DE60330154D1 - Resolvine: biotemplate zur durchführung therapeutischer anwendungen - Google Patents
Resolvine: biotemplate zur durchführung therapeutischer anwendungenInfo
- Publication number
- DE60330154D1 DE60330154D1 DE60330154T DE60330154T DE60330154D1 DE 60330154 D1 DE60330154 D1 DE 60330154D1 DE 60330154 T DE60330154 T DE 60330154T DE 60330154 T DE60330154 T DE 60330154T DE 60330154 D1 DE60330154 D1 DE 60330154D1
- Authority
- DE
- Germany
- Prior art keywords
- dha
- epa
- present
- compounds
- tri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 4
- 229960005135 eicosapentaenoic acid Drugs 0.000 abstract 4
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 4
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical class CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 2
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 235000020669 docosahexaenoic acid Nutrition 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 abstract 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 229940090949 docosahexaenoic acid Drugs 0.000 abstract 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40279802P | 2002-08-12 | 2002-08-12 | |
| PCT/US2003/025336 WO2004014835A2 (en) | 2002-08-12 | 2003-08-12 | Resolvins: biotemplates for therapeutic interventions |
| US10/639,714 US7585856B2 (en) | 2002-08-12 | 2003-08-12 | Resolvins: Biotemplates for novel therapeutic interventions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60330154D1 true DE60330154D1 (de) | 2009-12-31 |
Family
ID=31720623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60330154T Expired - Lifetime DE60330154D1 (de) | 2002-08-12 | 2003-08-12 | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7585856B2 (de) |
| EP (3) | EP2216318B1 (de) |
| JP (7) | JP4845378B2 (de) |
| AT (1) | ATE449057T1 (de) |
| AU (2) | AU2003258194B2 (de) |
| CA (1) | CA2495260C (de) |
| DE (1) | DE60330154D1 (de) |
| DK (1) | DK2216318T3 (de) |
| ES (1) | ES2700133T3 (de) |
| HU (1) | HUE041471T2 (de) |
| SI (1) | SI2216318T1 (de) |
| WO (1) | WO2004014835A2 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3846801A (en) | 2000-02-16 | 2001-08-27 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| US7700650B2 (en) | 2000-03-20 | 2010-04-20 | Trustees Of Boston University | Lipoxin analogs and method for the treatment of periodontal disease |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| CA2495260C (en) * | 2002-08-12 | 2012-05-29 | Brigham And Women's Hospital | Resolvins: biotemplates for novel therapeutic interventions |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| EP1755537A4 (de) * | 2004-04-14 | 2009-12-09 | Univ Boston | Verfahren und zusammensetzungen zur prävention oder behandlung von periodontopathien |
| JP2008520739A (ja) * | 2004-11-19 | 2008-06-19 | マーテック・バイオサイエンシーズ・コーポレーション | 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製および使用方法 |
| US20090318394A1 (en) * | 2004-11-19 | 2009-12-24 | Julie Nauroth | Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same |
| US7893106B2 (en) * | 2004-11-19 | 2011-02-22 | Martek Biosciences, Corporation | Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same |
| US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| EP1954291A1 (de) * | 2005-11-18 | 2008-08-13 | Trustees Of Boston University | Behandlung und prävention von knochenschwund mithilfe von resolvinen |
| WO2007090162A2 (en) * | 2006-01-31 | 2007-08-09 | Martek Biosciences Corporation | OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME |
| AU2007243282A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| JP2009545527A (ja) * | 2006-07-19 | 2009-12-24 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 粘膜炎の治療用の組成物及び方法 |
| WO2008063772A2 (en) * | 2006-10-13 | 2008-05-29 | The Brigham And Women's Hospital Inc. | Resolvin d series and protectin d1 mitigate acute kidney injury |
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| WO2008143642A2 (en) * | 2006-11-09 | 2008-11-27 | Children's Medical Center Corporation | Methods of treating and preventing ocular neovascularization with omega-3 polyunsaturated fatty acids |
| US20110190389A1 (en) * | 2007-02-20 | 2011-08-04 | Linda Arterburn | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| US20110027841A1 (en) * | 2007-12-21 | 2011-02-03 | Martek Biosciences Corporation | Method for preparation of oxylipins |
