JOP20170154B1 - تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة - Google Patents

تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة

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Publication number
JOP20170154B1
JOP20170154B1 JOP/2017/0154A JOP20170154A JOP20170154B1 JO P20170154 B1 JOP20170154 B1 JO P20170154B1 JO P20170154 A JOP20170154 A JO P20170154A JO P20170154 B1 JOP20170154 B1 JO P20170154B1
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JO
Jordan
Prior art keywords
compositions
disorders
treatment
methods
various diseases
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JOP/2017/0154A
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English (en)
Inventor
Jason Cummings W
A Demopulos Gregory
Dudler Thomas
Schwaeble Hans-Wilhelm
W Tjoelker Larry
L Wood Christie
Yabuki Munehisa
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Omeros Corp
Univ Leicester
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Publication of JOP20170154A1 publication Critical patent/JOP20170154A1/ar
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Abstract

يتعلق الاختراع الحالي بأجسام مضادة وتركيبات مثبطة لـ MASP-3 تشتمل على مثل هذه الأجسام المضادة للاستخدام في تثبيط التأثيرات غير الملائمة لتنشيط المتمم المعتمد على MASP-3.
JOP/2017/0154A 2016-08-01 2017-07-03 تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة JOP20170154B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662369674P 2016-08-01 2016-08-01
US201662419420P 2016-11-08 2016-11-08
US201762478336P 2017-03-29 2017-03-29

Publications (2)

Publication Number Publication Date
JOP20170154A1 JOP20170154A1 (ar) 2019-01-30
JOP20170154B1 true JOP20170154B1 (ar) 2023-03-28

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ID=61073545

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Application Number Title Priority Date Filing Date
JOP/2017/0154A JOP20170154B1 (ar) 2016-08-01 2017-07-03 تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة
JOP/2022/0244A JOP20220244A1 (ar) 2016-08-01 2022-10-03 أجسام مضادة ترتبط تحديداً بـ masp-3 لعلاج أمراض واضطرابات متنوعة
JOP/2022/0241A JOP20220241A1 (ar) 2016-08-01 2022-10-03 أحماض نووية تشفر أجسام مضادة ترتبط تحديدا بـ masp-3
JOP/2022/0243A JOP20220243A1 (ar) 2016-08-01 2022-10-03 أجسام مضادة ترتبط تحديداً بـ masp-3 لعلاج أمراض واضطرابات متنوعة
JOP/2022/0245A JOP20220245A1 (ar) 2016-08-01 2022-10-03 أجسام مضادة ترتبط تحديداً بـ masp-3 لعلاج أمراض واضطرابات متنوعة
JOP/2022/0242A JOP20220242A1 (ar) 2016-08-01 2022-10-03 أحماض نووية تشفر أجسام مضادة ترتبط تحديدا بـ masp-3

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JOP/2022/0244A JOP20220244A1 (ar) 2016-08-01 2022-10-03 أجسام مضادة ترتبط تحديداً بـ masp-3 لعلاج أمراض واضطرابات متنوعة
JOP/2022/0241A JOP20220241A1 (ar) 2016-08-01 2022-10-03 أحماض نووية تشفر أجسام مضادة ترتبط تحديدا بـ masp-3
JOP/2022/0243A JOP20220243A1 (ar) 2016-08-01 2022-10-03 أجسام مضادة ترتبط تحديداً بـ masp-3 لعلاج أمراض واضطرابات متنوعة
JOP/2022/0245A JOP20220245A1 (ar) 2016-08-01 2022-10-03 أجسام مضادة ترتبط تحديداً بـ masp-3 لعلاج أمراض واضطرابات متنوعة
JOP/2022/0242A JOP20220242A1 (ar) 2016-08-01 2022-10-03 أحماض نووية تشفر أجسام مضادة ترتبط تحديدا بـ masp-3

