JP4960087B2 - 血管保護物質の組合せおよびそれらを含む製剤 - Google Patents
血管保護物質の組合せおよびそれらを含む製剤 Download PDFInfo
- Publication number
- JP4960087B2 JP4960087B2 JP2006515963A JP2006515963A JP4960087B2 JP 4960087 B2 JP4960087 B2 JP 4960087B2 JP 2006515963 A JP2006515963 A JP 2006515963A JP 2006515963 A JP2006515963 A JP 2006515963A JP 4960087 B2 JP4960087 B2 JP 4960087B2
- Authority
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- Japan
- Prior art keywords
- composition according
- policosanol
- composition
- procyanidol
- primrose oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000000203 mixture Substances 0.000 title claims description 12
- 239000000126 substance Substances 0.000 title description 7
- 230000001681 protective effect Effects 0.000 title description 3
- 230000002792 vascular Effects 0.000 title description 3
- 238000009472 formulation Methods 0.000 title description 2
- 239000003921 oil Substances 0.000 claims description 11
- SBZWTSHAFILOTE-SOUVJXGZSA-N (2R,3S,4S)-leucocyanidin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3[C@H](O)[C@@H]2O)=CC=C(O)C(O)=C1 SBZWTSHAFILOTE-SOUVJXGZSA-N 0.000 claims description 10
- 150000003904 phospholipids Chemical class 0.000 claims description 9
- 229960001109 policosanol Drugs 0.000 claims description 9
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 9
- 241000245063 Primula Species 0.000 claims description 5
- 235000016311 Primula vulgaris Nutrition 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 4
- 235000012661 lycopene Nutrition 0.000 claims description 4
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 3
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims description 3
- 240000007817 Olea europaea Species 0.000 claims description 3
- 240000006365 Vitis vinifera Species 0.000 claims description 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 3
- 229920002770 condensed tannin Polymers 0.000 claims description 3
- 235000008524 evening primrose extract Nutrition 0.000 claims description 3
- 229940089020 evening primrose oil Drugs 0.000 claims description 3
- 239000010475 evening primrose oil Substances 0.000 claims description 3
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 3
- 229940114124 ferulic acid Drugs 0.000 claims description 3
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 3
- 235000001785 ferulic acid Nutrition 0.000 claims description 3
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims description 3
- 229960004999 lycopene Drugs 0.000 claims description 3
- 239000001751 lycopene Substances 0.000 claims description 3
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 3
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims description 3
- 208000019553 vascular disease Diseases 0.000 claims description 3
- 229940114081 cinnamate Drugs 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 230000000378 dietary effect Effects 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 235000010181 horse chestnut Nutrition 0.000 claims description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 2
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 claims description 2
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 claims description 2
- 235000009498 luteolin Nutrition 0.000 claims description 2
- 235000016709 nutrition Nutrition 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical class [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 2
- 241000157282 Aesculus Species 0.000 claims 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 claims 1
- 240000003553 Leptospermum scoparium Species 0.000 claims 1
- 235000015459 Lycium barbarum Nutrition 0.000 claims 1
- 239000003529 anticholesteremic agent Substances 0.000 claims 1
- 229940127226 anticholesterol agent Drugs 0.000 claims 1
- 235000019198 oils Nutrition 0.000 description 10
- 229930003802 tocotrienol Natural products 0.000 description 9
- 239000011731 tocotrienol Substances 0.000 description 9
- 235000019148 tocotrienols Nutrition 0.000 description 9
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 235000008390 olive oil Nutrition 0.000 description 3
- 239000004006 olive oil Substances 0.000 description 3
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 3
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
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- 241000207836 Olea <angiosperm> Species 0.000 description 2
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- 210000004369 blood Anatomy 0.000 description 2
- 238000012261 overproduction Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 description 1
- 241000157280 Aesculus hippocastanum Species 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
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- 241000196324 Embryophyta Species 0.000 description 1
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- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
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- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 241000219925 Oenothera Species 0.000 description 1
- 235000004496 Oenothera biennis Nutrition 0.000 description 1
- 235000002725 Olea europaea Nutrition 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
- 235000001855 Portulaca oleracea Nutrition 0.000 description 1
- 235000001466 Ribes nigrum Nutrition 0.000 description 1
- 241001312569 Ribes nigrum Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- GGCLNOIGPMGLDB-GYKMGIIDSA-N cholest-5-en-3-one Chemical compound C1C=C2CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 GGCLNOIGPMGLDB-GYKMGIIDSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N cinnamic acid Chemical class OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940030275 epigallocatechin gallate Drugs 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 235000002532 grape seed extract Nutrition 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002664 lycopenes Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229940068778 tocotrienols Drugs 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Mycology (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Botany (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
純粋なまたは抽出物としての、1種または複数のポリコサノールまたはそのエステル、
オコトリエノールおよび/またはリコペン、好ましくはトコトリエノール、
リン脂質と場合により複合体を形成した、1種または複数のプロシアニドールオリゴマー、
ω−3、ω−6不飽和脂肪酸に富む植物油
を含む、医薬の、食餌の、または栄養の組成物に関する。
コメポリコサノール(ポリコサノール70%) 15mg
トコトリエノール 14mg
プロシアニドールオリゴマー/リン脂質 320mg
メマツヨイグサ油 十分量で500mgにする
1日2カプセルで2ヶ月間治療後、患者の脂質パラメータは正常化を示し、エコドップラー(EcoDoppler)が立証したようにプラークの状態は改善を示した。
コメまたはオリーブ残油由来ポリコサノール 15mg
トコトリエノール 14mg
プロシアニドールオリゴマー/リン脂質 320mg
メマツヨイグサ油 合計で500mgにする十分量
オリーブ残油由来ポリコサノールフェルラ酸
エステル化物 30mg
トコトリエノール 14mg
プロシアニドールオリゴマー/リン脂質 250mg
メマツヨイグサ油 合計で500mgにする十分量
オクタコサニルフェルラート 12mg
トコトリエノール 12mg
没食子酸エピガロカテキン/ホスファチジルコリン1:1 250mg
エイコサペンタン酸エチル 合計で500mgにする十分量
コメまたはオリーブ残油由来ポリコサノールフェルラ酸
エステル化物 15mg
トコトリエノール 14mg
プロシアニドールオリゴマー/リン脂質 250mg
メマツヨイグサ油 合計で500mgにする十分量
コメまたはオリーブ残油由来ポリコサノール 15mg
トコトリエノール 14mg
プロシアニドールオリゴマー 150mg
メマツヨイグサ油 合計で500mgにする十分量
Claims (6)
- 純粋なまたは抽出物としての、1種または複数のポリコサノールまたはそのエステル、
リコペン、
リン脂質と複合体を形成した1種または複数のプロシアニドールオリゴマー、
メマツヨイグサ油
を含む、医薬の、食餌の、または栄養の、コレステロール低下剤用の組成物。 - ルテオリンをそれ自体で、または7,3’,4’−ヒドロキシエチル誘導体の形態でさらに含む、請求項1に記載の組成物。
- ポリコサノールが、フェルラ酸または他の様々に置換されたシンナマートでエステル化されている、請求項1または2に記載の組成物。
- プロシアニドールオリゴマーが、ヨーロッパブドウ、チャノキ、セイヨウトチノキ、オリーブに由来する、請求項1から3のいずれか一項に記載の組成物。
- 1単位投与形態当たり、ポリコサノールを5〜30mg、リコペンを1〜50mg、リン脂質と複合体を形成したプロアントシアニジンを100〜320mg、メマツヨイグサ油を150〜300mg含む、請求項1から4のいずれか一項に記載の組成物。
- 過剰な血漿脂質によって引き起こされる血管の疾病の予防用または治療用の、請求項1から5のいずれか一項に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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ITMI2003A001313 | 2003-06-27 | ||
IT001313A ITMI20031313A1 (it) | 2003-06-27 | 2003-06-27 | Associazioni di agenti vasoprotettori e formulazioni che li contengono. |
PCT/EP2004/006507 WO2005000041A1 (en) | 2003-06-27 | 2004-06-17 | Combinations of vasoprotective agents and formulations containing them |
Publications (2)
Publication Number | Publication Date |
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JP2007519603A JP2007519603A (ja) | 2007-07-19 |
JP4960087B2 true JP4960087B2 (ja) | 2012-06-27 |
Family
ID=30131309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006515963A Expired - Lifetime JP4960087B2 (ja) | 2003-06-27 | 2004-06-17 | 血管保護物質の組合せおよびそれらを含む製剤 |
Country Status (22)
Country | Link |
---|---|
US (3) | US20090036520A1 (ja) |
EP (1) | EP1638417B1 (ja) |
JP (1) | JP4960087B2 (ja) |
KR (1) | KR101165934B1 (ja) |
CN (1) | CN100475061C (ja) |
AU (1) | AU2004251009B2 (ja) |
BR (1) | BRPI0411811B1 (ja) |
CA (1) | CA2530660C (ja) |
DK (1) | DK1638417T3 (ja) |
ES (1) | ES2704633T3 (ja) |
HK (1) | HK1090519A1 (ja) |
HU (1) | HUE042048T2 (ja) |
IT (1) | ITMI20031313A1 (ja) |
MX (1) | MXPA05013625A (ja) |
NO (1) | NO330523B1 (ja) |
NZ (1) | NZ544399A (ja) |
PL (1) | PL1638417T3 (ja) |
PT (1) | PT1638417T (ja) |
RU (2) | RU2361430C2 (ja) |
SI (1) | SI1638417T1 (ja) |
TR (1) | TR201900241T4 (ja) |
WO (1) | WO2005000041A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8017153B2 (en) | 2006-02-07 | 2011-09-13 | U.S. Nutraceuticals, LLC | Dietary supplement composition for blood lipid health |
US8202541B2 (en) * | 2006-02-07 | 2012-06-19 | U.S. Nutraceuticals, LLC | Dietary supplement composition for blood lipid health |
JP4469407B1 (ja) * | 2009-06-30 | 2010-05-26 | 株式会社ファンケル | 血中中性脂肪低下剤 |
JP4469406B1 (ja) * | 2009-06-30 | 2010-05-26 | 株式会社ファンケル | 血中コレステロール低下剤 |
KR101294970B1 (ko) * | 2011-06-30 | 2013-08-09 | 고려대학교 산학협력단 | 폴리코사놀 에스터, 이의 제조 방법 및 이를 포함하는 첨가제 |
AU2014235779B2 (en) * | 2013-03-15 | 2015-11-26 | NanoRx, Inc. | Metadichol liquid and gel nanoparticle formulations |
IT201900020808A1 (it) * | 2019-11-11 | 2021-05-11 | Neilos S R L | Composizione per la riduzione del rischio cardiovascolare |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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IT1265312B1 (it) * | 1993-12-21 | 1996-10-31 | Indena Spa | Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di |
JP3142245B2 (ja) * | 1996-06-28 | 2001-03-07 | 株式会社資生堂 | 皮膚外用剤 |
IT1283143B1 (it) * | 1996-07-12 | 1998-04-07 | Indena Spa | Metodo di estrazione del licopene ed estratti che lo contengono |
JP2001511153A (ja) * | 1997-02-04 | 2001-08-07 | ブイ. コスバブ,ジョン | 血管変性性疾患の予防および処置のための組成物および方法 |
US5846569A (en) * | 1997-06-20 | 1998-12-08 | Creative Labs, Inc. | Colostrum supplement |
AU9209898A (en) * | 1997-09-02 | 1999-03-22 | Ricex Company, Inc., The | A method for treating hypercholesterolemia, hyperlipidemia, and atherosclerosis |