| WO2009143363A2 (en) * | 2008-05-21 | 2009-11-26 | The Brigham And Women's Hospital, Inc. | Functional metabolomics coupled microfluidic chemotaxis device and identification of novel cell mediators |
| ES2792676T3 (es) | 2008-09-16 | 2020-11-11 | Brigham & Womens Hospital Inc | Compuestos del ácido 14-hidroxi-docosahexaenoico |
| JP5523439B2 (ja) | 2009-02-20 | 2014-06-18 | 国立大学法人 東京大学 | 新規抗炎症性化合物 |
| WO2012170791A2 (en) * | 2011-06-10 | 2012-12-13 | The Brigham And Women's Hospital, Inc. | Docosahexaenoyl ethanolamides |
| EP2887923B1 (de) | 2012-08-24 | 2023-04-05 | Sun Pharmaceutical Industries Limited | Ophthalmische formulierung eines polyoxyllipids oder einer polyoxylfettsäure und behandlung von augenleiden |
| US9463177B2 (en) | 2012-09-10 | 2016-10-11 | The Regents Of The University Of California | Compounds and methods for modulating vascular injury |
| CN103588671A (zh) * | 2013-10-28 | 2014-02-19 | 史克勇 | 癌性疼痛治疗药物 |
| CN103588670A (zh) * | 2013-10-28 | 2014-02-19 | 史克勇 | 一种癌痛药物 |
| CN103601649A (zh) * | 2013-10-28 | 2014-02-26 | 史克勇 | 新型化合物 |
| CN103588673A (zh) * | 2013-10-29 | 2014-02-19 | 史克勇 | 癌痛药物 |
| FR3029836B1 (fr) * | 2014-12-11 | 2016-12-23 | Saint Gobain | Feuillete d'une feuille de materiau polymere epais et d'une feuille de verre mince |
| CN114377138A (zh) * | 2015-03-18 | 2022-04-22 | 福塞斯儿童牙科医院 | 使用脂氧素、消退素及其类似物稳定动脉粥状硬化斑块的方法 |
| ES2607715B1 (es) * | 2015-10-01 | 2018-01-17 | Solutex Na, Lcc | Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa |
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| WO2017205582A1 (en) | 2016-05-27 | 2017-11-30 | Forsyth Dental Infirmary For Children | Compositions and methods of treating cancer using lipid agonists and receptors thereof |
| CA3114750A1 (en) | 2018-10-09 | 2020-04-16 | University Of Rochester | Treatment of vulvovaginal disorders |
| US20230099067A1 (en) * | 2020-02-18 | 2023-03-30 | National University Corporation Hokkaido University | Stable equivalent of resolvin e2 |
| AU2023209802A1 (en) * | 2022-01-20 | 2024-08-29 | Mohamed BENDERDOUR | Resolvin analogs compounds, methods and uses thereof |
| WO2023168245A2 (en) | 2022-03-03 | 2023-09-07 | Thetis Pharmaceuticals Llc | Cyclodextrin complexes of specialized proresolving mediators |
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2003
- 2003-08-12 CA CA2495260A patent/CA2495260C/en not_active Expired - Lifetime
- 2003-08-12 EP EP09009237.0A patent/EP2216318B1/de not_active Expired - Lifetime
- 2003-08-12 DK DK09009237.0T patent/DK2216318T3/en active
- 2003-08-12 AU AU2003258194A patent/AU2003258194B2/en not_active Expired
- 2003-08-12 US US10/639,714 patent/US7585856B2/en not_active Expired - Lifetime
- 2003-08-12 EP EP18199438.5A patent/EP3584235A3/de not_active Withdrawn
- 2003-08-12 ES ES09009237T patent/ES2700133T3/es not_active Expired - Lifetime
- 2003-08-12 WO PCT/US2003/025336 patent/WO2004014835A2/en active Application Filing
- 2003-08-12 SI SI200332587T patent/SI2216318T1/sl unknown
- 2003-08-12 JP JP2004528101A patent/JP4845378B2/ja not_active Expired - Lifetime
- 2003-08-12 HU HUE09009237A patent/HUE041471T2/hu unknown
- 2003-08-12 EP EP03785253A patent/EP1537067B1/de not_active Expired - Lifetime
- 2003-08-12 AT AT03785253T patent/ATE449057T1/de not_active IP Right Cessation
- 2003-08-12 DE DE60330154T patent/DE60330154D1/de not_active Expired - Lifetime
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2009
- 2009-07-08 US US12/499,528 patent/US20100016432A1/en not_active Abandoned
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2010
- 2010-01-22 JP JP2010012499A patent/JP5410314B2/ja not_active Expired - Lifetime
- 2010-02-10 AU AU2010200473A patent/AU2010200473A1/en not_active Abandoned
- 2010-12-16 US US12/970,924 patent/US20130217771A1/en not_active Abandoned
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- 2012-11-29 JP JP2012261696A patent/JP6097536B2/ja not_active Expired - Lifetime
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2014
- 2014-10-24 JP JP2014217081A patent/JP2015025010A/ja not_active Withdrawn
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2016
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