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EP (1) EP3490603A4 (ar)
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KR (3) KR102624948B1 (ar)
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AU (4) AU2017306069B2 (ar)
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CA (3) CA3173979A1 (ar)
CL (1) CL2019000230A1 (ar)
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CR (1) CR20190105A (ar)
CU (1) CU24568B1 (ar)
EC (1) ECSP19015192A (ar)
GE (1) GEP20247593B (ar)
IL (3) IL298689B2 (ar)
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WO2017035401A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amide compounds for treatment of immune and inflammatory disorders
WO2017035405A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amino compounds for treatment of immune and inflammatory disorders
JP7133561B2 (ja) 2017-03-01 2022-09-08 アキリオン ファーマシューティカルズ,インコーポレーテッド 医学的障害の治療のためのアリール、ヘテロアリール及び複素環式医薬化合物
WO2018160891A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceutical, Inc. Pharmaceutical compounds for treatment of medical disorders
EP3814374A4 (en) * 2018-05-25 2022-03-09 Achillion Pharmaceuticals, Inc. BIOMARKERS OF NEPHROPATHY ASSOCIATED WITH THE ALTERNATIVE COMPLEMENT PATHWAY
US11814363B2 (en) 2018-09-06 2023-11-14 Achillion Pharmaceuticals, Inc. Morphic forms of danicopan
US11814391B2 (en) 2018-09-06 2023-11-14 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
EP3856164A4 (en) 2018-09-25 2022-07-13 Achillion Pharmaceuticals, Inc. MORPHIC FORMS OF COMPLEMENT FACTOR D INHIBITORS
CN110244053B (zh) * 2019-05-09 2022-03-11 北京大学第三医院(北京大学第三临床医学院) 用于诊断狼疮肾炎并肺动脉高压疾病的分子标志物及其用途
CN112812182B (zh) * 2019-11-15 2023-01-06 深圳宾德生物技术有限公司 一种靶向fgfr4的单链抗体、嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
AU2021209740A1 (en) * 2020-01-21 2022-07-14 Shanghai Biotroy Biotechnique Co., Ltd. SEMG2 antibody and use thereof
MX2023001937A (es) * 2020-08-18 2023-04-05 Omeros Corp Anticuerpos monoclonales, composiciones y métodos para detectar el factor d del complemento.
CN112950324B (zh) * 2021-03-15 2022-06-03 重庆邮电大学 一种知识图谱辅助的成对排序个性化电商推荐方法及系统
CN115304670A (zh) * 2021-05-07 2022-11-08 华南农业大学 一种猫冠状病毒核衣壳蛋白的鼠源单克隆抗体及其编码基因和应用
WO2023173036A2 (en) * 2022-03-10 2023-09-14 Omeros Corporation Masp-2 and masp-3 inhibitors, and related compositions and methods, for treatment of sickle cell disease

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
JP2958076B2 (ja) 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
US5856121A (en) 1994-02-24 1999-01-05 Case Western Reserve University Growth arrest homebox gene
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US7273925B1 (en) 1998-12-15 2007-09-25 Brigham And Women's Hospital, Inc. Methods and products for regulating lectin complement pathway associated complement activation
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
JP2003515338A (ja) * 1999-12-02 2003-05-07 クリスチャン イェンセニウス,イェンス 補体結合酵素、masp−3、及びその使用
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
CA2490007C (en) 2002-07-19 2011-05-24 Omeros Corporation Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from
JP4601426B2 (ja) 2002-09-06 2010-12-22 アレクシオン ファーマシューティカルズ, インコーポレイテッド 補体成分c5に対する抗体を使用する喘息の処置の方法
US20060140939A1 (en) 2003-02-21 2006-06-29 Fung Sek C M Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury
DE102004017370A1 (de) 2004-04-08 2005-10-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh PUFA-PKS Gene aus Ulkenia
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
SG2014010029A (en) 2005-08-19 2014-08-28 Abbott Lab Dual variable domain immunoglobin and uses thereof
ES2628973T3 (es) 2007-05-31 2017-08-04 University Of Washington Mutagénesis inducible de genes diana
KR101870378B1 (ko) 2009-07-17 2018-06-25 릭스하스피탈렛 보체 활성화의 억제제로서의 masp 이소형
EP2462161B1 (en) * 2009-08-06 2017-03-08 Immunas Pharma, Inc. Antibodies that specifically bind to a beta oligomers and use thereof
CA2780713A1 (en) * 2009-09-03 2011-03-10 Vancouver Biotech Ltd. Monoclonal antibodies against gonadotropin-releasing hormone receptor
CN102918061B (zh) * 2010-03-05 2016-06-08 霍夫曼-拉罗奇有限公司 针对人csf-1r的抗体及其用途
US20120122107A1 (en) 2010-11-16 2012-05-17 Aarhus Universitet Homeostatic multidomain protein, and uses for it
HUE049154T2 (hu) * 2011-05-04 2020-09-28 Omeros Corp Készítmények a MASP-2-függõ komplement-aktiválás gátlására
ES2670668T3 (es) * 2012-04-06 2018-05-31 Omeros Corporation Composiciones y métodos para inhibir la MASP-1 y/o la MASP-3 para el tratamiento de la hemoglobinuria nocturna paroxísmica
RU2709351C2 (ru) * 2012-06-18 2019-12-17 Омерос Корпорейшн Композиции и способы ингибирования masp-1, и/или masp-2, и/или masp-3 для лечения различных заболеваний и нарушений
CA2901960C (en) * 2013-02-20 2022-10-04 Novartis Ag Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor
MX2015012225A (es) * 2013-03-13 2016-01-08 Prothena Biosciences Ltd Inmunoterapia tau.
MX2016009954A (es) * 2014-01-29 2017-02-23 Dana Farber Cancer Inst Inc Anticuerpos contra el dominio extracelular de muc1-c (muc1-c/ecd).

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