Manpreet Vick S Wadhwa
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BRPI0417197A publication Critical patent/BRPI0417197A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)

Abstract

"SAIS DE METAIS DE PARECOXIB COMO PRó-DROGAS DO INIBIDOR DE COX-2 VALDECOXIB PARA TRATAMENTO DE INFLAMAçãO, DOR E/OU FEBRE". Compostos tendo a estrutura MgX¬ 1¬X¬ 2¬, onde X¬ 1¬ é anion parecoxib e X¬ 2¬ é como selecionado do grupo consistindo em anion parecoxib, cloreto, brometo, sulfato, fosfato, nitrato, acetato, propionato, succinato, glicolato, estearato, lactato, malato, tartarato, citrato, ascorbato, glutamato, benzoato, salicilato, metano sulfonato, e tolueno sulfonato são mostrados; também são mostrados compostos tendo a estrutura MX¬ 1¬(X¬ 2¬)~ n~ onde M é um cátion metálico selecionado do grupo consistindo em Ca¬ 2+¬, Zn¬ 2+¬, e K¬ +¬; X¬ 1¬ é anion pare coxib; X¬ 2¬ é selecionado do grupo consistindo em anion parecoxib e um outro anion farmaceuticamente aceitável; e n é O quando M é K¬ +¬ e n é 1 quando M é Ca¬ 2+¬ ou Zn¬ 2+¬; composições da invenção são úteis no tratamento e prevenção de uma ampla variedade de desordens mediadas por COX-2, incluindo inflamação, dor e/ou febre.
BRPI0417197-7A 2003-12-24 2004-12-13 sais de metais de parecoxib como pró-drogas do inibidor de cox-2 valdecoxib para tratamento de inflamação, dor e/ou febre BRPI0417197A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53284903P 2003-12-24 2003-12-24
PCT/IB2004/004203 WO2005065684A1 (en) 2003-12-24 2004-12-13 Metal salts of parecoxib as prodrugs of the cox-2 inhibitor valdecoxib for the treatment of inflammation, pain and/or fever

Publications (1)

Publication Number Publication Date
BRPI0417197A true BRPI0417197A (pt) 2007-03-06

Family

ID=34748827

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417197-7A BRPI0417197A (pt) 2003-12-24 2004-12-13 sais de metais de parecoxib como pró-drogas do inibidor de cox-2 valdecoxib para tratamento de inflamação, dor e/ou febre

Country Status (5)

Country Link
EP (1) EP1708700A1 (pt)
JP (1) JP2007517013A (pt)
BR (1) BRPI0417197A (pt)
CA (1) CA2551523A1 (pt)
WO (1) WO2005065684A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106908525B (zh) * 2017-01-16 2019-07-23 山东省药学科学院 一种测定帕瑞昔布中间体和帕瑞昔布有关物质的分析方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9720035B (sl) * 1996-04-12 2009-10-31 Searle & Co Substituirani benzensulfonamidni derivati kot predzdravila COX-2 inhibitorjev
IL163780A0 (en) * 2002-03-15 2005-12-18 Pharmacia Corp Crystalline parecoxib sodium
BR0312111A (pt) * 2002-06-26 2005-03-29 Pharmacia Corp Formulação estável, lìquida, parenteral de parecoxib
US20040127531A1 (en) * 2002-11-21 2004-07-01 Lu Guang Wei Adhesive coated sheet for dermal delivery of a selective cyclooxygenase-2 inhibitor

Also Published As

Publication number Publication date
JP2007517013A (ja) 2007-06-28
CA2551523A1 (en) 2005-07-21
EP1708700A1 (en) 2006-10-11
WO2005065684A1 (en) 2005-07-21

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired