AU2014218976B2 - Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor - Google Patents

Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor Download PDF

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AU2014218976B2
AU2014218976B2 AU2014218976A AU2014218976A AU2014218976B2 AU 2014218976 B2 AU2014218976 B2 AU 2014218976B2 AU 2014218976 A AU2014218976 A AU 2014218976A AU 2014218976 A AU2014218976 A AU 2014218976A AU 2014218976 B2 AU2014218976 B2 AU 2014218976B2
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sequence
acid sequence
amino acid
car
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AU2014218976A1 (en
Inventor
Jennifer BROGDON
Laura Alexandra JOHNSON
Carl H. June
Andreas Loew
Marcela Maus
Hideho Okada
John Scholler
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Novartis AG
University of Pennsylvania
University of Pittsburgh
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Novartis AG
University of Pennsylvania
University of Pittsburgh
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/14—Blood; Artificial blood
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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AU2014218976A 2013-02-20 2014-02-20 Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor Active AU2014218976B2 (en)

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AU2019201075A AU2019201075B2 (en) 2013-02-20 2019-02-15 Treatment of cancer using humanized anti-EGFRVIII chimeric antigen receptor

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US201361767071P 2013-02-20 2013-02-20
US61/767,071 2013-02-20
US201361888255P 2013-10-08 2013-10-08
US61/888,255 2013-10-08
PCT/US2014/017364 WO2014130657A1 (en) 2013-02-20 2014-02-20 Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor

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