IT1296920B1 (it) * | 1997-12-04 | 1999-08-03 | Indena Spa | Uso di complessi di estratti vitis vinifera con fosfolipidi come agenti anti-aterosclerotici |
AT407821B (de) * | 1998-03-24 | 2001-06-25 | Franz Dr Stueckler | Mittel auf der basis von naturstoffen |
KR20000019717A (ko) * | 1998-09-15 | 2000-04-15 | 박호군 | 루틴 및 쿼세틴을 포함하는 고지혈증, 동맥경화증 및 간 질환의예방 및 치료용 조성물 |
FR2792831B1 (fr) * | 1999-04-28 | 2001-08-03 | Bionatec Sarl | Composition a destination cosmetique et/ou dietetique comprenant un melange de lycopene et d'extrait de feuille d'olivier |
KR100319397B1 (ko) | 1999-07-12 | 2002-01-05 | 남 승 우 | 천연식물소재 추출물을 이용한 항혈전 및 고지혈증 억제 조성물 |
US6667064B2 (en) * | 2000-08-30 | 2003-12-23 | Pilot Therapeutics, Inc. | Composition and method for treatment of hypertriglyceridemia |
US20020120001A1 (en) * | 2000-10-13 | 2002-08-29 | Ashni Naturaceuticals, Inc. | Compositions containing tryptamines, cartenoids and tocotrienols and having synergistic antioxidant effect |
IT1320180B1 (it) * | 2000-12-29 | 2003-11-26 | Hunza Di Marazzita Maria Carme | Preparazioni nutrizionali e terapeutiche dotate di attivita'antiossidante ed in grado di controllare gli eccessi ponderali e |
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2003
- 2003-06-27 IT IT001313A patent/ITMI20031313A1/it unknown
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2004
- 2004-06-17 ES ES04739969T patent/ES2704633T3/es not_active Expired - Lifetime
- 2004-06-17 SI SI200432457T patent/SI1638417T1/sl unknown
- 2004-06-17 BR BRPI0411811-1A patent/BRPI0411811B1/pt not_active IP Right Cessation
- 2004-06-17 DK DK04739969.6T patent/DK1638417T3/en active
- 2004-06-17 NZ NZ544399A patent/NZ544399A/en unknown
- 2004-06-17 PL PL04739969T patent/PL1638417T3/pl unknown
- 2004-06-17 AU AU2004251009A patent/AU2004251009B2/en not_active Ceased
- 2004-06-17 CN CNB2004800177716A patent/CN100475061C/zh not_active Expired - Fee Related
- 2004-06-17 JP JP2006515963A patent/JP4960087B2/ja not_active Expired - Lifetime
- 2004-06-17 KR KR1020057024537A patent/KR101165934B1/ko active IP Right Grant
- 2004-06-17 PT PT04739969T patent/PT1638417T/pt unknown
- 2004-06-17 HU HUE04739969A patent/HUE042048T2/hu unknown
- 2004-06-17 MX MXPA05013625A patent/MXPA05013625A/es active IP Right Grant
- 2004-06-17 EP EP04739969.6A patent/EP1638417B1/en not_active Expired - Lifetime
- 2004-06-17 WO PCT/EP2004/006507 patent/WO2005000041A1/en active Application Filing
- 2004-06-17 TR TR2019/00241T patent/TR201900241T4/tr unknown
- 2004-06-17 US US10/562,214 patent/US20090036520A1/en not_active Abandoned
- 2004-06-17 RU RU2005140574/13A patent/RU2361430C2/ru not_active IP Right Cessation
- 2004-06-17 CA CA2530660A patent/CA2530660C/en not_active Expired - Fee Related
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2005
- 2005-12-23 NO NO20056162A patent/NO330523B1/no not_active IP Right Cessation
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2006
- 2006-10-17 HK HK06111347.1A patent/HK1090519A1/xx not_active IP Right Cessation
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2009
- 2009-03-12 RU RU2009109089/13A patent/RU2489907C2/ru not_active IP Right Cessation
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2010
- 2010-03-10 US US12/721,015 patent/US20100160427A1/en not_active Abandoned
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2011
- 2011-02-24 US US13/033,826 patent/US8206759B2/en not_active Expired - Fee Related
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