KR102313997B1 - 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 - Google Patents
인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 Download PDFInfo
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- KR102313997B1 KR102313997B1 KR1020157025483A KR20157025483A KR102313997B1 KR 102313997 B1 KR102313997 B1 KR 102313997B1 KR 1020157025483 A KR1020157025483 A KR 1020157025483A KR 20157025483 A KR20157025483 A KR 20157025483A KR 102313997 B1 KR102313997 B1 KR 102313997B1
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020217032762A KR102509562B1 (ko) | 2013-02-20 | 2014-02-20 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767071P | 2013-02-20 | 2013-02-20 | |
| US61/767,071 | 2013-02-20 | ||
| US201361888255P | 2013-10-08 | 2013-10-08 | |
| US61/888,255 | 2013-10-08 | ||
| PCT/US2014/017364 WO2014130657A1 (en) | 2013-02-20 | 2014-02-20 | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217032762A Division KR102509562B1 (ko) | 2013-02-20 | 2014-02-20 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160015195A KR20160015195A (ko) | 2016-02-12 |
| KR102313997B1 true KR102313997B1 (ko) | 2021-10-20 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237008246A Active KR102685501B1 (ko) | 2013-02-20 | 2014-02-20 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
| KR1020217032762A Active KR102509562B1 (ko) | 2013-02-20 | 2014-02-20 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
| KR1020157025483A Active KR102313997B1 (ko) | 2013-02-20 | 2014-02-20 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237008246A Active KR102685501B1 (ko) | 2013-02-20 | 2014-02-20 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
| KR1020217032762A Active KR102509562B1 (ko) | 2013-02-20 | 2014-02-20 | 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료 |
Country Status (20)
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| AU (2) | AU2014218976B2 (enExample) |
| BR (1) | BR112015019603A2 (enExample) |
| CA (1) | CA2901960C (enExample) |
| DK (1) | DK2958943T3 (enExample) |
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| RU (1) | RU2708032C2 (enExample) |
| SG (1) | SG11201505896YA (enExample) |
| WO (1) | WO2014130657A1 (enExample) |
Families Citing this family (227)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140127816A (ko) | 2012-02-22 | 2014-11-04 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암의 치료에 유용한 t 세포의 지속성 집단을 생성시키기 위한 조성물 및 방법 |
| WO2014100615A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| US9573988B2 (en) | 2013-02-20 | 2017-02-21 | Novartis Ag | Effective targeting of primary human leukemia using anti-CD123 chimeric antigen receptor engineered T cells |
| CN111139256A (zh) | 2013-02-20 | 2020-05-12 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
| US9745368B2 (en) | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US10676528B2 (en) * | 2013-12-06 | 2020-06-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thymic stromal lymphopoietin receptor-specific chimeric antigen receptors and methods using same |
| US10640569B2 (en) | 2013-12-19 | 2020-05-05 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
| EP4420663A3 (en) | 2013-12-20 | 2024-10-30 | Novartis AG | Regulatable chimeric antigen receptor |
| ES2963718T3 (es) | 2014-01-21 | 2024-04-01 | Novartis Ag | Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras |
| US10189908B2 (en) | 2014-02-05 | 2019-01-29 | The University Of Chicago | Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants |
| CA2937750A1 (en) * | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methods for activating t cells using an inducible chimeric polypeptide |
| CA2942101A1 (en) | 2014-03-21 | 2015-09-24 | Abbvie Inc. | Anti-egfr antibodies and antibody drug conjugates |
| LT3129470T (lt) | 2014-04-07 | 2021-07-12 | Novartis Ag | Vėžio gydymas naudojant anti-cd19 chimerinį antigeno receptorių |
| WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
| CN107109420A (zh) | 2014-07-21 | 2017-08-29 | 诺华股份有限公司 | 使用cll-1嵌合抗原受体的癌症治疗 |
| SG10201913765YA (en) | 2014-07-21 | 2020-03-30 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
| JP7054622B2 (ja) | 2014-07-21 | 2022-04-14 | ノバルティス アーゲー | ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置 |
| CA2956307A1 (en) * | 2014-07-29 | 2016-02-04 | Pfizer Inc. | Egfrviii specific chimeric antigen receptors for cancer immunotherapy |
| EP3660042B1 (en) | 2014-07-31 | 2023-01-11 | Novartis AG | Subset-optimized chimeric antigen receptor-containing t-cells |
| AU2015305531B2 (en) | 2014-08-19 | 2021-05-20 | Novartis Ag | Anti-CD123 chimeric antigen receptor (CAR) for use in cancer treatment |
| US11111288B2 (en) | 2014-08-28 | 2021-09-07 | Bioatla, Inc. | Conditionally active chimeric antigen receptors for modified t-cells |
| ES3034398T3 (en) | 2014-08-28 | 2025-08-18 | Bioatla Inc | Conditionally active chimeric antigen receptors for modified t-cells |
| CA2959168A1 (en) | 2014-09-02 | 2016-03-10 | Bellicum Pharmaceuticals, Inc. | Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides |
| WO2016034666A1 (en) | 2014-09-04 | 2016-03-10 | Cellectis | Trophoblast glycoprotein (5t4, tpbg) specific chimeric antigen receptors for cancer immunotherapy |
| KR20250067191A (ko) | 2014-09-17 | 2025-05-14 | 노파르티스 아게 | 입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화 |
| CN114107424A (zh) | 2014-10-08 | 2022-03-01 | 诺华股份有限公司 | 预测针对嵌合抗原受体疗法的治疗应答性的生物标志及其用途 |
| CA2972597A1 (en) | 2014-12-29 | 2016-07-07 | Novartis Ag | Methods of making chimeric antigen receptor-expressing cells |
| WO2016112272A1 (en) * | 2015-01-09 | 2016-07-14 | Metastat, Inc. | Method of use for inhibitors of epidermal growth factor receptor variant iii |
| WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
| CN107683289B (zh) | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2结合剂和其在癌症治疗中的用途 |
| EP3250611B1 (en) | 2015-01-26 | 2021-04-21 | The University of Chicago | Car t-cells recognizing cancer-specific il 13r-alpha2 |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| US20160228547A1 (en) * | 2015-02-06 | 2016-08-11 | Batu Biologics, Inc. | Chimeric antigen receptor targeting of tumor endothelium |
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| Cancer Sci., 2010, 제101권, 제12호, 페이지 2518-2524* |
| Human Gene Therapy, 2012, 제23권, 페이지 1043-1053* |
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